公开(公告)号：US20080194481A1

公开(公告)日：2008-08-14

申请号：US11932823

申请日：2007-10-31

申请人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

发明人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P9/00 ,  A61P1/00 ,  A61P25/00 ,  C12N1/00 ,  C12N1/20 ,  C12P21/04

CPC分类号： C07K14/58 ,  C07K14/765 ,  C07K2319/01

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US08143026B2

公开(公告)日：2012-03-27

申请号：US12534585

申请日：2009-08-03

申请人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben ,  Paul A. Moore ,  Jason B. Bock ,  David LaFleur

发明人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben ,  Paul A. Moore ,  Jason B. Bock ,  David LaFleur

IPC分类号： C12N15/62 ,  C12N15/81 ,  C12N15/85 ,  C12N15/14 ,  C12N15/16

CPC分类号： C07K14/765 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/35 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

公开(公告)号：US20080004206A1

公开(公告)日：2008-01-03

申请号：US11495624

申请日：2006-07-31

申请人： Craig Rosen ,  Adam Bell ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Jason Bock ,  Michael Laird ,  William Haseltine ,  Douglas Woods ,  Mani Subramanian

发明人： Craig Rosen ,  Adam Bell ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Jason Bock ,  Michael Laird ,  William Haseltine ,  Douglas Woods ,  Mani Subramanian

IPC分类号： A61K38/38 ,  C07H21/04 ,  C07K14/76 ,  C12N15/00 ,  C12N5/00

CPC分类号： C07K14/765 ,  A61K38/38 ,  A61K47/643 ,  C07K2319/31

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20070048282A1

公开(公告)日：2007-03-01

申请号：US11500314

申请日：2006-08-08

申请人： Craig Rosen ,  William Haseltine ,  Paul Moore ,  Jason Bock ,  Adam Bell ,  Yanggu Shi ,  David LaFleur

发明人： Craig Rosen ,  William Haseltine ,  Paul Moore ,  Jason Bock ,  Adam Bell ,  Yanggu Shi ,  David LaFleur

IPC分类号： A61K38/21 ,  A61K38/38 ,  C12P21/04 ,  C12N15/00

CPC分类号： C07K14/765 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/35 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20070172830A1

公开(公告)日：2007-07-26

申请号：US10849979

申请日：2004-05-21

申请人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

发明人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

IPC分类号： C12Q1/68 ,  A61K48/00 ,  A61K38/17 ,  C07K14/47 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070154910A1

公开(公告)日：2007-07-05

申请号：US11565909

申请日：2006-12-01

申请人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

发明人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further re lates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20060281095A1

公开(公告)日：2006-12-14

申请号：US11002754

申请日：2004-12-03

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：US20050208622A1

公开(公告)日：2005-09-22

申请号：US10970493

申请日：2004-10-22

申请人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

发明人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/47

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20050037467A1

公开(公告)日：2005-02-17

申请号：US10936773

申请日：2004-09-09

申请人： Steven Ruben ,  Ping Feng ,  David LaFleur ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Yi Li ,  ZhiZhen Zeng ,  Kenneth Carter ,  Gregory Endress ,  Ying-Fei Wei ,  Ping Fan ,  Craig Rosen

发明人： Steven Ruben ,  Ping Feng ,  David LaFleur ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Yi Li ,  ZhiZhen Zeng ,  Kenneth Carter ,  Gregory Endress ,  Ying-Fei Wei ,  Ping Fan ,  Craig Rosen

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070154918A1

公开(公告)日：2007-07-05

申请号：US11608978

申请日：2006-12-11

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。