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公开(公告)号:US20090082264A1
公开(公告)日:2009-03-26
申请号:US11735351
申请日:2007-04-13
申请人: Carrie L. Fischer , Craig A. Rosen , Daniel R. Soppet , Steven M. Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David W. LaFleur , Paul A. Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles E. Birse
发明人: Carrie L. Fischer , Craig A. Rosen , Daniel R. Soppet , Steven M. Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David W. LaFleur , Paul A. Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles E. Birse
IPC分类号: A61K38/00 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12Q1/68 , G01N33/566 , A61P43/00 , C12Q1/02 , A61K31/70 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号: A01C23/024 , A61K38/00 , C07K14/47 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5091 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US07459531B2
公开(公告)日:2008-12-02
申请号:US11565909
申请日:2006-12-01
申请人: Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人: Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号: C07K14/47
CPC分类号: C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20090247482A1
公开(公告)日:2009-10-01
申请号:US12275899
申请日:2008-11-21
申请人: Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人: Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
CPC分类号: C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US06806351B2
公开(公告)日:2004-10-19
申请号:US09774639
申请日:2001-02-01
申请人: Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
发明人: Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
IPC分类号: C07K14435
CPC分类号: C07K14/47
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US07381800B2
公开(公告)日:2008-06-03
申请号:US10874484
申请日:2004-06-24
申请人: Yanggu Shi , Paul E. Young , Reinhard Ebner , Daniel R. Soppet , Steven M. Ruben
发明人: Yanggu Shi , Paul E. Young , Reinhard Ebner , Daniel R. Soppet , Steven M. Ruben
CPC分类号: C07K14/47
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20090042792A1
公开(公告)日:2009-02-12
申请号:US11962255
申请日:2007-12-21
申请人: Yanggu Shi , Paul E. Young , Reinhard Ebner , Daniel R. Soppet , Steven M. Ruben
发明人: Yanggu Shi , Paul E. Young , Reinhard Ebner , Daniel R. Soppet , Steven M. Ruben
IPC分类号: A61K38/00 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12Q1/02 , A61P31/00 , G01N33/566 , C12Q1/68 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号: C07K14/47
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US06342581B1
公开(公告)日:2002-01-29
申请号:US09227357
申请日:1999-01-08
IPC分类号: A61K3800
CPC分类号: C12N9/00 , A61K38/00 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US06632920B1
公开(公告)日:2003-10-14
申请号:US09716129
申请日:2000-11-17
申请人: Henrik S. Olsen , Steven M. Ruben , Craig A. Rosen , Laurie A. Brewer , Reinhard Ebner , Roxanne Duan , Kimberly Florence
发明人: Henrik S. Olsen , Steven M. Ruben , Craig A. Rosen , Laurie A. Brewer , Reinhard Ebner , Roxanne Duan , Kimberly Florence
IPC分类号: A61K3800
CPC分类号: C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。 PTEXT>
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公开(公告)号:US06486301B1
公开(公告)日:2002-11-26
申请号:US09231788
申请日:1999-01-15
申请人: Reinhard Ebner , Marianne Murphy , Steven M. Ruben , Jing-Shan Hu , D. Roxanne Duan , Kimberly A. Florence , Craig A. Rosen
发明人: Reinhard Ebner , Marianne Murphy , Steven M. Ruben , Jing-Shan Hu , D. Roxanne Duan , Kimberly A. Florence , Craig A. Rosen
IPC分类号: C07K14475
CPC分类号: C07K14/47 , A61K38/00 , C07K14/54 , C07K2319/00 , C12N2799/026
摘要: The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译: 本发明涉及作为细胞因子多肽家族成员的新型IL-20蛋白。 特别地,提供编码人IL-20蛋白的分离的核酸分子。 还提供了IL-20多肽,载体,宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL-20活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号:US07169565B2
公开(公告)日:2007-01-30
申请号:US10960251
申请日:2004-10-08
申请人: Steven M. Ruben , Craig A. Rosen , Reinhard Ebner , Yanggu Shi
发明人: Steven M. Ruben , Craig A. Rosen , Reinhard Ebner , Yanggu Shi
IPC分类号: G01N33/53 , C12N5/12 , C12N1/20 , C12N5/06 , C12N5/16 , C12N5/22 , C07K16/00 , C07K16/18 , C12P21/08
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , G01N33/6893
摘要: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及87种新的人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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