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公开(公告)号：US08224430B2
公开(公告)日：2012-07-17
申请号：US12585861
申请日：2009-09-28
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson , Bruce Hopenfeld , Michael Sasha John
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson , Bruce Hopenfeld , Michael Sasha John
IPC分类号： A61N1/00
CPC分类号： A61B5/0456 , A61B5/0006 , A61B5/0031 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： A system for the detection of cardiac events occurring in a human patient is provided. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal and a patient alarm means is further provided and electrically coupled to the electrical signal processor. The electrical signal is acquired in the form of electrogram segments, which are categorized according to heart rate, ST segment shift and type heart rhythm (normal or abnormal). Baseline electrogram segments are tracked over time.
摘要翻译： 提供了一种用于检测在人类患者中发生的心脏事件的系统。 系统中包括至少两个电极，以从患者的心脏获得电信号。 电信号处理器电耦合到电极以处理电信号，并且还提供患者报警装置并电耦合到电信号处理器。 电信号是以心律，ST段移位和心律（正常或异常）分为心电图段的形式获得的。 基线电描绘片段随时间跟踪。
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公开(公告)号：US20120158116A1
公开(公告)日：2012-06-21
申请号：US12969134
申请日：2010-12-15
CPC分类号： A61F2/958 , A61F2/915 , A61F2/962 , A61F2002/91575 , A61F2002/9522 , A61F2002/9583 , A61L31/02 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/416 , Y10T29/49826 , Y10T29/49888 , Y10T29/49913
摘要： A balloon disposed near a distal end of the catheter tubing and moving between deflated and inflated states, and proximal and distal stent retention bands concentrically arranged around respective proximal and distal end portions of the balloon. The proximal stent retention band has a distal end located within 2 mm of the proximal end of a stent coaxially received by the balloon and the distal stent retention band has a largest diameter within 2 mm of the distal end of the stent received by the balloon.
摘要翻译： 设置在导管管的远端附近并在放气和膨胀状态之间移动的气囊，以及同心地布置在气囊的相应近端部分和远端部分的近端和远端支架保持带。 近端支架保持带的远端位于由球囊同轴接收的支架的近端的2mm内，并且远侧支架保持带具有由球囊接收的支架远端的2mm内的最大直径。
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公开(公告)号：US20120065222A1
公开(公告)日：2012-03-15
申请号：US13047440
申请日：2011-03-14
IPC分类号： A61K31/436 , A61P17/02
CPC分类号： A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2/0063 , A61F2013/00451 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/424 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/626
摘要： Disclosed is a cytostatic drug attached to a sterile sheet that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This sheet onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICEL™ absorbable hemostat gauze-like sheet with an anti-proliferative drug such as sirolimus, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions or scar tissue. Another embodiment of this invention is a cytostatic drug attached to a sheet that is placed at the site of an anastomosis to decrease scar tissue formation from within the vessel at the site of the anastomosis.
摘要翻译： 公开了附着在无菌片上的细胞生长抑制药物，其被设计为放置在体内组织之间以防止术后粘连的形成，这些粘连真的是瘢痕组织形成。 药物放置在药物上或其中的片材可以是永久植入物，也可以是可生物降解的。 通过用诸如西罗莫司之类的抗增殖药物浸渍诸如Johnson＆Johnson SURGICEL TM可吸收止血纱布片的现有产品，可生物降解的药物浸渍网将作为细胞增殖的障碍，因此成为威慑 形成粘连或瘢痕组织。 本发明的另一个实施方案是连接到片材上的细胞生长抑制药物，其被放置在吻合部位以减少在吻合部位的血管内的瘢痕组织形成。
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公开(公告)号：US08080052B2
公开(公告)日：2011-12-20
申请号：US10185250
申请日：2002-06-28
申请人： Robert Burgermeister , David C. Majercak , David R. Fischell , Hikmat Hojeibane , Robert E. Fischell
发明人： Robert Burgermeister , David C. Majercak , David R. Fischell , Hikmat Hojeibane , Robert E. Fischell
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013
摘要： The present invention envisions an improved flexible connecting link used in conjunction with in-phase and half-phase circumferential sets of strut members. By increasing the total length and diagonality of the undulating connecting links, the present invention is a stent that provides increased flexibility during delivery and enhanced conformability to the shape of a curved artery when the stent is deployed into a curved vessel such as a tortuous coronary artery.
摘要翻译： 本发明设想了一种改进的柔性连接链节，其与支柱构件的同相和半相周向组合一起使用。 通过增加起伏的连接链节的总长度和对角线，本发明是一种支架，其在输送期间提供增加的灵活性，并且当支架部署到诸如曲折冠状动脉的弯曲容器时对弯曲动脉的形状具有增强的适应性 。
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公开(公告)号：US08024028B2
公开(公告)日：2011-09-20
申请号：US12379627
申请日：2009-02-26
IPC分类号： A61B5/04
CPC分类号： A61N1/37235 , A61B5/0031 , A61B5/0452 , A61B5/0472 , A61B5/413 , A61N1/025 , A61N1/37247
摘要： Disclosed is a “tracker system” that includes implanted electrical leads which are part of an implanted cardiotracker plus external equipment that includes external alarm means and a physician's programmer. The tracker system is designed to monitor the degradation of a patient's cardiovascular condition from one or more causes. These causes include the rejection of a transplanted heart and/or the progression of a stenosis in a coronary artery. As one or more stenoses in a coronary artery become progressively more narrow thereby causing reduced blood flow to the heart muscle coronary circulation, the tracker system can alert the patient by either or both internal and/or external alarm means to take the appropriate medical action. The physician's programmer can be used to display histograms of key heart signal parameters that are indicative of the patient's cardiovascular condition.
摘要翻译： 公开了一种“跟踪器系统”，其包括植入的电引线，其是植入式心脏病治疗仪的一部分以及包括外部警报装置和医师程序员的外部设备。 跟踪器系统被设计成从一个或多个原因监测患者的心血管疾病的恶化。 这些原因包括移植心脏的排斥和/或冠状动脉狭窄进展。 由于冠状动脉中的一个或多个狭窄变得越来越窄，从而导致血液流向心脏肌肉冠状动脉循环的减少，所以跟踪器系统可以通过内部和/或外部报警装置中的一个或两个来警告患者以采取适当的医疗行动。 医师的程序员可用于显示指示患者心血管疾病的关键心脏信号参数的直方图。
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公开(公告)号：US07844323B2
公开(公告)日：2010-11-30
申请号：US11812827
申请日：2007-06-22
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.
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公开(公告)号：US06936065B2
公开(公告)日：2005-08-30
申请号：US10158714
申请日：2002-05-30
CPC分类号： A61F2/95 , A61F2/958 , A61M2025/0186 , A61M2025/1004
摘要： The present invention is a stent delivery system that uses short section of guidewire fixedly attached to the distal section of a balloon angioplasty catheter onto which a stent is co-axially mounted. By not having a guidewire that slides through the balloon of the balloon angioplasty catheter, the deflated balloon on which the stent is mounted can have a reduced diameter. Therefore, the outer diameter of the pre-deployed stent mounted onto that balloon is also minimized. This provides a smaller profile, i.e., a smaller outer diameter, for the stent. The time to perform a stent delivery procedure is reduced; a separate guidewire does not have to be placed prior to using the stent delivery system to place the stent at the site of a stenosis. Another embodiment of the present invention has a core wire that extends for nearly the entire length of the stent delivery system, the guidewire having different levels of stiffness for different portions of the core wire's length.
摘要翻译： 本发明是一种支架输送系统，其使用固定连接到气囊血管成形术导管的远侧部分的导线短段，支架同轴安装在该支架上。 通过不具有穿过球囊血管成形术导管的球囊的导丝，其上安装支架的放气球可具有减小的直径。 因此，安装在该球囊上的预先展开的支架的外径也被最小化。 这为支架提供了更小的外形，即较小的外径。 执行支架递送程序的时间减少; 在使用支架输送系统将支架置于狭窄部位之前，不必放置单独的导丝。 本发明的另一个实施例具有延伸到支架输送系统的整个长度的芯线，该导丝对于芯线长度的不同部分具有不同的刚度水平。
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28.发明授权System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes 有权用空间分离的检测和刺激电极控制癫痫发作的系统和方法公开(公告)号：US06597954B1
公开(公告)日：2003-07-22
申请号：US09724805
申请日：2000-11-28
IPC分类号： A61N136
CPC分类号： A61N1/0529 , A61B5/0002 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61M5/14276 , A61N1/0534 , A61N1/36064 , A61N1/36082 , G06F19/00
摘要： A system and method for controlling epilepsy and other neurological disorders by providing electrical stimulation to a patient's brain in response to detected neurological conditions. An implantable device includes a stimulation subsystem coupled to a stimulation electrode to provide responsive electrical brain stimulation in response to an event detected via an on-board processor's analysis of data received from a detection subsystem coupled to a detection electrode located in a different portion of the patient's brain.
摘要翻译： 一种通过响应于检测到的神经病症向患者的大脑提供电刺激来控制癫痫和其他神经障碍的系统和方法。 可植入装置包括耦合到刺激电极的刺激子系统，以响应于经由车载处理器对从耦合到位于所述第二部分的不同部分的检测电极的检测子系统接收的数据的分析而检测的事件来响应电脑刺激 病人的大脑
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29.发明授权Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke 有权用于感染和治疗急性心肌梗死和治疗中风的植入式反应系统公开(公告)号：US06468263B1
公开(公告)日：2002-10-22
申请号：US09860693
申请日：2001-05-21
IPC分类号： A61K922
CPC分类号： A61B5/0452 , A61B5/0031 , A61N1/362
摘要： Disclosed is a completely implantable system that can detect the occurrence of a myocardial infarction, i.e., a heart attack, and automatically inject a thrombolytic and/or anti-thrombogenic agent into the bloodstream to promptly dissolve the thrombus that caused the myocardial infarction and prevent the formation of additional thrombi. It is well known that a myocardial infarction can be detected from a patient's electrocardiogram by noting an ST segment voltage deviation. Upon detection of a myocardial infarction, an ST segment deviation electronic detection circuit within the implanted device can produce an output signal that can cause a thrombolytic and/or anti-thrombogenic agent contained within an implanted, pressurized reservoir to immediately and automatically release medications into the patient's bloodstream. A patient warning system is also provided by an audio alarm or an electrical tickle within the human body indicating that a myocardial infarction has been detected. An externally located part of the system, in the form of a patient operated initiator, can be used to trigger the release of medication as soon as a first sign of a stroke has been detected in order to prevent damage to brain tissue that would be caused by that stroke. Thus the system can be used to prevent trissue damage from either a myocardial infarction or a stroke. The implanted system can also send a radio message to an externally located receiver that automatically dials an emergency rescue team to take the patient to a hospital for continuing treatment of a myocardial infarction or a stroke.
摘要翻译： 公开了一种完全可植入的系统，其可以检测心肌梗死的发生，即心脏病发作，并自动将血栓溶解和/或抗血栓形成剂注射到血流中，以迅速溶解引起心肌梗死的血栓，并防止 形成额外的血栓。 众所周知，通过注意到ST段电压偏差，可以从患者的心电图中检测出心肌梗死。 在检测到心肌梗塞时，植入装置内的ST段偏移电子检测电路可以产生输出信号，其可以引起包含在植入的加压贮存器内的血栓溶解和/或抗血栓形成剂立即并自动将药物释放到 病人的血液。 患者预警系统还由人体内的音频警报器或电子痒痒声提供，表明已经检测到心肌梗死。 只要已经检测出中风的第一个迹象，为了防止会导致的脑组织的损伤，可以使用以病人操作的引发剂的形式的系统的外部定位部分，以触发药物的释放 中风。 因此，该系统可用于防止心肌梗塞或中风的三体损伤。 植入的系统还可以向外部定位的接收器发送无线电消息，自动拨打紧急救援队以将病人带到医院继续治疗心肌梗死或中风。
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公开(公告)号：US06459936B2
公开(公告)日：2002-10-01
申请号：US09932175
申请日：2001-08-17
IPC分类号： A61N118
CPC分类号： A61N1/36135 , A61N1/36017 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36075 , A61N1/37252
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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