公开(公告)号：US20070260284A1

公开(公告)日：2007-11-08

申请号：US11381211

申请日：2006-05-02

Applicant: Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

Inventor： Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

IPC: A61N1/362

CPC classification number: A61N1/36114 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/3956

Abstract: Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.

Abstract translation: 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适用于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。

公开(公告)号：US20060293716A1

公开(公告)日：2006-12-28

申请号：US11469620

申请日：2006-09-01

Applicant: Andrew Kramer ,  Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

Inventor： Andrew Kramer ,  Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC: A61N1/36

CPC classification number: A61N1/3627 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/368

Abstract: An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

公开(公告)号：US20060259088A1

公开(公告)日：2006-11-16

申请号：US11129058

申请日：2005-05-13

Applicant: Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

Inventor： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

IPC: A61N1/362

CPC classification number: A61N1/056 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/37205 ,  A61N1/3787 ,  A61N2001/0585

Abstract: An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

公开(公告)号：US20060217773A1

公开(公告)日：2006-09-28

申请号：US11088231

申请日：2005-03-23

Applicant: Qingsheng Zhu ,  Joseph Pastore ,  Rodney Salo

Inventor： Qingsheng Zhu ,  Joseph Pastore ,  Rodney Salo

IPC: A61N1/362

CPC classification number: A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

公开(公告)号：US20060161209A1

公开(公告)日：2006-07-20

申请号：US11037309

申请日：2005-01-18

Applicant: Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

Inventor： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/362

CPC classification number: A61N1/365 ,  A61N1/36592

Abstract: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

Abstract translation: 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

公开(公告)号：US20050288721A1

公开(公告)日：2005-12-29

申请号：US10862716

申请日：2004-06-07

Applicant: Steven Girouard ,  Jeffrey Ross ,  Rodney Salo

Inventor： Steven Girouard ,  Jeffrey Ross ,  Rodney Salo

IPC: A61M5/142 ,  A61M5/172 ,  A61N1/362 ,  A61N1/365

CPC classification number: A61M5/14276 ,  A61M5/1723 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61M2210/125 ,  A61M2230/00 ,  A61N1/36585

Abstract: A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.

Abstract translation: 系统提供心脏起搏治疗和化学和/或生物治疗以调节心肌梗塞（MI）后心脏中的心肌组织生长。 该系统包括用于将一个或多个药剂释放到MI区域以调节该区域中的心肌组织生长的药剂递送装置，以及心律管理（CRM）装置，以递送起搏脉冲以增强一种或多种药剂的作用 改变心肌壁压力和心脏工作量。 在一个实施例中，该系统是包括可植入剂递​​送装置和可植入CRM装置的可植入系统。

公开(公告)号：US20050149143A1

公开(公告)日：2005-07-07

申请号：US10745921

申请日：2003-12-24

Applicant: Imad Libbus ,  Rodney Salo

Inventor： Imad Libbus ,  Rodney Salo

IPC: A61N1/36 ,  A61N1/365 ,  A61N1/18

CPC classification number: A61N1/36117 ,  A61N1/36057 ,  A61N1/36564

Abstract: An aspect relates to an implantable medical device. An embodiment of the device comprises a pulse generator, sensor circuitry, a lead, and a controller. The pulse generator generates baroreflex stimulation pulses. The lead is adapted to be electrically connected to the pulse generator and to the sensor circuitry. The lead includes an electrode to distribute the baroreflex stimulation pulses to a baroreflex site and a pressure sensor to provide a signal indicative of blood pressure to the sensor circuitry. The controller is connected to the pulse generator and the sensor circuitry. The controller adapted to adjust the baroreflex stimulation pulses based on the blood pressure. Other aspects are provided herein.

Abstract translation: 一个方面涉及可植入医疗装置。 该装置的实施例包括脉冲发生器，传感器电路，引线和控制器。 脉冲发生器产生压力反射刺激脉冲。 引线适于电连接到脉冲发生器和传感器电路。 引线包括用于将压力反射刺激脉冲分布到压力反射部位的电极和压力传感器，以向传感器电路提供指示血压的信号。 控制器连接到脉冲发生器和传感器电路。 控制器适于基于血压调节压力反射刺激脉冲。 本文提供了其他方面。

公开(公告)号：US20050102002A1

公开(公告)日：2005-05-12

申请号：US10703398

申请日：2003-11-07

Applicant: Rodney Salo ,  Matthew Salo

Inventor： Rodney Salo ,  Matthew Salo

IPC: A61N1/362 ,  A61N1/365 ,  A61N1/372

CPC classification number: A61N1/3627 ,  A61N1/36514

Abstract: Pacing pulses are delivered to one or more cardiac regions to improve diastolic performance in patients having diastolic dysfunction and/or heart failure. A cardiac pacing system executes a pacing algorithm using a parameter indicative of the diastolic performance as an input. The pacing pulses excite the one or more cardiac regions to redistribute the loading on the ventricular wall during diastole, thereby improving the diastolic performance by lowering the degree of cardiac wall motion dyssynchrony associated with diastolic dysfunction.

Abstract translation: 将起搏脉冲输送到一个或多个心脏区域以改善具有舒张功能障碍和/或心力衰竭的患者的舒张性能。 心脏起搏系统使用表示舒张性能的参数作为输入来执行起搏算法。 起搏脉冲激发一个或多个心脏区域以在舒张期期间重新分布心室壁上的负荷，从而通过降低与舒张功能障碍相关的心脏壁运动不同步的程度来改善舒张性能。

公开(公告)号：US07738967B2

公开(公告)日：2010-06-15

申请号：US11651311

申请日：2007-01-09

Applicant: Rodney Salo

Inventor： Rodney Salo

IPC: A61N1/00

CPC classification number: A61N1/056 ,  A61N1/3627 ,  A61N1/3655 ,  A61N1/36571 ,  A61N2001/0585

Abstract: Methods of cardiac pacing involve sensing left ventricular electrical rhythms, sensing left ventricular blood flow rate, and sensing a coronary vein blood temperature. The methods further involve modifying delivery of synchronized electrical signals to the patient's heart based at least in part on the sensed coronary vein blood temperature and sensed left ventricular flow rate.

Abstract translation: 心脏起搏方法涉及感测左心室电节律，感测左心室血流速度，以及感测冠状静脉血液温度。 所述方法还包括至少部分地基于感测的冠状静脉血液温度和感测的左心室流率来修改同步电信号到患者心脏的传送。

公开(公告)号：US20080300643A1

公开(公告)日：2008-12-04

申请号：US12221332

申请日：2008-08-01

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61N1/37

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: Pacing left and right ventricles of the heart for delivery of heart failure therapy involves measuring right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. At least one parameter of a heart failure pacing therapy is adjusted based on the parameter to improve synchronization of the right and left ventricles.

Abstract translation: 心脏左心室和右心室起搏用于心力衰竭治疗，用于测量右心室压（RV）压力和左心室压（LV）压力，并计算从RV和LV压力测量中的一个或两个发展的参数。 该参数表示左心室和右心室同步的程度。 基于参数调整心力衰竭起搏治疗的至少一个参数，以改善右心室和左心室的同步。