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    Electrical pacing therapy for treating mitral regurgitation
    1.
    发明申请
    Electrical pacing therapy for treating mitral regurgitation 审中-公开
    用于治疗二尖瓣反流的电起搏治疗

    公开(公告)号：US20060173504A1

    公开(公告)日：2006-08-03

    申请号：US11046215

    申请日：2005-01-28

    申请人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

    发明人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

    摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过以在早期心室收缩期间预激活该区域的方式向左心室的选定区域（例如二尖瓣装置附近的一个）提供起搏刺激，可获得有益效果，其可以防止或减少 二尖瓣反流。

    Controlled delivery of electrical pacing therapy for treating mitral regurgitation
    2.
    发明申请
    Controlled delivery of electrical pacing therapy for treating mitral regurgitation 审中-公开
    用于治疗二尖瓣反流的电起搏治疗的控制递送

    公开(公告)号：US20060173505A1

    公开(公告)日：2006-08-03

    申请号：US11116955

    申请日：2005-04-28

    申请人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

    发明人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus or papillary muscles in a manner that pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

    摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过在左心室的选定区域（例如在二尖瓣装置或乳头肌附近的区域）以在早期心室收缩期间预激活该区域的方式提供起搏刺激，可以获得有益效果，其可以预防或减少 二尖瓣反流的程度。

    Linear stimulation of the heart for improved hemodynamic benefit
    4.
    发明申请
    Linear stimulation of the heart for improved hemodynamic benefit 审中-公开
    心脏的线性刺激改善血液动力学效益

    公开(公告)号：US20050102000A1

    公开(公告)日：2005-05-12

    申请号：US10981019

    申请日：2004-11-03

    申请人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

    发明人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

    IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/36

    CPC分类号： A61N1/3627 ,  A61N1/3684

    摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.

    摘要翻译： 用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。 线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。 线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。 通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

    Lead and delivery system to detect and treat a myocardial infarction region
    5.
    发明申请
    Lead and delivery system to detect and treat a myocardial infarction region 审中-公开
    用于检测和治疗心肌梗死区域的牵引和传递系统

    公开(公告)号：US20070100383A1

    公开(公告)日：2007-05-03

    申请号：US11261202

    申请日：2005-10-28

    申请人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

    发明人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0587 ,  A61N1/059 ,  A61N1/3627

    摘要： A method includes mounting an anchor member to a surface of a heart, the anchor member having a tension member coupled to the anchor member, advancing a lead body along the tension member, the lead body including a plurality of electrodes disposed along the lead body, identifying an MI region of the heart, positioning the plurality of electrodes at or near the MI region, affixing the tension member to the lead body to hold the electrodes in position, and delivering pulses through the plurality of electrodes to the heart.

    摘要翻译： 一种方法包括将锚定构件安装到心脏的表面，所述锚定构件具有联接到所述锚定构件的张紧构件，使所述引线体沿着所述张紧构件前进，所述引线主体包括沿着所述引线主体设置的多个电极， 识别心脏的MI区域，将多个电极定位在MI区域处或附近，将张紧构件固定到引线体以将电极保持在适当位置，并且将脉冲通过多个电极传递到心脏。

    Method and apparatus for controlling cardiac therapy based on electromechanical timing
    6.
    发明申请
    Method and apparatus for controlling cardiac therapy based on electromechanical timing 有权
    基于机电定时控制心脏治疗的方法和装置

    公开(公告)号：US20060293714A1

    公开(公告)日：2006-12-28

    申请号：US11168024

    申请日：2005-06-28

    申请人： Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

    发明人： Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627 ,  A61M5/14276 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3756

    摘要： Devices and methods for therapy control based on electromechanical timing involve detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.

    摘要翻译： 基于机电定时的治疗控制的装置和方法涉及检测患者心脏的电激活，以及检测由电激活引起的机械心脏活动。 在电激活和机械活动之间确定时序关系。 基于时间关系控制治疗。 该治疗可以改善患者心脏的心室内不同步，或治疗患者心脏的舒张期和收缩功能障碍和/或不同步中的至少一种。 可以通过感测向心脏传递电刺激脉冲或感测患者心脏的固有去极化来检测电激活。 可以通过感测心脏声音，左心室阻抗，心室压力，右心室压力，左心房压力，右心房压力，全身动脉压力和肺动脉压力中的一个或多个的变化来检测机械活动。

    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
    9.
    发明申请
    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure 有权
    在缺血后或心力衰竭期间调节细胞代谢的方法和装置

    公开(公告)号：US20080091138A1

    公开(公告)日：2008-04-17

    申请号：US11998969

    申请日：2007-12-03

    申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

    摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

    摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。