摘要:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
摘要:
A multi-fold peel-off coupon redemption card includes a plurality of coupons releasably adhered to a base with a release liner. The release liner is composed of a material, such as a dry release adhesive or evaporative adhesive, such that when a coupon is removed from the base substantially no effective adhesive remains on the removed coupon. Each coupon preferably includes promotion indicia and an electronic redemption indicia. The electronic redemption indicia is preferably printed on a face of the coupon facing the base so that each coupon can be electronically redeemed while having sufficient space for the promotion indicia on the opposite face of the coupon.
摘要:
A system and method for providing access and/or roaming features on a network system. The network system includes a plurality of wireless and/or wired access points coupled to a network. Access points (APs) for the network may be widely distributed in various facilities, such as airports, mass-transit stations, and various businesses. The network may couple to a wide area network, such as the Internet. In one embodiment, a portable computing device (PCD) of a user may store identification information which uniquely indicates a network provider of a plurality of possible network providers. The identification information may also or instead indicate an access or privilege level of the user. Each of the access points are operable to “listen for” or detect identification information associated with numerous different providers. When the access point receives the identification information from a PCD of a user, the access point may determine the appropriate network provider for the portable computing device using the identification information. Network access may then be provided to the portable computing device through the determined network provider. Thus the network system is useable by subscribers of each of the plurality of possible network providers, thereby enabling subscribers to “roam” on various wireless networks, including networks maintained by other providers. The access information may also include an access level which indicates the user's access or privilege level. Thus, the local network may provide various local resources which are available to users having a first access level, and users with a second access level may not be entitled to view or utilize these network resources on the network, but may be simply provided external Internet access.
摘要:
A system and method for metering usage of a data processing system and scaling system performance is disclosed. In one embodiment, an authorization key is purchased that specifies both a baseline performance level and a ceiling performance level. After the key is installed on the data processing system, the system performance level is monitored and averaged over predetermined time periods. The customer is charged on a “pay-as-you-go” basis for any time periods during which the average performance level exceeds the baseline performance level. Performance of the data processing system is not allowed to exceed the ceiling level obtained with the authorization key. In one embodiment, the baseline level may be set to zero so that all performance consumption is purchased by the customer as it is utilized. A report may be generated that includes data upon which analysis of the measured processor utilization data may be performed.
摘要:
A cable distribution box, including an authentication device obtaining authentication information from an authentication medium, an access administration system operatively connected to the authentication device for verifying the authentication information and collecting work log data, and an access control system operatively connected to the access administration system granting access to the cable distribution box when the authentication information is verified.
摘要:
A combustor dome assembly for a gas turbine engine having a longitudinal centerline axis extending therethrough, including: an annular dome plate having an inner portion, an outer portion, a forward surface and a plurality of circumferentially spaced openings formed therein, wherein a radial section is defined between adjacent openings; an annular outer cowl connected to the outer portion of the dome plate; an annular inner cowl connected to the inner portion of the dome plate; and, a swirler located between the forward surface of the dome plate and the inner and outer cowls in substantial alignment with each of the openings in the dome plate. Each swirler further includes a forward portion and an aft portion and is retained by at least one tab member located upstream thereof so as to be movable in a radial and axial direction.
摘要:
This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
摘要:
An electrically moveable window assembly and control mechanism for a motor vehicle is disclosed in which when a detachable rear roof section is removed or a retractable rear roof section is folded a frameless window supported by a rear door of the motor vehicle is automatically retracted into the door to prevent it becoming damaged.
摘要:
Apparatus for detecting molecular vapors in an atmospheric region includes an interferometer which monitors light parameter data signals received and provides an interferometer light parameter signal corresponding to the light parameter data signals at a plurality of frequencies. The apparatus further includes an interferogram detector/converter which records and digitizes the interferometer light parameter signal to generate a plurality of discrete data points wherein each discrete data point corresponds to the interferometer light parameter signal at a specific frequency. The apparatus also includes a Fourier transform circuit for receiving the discrete interferometer light parameter signal and providing a Fourier transformed molecular parameter data signal. The apparatus further includes a probabilistic neural network for receiving and sorting the Fourier transformed molecular parameter data signals without the use of a priori training data.
摘要:
In various embodiments, provided are hydrophilically-modified silicone compositions comprising substantially spherical elastomeric microparticles, methods of making such compositions, and silicone pastes, personal care, and healthcare products comprising such silicone compositions.