公开(公告)号：US09810604B2

公开(公告)日：2017-11-07

申请号：US14781200

申请日：2014-03-27

Applicant: Sekisui Medical Co., Ltd.

Inventor： Takuya Yotani ,  Takayuki Oka ,  Hideki Muraki

IPC: G01N35/10 ,  G01N1/14 ,  G01N30/16 ,  G01N15/14 ,  G01N33/49 ,  G01N30/18 ,  G01N30/88

CPC classification number: G01N1/14 ,  G01N15/1429 ,  G01N30/16 ,  G01N30/18 ,  G01N33/491 ,  G01N33/4915 ,  G01N35/1016 ,  G01N35/1095 ,  G01N2015/1486 ,  G01N2030/8822

Abstract: Provided is a sample injection device for flow-type analysis including a cylindrical needle (27) which penetrates through an upper wall and a lower wall of a sample injection portion (22) of a carrier-liquid channel through ring-like sealing members (25, 26). The needle (27) includes an inner hole (41) which is closed on a side of a lower end of the needle (27) and open on an outer peripheral surface as a horizontal hole (42). The needle moving unit (44) induces the needle (27) to move downward so that the horizontal hole (42) faces an inside of a sample vessel (40) to draw the sample to the inside of the needle (27). Then the moving unit (44) induces the needle (27) to move upward so that the horizontal hole (42) faces an inside of the sample injection portion (22) to inject the sample in the inside of the needle (27). At an intermediate position, washing liquid is discharged from the horizontal hole (42) of the needle (27), and the washing liquid is recovered via a discharge path (15).

公开(公告)号：US09447460B2

公开(公告)日：2016-09-20

申请号：US14669735

申请日：2015-03-26

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Takuya Yotani ,  Eiji Kiyotoh ,  Koji Ushizawa

IPC: C12Q1/68 ,  C07H21/00

CPC classification number: C12Q1/6844 ,  C12Q1/6858 ,  C12Q2565/137

Abstract: An object of the present invention is to provide a method for rapidly and simply detecting single nucleotide polymorphisms. The present invention is a method for detecting single nucleotide polymorphisms, comprising analyzing wild-type and mutant-type products amplified by an AS-PCR method using ion-exchange chromatography.

Abstract translation: 本发明的目的是提供一种快速简单地检测单核苷酸多态性的方法。 本发明是用于检测单核苷酸多态性的方法，其特征在于，包括分析通过使用离子交换色谱法的AS-PCR方法扩增的野生型和突变型产物。

公开(公告)号：US20160153942A1

公开(公告)日：2016-06-02

申请号：US14905472

申请日：2014-07-17

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Takuya Yotani ,  Hiroaki Taira ,  Takayuki Oka ,  Hideki Muraki

IPC: G01N30/34 ,  G01N33/49 ,  G01N30/16

CPC classification number: G01N30/34 ,  G01N30/16 ,  G01N30/88 ,  G01N33/491 ,  G01N2030/027 ,  G01N2030/347 ,  G01N2030/8822

Abstract: A gradient liquid feed device allows reduction in size of a high performance liquid chromatography type sample analyzer. The gradient liquid feed device includes a plurality of carrier liquid reservoir tanks configured to store carrier liquids of mutually different compositions, a plurality of single plunger pumps capable of drawing and discharging the carrier liquid from the plurality of carrier liquid reservoir tanks, a mixer configured to mix the carrier liquids discharged from the plurality of liquid feed pumps and feed the mixed carrier liquid, and a pulse damper in communication with the mixer and configured to absorb pulsation that may occur during liquid feeding. The single plunger pumps have a function for variably setting a length of stroke for drawing and discharging the carrier liquid and a function for variably setting a ratio between the carrier liquid drawing time and the carrier liquid discharge time.

Abstract translation: 梯度液体供给装置允许降低高效液相色谱型样品分析仪的尺寸。 梯度液体供给装置包括：多个载液储存箱，其配置成储存相互不同组成的载液;多个单柱塞泵，能够从多个载液储罐中抽吸和排出载液;混合器， 混合从多个液体供给泵排出的载液，并输送混合载液，以及与混合器连通的脉冲阻尼器，并配置成吸收在液体供给期间可能发生的脉动。 单柱塞泵具有用于可变地设定用于抽吸和排出载液的行程长度的功能，以及用于可变地设定载液时间与载液排出时间之间的比率的功能。

公开(公告)号：US20160103103A1

公开(公告)日：2016-04-14

申请号：US14775402

申请日：2014-03-11

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Takuya Yotani ,  Takayuki Oka ,  Hideki Muraki

IPC: G01N30/60 ,  G01N30/16

CPC classification number: G01N30/6026 ,  G01N30/16 ,  G01N30/6004 ,  G01N30/603 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/606 ,  G01N2030/8822

Abstract: A cylindrical column body (101) holds a filler. A pair of end caps (105, 106) covers both ends of the column body (101) and has a flow hole for a carrier liquid (111, 112) arranged in the center thereof. An end surface on the side of a large diameter portion (113a, 114a) of a pair of columnar joint members (113, 114) contacts an end surface of the pair of end caps (105, 106) and also has a communication hole (115, 116) arranged in the center thereof. A sealing member (117, 118) is arranged on a contact surface between the end cap (105, 106) and the joint member (113, 114). A bottomed cylindrical case (121) accommodates the pair of end caps (105, 106) and a large diameter portion of the pair of joint members (113, 114) in an engaged state. A cover member (124) is detachably installed on a side of an opening of the case (121).

Abstract translation: 圆柱形柱体（101）保持填料。 一对端盖（105,106）覆盖柱体（101）的两端，并具有用于布置在其中心的载液（111,112）的流动孔。 一对柱状接头构件（113,114）的大径部（113a，114a）侧的端面与一对端盖（105,106）的端面接触，并且还具有连通孔 115,116）。 密封构件（117,118）布置在端盖（105,106）和接头构件（113,114）之间的接触表面上。 有底的圆筒形壳体（121）在一对接合状态下容纳一对端盖（105,106）和一对接头构件（113,114）的大直径部分。 盖构件（124）可拆卸地安装在壳体（121）的开口的一侧。

公开(公告)号：USD740408S1

公开(公告)日：2015-10-06

申请号：US29480030

申请日：2014-01-22

Applicant: SEKISUI MEDICAL CO., LTD. ,  SEKISUI TECHNO MOLDING CO., LTD.

Designer： Satoru Tominaga ,  Takashi Yosida ,  Takuya Yotani ,  Hiroaki Taira ,  Yuriko Yamada

公开(公告)号：USD739006S1

公开(公告)日：2015-09-15

申请号：US29480091

申请日：2014-01-23

Applicant: SEKISUI MEDICAL CO., LTD. ,  SEKISUI TECHNO MOLDING CO., LTD.

Designer： Satoru Tominaga ,  Takashi Yosida ,  Takuya Yotani ,  Hiroaki Taira ,  Yuriko Yamada

公开(公告)号：US20140287453A1

公开(公告)日：2014-09-25

申请号：US14357274

申请日：2012-11-09

Applicant: Sekisui Medical Co., Ltd.

Inventor： Takayuki Oka ,  Takuya Yotani ,  Hideki Muraki

IPC: G01N1/14

CPC classification number: G01N1/14 ,  G01N30/18 ,  G01N30/20 ,  G01N2030/8822

Abstract: When injecting a sample into carrier-liquid channels (3A and 3B), injection shock is prevented. Septa 13 and 14 constitute the upper wall and the lower wall of a sample injection part (11) of the carrier-liquid channels (3A and 3B). A needle (27) can vertically penetrate the septum (13) on the upper wall side and also penetrate the septum (14) on the lower wall side. A needle moving unit (28) induces the needle (27) to penetrate the septum (14) on the lower wall side and induces the tip of the needle to face the inside of a sample vessel (26). A measurement pump (29) is operated for drawing and as a result a sample is drawn into the needle (27). Next, the needle (27) is extracted from the septum (14) on the lower wall side, the tip of the needle is induced to face the inside of the sample injection part (11), the measurement pump (29) is caused to discharge and as a result the sample within the needle (27) is injected.

Abstract translation: 当将样品注入载液通道（3A和3B）时，可防止注射冲击。 隔垫13和14构成载液通道（3A和3B）的样品注入部分（11）的上壁和下壁。 针（27）可以垂直地穿透上壁侧的隔膜（13）并且还穿过下壁侧的隔膜（14）。 针移动单元（28）引导针（27）穿过下壁侧的隔膜（14），并且引导针的尖端面对样品容器（26）的内部。 操作测量泵（29）进行拉伸，结果将样品吸入针（27）。 接下来，从下壁侧的隔膜（14）取出针（27），引导针尖朝向试样注入部（11）的内部，使测定用泵（29） 放电，结果注射针（27）内的样品。