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    Method for biotechnological production of dihydrochalcones
    22.
    发明授权
    Method for biotechnological production of dihydrochalcones 有权
    二氢查耳酮生物技术生产方法

    公开(公告)号：US09359622B2

    公开(公告)日：2016-06-07

    申请号：US13954957

    申请日：2013-07-30

    Applicant: Symrise AG

    Inventor： Jens Michael Hilmer ,  Egon Gross ,  Gerhard Krammer ,  Jakob Peter Ley ,  Mechthild Gall ,  Uwe Bornscheuer ,  Maren Thomsen ,  Christin Peters ,  Patrick Jonczyk ,  Sascha Beutel ,  Thomas Scheper

    IPC: C12P7/26 ,  C12N1/21 ,  C12N9/02 ,  C12N9/90 ,  C12N15/53 ,  C12N15/61 ,  C12N15/63 ,  C12R1/01 ,  C12R1/19 ,  C12R1/645 ,  C12R1/865 ,  C12R1/84

    CPC classification number: C12P7/26 ,  C12N9/001 ,  C12N9/90 ,  C12R1/01 ,  C12R1/19 ,  C12R1/645 ,  C12R1/84 ,  C12R1/865 ,  C12Y103/01031 ,  C12Y505/01006 ,  Y02P20/52

    Abstract: A method for production of a dihydrochalcone, especially of phloretin, using a transgenic microorganism, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a′), comprising or consisting of a gene coding for a plant chalcone isomerase, and a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, corresponding transgenic microorganisms, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a′), comprising or consisting of a gene coding for a plant chalcone isomerase, and/or a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, and host cells, containing one or more identical or different such vectors.

    Abstract translation: 使用含有核酸部分（a）的转基因微生物来制造二氢查耳酮，特别是花旗素的二氢查耳酮的方法，其包含编码细菌查耳酮异构酶的基因和/或核酸部分（a'），或由编码细菌查耳酮异构酶的基因组成。 包含编码植物查耳酮异构酶的基因或核酸部分（b），其包含编码细菌酸酸酯还原酶的基因或由其组成，所述基因含有核酸部分（a），相应的转基因微生物，其包含 或由编码细菌查耳酮异构酶的基因和/或由编码植物查尔酮异构酶的基因组成或由编码植物查耳酮异构酶的核酸部分（a'）组成的核酸部分（a'），和/或核酸部分（b） 由编码细菌酸酯还原酶的基因和含有一个或多个相同或不同的这种载体的宿主细胞组成。

    Metal-Complexing Aroma Compounds For Use In Aroma Stabilization
    23.
    发明申请
    Metal-Complexing Aroma Compounds For Use In Aroma Stabilization 有权
    金属络合香气化合物用于香气稳定

    公开(公告)号：US20130280401A1

    公开(公告)日：2013-10-24

    申请号：US13862449

    申请日：2013-04-14

    Applicant: Symrise AG

    Inventor： Andreas Degenhardt ,  Gerhard Krammer ,  Michael Backes

    IPC: A23L3/3526 ,  A23L3/3508 ,  A23L3/3499

    CPC classification number: A23L3/3526 ,  A23L2/44 ,  A23L3/3499 ,  A23L3/3508 ,  A23L27/60 ,  C11B5/0021 ,  C11B5/0035 ,  C11B5/005 ,  C11B5/0085 ,  C11B5/0092

    Abstract: The present invention relates to the use of one or more compounds of the formulae and/or pharmaceutically acceptable salts thereof for inhibiting the oxidation of fatty acids and/or triacylglycerols; and/or the rancidification of products that includes one or more of fatty acids and/or one or a plurality of triacylglycerols; and/or chemical and/or sensory changes of products that includes one or more of fatty acids and/or one or a plurality of triacylglycerols, caused by the action of the oxygen of the air. Corresponding mixtures and orally consumable preparations and methods are also described.

    Abstract translation: 本发明涉及一种或多种式和/或其药学上可接受的盐的化合物用于抑制脂肪酸和/或三酰基甘油的氧化的用途; 和/或包含一种或多种脂肪酸和/或一种或多种三酰基甘油的产品的酸化; 和/或由空气氧气的作用引起的包含脂肪酸和/或一种或多种三酰基甘油的一种或多种的产品的化学和/或感官变化。 还描述了相应的混合物和口服消耗品的制备方法。

    ORAL COMPOSITIONS
    26.
    发明申请
    ORAL COMPOSITIONS 有权
    口腔组成

    公开(公告)号：US20140234412A1

    公开(公告)日：2014-08-21

    申请号：US14179170

    申请日：2014-02-12

    Applicant: Symrise AG

    Inventor： Jakob Ley ,  Sabine Widder ,  Veronika Somoza ,  Barbara Rohm ,  Matthias Zaunschirm ,  Gerhard Krammer

    IPC: A61K31/16 ,  A23K1/16 ,  A23L1/30

    CPC classification number: A23K20/105 ,  A23L33/10 ,  A23L33/30 ,  A61K31/16 ,  A61K31/164

    Abstract: Suggested are new compositions for oral ingestion, comprising at least one active agent from the group of alkamides. The compositions which are orally ingested reduce the uptake of free fatty acids in the adipocytes and at the same time stimulate the release of serotonin and dopamine, which leads to a reduction of appetite, a feeling of satiety and a positive mood. In doing so, the new compositions are thus perfectly suitable to counteract any undesired gain of weight.

    Abstract translation: 建议的是用于口服摄取的新组合物，其包含至少一种来自该组烷酰胺的活性剂。 口服摄入的组合物降低脂肪细胞中游离脂肪酸的摄取量，同时刺激5-羟色胺和多巴胺的释放，这导致食欲降低，饱腹感和积极情绪。 因此，新组合物非常适合抵消任何不希望的重量增加。

    N-Nonanoylvanillylamine as an agent for reducing the appetite, as an agent for imparting a feeling of fullness and as a mood enhancer, and corresponding substance mixtures, orally consumable products and methods
    28.
    发明申请
    N-Nonanoylvanillylamine as an agent for reducing the appetite, as an agent for imparting a feeling of fullness and as a mood enhancer, and corresponding substance mixtures, orally consumable products and methods 审中-公开
    N-壬酰基乙烯胺作为减轻食欲的药剂，作为赋予丰满感的药剂和作为情绪增强剂的药剂，以及相应的物质混合物，口服消费品和方法

    公开(公告)号：US20130178534A1

    公开(公告)日：2013-07-11

    申请号：US13736414

    申请日：2013-01-08

    Applicant: Symrise AG

    Inventor： Jakob Ley ,  Gerhard Krammer ,  Veronika Somoza ,  Barbara Rohm ,  Mark Somoza

    IPC: A61K31/165 ,  A61K45/06 ,  C07C233/22

    CPC classification number: A61K31/165 ,  A23L33/10 ,  A23L33/17 ,  A23L33/30 ,  A61K45/06 ,  C07C233/22

    Abstract: There is described primarily N-nonanoylvanillylamine for use in a therapeutic method as (a) an agent for reducing the appetite and/or (b) an agent for imparting a feeling of fullness and/or (c) a mood enhancer, as well as the non-therapeutic use of N-nonanoylvanillylamine as (a) an agent for reducing the appetite and/or (b) an agent for imparting a feeling of fullness and/or (c) a mood enhancer. The non-therapeutic use of corresponding substance mixtures is also further described. Finally, the invention relates also to orally consumable products (in particular foodstuffs, feeds and medicaments) comprising N-nonanoylvanillylamine, wherein the N-nonanoylvanillylamine is present in a concentration that (a) reduces the appetite and/or (b) brings about a feeling of fullness and/or (c) enhances the mood, but which concentration is low.

    Abstract translation: 主要描述了用于治疗方法的N-壬酰基乙烯基胺，其为（a）用于降低食欲的药剂和/或（b）赋予饱胀感的药剂和/或（c）心境增强剂，以及 N-壬酰乙烯胺的非治疗用途为（a）降低食欲的药剂和/或（b）赋予饱胀感的药剂和/或（c）心境增强剂。 还进一步描述了相应物质混合物的非治疗用途。 最后，本发明还涉及包含N-壬酰基乙烯基胺的口服消耗品（特别是食品，饲料和药物），其中N-壬酰基乙烯基胺以（a）降低食欲和/或（b）产生 充满感和/或（c）增强情绪，但哪种浓度较低。

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