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公开(公告)号：US5882813A
公开(公告)日：1999-03-16
申请号：US893000
申请日：1997-07-15
申请人： Yoshimasa Matsushima , Tohru Kobayashi , Hiroshi Sugiyama , Yoko Takahashi , Toshimitsu Hagiwara
发明人： Yoshimasa Matsushima , Tohru Kobayashi , Hiroshi Sugiyama , Yoko Takahashi , Toshimitsu Hagiwara
CPC分类号： G03G5/0668 , G03G5/0614 , G03G5/0616 , G03G5/0666 , G03G5/0672
摘要： An electrophotographic photoreceptor comprising a charge transporting material containing at least one triphenylamine compound represented by general formula (1) and at least one compound selected from the group consisting of a hydrazone compound, a triphenylamine dimer compound and a distyryl compound: ##STR1## said charge transporting material being able to express high carrier mobility, being high in solubility in a binder polymer, and being able to form a homogeneous charge transporting layer.
摘要翻译： 一种电子照相感光体，包含含有至少一种由通式（1）表示的三苯胺化合物和至少一种选自腙化合物，三苯胺二聚体化合物和二苯乙烯基化合物的化合物的电荷输送材料： ）+ TR
所述电荷输送材料能够表现出高的载流子迁移率，在粘合剂聚合物中的溶解度高，并且能够形成均匀的电荷输送层。 -
22.发明授权
公开(公告)号：US5452146A
公开(公告)日：1995-09-19
申请号：US161391
申请日：1993-12-06
申请人： Hiroshige Okamoto , Hiraku Inoue , Yoko Takahashi , Yutaka Miki
发明人： Hiroshige Okamoto , Hiraku Inoue , Yoko Takahashi , Yutaka Miki
CPC分类号： G11B5/02 , G11B15/026 , G11B5/0086 , G11B5/035
摘要： A recording current setting method comprises the steps of: recording signals on a tape by changing, by steps, recording current for the tape; detecting a reproduced signal level at each recording current; and determining an optimal recording current from a middle point between a first recording current at which a reproduced signal level first exceeds a threshold level as a result of increasing, by steps, the recording current and a second recording current at which a reproduced signal level first exceeds the threshold level as a result of decreasing, by steps, the recording current. An information signal recording apparatus using the method is also disclosed.
摘要翻译： 记录电流设定方法包括以下步骤：通过逐步改变记录磁带的电流来在磁带上记录信号; 在每个记录电流下检测再现信号电平; 并且通过逐步地增加记录电流和再现信号电平的第二记录电流，从再现信号电平首先超过阈值电平的第一记录电流之间的中点确定最佳记录电流 作为通过逐步减小记录电流的结果，超过阈值水平。 还公开了使用该方法的信息信号记录装置。
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23.发明授权Therapeutic muscular dystrophy drug having bubble liposome loaded with morpholino as active ingredient 有权具有负载吗啉代作为活性成分的气泡脂质体的治疗性肌营养不良药物公开(公告)号：US09457102B2
公开(公告)日：2016-10-04
申请号：US14116316
申请日：2012-04-25
CPC分类号： A61K47/48815 , A61K9/0019 , A61K9/1271 , A61K41/0028 , A61K47/24 , A61K47/6911 , C12N15/113 , C12N15/88 , C12N2310/11 , C12N2310/3233 , C12N2310/3515 , C12N2320/32 , C12N2320/33
摘要： To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
摘要翻译： 为了提供引入具有显着增强的细胞渗透性的PMO的技术，导致显着提高的引入效率，从而提供显着改善DMD的医学状况的治疗药物。 还提供了杜烯肌营养不良的治疗药物，其包括作为活性成分的具有与其表面结合的特异性吗啉代低聚物（PMO）的泡沫脂质体，其中将PMO引入肌肉的肌肉纤维（肌肉细胞） 通过将治疗药物施用到肌肉组织中或进入血管，然后经皮超声照射到肌肉组织，从而高效地进行组织。
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公开(公告)号：US20130116296A1
公开(公告)日：2013-05-09
申请号：US13810030
申请日：2011-07-14
IPC分类号： C07D405/06 , C07D231/20 , C07D231/22
CPC分类号： C07D231/20 , C07D231/18 , C07D231/22 , C07D231/38 , C07D231/44 , C07D405/06 , C07D493/08
摘要： The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are independently hydrogen or C1-6 alkyl etc.; R5 is C4-7 alkyl or —(CR8R9)r-E; R6, R7, R8 and R9 are independently hydrogen, fluorine or C1-6 alkyl; A is C6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C3-8 cycloalkyl or C6-10 aryl etc.; L is oxygen, sulfur or —NR10—; n is 1, 2 or 3; R10 is hydrogen or C1-6 alkyl etc.; and X is hydrogen or halogen etc.
摘要翻译： 本发明涉及还显示5-HT 2C拮抗作用（抗抑郁和抗焦虑作用）的5-羟色胺再摄取抑制剂，特别是包含化合物（1）：或其药学上可接受的盐的5-HT 2C反向激动作用其中R1，R2 ，R3和R4独立地是氢或C1-6烷基等; R5是C4-7烷基或 - （CR8R9）r-E; R6，R7，R8和R9独立地是氢，氟或C1-6烷基; A为C6-10芳基或杂芳基等; r为1,2,3或4; E为C3-8环烷基或C6-10芳基等; L是氧，硫或-NR10-; n为1,2或3; R 10是氢或C 1-6烷基等; X为氢或卤素等。
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公开(公告)号：US07781479B2
公开(公告)日：2010-08-24
申请号：US11795147
申请日：2006-01-12
申请人： Yoko Takahashi , Ryu Nagata , Kantaro Ushiroda
发明人： Yoko Takahashi , Ryu Nagata , Kantaro Ushiroda
IPC分类号： A61K31/405 , A61K31/404 , A61K31/192 , C07D209/04 , C07D209/12
CPC分类号： C07D233/64 , C07D209/12 , C07D231/56 , C07D235/12 , C07D471/04
摘要： A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.
摘要翻译： 下式（1）的化合物或其前药或药学上可接受的盐可用作糖尿病药物或预防性或血糖调节剂或高脂血症治疗剂等，其中环Z为任选取代的杂芳基 W4为单键，低级亚烷基等，Ar2为任意取代的芳基等，W3为单键，低级亚烷基等，Ar1为任意取代的亚芳基等，W1，W2分别为 是任选取代的低级亚烷基等，并且R 1是羧基，烷氧基羰基。
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公开(公告)号：USD444170S1
公开(公告)日：2001-06-26
申请号：US29118817
申请日：2000-02-16
申请人： Yoshihiro Ichi , Yoko Takahashi
设计人： Yoshihiro Ichi , Yoko Takahashi
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公开(公告)号：US20080167306A1
公开(公告)日：2008-07-10
申请号：US11795147
申请日：2006-01-12
申请人： Yoko Takahashi , Ryu Nagata , Kantaro Ushiroda
发明人： Yoko Takahashi , Ryu Nagata , Kantaro Ushiroda
IPC分类号： A61K31/5377 , C07D207/00 , A61K31/40 , C07D209/04 , A61K31/404 , C07D213/02 , A61K31/437 , C07D231/10 , A61P9/00 , A61P3/10 , A61K31/415 , C07D235/04 , A61K31/4184 , C07D231/54 , C07D221/02 , C07D295/00
CPC分类号： C07D233/64 , C07D209/12 , C07D231/56 , C07D235/12 , C07D471/04
摘要： A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.
摘要翻译： 下式（1）的化合物或其前药或药学上可接受的盐可用作糖尿病药物或预防性或血糖调节剂或高脂血症治疗剂等，其中环Z为任选取代的杂芳基 ，W 4是单键，低级亚烷基等，Ar 2是任选取代的芳基等，W 3是 单键，低级亚烷基等，Ar 1是任选取代的亚芳基等，W 1和W 2中的每一个是 任选取代的低级亚烷基等，R 1是羧基，烷氧基羰基。
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28.发明授权
公开(公告)号：US5840811A
公开(公告)日：1998-11-24
申请号：US786253
申请日：1997-01-22
申请人： Yoji Hori , Tohru Kobayashi , Hideyuki Hongo , Akio Yamaguchi , Yoko Takahashi , Takashi Imai , Toshimitsu Hagiwara
发明人： Yoji Hori , Tohru Kobayashi , Hideyuki Hongo , Akio Yamaguchi , Yoko Takahashi , Takashi Imai , Toshimitsu Hagiwara
IPC分类号： C08G63/06 , C08G63/08 , C08G63/82 , C08L101/16 , C08G63/85
CPC分类号： C08G63/823 , C08G63/08
摘要： An optically active block polyester copolymer formed of structural units represented by the following general formulas (I) and (II): ##STR1## wherein represents for an asymmetric carbon atom and m and n each represents a natural number in the range of from 300 to 5000 is obtained by subjecting an optically active butyrolactone and a species of lactone other than the optically active butyrolactone to sequential ringopening copolymerization in the presence of a catalyst. This optically active block polyester copolymer possesses a high molecular weight and a high melting point (not less than 130.degree. C.) and forms a biodegradable and hydrolyzable material of high strength capable of tolerating the impacts of actual use.
摘要翻译： 由以下通式（I）和（II）表示的结构单元形成的光学活性嵌段聚酯共聚物：式（I）公制碳原子，m和n各自表示300-5000的自然数 是通过使光学活性丁内酯和除光学活性丁内酯以外的其他种类的内酯在催化剂存在下进行顺序环环化共聚获得的。 该光学活性嵌段聚酯共聚物具有高分子量和高熔点（不低于130℃），并形成能够耐受实际影响的高强度的可生物降解和可水解的材料。
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公开(公告)号：US5824751A
公开(公告)日：1998-10-20
申请号：US592518
申请日：1996-01-26
摘要： The biodegradable composition comprises at least poly(beta-hydroxybutyric acid) or a biodegradable copolymer thereof and a stereospecifically regular block copolymer having the structure units of formula (I): ##STR1## where R1 is a hydrocarbon group having 1 to 14 carbon atoms, optionally including double bonds, oxygen atoms or both of them; and m and n are respectively an integer ranging from 300 to 5,000, or having the structure units of formula (II): ##STR2## where R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are either a hydrogen atom or a methyl group; and m and n are respectively an integer ranging from 300 to 5,000.
摘要翻译： 可生物降解组合物至少包含聚（β-羟基丁酸）或其可生物降解的共聚物和具有式（I）结构单元的立体专一规则嵌段共聚物：其中R 1为具有1至14个碳原子的烃基 碳原子，任选地包括双键，氧原子或它们两者; m和n分别为300-5000的整数，或具有式（II）的结构单元：其中R 2，R 3，R 4和R 5为氢原子或甲基; m和n分别为300-5000的整数。
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30.发明授权Block copolymer of polyesters and polycarbonates and process for preparation thereof 失效聚酯和聚碳酸酯的嵌段共聚物及其制备方法
公开(公告)号：US5631344A
公开(公告)日：1997-05-20
申请号：US549544
申请日：1995-10-27
IPC分类号： C08G63/64 , C08G63/85 , C08G64/18 , C08L101/16 , C08G63/78
摘要： The block copolymer of polyesters and polycarbonates comprises at least one of each of the constituting units of (I) and (II) having the general formulae: ##STR1## where the sign * indicates an asymmetric carbon atom; R.sub.1, R.sup.2, R.sup.3 and R.sup.4 are either a hydrogen atom or a methyl group; m and n are respective a natural numbers ranging from 300 to 5000: The block copolymer is obtained by successive ring-opening and copolymerization of optically active .beta.-butyrolactones and cyclic carbonates in the presence of a catalyst.The block polymer obtained has high molecular weight and high melting temperature, and can thus be used as a high strength material for practical use and which has bio-degradable and hydrolyzable nature.
摘要翻译： 聚酯和聚碳酸酯的嵌段共聚物包含具有以下通式的（I）和（II）的每个构成单元中的至少一个：符号*表示不对称碳 原子; R1，R2，R3和R4是氢原子或甲基; m和n分别为300至5000的自然数：嵌段共聚物通过在催化剂存在下连续的开环和共聚光学活性的β-丁内酯和环状碳酸酯而获得。 所得到的嵌段聚合物具有高分子量和高熔点温度，因此可用作实际使用的高强度材料，其具有生物降解性和水解性。
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