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    Sclerostin and the inhibition of WNT signaling and bone formation
    22.
    发明授权
    Sclerostin and the inhibition of WNT signaling and bone formation 有权
    硬皮蛋白和抑制WNT信号和骨形成

    公开(公告)号：US08461155B2

    公开(公告)日：2013-06-11

    申请号：US11084668

    申请日：2005-03-18

    申请人： Dianqing (Dan) Wu ,  Xiaofeng Li

    发明人： Dianqing (Dan) Wu ,  Xiaofeng Li

    IPC分类号： A61K31/535 ,  C07C50/18

    CPC分类号： G01N33/6893 ,  G01N33/6887 ,  G01N2500/00 ,  G06F19/12

    摘要： The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass (HBM). In this report, we found that sclerostin could antagonize canonical Wnt signaling in human embryonic kidney A293 cells and mouse osteoblastic MC3T3 cells. This sclerostin-mediated antagonism could be reversed by over-expression of Wnt coreceptor LRP5. In addition, we found that sclerostin bound to LRP5 as well as LRP6 and identified the first two YWTD-EGF repeat domains of LRP5 as being responsible for the binding. Although these two repeat domains are required for transducing canonical Wnt signals, canonical Wnt did not appear to compete with sclerostin for binding to LRP5. Examination of the expression of sclerostin and Wnt7b, an autocrine canonical Wnt, during primary calvarial osteoblast differentiation revealed that sclerostin is expressed at the late stages of osteoblast differentiation coinciding with the expression of osteogenic marker osteocalcin and trailing after the expression of Wnt7b. Given the plethora of evidence indicating that canonical Wnt signaling stimulates osteogenesis, we believe that the HBM phenotype associated with the loss of sclerostin may at least in part be attributed to an increase in canonical Wnt signaling resulting from the reduction in sclerostin-mediated Wnt antagonism.

    摘要翻译： SOST基因产物硬化蛋白的丧失导致以高骨量（HBM）为特征的硬皮病。 在本报告中，我们发现硬皮蛋白可以拮抗人类胚胎肾A293细胞和小鼠成骨细胞MC3T3细胞中的典型Wnt信号。 这种硬脂蛋白介导的拮抗作用可以通过Wnt共同受体LRP5的过度表达来逆转。 此外，我们发现硬骨素与LRP5以及LRP6结合，并鉴定出LRP5的前两个YWTD-EGF重复结构域负责结合。 虽然这两个重复结构域是转导规范Wnt信号所必需的，但是典型的Wnt似乎没有与硬皮蛋白竞争结合LRP5。 在原发性颅骨成骨细胞分化过程中，考察了sclerostin和Wnt7b（一种自分泌标准Wnt）的表达，表明硬骨素在成骨细胞分化后期表达，与成骨标志物骨钙素表达相符，Wnt7b表达后表达。 鉴于许多证据表明典型的Wnt信号传导刺激成骨，我们认为与硬化蛋白的丧失有关的HBM表型可能至少部分归因于由于硬骨素介导的Wnt拮抗作用降低导致的典型Wnt信号传导的增加。

    ELECTRONIC LIGHTING DEVICE AND METHOD FOR MANUFACTURING SAME
    24.
    发明申请
    ELECTRONIC LIGHTING DEVICE AND METHOD FOR MANUFACTURING SAME 有权
    电子照明装置及其制造方法

    公开(公告)号：US20120134157A1

    公开(公告)日：2012-05-31

    申请号：US13325754

    申请日：2011-12-14

    申请人： Xiaofeng Li

    发明人： Xiaofeng Li

    IPC分类号： F21V21/14 ,  F21V33/00 ,  H05K13/04

    CPC分类号： F21S10/046 ,  F21K9/00 ,  F21S6/001 ,  F21S9/02 ,  F21S10/04 ,  F21S10/043 ,  F21V23/001 ,  F21V23/04 ,  F21V23/0407 ,  F21W2121/00 ,  F21Y2101/00 ,  F21Y2115/10 ,  H01F7/064 ,  H05B37/0281 ,  Y10S362/81 ,  Y10T29/49002 ,  Y10T29/4902

    摘要： An electronic lighting device may comprise an enclosure, a light-emitting element, a flame sheet and a swing mechanism. The flame sheet is movably supported or suspended on the enclosure, and may comprise an upper sheet which is of a flame-like shape. The upper sheet is configured to be exposed above the top of the enclosure. Light from the light-emitting element intersects with the surface of the upper sheet so that the light projects onto the surface of the upper sheet. The swing mechanism is disposed beneath the flame sheet and can apply a force on the flame sheet to actuate the flame sheet to sway or swing. By the present application, a visual experience of true fire can be achieved and an interestedness and appreciation can be improved. A method for manufacturing the same is disclosed.

    摘要翻译： 电子照明装置可以包括外壳，发光元件，火焰片和摆动机构。 火焰片可移动地支撑或悬挂在外壳上，并且可以包括具有火焰状形状的上片。 上片被配置为暴露在外壳顶部的上方。 来自发光元件的光与上片的表面相交，使得光投射到上片的表面上。 摆动机构设置在火焰片的下方，并且可以在火焰片上施加力以致动火焰片摇摆或摆动。 通过本申请，可以实现真实的视觉体验，并且可以改善感兴趣和欣赏。 公开了一种制造该方法的方法。

    DYNAMICALLY CHANGING A GARBAGE COLLECTOR IN A MANAGED RUNTIME SYSTEM
    26.
    发明申请
    DYNAMICALLY CHANGING A GARBAGE COLLECTOR IN A MANAGED RUNTIME SYSTEM 审中-公开
    在管理运行系统中动态更改收集收集器

    公开(公告)号：US20090307292A1

    公开(公告)日：2009-12-10

    申请号：US12442940

    申请日：2006-09-26

    申请人： Xiaofeng Li ,  Ming Wu

    发明人： Xiaofeng Li ,  Ming Wu

    IPC分类号： G06F12/00 ,  G06F17/30

    CPC分类号： G06F12/0269

    摘要： Machine-readable media, methods, and apparatus are described to dynamically change a garbage collector in a managed runtime system (1022). In some embodiments, a first garbage collector is loaded into the managed runtime system (1022) during a runtime stage of the managed runtime system (1022). The first garbage collector is further activated to manage a heap organization (203) of the managed runtime system (1022) in place of a second garbage collector of the managed runtime system (1022) during the runtime stage.

    摘要翻译： 描述了机器可读介质，方法和装置来动态地改变托管运行时系统中的垃圾收集器（1022）。 在一些实施例中，在管理的运行时系统（1022）的运行阶段期间，将第一垃圾收集器加载到托管运行系统（1022）中。 第一垃圾收集器被进一步激活以管理在运行阶段期间管理的运行时系统（1022）的堆组织（203）来代替被管理的运行时系统（1022）的第二垃圾收集器。

    Compositions and Methods for Bone Formation and Remodeling
    28.
    发明申请
    Compositions and Methods for Bone Formation and Remodeling 有权
    骨形成和重塑的组成和方法

    公开(公告)号：US20060198791A2

    公开(公告)日：2006-09-07

    申请号：US10849067

    申请日：2004-05-19

    申请人： Dianqing Wu ,  Yazhou Zhang ,  Peng Liu ,  Xiaofeng Li ,  Jie Zhang ,  Jufang Shan ,  Dean Engelhardt

    发明人： Dianqing Wu ,  Yazhou Zhang ,  Peng Liu ,  Xiaofeng Li ,  Jie Zhang ,  Jufang Shan ,  Dean Engelhardt

    IPC分类号： A61K9/68 ,  A61K7/28 ,  G01N33/53 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

    CPC分类号： G01N33/6893 ,  A61K38/00 ,  G01N33/6887 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/108

    摘要： Abstract of the DisclosureThe mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors’ transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. Together with the observation that osteoblast cells produce autocrine canonical Wnt, Wnt7b, and that osteocytes produce paracrine Dkk1, we believe that the G171V mutation may cause an increase in Wnt activity in osteoblasts by reducing the number of targets for paracrine Dkk1 to antagonize without affecting the activity of autocrine Wnt.

    摘要翻译： 公开摘要研究了Wnt共同受体LRP5的高骨量（HBM）突变（G171V）调节规范Wnt信号传导的机制。 以前显示突变可以降低Dkk蛋白-1介导的拮抗作用，这表明G171位于第一个YWTD重复结构域可能是Dkk蛋白介导的拮抗作用的原因。 然而，我们发现第三个YWTD重复，但不是第一个重复结构域，是DKK1介导的拮抗作用所必需的。 相反，我们发现G171V突变破坏了LRP5与Mesd的相互作用，Mesd是共受体转运到细胞表面所需的LRP5 / 6的伴侣蛋白，导致细胞表面上较少的LRP5分子。 尽管细胞表面LRP5分子水平的降低导致旁分泌范例中Wnt信号传导的降低，但突变似乎不影响共表达Wnt在自分泌范式中的活性。 连同观察到成骨细胞产生自分泌的正常Wnt，Wnt7b，并且该骨细胞产生旁分泌的Dkk1，我们认为G171V突变可能通过减少旁分泌Dkk1靶向拮抗的数目而引起成骨细胞中Wnt活性的增加，而不影响 自分泌Wnt的活性。

    Electronic scented candle and fragrance container
    30.
    发明授权
    Electronic scented candle and fragrance container 有权

    公开(公告)号：US10967090B2

    公开(公告)日：2021-04-06

    申请号：US16376835

    申请日：2019-04-05

    申请人： Xiaofeng Li

    发明人： Xiaofeng Li

    IPC分类号： A61L9/03 ,  F21S10/00 ,  F21S9/02 ,  F21S10/04 ,  F21W121/00

    摘要： An electronic scented candle is described that includes a flame piece, a shell including an installation chamber, a fragrance container that is removably positioned inside the installation chamber, a scent chamber, and a liquid suction channel positioned within the fragrance container. One end of the liquid suction channel protrudes from the fragrance container into the scent chamber and anther end of the liquid suction channel is positioned within the fragrance container to draw a fragrance material from the fragrance container to the scent chamber. A scent outlet in communication with the scent chamber allows scent from the chamber to reach an external environment of the electronic scented candle, and an air inlet in communication with the scent chamber directs air from the external environment to the scent chamber. A heating device heats the content of the scent chamber to allow rapid dissemination of the scent chamber into an external environment.