利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

42 条记录 (耗时 0.075 秒)

    Glycopegylated Granulocyte Colony Stimulating Factor
    26.
    发明申请
    Glycopegylated Granulocyte Colony Stimulating Factor 审中-公开
    糖基化粒细胞集落刺激因子

    公开(公告)号：US20070254836A1

    公开(公告)日：2007-11-01

    申请号：US10579620

    申请日：2004-12-03

    申请人： Shawn Defrees ,  Henrik Clausen ,  David Zopf ,  Zhi-Guang Wang ,  Caryn Bowe ,  Marc Schwartz ,  Bingyuan Wu

    发明人： Shawn Defrees ,  Henrik Clausen ,  David Zopf ,  Zhi-Guang Wang ,  Caryn Bowe ,  Marc Schwartz ,  Bingyuan Wu

    IPC分类号： A61K38/22 ,  A61P31/00 ,  A61P37/04 ,  C07K14/75 ,  C12P21/06

    CPC分类号： A61K38/193 ,  A61K47/60 ,  C07K14/535

    摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供粒细胞集落刺激因子和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。

    Glycopegylated granulocyte colony stimulating factor
    28.
    发明申请
    Glycopegylated granulocyte colony stimulating factor 有权
    糖基化的粒细胞集落刺激因子

    公开(公告)号：US20070014759A1

    公开(公告)日：2007-01-18

    申请号：US11166404

    申请日：2005-11-02

    申请人： Shawn DeFrees ,  Henrik Clausen ,  David Zopf ,  Zhi-Guang Wang ,  Caryn Bowe

    发明人： Shawn DeFrees ,  Henrik Clausen ,  David Zopf ,  Zhi-Guang Wang ,  Caryn Bowe

    IPC分类号： A61K38/19 ,  C07K14/53 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06

    CPC分类号： A61K38/193

    摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供粒细胞集落刺激因子和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。

    Activated forms of water-soluble polymers
    29.
    发明申请
    Activated forms of water-soluble polymers 审中-公开
    活性形式的水溶性聚合物

    公开(公告)号：US20060276618A1

    公开(公告)日：2006-12-07

    申请号：US10549520

    申请日：2004-03-18

    申请人： Shawn DeFrees ,  David Zopf ,  Caryn Bowe

    发明人： Shawn DeFrees ,  David Zopf ,  Caryn Bowe

    IPC分类号： C08G65/34

    CPC分类号： C08G65/333 ,  C08G65/337

    摘要： The present invention provides compositions of activated water-soluble polymers for preparing water-soluble polymer-modified peptides. Exemplary compounds of the invention include water-soluble polymers covalently attached to activated leaving groups wherein the water-soluble polymer is a member selected from PEG, PPG, PEG derivatives, and PPG derivatives, and the activated leaving group is a member selected from (formula I).

    摘要翻译： 本发明提供了用于制备水溶性聚合物改性肽的活性水溶性聚合物的组合物。 本发明的示例性化合物包括共价连接到活化离去基团的水溶性聚合物，其中水溶性聚合物是选自PEG，PPG，PEG衍生物和PPG衍生物的成员，活化的离去基团是选自（式 一世）。

    Glycopegylated erythropoietin formulations
    30.
    发明申请
    Glycopegylated erythropoietin formulations 有权
    糖基化促红细胞生成素制剂

    公开(公告)号：US20060287224A1

    公开(公告)日：2006-12-21

    申请号：US11440839

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert Bayer ,  David Zopf ,  Jichao Kang ,  Walter Willett

    发明人： Shawn DeFrees ,  Robert Bayer ,  David Zopf ,  Jichao Kang ,  Walter Willett

    IPC分类号： A61K38/16

    CPC分类号： C07K14/505 ,  A61K38/1816 ,  A61K47/549 ,  A61K47/60

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。