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    Pharmaceutical composition for treating CAPRIN-1 expressing cancer
    21.
    发明授权
    Pharmaceutical composition for treating CAPRIN-1 expressing cancer 有权
    用于治疗表达CAPRIN-1的癌症的药物组合物

    公开(公告)号：US08709418B2

    公开(公告)日：2014-04-29

    申请号：US13576955

    申请日：2011-02-04

    申请人： Fumiyoshi Okano ,  Takanori Saito

    发明人： Fumiyoshi Okano ,  Takanori Saito

    IPC分类号： A61K39/395 ,  C07K16/30 ,  A61K35/02

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3053 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734

    摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody comprising a heavy chain variable region that comprises SEQ ID NOS: 39, 40, and 41 and a light chain variable region that comprises SEQ ID NOS: 43, 44, and 45 or a fragment thereof as an active ingredient and having immunological reactivity with a CAPRIN-1 protein.

    摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体而言，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含含有包含SEQ ID NO：39,40和41的重链可变区的抗体和包含SEQ ID NO：39,40和41的轻链可变区， NOS：43,44和45或其片段作为活性成分，并与CAPRIN-1蛋白具有免疫反应性。

    IMMUNITY-INDUCING AGENT
    22.
    发明申请
    IMMUNITY-INDUCING AGENT 有权
    免疫诱导剂

    公开(公告)号：US20110123492A1

    公开(公告)日：2011-05-26

    申请号：US13056122

    申请日：2009-08-05

    申请人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    发明人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    IPC分类号： A61K38/20 ,  C12N15/63 ,  C07K14/47 ,  A61K39/00 ,  A61K38/21 ,  C12N5/078 ,  C12N5/0783 ,  A61P35/00 ,  A61P37/04 ,  C07K7/06 ,  A61P35/02

    CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K38/19 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C12N5/0634 ,  C12N5/0636 ,  A61K2300/00

    摘要： The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a), (b), and (c): (a) a polypeptide of at least seven contiguous amino acids of the amino acid sequence shown by any even SEQ ID number selected from SEQ ID NOs: 2 to 30 listed in the Sequence Listing; (b) a polypeptide of at least seven amino acids having 90% or more sequence identity with the polypeptide (a); and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof, or a recombinant vector comprising a polynucleotide encoding said polypeptide and capable of expressing said polypeptide in vivo.

    摘要翻译： 本发明涉及一种免疫诱导剂，其包含作为活性成分的至少一种具有免疫诱导活性的多肽，其选自多肽（a），（b）和（c）：（a）多肽 氨基酸序列的至少七个连续氨基酸由选自序列表中所列的SEQ ID NO：2至30的任何偶数SEQ ID号表示; （b）与多肽（a）具有90％或更多序列同一性的至少7个氨基酸的多肽; 以及（c）包含多肽（a）或（b）作为其部分序列的多肽，或包含编码所述多肽并能够在体内表达所述多肽的多核苷酸的重组载体。

    Immunity-inducing agent and method for detection of cancer
    24.
    发明授权
    Immunity-inducing agent and method for detection of cancer 有权
    免疫诱导剂和癌症检测方法

    公开(公告)号：US08901082B2

    公开(公告)日：2014-12-02

    申请号：US13002629

    申请日：2009-07-10

    申请人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    发明人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    IPC分类号： A61K38/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/00 ,  A61P35/00 ,  C07K14/47 ,  A61K31/711 ,  A61K39/00 ,  G01N33/574

    CPC分类号： C07K14/47 ,  A61K31/711 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/55566 ,  G01N33/57415 ,  G01N33/57426

    摘要： An immunity-inducing agent comprising as an effective ingredient(s) at least one polypeptide selected from the following polypeptides, the polypeptide(s) having an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo can be used for therapy and/or prophylaxis of cancer: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in the odd number IDs of SEQ ID NOs:3 to 95 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof. Further, since the above polypeptide(s) react(s) with antibodies existing specifically in serum of a cancer patient, it is possible to detect cancer in a living body by measuring the antibodies in a sample.

    摘要翻译： 一种免疫诱导剂，其包含选自以下多肽的至少一种多肽，具有免疫诱导活性/活性的多肽或作为有效成分的重组载体（s）的有效成分 ），其可以用于治疗和/或预防癌症：（a）基本上包含编码多肽并且能够在体内表达多肽的多核苷酸的多核苷酸 在SEQUENCE LISTING中SEQ ID NO：3至95的奇数ID中显示的任何一个氨基酸序列中不少于7个连续氨基酸; （b）与多肽（a）具有不小于90％的序列同一性并且基本上由不少于7个氨基酸组成的多肽; 和（c）包含多肽（a）或（b）作为其部分序列的多肽。 此外，由于上述多肽与癌症患者的血清中特异性存在的抗体反应，因此可以通过测量样品中的抗体来检测活体中的癌症。

    Method for inducing immunity with a peptide fragment from human CAPRIN-1
    25.
    发明授权
    Method for inducing immunity with a peptide fragment from human CAPRIN-1 有权
    用人CAPRIN-1从肽片段诱导免疫的方法

    公开(公告)号：US08454968B2

    公开(公告)日：2013-06-04

    申请号：US13056122

    申请日：2009-08-05

    申请人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    发明人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/04 ,  C12N15/00

    CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K38/19 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C12N5/0634 ,  C12N5/0636 ,  A61K2300/00

    摘要： The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a), (b), and (c): (a) a polypeptide of at least seven contiguous amino acids of the amino acid sequence shown by any even SEQ ID number selected from SEQ ID NOs: 2 to 30 listed in the Sequence Listing; (b) a polypeptide of at least seven amino acids having 90% or more sequence identity with the polypeptide (a); and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof, or a recombinant vector comprising a polynucleotide encoding said polypeptide and capable of expressing said polypeptide in vivo.

    摘要翻译： 本发明涉及一种免疫诱导剂，其包含作为活性成分的至少一种具有免疫诱导活性的多肽，其选自多肽（a），（b）和（c）：（a）多肽 氨基酸序列的至少七个连续氨基酸由选自序列表中所列的SEQ ID NO：2至30的任何偶数SEQ ID号表示; （b）与多肽（a）具有90％或更多序列同一性的至少7个氨基酸的多肽; 以及（c）包含多肽（a）或（b）作为其部分序列的多肽，或包含编码所述多肽并能够在体内表达所述多肽的多核苷酸的重组载体。

    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
    27.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER 有权
    用于治疗和/或预防癌症的药物组合物

    公开(公告)号：US20120321641A1

    公开(公告)日：2012-12-20

    申请号：US13576955

    申请日：2011-02-04

    申请人： Fumiyoshi Okano ,  Takanori Saito

    发明人： Fumiyoshi Okano ,  Takanori Saito

    IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/22

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3053 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734

    摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody comprising a heavy chain variable region that comprises SEQ ID NOS: 39, 40, and 41 and a light chain variable region that comprises SEQ ID NOS: 43, 44, and 45 or a fragment thereof as an active ingredient and having immunological reactivity with a CAPRIN-1 protein.

    摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体而言，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含含有包含SEQ ID NO：39,40和41的重链可变区的抗体和包含SEQ ID NO：39,40和41的轻链可变区， NOS：43,44和45或其片段作为活性成分，并与CAPRIN-1蛋白具有免疫反应性。

    IMMUNITY-INDUCING AGENT AND METHOD FOR DETECTION OF CANCER
    28.
    发明申请
    IMMUNITY-INDUCING AGENT AND METHOD FOR DETECTION OF CANCER 有权
    免疫诱导剂和检测癌症的方法

    公开(公告)号：US20110130343A1

    公开(公告)日：2011-06-02

    申请号：US13002629

    申请日：2009-07-10

    申请人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    发明人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

    IPC分类号： A61K38/08 ,  A61K31/7084 ,  C12N5/00 ,  G01N33/574 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61P35/00

    CPC分类号： C07K14/47 ,  A61K31/711 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/55566 ,  G01N33/57415 ,  G01N33/57426

    摘要： An immunity-inducing agent comprising as an effective ingredient(s) at least one polypeptide selected from the following polypeptides, the polypeptide(s) having an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo can be used for therapy and/or prophylaxis of cancer: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in the odd number IDs of SEQ ID NOs:3 to 95 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof. Further, since the above polypeptide(s) react(s) with antibodies existing specifically in serum of a cancer patient, it is possible to detect cancer in a living body by measuring the antibodies in a sample.

    摘要翻译： 一种免疫诱导剂，其包含选自以下多肽的至少一种多肽，具有免疫诱导活性/活性的多肽或作为有效成分的重组载体（s）的有效成分 ），其可以用于治疗和/或预防癌症：（a）基本上包含编码多肽并且能够在体内表达多肽的多核苷酸的多核苷酸 在SEQUENCE LISTING中SEQ ID NO：3至95的奇数ID中显示的任何一个氨基酸序列中不少于7个连续氨基酸; （b）与多肽（a）具有不小于90％的序列同一性并且基本上由不少于7个氨基酸组成的多肽; 和（c）包含多肽（a）或（b）作为其部分序列的多肽。 此外，由于上述多肽与癌症患者的血清中特异性存在的抗体反应，因此可以通过测量样品中的抗体来检测活体中的癌症。