公开(公告)号：US12145960B2

公开(公告)日：2024-11-19

申请号：US17287255

申请日：2019-10-24

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20240279479A1

公开(公告)日：2024-08-22

申请号：US18621997

申请日：2024-03-29

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

CPC classification number: C09B62/365 ,  C09K11/06 ,  G01N33/582 ,  C09K2211/1018

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US20240174709A1

公开(公告)日：2024-05-30

申请号：US18522886

申请日：2023-11-29

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US11958877B2

公开(公告)日：2024-04-16

申请号：US18178802

申请日：2023-03-06

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230407389A1

公开(公告)日：2023-12-21

申请号：US18449601

申请日：2023-08-14

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Megha Cila

IPC: C12Q1/6874 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6876

CPC classification number: C12Q1/6874 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6876 ,  C12Q1/6806

Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.

公开(公告)号：US20230295437A1

公开(公告)日：2023-09-21

申请号：US18130212

申请日：2023-04-03

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B11/24 ,  C09B69/00 ,  C07F7/08

CPC classification number: C09B11/24 ,  C09B69/008 ,  C07F7/0803 ,  C07F7/083 ,  C07F7/0825 ,  C07H23/00

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

公开(公告)号：US20250154583A1

公开(公告)日：2025-05-15

申请号：US18940449

申请日：2024-11-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Ronald Graham

IPC: C12Q1/6874 ,  C12Q1/6818

Abstract: Disclosed herein, inter alia, are nucleotide compounds including cleavable moieties and fluorophore moieties, and methods of use thereof.

公开(公告)号：US12215122B2

公开(公告)日：2025-02-04

申请号：US18522886

申请日：2023-11-29

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20240316036A1

公开(公告)日：2024-09-26

申请号：US18441561

申请日：2024-02-14

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Surya Adhikari

IPC: A61K31/4745 ,  A61K47/68 ,  C07K16/18

CPC classification number: A61K31/4745 ,  A61K47/68037 ,  C07K16/18

Abstract: Disclosed herein, inter alia, are therapeutic and theragnostic compounds and methods of use thereof.

公开(公告)号：US20240269156A1

公开(公告)日：2024-08-15

申请号：US18543979

申请日：2023-12-18

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Surya Adhikari

IPC: A61K31/704 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/5355 ,  A61K31/7068

CPC classification number: A61K31/704 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/5355 ,  A61K31/7068

Abstract: Disclosed herein, inter alia, are methods and compounds including cleavable moieties, and methods of use thereof.