公开(公告)号：US20190049428A1

公开(公告)日：2019-02-14

申请号：US16077305

申请日：2016-11-16

Applicant: Sony Corporation

Inventor： Aya Murata ,  Yoshihito Hayashi ,  Kenzo Machida ,  Marcaurele Brun

IPC: G01N33/49 ,  G01N11/00 ,  G01N27/22 ,  G01N35/00 ,  G01N33/50

Abstract: There are provided a new device and a new method for measurement of platelet aggregability which can be used for monitoring in an anti-platelet therapy.A platelet aggregability analyzing device includes: a blood coagulation system analyzing section that analyzes platelet aggregability on the basis of measurement data on a coagulation process of a platelet-containing sample to which a platelet inducing substance has been added; and an output control section that controls output of a result of an analysis by the blood coagulation system analyzing section.

公开(公告)号：US20180052181A1

公开(公告)日：2018-02-22

申请号：US15556135

申请日：2016-02-09

Applicant: Sony Corporation

Inventor： Kenzo Machida ,  Marcaurele Brun ,  Yoshihito Hayashi ,  Kaori Kawaguchi ,  Seungmin Lee

IPC: G01N33/86 ,  G01N33/50 ,  G01N27/22

CPC classification number: G01N33/86 ,  G01N27/22 ,  G01N27/221 ,  G01N33/49 ,  G01N33/5094 ,  G01N33/53 ,  G01N33/556

Abstract: Provided is a technology useful for verifying measurement accuracy before measurement of an electrical characteristic of blood samples.A sample for use in electrical characteristic measurement is provided including erythrocytes incompletely fixed with a fixative, the fixed erythrocytes being such that an electrical characteristic of a mixture of the fixed erythrocytes and plasma components can change over time. An electrical characteristic measurement method is provided including measuring an electrical characteristic of the sample for use in electrical characteristic measurement over time before measuring an electrical characteristic of blood samples over time. An electrical characteristic measurement device is provided including a determination unit configured to determine measurement accuracy on the basis of a predetermined reference value and measured values based on the electrical characteristic measured using the sample for use in electrical characteristic measurement.

公开(公告)号：US20170030934A1

公开(公告)日：2017-02-02

申请号：US15302914

申请日：2015-04-09

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49

CPC classification number: G01N33/86 ,  G01N33/4905 ,  G01N33/491

Abstract: A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.

Abstract translation: 1.一种血液状态分析装置（1），其用于凝血时间检测时使用的血液样本的状态，所述血液样本包括等离子体和至少一种试剂，该校正单元（11）构成为校正测定的血液凝固 基于血浆中的至少一种试剂的参考浓度与参照血液凝固评价结果之间的关系的血液样品的评价结果​​，所述至少一种试剂是抗凝治疗脱模剂，凝血活化剂，抗凝血剂，血小板活化剂 ，抗血小板药物或其组合，并存在于血液样品中。 例如，这种装置（1）允许相对于存在于血液样品中的抗凝剂药物的浓度校正血液凝固时间结果。

公开(公告)号：US20160018346A1

公开(公告)日：2016-01-21

申请号：US14772550

申请日：2014-02-20

Applicant: SONY CORPORATION

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Yoichi Katsumoto

IPC: G01N27/02 ,  G01N15/05 ,  G01N33/49

CPC classification number: G01N27/02 ,  G01N15/05 ,  G01N27/221 ,  G01N33/49 ,  G01N2015/055 ,  G01N2333/805

Abstract: There is provided a blood condition analyzing device including an erythrocyte quantitative evaluation unit configured to evaluate a hematocrit value and/or a hemoglobin amount on the basis of an electrical characteristic of a blood sample at a frequency of 2 to 25 MHz.

Abstract translation: 提供一种血液分析装置，其包括：红细胞定量评价单元，其被配置为基于2至25MHz的频率的血液样品的电特性来评估血细胞比容值和/或血红蛋白量。

公开(公告)号：US11630099B2

公开(公告)日：2023-04-18

申请号：US16696783

申请日：2019-11-26

Applicant: Sony Corporation

Inventor： Marcaurele Brun ,  Yoshihito Hayashi ,  Ludovic Keiser

IPC: G01N33/49 ,  G01N27/22 ,  G01N27/06

Abstract: There is provided a blood condition analyzing device including: an extraction unit configured to use temporal change data of an electrical characteristic of blood at an arbitrary frequency to extract a feature of the data; and a blood condition evaluation unit configured to evaluate a condition change of blood from a feature extracted in the extraction unit.

公开(公告)号：US20200174027A1

公开(公告)日：2020-06-04

申请号：US16543222

申请日：2019-08-16

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Yoichi Katsumoto ,  Marcaurele Brun

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/02

Abstract: A blood state evaluation device, blood state evaluation system, blood state evaluation method, and program that enable evaluation of the risk of thrombosis easily and precisely is provided. An electrical characteristic of blood being an evaluation target is chronologically measured in two or more frequencies or two or more frequency bands. On the basis of chronological change data of the measured electrical characteristic of the blood, a state of blood is evaluated.

公开(公告)号：US10578604B2

公开(公告)日：2020-03-03

申请号：US15509091

申请日：2015-08-10

Applicant: SONY CORPORATION

Inventor： Kenzo Machida ,  Marcaurele Brun ,  Yoshihito Hayashi

IPC: G01N33/49 ,  G01N27/02

Abstract: To an electrical characteristic measuring device that further improves the accuracy of measurement of an electrical characteristic of a blood sample. Provided is an electrical characteristic measuring device including: a measuring unit configured to measure an electrical characteristic of a blood sample; and an alert generation unit configured to issue an alert signal when an erythrocyte sedimentation rate in the blood sample exceeds a prescribed standard during measurement of the blood sample.

公开(公告)号：US10527605B2

公开(公告)日：2020-01-07

申请号：US14772483

申请日：2014-02-20

Applicant: Sony Corporation

Inventor： Marcaurele Brun ,  Yoshihito Hayashi ,  Ludovic Keiser

IPC: G01N33/49 ,  G01N27/22 ,  G01N27/06

Abstract: There is provided a blood condition analyzing device including: an extraction unit configured to use temporal change data of an electrical characteristic of blood at an arbitrary frequency to extract a feature of the data; and a blood condition evaluation unit configured to evaluate a condition change of blood from a feature extracted in the extraction unit.

公开(公告)号：US20150077144A1

公开(公告)日：2015-03-19

申请号：US14391090

申请日：2013-03-05

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marc-Aurele Brun ,  Isao Uchimura

IPC: G01N33/487 ,  G01N33/49 ,  G01N27/06

CPC classification number: G01N33/48707 ,  G01N27/026 ,  G01N27/06 ,  G01N33/4905

Abstract: There is provided a blood coagulation system analyzer, including a measurement section and an analysis section. The measurement section measures a time change of impedance of a blood sample, which is obtainable by applying an alternating electric field to the blood sample. The analysis section extracts a parameter indicating the characteristics of the impedance from the measured data of the time change of the impedance. Furthermore, the analysis section analyzes a degree of enhancement of blood coagulation on the basis of a comparison of the extracted parameter with at least one reference value which defines the criteria of the enhancement of blood coagulation.

Abstract translation: 提供了一种血液凝固系统分析仪，包括测量部分和分析部分。 测量部分测量通过向血液样本施加交变电场而获得的血液样本的阻抗的时间变化。 分析部从阻抗的时间变化的测定数据中提取表示阻抗的特性的参数。 此外，分析部分基于提取的参数与限定凝血增强标准的至少一个参考值的比较来分析血液凝固的程度。

公开(公告)号：US20140162348A1

公开(公告)日：2014-06-12

申请号：US14095657

申请日：2013-12-03

Applicant: Sony Corporation

Inventor： Yoichi Katsumoto ,  Marcaurele Brun ,  Yoshihito Hayashi

IPC: G01N33/86

Abstract: There is provided an electrical measuring container of a biological sample in a liquid phase, including at least a biological sample holding section configured to accommodate a biological sample in a liquid phase and made of a resin, and an electrical conductive section fixed to the biological sample holding section. In a state in which a portion of the electrical conductive section is buried in the biological sample holding section, the biological sample holding section and the electrical conductive section are integrally formed with each other.

Abstract translation: 提供了一种液相生物样品的电量测量容器，至少包括生物样品保持部分，该生物样品保持部分构造成容纳液相中的生物样品并由树脂制成，并且固定在生物样品上的导电部分 持有部分。 在导电部的一部分埋设在生物样品保持部中的状态下，生物样品保持部和导电部彼此一体形成。