公开(公告)号：US11680925B2

公开(公告)日：2023-06-20

申请号：US14952360

申请日：2015-11-25

申请人： Polymer Technology Systems, Inc.

发明人： Gary L. Hughes ,  Ryan D. Jesswein

IPC分类号： G01N27/327 ,  G01N33/49 ,  G01N15/05

CPC分类号： G01N27/3274 ,  G01N27/3271 ,  G01N27/3273 ,  G01N27/3275 ,  G01N27/3277 ,  G01N33/49 ,  G01N2015/055 ,  G01N2333/904 ,  G01N2496/80

摘要： A system for determining a level of hematocrit includes a test strip configured to receive a sample; a meter configured to receive the test strip; and further including circuitry and a microprocessor, the circuitry and microprocessor configured to apply electrical energy to the test strip and the sample and determine an electrical property of the sample, either the impedance phase angle or the impedance magnitude of the test strip and the sample and, based on the electrical property, calculate the level of hematocrit in the sample.

公开(公告)号：US20180364268A1

公开(公告)日：2018-12-20

申请号：US16072412

申请日：2017-01-24

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Stefan Kluckner ,  Yao-Jen Chang ,  Terrence Chen ,  Benjamin S. Pollack

IPC分类号： G01N35/00 ,  G06T7/00 ,  G01B11/245

CPC分类号： G01N35/00732 ,  G01B11/245 ,  G01F23/0076 ,  G01N15/042 ,  G01N35/1016 ,  G01N2015/047 ,  G01N2015/055 ,  G01N2035/0401 ,  G01N2035/0406 ,  G01N2035/0493 ,  G01N2035/1018 ,  G01N2035/1025 ,  G06T5/009 ,  G06T5/50 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/143 ,  G06T7/62 ,  G06T2207/10024 ,  G06T2207/10036 ,  G06T2207/10144 ,  G06T2207/10152 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/20208 ,  G06T2207/20221

摘要： A model-based method of classifying a specimen in a specimen container. The method includes capturing images of the specimen and container at multiple different exposures times, at multiple different spectra having different nominal wavelengths, and at different viewpoints by using multiple cameras. From the captured images, 2D data sets are generated. The 2D data sets are based upon selection of optimally-exposed pixels from the multiple different exposure images to generate optimally-exposed image data for each spectra. Based upon these 2D data sets, various components are classified using a multi-class classifier, such as serum or plasma portion, settled blood portion, gel separator (if present), tube, air, or label. From the classification data and 2D data sets, a 3D model can be generated. Specimen testing apparatus and quality check modules adapted to carry out the method are described, as are other aspects.

公开(公告)号：US20170160177A1

公开(公告)日：2017-06-08

申请号：US15435842

申请日：2017-02-17

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： David D. Hyde ,  Michael W. LaCourt ,  Tracy McDonald ,  Christopher M. Parobek

IPC分类号： G01N15/04 ,  G01N33/49 ,  G01N35/10 ,  G01N15/05

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N33/491 ,  G01N35/1009 ,  G01N2015/055

摘要： A method for determining a condition in a blood sample includes: providing a sample of blood; providing a metering probe having a pump for aspirating and dispensing; inserting the metering probe a selected distance into the blood sample; measuring the pressure between the sample and pump during sample aspiration or sample dispense; comparing the measured pressure with a reference value; and signaling the presence or absence of the condition. A method for confirming or detecting the presence of a selected layer of blood component in a centrifuged blood sample includes: measuring a pressure of a suspected selected layer in a metering probe during aspiration or dispense; comparing the measured pressure with a reference value, wherein if the measured pressure and the reference value are substantially identical then the selected layer of the blood component is confirmed. In a preferred embodiment the reference value is a pre-selected pressure range.

公开(公告)号：US20160290910A1

公开(公告)日：2016-10-06

申请号：US15090649

申请日：2016-04-05

申请人： ARKRAY, Inc.

发明人： Megumi Saeda ,  Hisashi Kaneda

IPC分类号： G01N15/05 ,  G01N27/327 ,  G01N27/416 ,  G01N27/02 ,  C12Q1/00

CPC分类号： G01N15/05 ,  C12Q1/006 ,  G01N27/028 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/4166 ,  G01N2015/0065 ,  G01N2015/055

摘要： Provided is a method for measuring the concentration of a substance in a blood sample, the method comprising the steps of: supplying the blood sample to a biosensor comprising a hematocrit electrode for measuring a hematocrit value on the surface of which electrode an electrically conductive polymer is coated by physical adsorption in the absence of a crosslinking agent; and calculating the concentration of the substance from the measured value of a first current resulting from application of a first voltage; and correcting the concentration of the substance with the value of a second current resulting from application of a second voltage or the hematocrit value calculated from the value of the second current.

摘要翻译： 提供了一种用于测量血液样品中物质浓度的方法，所述方法包括以下步骤：将血液样品供应到生物传感器，所述生物传感器包括用于测量导电聚合物的电极表面上的血细胞比容值的血细胞比容电极 在没有交联剂的情况下通过物理吸附涂覆; 以及从施加第一电压得到的第一电流的测量值计算所述物质的浓度; 以及通过施加第二电压产生的第二电流的值或从第二电流的值计算的血细胞比容值来校正物质的浓度。

公开(公告)号：US20160091408A1

公开(公告)日：2016-03-31

申请号：US14777771

申请日：2013-04-03

申请人： EDAN INSTRUMENTS INC.

发明人： Xiaofei XIANG ,  Yinhui LU ,  Zhixiang ZHAO

IPC分类号： G01N15/05 ,  G01N15/06

CPC分类号： G01N15/05 ,  A61B5/14535 ,  G01N15/0656 ,  G01N33/49 ,  G01N2015/055

摘要： The present invention relates to a detection system for improving accuracy of hematocrit measurement and an operation control method. The detection system for hematocrit measurement comprises a central processing unit, an excitation source unit, a blood sample unit, a precise measurement circuit unit and a signal collecting unit. The present invention has the beneficial effects that the HCT measurement precision is improved by generating a sine wave by the excitation source unit and performing control by the central processing unit; the detection system of the present invention is simple and reliable, and implements precise measurement; and the measurement precision in the present invention is far greater than that of a conventional measurement technology and can be within 0.2%. Furthermore, due to a self-detection function, the measurement is quite reliable without the risk of resulting incorrect measurement data from a circuit failure.

摘要翻译： 本发明涉及一种用于提高血细胞比容测量精度的检测系统和操作控制方法。 用于血细胞比容测量的检测系统包括中央处理单元，激发源单元，血液采样单元，精确测量电路单元和信号收集单元。 本发明具有通过由激励源单元生成正弦波并由中央处理单元进行控制来提高HCT测量精度的有益效果。 本发明的检测系统简单可靠，实现精确测量; 并且本发明的测量精度远远大于常规测量技术的测量精度，并且可以在0.2％以内。 此外，由于具有自检功能，测量结果相当可靠，不会产生电路故障导致的不正确的测量数据。

公开(公告)号：US20150029508A1

公开(公告)日：2015-01-29

申请号：US14331386

申请日：2014-07-15

申请人： SYSMEX CORPORATION

发明人： Akio TOYODA ,  Shinjirou AKAMATSU

IPC分类号： G01N33/49 ,  G01N21/51 ,  G01N35/00

CPC分类号： G01N33/492 ,  G01N15/05 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/6458 ,  G01N33/4915 ,  G01N35/00871 ,  G01N2015/0065 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/055 ,  G01N2035/00881 ,  G01N2035/009 ,  G01N2035/0091 ,  Y02A90/22 ,  Y02A90/24 ,  Y02A90/26

摘要： A sample analyzing apparatus comprising a measurement unit configured to measure samples obtained from subjects, an obtaining unit configured to obtain the presence or absence of a disease regarding each sample, a memory in which a measurement result obtained by the measurement unit and the presence or absence of the disease obtained by the obtaining unit are stored in association with the sample, and a communication unit configured to transmit disease information based on the presence or absence of the disease stored in the memory to a receiving apparatus installed in an external facility.

摘要翻译： 一种样本分析装置，包括：测量单元，被配置为测量从对象获得的样本;获取单元，被配置为获得关于每个样本的疾病的存在或不存在;其中由所述测量单元获得的测量结果和存在或不存在的存储器 由所述获取单元获得的疾病与所述样本相关联地存储，以及通信单元，被配置为基于存储在所述存储器中的所述疾病的存在或不存在将疾病信息发送到安装在外部设施中的接收装置。

公开(公告)号：US20130203107A1

公开(公告)日：2013-08-08

申请号：US13692611

申请日：2012-12-03

申请人： Abbott Point of Care, Inc.

发明人： Niten V. Lalpuria ,  Stephen C. Wardlaw

IPC分类号： G01N21/17

CPC分类号： G01N21/17 ,  G01N15/05 ,  G01N2015/055 ,  G06T7/0012 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024 ,  Y10T436/11

摘要： A method for determining the area of an analysis chamber covered by a biologic fluid sample quiescently residing within the chamber is provided. The chamber has a first panel with an interior surface, and a second panel with an interior surface, both of which panels are transparent. The method includes the steps of: a) illuminating the sample residing within the analysis chamber at one or more wavelengths operable to highlight interfaces between the sample and air, and to highlight a constituent within the sample; b) imaging the sample along the one or more wavelengths, and producing image signals representative of the interaction of the one or more wavelengths with the sample; c) determining a location of at least one interface between the sample and air, using the image signals; d) determining a location of one or more constituents within the sample relative to the at least one sample-air interface using the image signals; and e) determining an area of the chamber containing the sample, using the location of the one or more constituents and the at least one sample-air interface.

公开(公告)号：US20130170729A1

公开(公告)日：2013-07-04

申请号：US13673644

申请日：2012-11-09

申请人： Abbott Point of Care, Inc.

发明人： Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten V. Lalpuria ,  Jeremy R. Hill

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  G01N15/05 ,  G01N33/49 ,  G01N2015/055

摘要： A method and apparatus for identifying reticulocytes within a blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, and the chamber has a known or determinable height extending between the interior surfaces of panels, which height is such that at least one red blood cell, or an aggregate of red blood cells, within the sample contacts both of the interior surfaces; b) admixing a supravital dye with the sample, which dye is operable to cause reticulin to fluoresce when excited by light of one or more predetermined wavelengths; c) imaging the sample using light that includes the one or more predetermined wavelengths that cause reticulin to fluoresce; d) imaging the sample using light that is absorbed by hemoglobin to produce values of optical density on a per image unit basis; and e) identifying reticulocytes within the sample using the image of the sample created with light that causes the dyed reticulin to fluoresce, and using the per image unit optical density values.

摘要翻译： 提供了一种用于鉴定血液样本内的网织红细胞的方法和装置。 该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，并且室具有在面板的内表面之间延伸的已知或可确定的高度，其高度使得至少一个 样品内的红血细胞或红细胞聚集体接触两个内表面; b）将supravital染料与样品混合，该染料可操作以在由一种或多种预定波长的光激发时使网状蛋白发荧光; c）使用包括导致网状蛋白发荧光的一个或多个预定波长的光成像样品; d）使用被血红蛋白吸收的光进行成像，以产生基于每个图像单位的光密度值; 以及e）使用由导致染色的网状蛋白发荧光的光产生的样品的图像，以及使用每个图像单位的光密度值来鉴定样品内的网织红细胞。

公开(公告)号：US20120140230A1

公开(公告)日：2012-06-07

申请号：US13389761

申请日：2010-08-05

申请人： Kerry L. Miller

发明人： Kerry L. Miller

IPC分类号： G01N21/59 ,  G01N21/55

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N21/25 ,  G01N35/00603 ,  G01N2015/045 ,  G01N2015/055

摘要： A method of inspecting a clinical specimen for a presence of one or more interferents, such as those that might be found within clinical analytical blood specimens by subjecting the specimen to centrifugation to separate the specimen into a red blood cell portion and a blood serum or plasma portion is provided. Subsequent to the centrifuging procedure, the serum or plasma portion of the clinical analytical specimen may be tested for the presence of one or more interferents such as hemolysis, icterus, lipemia, or liquid nonuniformities therein. Additionally, physical dimensional characteristics of the sample container and/or specimen may be determined. Apparatus for carrying out the method are described, as are other aspects.

摘要翻译： 检查临床样本中存在一种或多种干扰物的方法，例如通过使样本离心分离到红细胞部分和血清或血浆中的临床分析血液标本中可能存在的那些 提供部分。 离心过程之后，可以测试临床分析样品的血清或血浆部分中存在一种或多种干扰物，例如溶血，黄疸，脂血症或液体不均匀性。 此外，可以确定样品容器和/或样品的物理尺寸特性。 与其他方面一样，描述了用于执行该方法的装置。

公开(公告)号：US07527740B2

公开(公告)日：2009-05-05

申请号：US10492256

申请日：2002-09-14

申请人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

发明人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

IPC分类号： B01D37/00 ,  B01D11/00

CPC分类号： G01N15/05 ,  A61M1/3693 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  G01N33/491 ,  G01N2015/055 ,  G01N2015/1486 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying the dispersion to a junction, a first drain channel for draining fluid having a reduced particle concentration away from the junction, and a second drain channel for draining fluid having an increased particle concentration away from the junction. The fluid flows so much faster in the second drain channel than in the first drain channel that due to the different flow speeds the dispersed particles preferentially flow at the junction further in the second drain channel.

摘要翻译： 一种用于从流体分散体中分离颗粒的方法，特别是用于从生物样品中分离出红细胞成分，尤其是血液。 适于执行该方法的分离模块具有带有流动通道的基底，包括用于将分散体供应到结点的进料通道，用于排出离开结点的具有降低的粒子浓度的流体的第一排出通道和用于 具有离开结点的具有增加的颗粒浓度的排出流体。 在第二排水通道中流体流动比在第一排水通道中要快得多，由于不同的流速，分散的颗粒优先在第二排水通道中的结点处流动。