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54 条记录 (耗时 0.028 秒)

    Compositions and methods for the delivery of poorly water soluble drugs and methods of treatment
    22.
    发明授权
    Compositions and methods for the delivery of poorly water soluble drugs and methods of treatment 有权
    用于递送水溶性差的药物的组合物和方法以及治疗方法

    公开(公告)号：US08221779B2

    公开(公告)日：2012-07-17

    申请号：US12394833

    申请日：2009-02-27

    申请人： Jeffrey M. Jonas ,  Roger A. Rajewski ,  Bala Subramaniam ,  Katherine F. Terranova

    发明人： Jeffrey M. Jonas ,  Roger A. Rajewski ,  Bala Subramaniam ,  Katherine F. Terranova

    IPC分类号： A61F2/02

    CPC分类号： A61K9/10 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/1688 ,  A61K47/44

    摘要： The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water-soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 μm. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions.

    摘要翻译： 本发明的本实施方案通常涉及包含以0.1至5μm的纳米颗粒尺寸重结晶的难溶于水的化合物的悬浮液的组合物。 此外，本发明的实施方案涉及用于制备和施用这些组合物给患者以预防和治疗疾病状态的方法。 特别地，本发明的实施方案涉及包含难溶性水溶性化合物如抗虚证和抗生素的悬浮液在纳米颗粒中的组合物，以及通过腹膜内和静脉内施用预防和治疗慢性疾病状态如癌症的方法 这样的组合物。

    Method and apparatus for acquiring a synchronization signal
    25.
    发明授权
    Method and apparatus for acquiring a synchronization signal 有权

    公开(公告)号：US07042854B2

    公开(公告)日：2006-05-09

    申请号：US09768726

    申请日：2001-01-24

    申请人： Bassel Beidas ,  Olga Ritterbush ,  Stanley Kay ,  Yezdi Antia ,  Bala Subramaniam

    发明人： Bassel Beidas ,  Olga Ritterbush ,  Stanley Kay ,  Yezdi Antia ,  Bala Subramaniam

    IPC分类号： H04B7/212

    CPC分类号： H04J3/0611 ,  H04B7/2125 ,  H04L7/0004

    摘要： A method and system for acquiring a time division multiplexed synchronization signal in a satellite communication system is provided. The signal is provided as a series of frames with beacon signals time division multiplexed into at least one time slot of each frame. The beacon signal in each frame comprises a unique word sequence, which is the same in each frame, and a portion of a PN sequence. The entire PN sequence is distributed into a plurality of frames forming a superframe. Initially, the power level of the incoming signal is determined by locating the maximum power received in half time slot intervals. Next a series of frames are correlated against the expected unique word, each at one of a plurality of possible frequencies. The frequency generating the maximum correlation with the unique word is selected. The frequency is fine tuned by comparing the actual arrival time of the unique word in each frame with the estimated arrival time based on the current frequency, and adjusting the frequency accordingly. Also, the start of the superframe is located by correlating the PN sequence portion of each beacon signal against a known PN sequence until a match is found. Once the frequency offset is reduced below a threshold value, and the start of the PN sequence of the incoming signal is located, acquisition is completed.

    Precipitation of proteins from organic solutions
    26.
    发明授权
    Precipitation of proteins from organic solutions 失效
    从有机溶液中沉淀蛋白质

    公开(公告)号：US06562952B1

    公开(公告)日：2003-05-13

    申请号：US09703221

    申请日：2000-10-31

    申请人： Roger A. Rajewski ,  Bala Subramaniam ,  William K. Snavely ,  Fenghui Niu

    发明人： Roger A. Rajewski ,  Bala Subramaniam ,  William K. Snavely ,  Fenghui Niu

    IPC分类号： A23J100

    CPC分类号： A61K9/1688

    摘要： A process for forming small micron-sized (1-10 &mgr;m) protein particles is provided wherein a protein, a solvent system for the protein and an antisolvent for the protein solvent system are contacted under conditions to at least partially dissolve the protein solvent system in the antisolvent, thereby causing precipitation of the protein. The solvent system is made up of at least in part of a halogenated organic alcohol, most preferably 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). Preferably, a solution of the protein in the solvent system is sprayed through a nozzle into a precipitation zone containing the antisolvent (preferably CO2) under near- or supercritical conditions.

    摘要翻译： 提供了形成小微米尺寸（1-10μm）蛋白质颗粒的方法，其中蛋白质，用于蛋白质的溶剂体系和蛋白质溶剂体系的抗溶剂在至少部分溶解蛋白质溶剂体系的条件下接触 抗溶剂，从而引起蛋白质的沉淀。 溶剂系统由至少部分卤代有机醇，最优选1,1,1,3,3,3-六氟-2-丙醇（HFIP）组成。 优选地，在近或超临界条件下，将蛋白质在溶剂系统中的溶液通过喷嘴喷射到含有抗溶剂（优选CO 2）的沉淀区中。

    Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
    27.
    发明授权
    Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent 失效
    通过从喷射到压缩抗溶剂中的有机溶液重结晶进行颗粒微粉化和纳米化的方法

    公开(公告)号：US5874029A

    公开(公告)日：1999-02-23

    申请号：US723463

    申请日：1996-10-09

    申请人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    发明人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    IPC分类号： A61K9/16 ,  A61K9/50 ,  B01J2/04 ,  B05D1/02 ,  B29B9/00

    CPC分类号： B05D1/025 ,  A61K9/1676 ,  A61K9/1688 ,  B01J2/04 ,  A61K9/1694 ,  A61K9/5089 ,  B05D2401/90 ,  Y10S977/773

    摘要： A method and an apparatus useful for the production of microparticles and nanoparticles are disclosed in which a compressed fluid and a solution including a solvent and a solute are introduced into a nozzle to produce a mixture. The mixture is then passed out of the nozzle to produce a spray of atomized droplets. The atomized droplets are contacted with a supercritical antisolvent to cause depletion of the solvent in the droplets so that particles are produced from the solute. Preferably, these particles have an average diameter of 0.6 .mu.m or less. The invention can be used in the pharmaceutical, food, chemical, electronics, catalyst, polymer, pesticide, explosives, and coating industries, all of which have a need for small-diameter particles.

    摘要翻译： 公开了一种用于生产微粒和纳米颗粒的方法和装置，其中将压缩流体和包含溶剂和溶质的溶液引入喷嘴中以产生混合物。 然后将混合物从喷嘴中排出以产生雾化液滴的喷雾。 雾化的液滴与超临界反溶剂接触以引起液滴中溶剂的消耗，使得从溶质中产生颗粒。 优选地，这些颗粒的平均直径为0.6μm以下。 本发明可用于制药，食品，化工，电子，催化剂，聚合物，农药，爆炸物和涂料工业，所有这些都需要小直径颗粒。

    ALKYLENE EPOXIDATION WITH MESOPOROUS CATALYSTS
    28.
    发明申请
    ALKYLENE EPOXIDATION WITH MESOPOROUS CATALYSTS 有权
    亚烷基氧化与多孔催化剂

    公开(公告)号：US20150191442A1

    公开(公告)日：2015-07-09

    申请号：US14409503

    申请日：2013-06-27

    申请人： Bala Subramaniam ,  Anand Ramanathan ,  Madhav Ghanta ,  Wenjuan Yan

    发明人： Bala Subramaniam ,  Anand Ramanathan ,  Madhav Ghanta ,  Wenjuan Yan

    IPC分类号： C07D301/19

    CPC分类号： C07D301/19 ,  C07D301/12

    摘要： A process for epoxidizing an olefin comprising contacting an olefin with an oxidant in the presence of an insoluble oxidation catalyst in a solvent system comprising an organic water-miscible solvent to form an alkylene oxide. The insoluble oxidation catalyst comprises a metal, preferably selected from the group consisting of tungsten, cerium, and niobium. The metal is directly incorporated within a solid mesoporous silicate support, such as one selected from the group consisting of KIT-5, KIT-6, and TUD-1.

    摘要翻译： 一种使烯烃环氧化的方法，包括使烯烃与氧化剂在不溶性氧化催化剂存在下在包含有机水混溶性溶剂的溶剂体系中接触以形成烯化氧。 不溶性氧化催化剂包含优选选自钨，铈和铌的金属。 将金属直接掺入固体介孔硅酸盐载体中，例如选自KIT-5，KIT-6和TUD-1的一种。

    ALKYLATION CATALYZED BY BINARY MIXTURES OF ACID AND IONIC LIQUID
    30.
    发明申请
    ALKYLATION CATALYZED BY BINARY MIXTURES OF ACID AND IONIC LIQUID 审中-公开
    酸和液体二元混合催化的烷基化

    公开(公告)号：US20100331599A1

    公开(公告)日：2010-12-30

    申请号：US12797450

    申请日：2010-06-09

    申请人： Bala Subramaniam ,  Aaron Scurto ,  Shengwei Tang

    发明人： Bala Subramaniam ,  Aaron Scurto ,  Shengwei Tang

    IPC分类号： C07C2/58 ,  B01J37/30

    CPC分类号： B01J31/0222 ,  B01J31/0239 ,  B01J31/0284 ,  B01J31/0285 ,  B01J31/0289 ,  C07C2/62 ,  C07C11/02

    摘要： An alkylation catalyst can include: a Brønsted acid ionic liquid; and a strong Brønsted acid that is not considered an ionic liquid. The Brønsted acid ionic liquid can be selected from the group consisting of [BMIm]HSO4, [MBSIm]HSO4, [MBSIm]OTf, [MPSIm]OTf, and [OMIm]HSO4 or the like. In one aspect, the strong Brønsted acid is selected from the group consisting of sulfuric acid, hydrochloric acid (HCl), hydrobromic acid (HBr), HF, hydrogen iodide (HI), phosphoric acid, trifluoromethanesulfonic (triflic) acid. In one aspect, the strong Brønsted acid is present at more than about 50 wt % of the composition; however, the Brønsted acid can vary from about 10 wt % to about 99 wt %, more preferably about 20 wt % to about 90 wt %, and most preferably about 40 wt % to about 80 wt %.

    摘要翻译： 烷基化催化剂可以包括：布朗斯台德酸离子液体; 和强烈的布朗斯台德酸，不被认为是离子液体。 布朗斯台德酸性离子液体可以选自[BMIm] HSO4，[MBSIm] HSO4，[MBSIm] OTf，[MPSIm] OTf和[OMIm] HSO4等。 一方面，强布朗斯台德酸选自硫酸，盐酸（HCl），氢溴酸（HBr），HF，碘化氢（HI），磷酸，三氟甲磺酸（三氟）酸。 在一个方面，强布朗斯台德酸以组合物的大于约50重量％存在; 然而，布朗斯台德酸可以在约10重量％至约99重量％，更优选约20重量％至约90重量％，最优选约40重量％至约80重量％的范围内变化。