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38 条记录 (耗时 0.033 秒)

    Pyridazinone derivatives
    22.
    发明授权
    Pyridazinone derivatives 失效
    哒嗪酮衍生物

    公开(公告)号：US4639451A

    公开(公告)日：1987-01-27

    申请号：US504039

    申请日：1983-06-03

    申请人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Joji Kamiya ,  Yasuhito Tanaka ,  Takuo Nakano

    发明人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Joji Kamiya ,  Yasuhito Tanaka ,  Takuo Nakano

    IPC分类号： C07D237/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/50

    CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

    摘要： This invention relates to pyridazinone derivatives of the general formula: ##STR1## [wherein R.sup.1 stands for a hydrogen atom or a lower alkyl group; R.sup.2 for a hydrogen atom or a lower alkyl group; and A for (i) a ring selected from a benzene ring, a furan ring, a thiophene ring and a pyridine ring (on which ring 1-3 substituents or atoms selected from amino groups, nitro groups, lower alkanoylamino groups, hydroxyl groups, lower alkanoyloxy groups, sulfamoyl groups and halogen atoms may be present), or (ii) a grouping of the formula: ##STR2## (wherein R.sup.3 stands for a hydrogen atom, a lower alkyl group, a phenyl(lower)alkyl, a hydroxyphenyl(lower)alkyl group, a lower alkylmercapto(lower)alkyl group, a benzylmercapto(lower)alkyl group, a guanidino(lower)alkyl group, a nitroguanidino(lower)alkyl group, an indolyl(lower)alkyl group, a carbamoyl(lower)alkyl group or a carboxy(lower)alkyl group, R.sup.4 for a hydrogen atom or a lower alkyl group, R.sup.5 for a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a benzoyl or a benzyloxycarbonyl group, and R.sup.3 and R.sup.4 may be combined to form a grouping of the formula: ##STR3## which forms a ring), or (iii) a grouping of the formula: ##STR4## (wherein R.sup.6, R.sup.7 and R.sup.8 each stand for a hydrogen atom or a lower alkyl group, B is an oxygen atom or a sulfur atom, R.sup.9 stands for a hydrogen atom or a lower alkanoyl group, and n is 0 or 1)].

    摘要翻译： PCT No.PCT / JP82 / 00415 Sec。 371日期：1983年6月3日 102（e）日期1983年6月3日PCT提交1982年10月20日PCT公布。 第WO83 / 01447号公报 日本1983年4月28日。本发明涉及以下通式的哒嗪酮衍生物：其中R1代表氢原子或低级烷基; R2为氢原子或低级烷基; A为（i）选自苯环，呋喃环，噻吩环和吡啶环的环（其中1-3个取代基或选自氨基，硝基，低级烷酰基氨基，羟基， 低级烷酰氧基，氨磺酰基和卤素原子可以存在），或（ii）下式的基团：其中R3代表氢原子，低级烷基，苯基（低级）烷基，羟基苯基 （低级）烷基，低级烷基巯基（低级）烷基，苄基巯基（低级）烷基，胍基（低级）烷基，硝基胍基（低级）烷基，吲哚基（低级）烷基，氨基甲酰基 低级）烷基或羧基（低级）烷基，R4表示氢原子或低级烷基，R5表示氢原子，低级烷基，低级链烷酰基，苯甲酰基或苄氧基羰基，R3和 R4可以组合以形成下式的分组：形成环的），或（iii）下式的分组：（ 其中R6，R7和R8各自代表氢原子或低级烷基，B是氧原子或硫原子，R9代表氢原子或低级烷酰基，n是0或1）]。

    Benzothiazepine derivatives and their method of preparation
    23.
    发明授权
    Benzothiazepine derivatives and their method of preparation 失效
    苯并硫氮杂衍生物及其制备方法

    公开(公告)号：US4539151A

    公开(公告)日：1985-09-03

    申请号：US625815

    申请日：1984-06-28

    申请人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka

    发明人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka

    IPC分类号： C07D281/10 ,  C07D281/02

    CPC分类号： C07D281/10 ,  Y02P20/55

    摘要： This invention relates to benzothiazepine derivatives of the general formula ##STR1## where Y is hydrogen, a CHR.sub.3 --COOR.sub.1 group, an alkanoyl group or a --COO(CH.sub.2).sub.n R.sub.4 group where R.sub.1 is hydrogen or a lower alkyl group, R.sub.3 is hydrogen, an alkyl group, an alkylphenyl group or an aryl-lower alkyl group, R.sub.4 is an aryl group and n is a whole number of 1 to 10, and to their method of preparation.The benzothiazepine derivatives of this invention, including their salts, have an inhibitory effect on the angiotensin converting enzyme and are useful as raw materials or intermediates for the synthesis of antihypertensive agents and as intermediates for the manufacture of other drugs, agricultural chemicals and industrial chemicals.

    摘要翻译： 本发明涉及通式为（I）的苯并硫氮杂衍生物，其中Y为氢，CHR 3 -COOR 1基，烷酰基或-COO（CH 2）n R 4基，其中R 1为氢或低级烷基，R 3 是氢，烷基，烷基苯基或芳基 - 低级烷基，R4是芳基，n是整数1〜10，以及它们的制备方法。 本发明的苯并硫氮杂衍生物，包括其盐，对血管紧张素转化酶具有抑制作用，可用作合成抗高血压药物的原料或中间体，也可用作制造其它药物，农药和工业化学品的中间体。

    6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds
    24.
    发明授权
    6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds 失效
    （取代的苯基）-4,5-二氢-3（2H） - 哒嗪酮化合物

    公开(公告)号：US4521415A

    公开(公告)日：1985-06-04

    申请号：US454021

    申请日：1982-12-28

    申请人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Joji Kamiya ,  Yasuhito Tanaka ,  Takuo Nakano

    发明人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Joji Kamiya ,  Yasuhito Tanaka ,  Takuo Nakano

    IPC分类号： A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D401/12 ,  C07D403/12

    CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D403/12

    摘要： 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds possessing strong platelet aggregation inhibiting activity and blood pressure depressing activity, having the general formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen, lower alkyl, lower alkylthio or the grouping R.sup.5 --NH-- where R.sup.5 is lower alkyl; R.sup.3 is phenyl, pyridyl, benzyl, lower alkyl or a substituted phenyl group carrying at any desired position on the benzene ring thereof the grouping: ##STR2## where R.sup.1 has the same meaning as given above; R.sup.4 is hydrogen or halogen; n is 0 or 1; and when both R.sup.2 and R.sup.3 are lower alkyl groups, R.sup.2 and R.sup.3 may be combined together with the bridging member ##STR3## where m is 2 or 3, as well as physiologically acceptable acid-addition salts thereof, and processes for preparing them.

    摘要翻译： 具有强烈的血小板聚集抑制活性和降低血压的6-（取代的苯基）-4,5-二氢-3（2H） - 哒嗪酮化合物，具有以下通式：其中R 1为氢或低级烷基 ; R2是氢，低级烷基，低级烷硫基或分组R5-NH-，其中R5是低级烷基; R3是苯基，吡啶基，苄基，低级烷基或在其苯环上的任何所需位置携带的取代苯基，其分子式如下：其中R 1具有与上述相同的含义; R4是氢或卤素; n为0或1; 当R 2和R 3均为低级烷基时，R 2和R 3可以与m为2或3的桥连基团以及其生理上可接受的酸加成盐组合在一起，以及制备方法 他们。

    L-nucleic acid derivatives and process for the synthesis thereof
    25.
    发明授权
    L-nucleic acid derivatives and process for the synthesis thereof 有权
    L-核酸衍生物及其合成方法

    公开(公告)号：US07125983B2

    公开(公告)日：2006-10-24

    申请号：US10433004

    申请日：2001-11-29

    申请人： Hajime Iizuka ,  Kazuhiko Togashi ,  Tsuneji Suzuki

    发明人： Hajime Iizuka ,  Kazuhiko Togashi ,  Tsuneji Suzuki

    IPC分类号： C07H19/06 ,  C07H19/09

    CPC分类号： C07D498/04 ,  C07D498/14 ,  C07H9/06 ,  C07H19/06 ,  C07H19/073 ,  C07H19/09

    摘要： A novel method has been found to produce 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine. A novel method has been further found to L-2′-deoxyribose derivatives as a useful synthetic intermediate through L-2,2′-anhydro-5,6-dihydrocyclouridine derivative. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now.

    摘要翻译： 已经发现一种新的方法生产2,2'-脱水-1-（β-L-阿拉伯呋喃糖基）胸腺嘧啶作为新的有用的中间体化合物。 已经进一步发现一种从2,2'-脱水-1-（β-L-阿拉伯呋喃糖基）胸腺嘧啶产生胸苷的新方法。 通过L-2,2'-脱水-5,6-二氢环尿苷衍生物，进一步发现L-2'-脱氧核糖衍生物作为有用的合成中间体的新方法。 根据这些方法，合成各种L-核酸衍生物，其合成迄今难以实现。

    Benzothiazepine derivatives and their methods of preparation
    29.
    发明授权
    Benzothiazepine derivatives and their methods of preparation 失效
    苯并硫氮杂衍生物及其制备方法

    公开(公告)号：US4539150A

    公开(公告)日：1985-09-03

    申请号：US625656

    申请日：1984-06-28

    申请人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Isao Shirakawa

    发明人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Isao Shirakawa

    IPC分类号： C07D281/10 ,  C07D281/02

    CPC分类号： C07D281/10

    摘要： This invention relates to benzothiazepine derivatives of the general formula ##STR1## where K is hydrogen or a --CH.sub.2 COOR.sub.2 group where R.sub.2 is hydrogen or a lower alkyl group, Z is hydrogen or phenyl except when both K and Z are hydrogen, and Y is hydrogen, a --CHR.sub.3 --COOR.sub.1 group, an alkanoyl group or a --COO(CH.sub.2).sub.n R.sub.4 group where R.sub.1 is hydrogen or a lower alkyl group, R.sub.3 is hydrogen, an alkyl group, an alkylphenyl group or an aryl-lower alkyl group, R.sub.4 is an aryl group and n is a whole number of 1 to 10, and to their methods of preparation.The benzothiazepine derivatives of this invention, including their salts, have a powerful inhibitory effect on the angiotensin converting enzyme and exert a marked depressor effect in such models of hypertension as spontaneously occurring hypertensive rats and the like, so that they are useful as drugs for the treatment of hypertension and other cardiovascular diseases. In addition, these compounds are also useful as intermediates for the synthesis of coronary dilators, psychotropic drugs and the like.

    摘要翻译： 本发明涉及通式为（I）的苯并硫氮杂衍生物，其中K是氢或-CH 2 COOR 2基团，其中R 2是氢或低级烷基，Z是氢或苯基，除了当K和Z都是氢时， Y是氢，-CHR 3 -COOR 1基团，烷酰基或-COO（CH 2）n R 4基团，其中R 1是氢或低级烷基，R 3是氢，烷基，烷基苯基或芳基 - 低级烷基 基团，R 4为芳基，n为1〜10的整数，及其制备方法。 包括其盐在内的本发明的苯并硫氮杂衍生物对血管紧张素转化酶具有强大的抑制作用，并且在自发发生的高血压大鼠等高血压模型中发挥明显的抑制作用，因此它们可用作药物 治疗高血压等心血管疾病。 此外，这些化合物也可用作合成冠状动脉扩张剂，精神药物等的中间体。

    Pickup device
    30.
    发明申请
    Pickup device 失效
    拾取装置

    公开(公告)号：US20050229196A1

    公开(公告)日：2005-10-13

    申请号：US11100920

    申请日：2005-04-07

    申请人： Hajime Iizuka ,  Yasuhito Kojima ,  Koichi Takezawa

    发明人： Hajime Iizuka ,  Yasuhito Kojima ,  Koichi Takezawa

    IPC分类号： G11B7/12 ,  G11B7/00 ,  G11B7/085 ,  G11B7/09 ,  H05K1/02 ,  H05K1/18 ,  H05K9/00

    CPC分类号： G11B7/12 ,  G11B7/08582 ,  G11B2007/0006 ,  H05K1/0218 ,  H05K1/189 ,  H05K2201/055

    摘要： A pickup device comprises a flexible circuit member including a main circuit portion on which electric or electronic components are mounted and a sub-circuit portion connected to the main circuit portion. The pickup device further comprises a housing on which the flexible circuit member is mounted. Each of the main circuit portion and the sub-circuit portion has a single-sided structure and includes a ground portion. The sub-circuit portion is folded with respect to the main circuit portion. The flexible circuit member is mounted on the housing while the main circuit portion and the sub-circuit portion are held in an overlapping arrangement. With this arrangement, S/N ratio of electric signals can be improved while achieving cost reduction.

    摘要翻译： 拾取装置包括柔性电路构件，该柔性电路构件包括安装有电子或电子部件的主电路部分和连接到主电路部分的子电路部分。 拾取装置还包括其上安装有柔性电路构件的壳体。 主电路部分和子电路部分中的每一个具有单面结构并且包括接地部分。 副电路部分相对于主电路部折叠。 柔性电路部件安装在壳体上，而主电路部分和副电路部分保持重叠的布置。 通过这种布置，可以提高电信号的S / N比，同时实现成本降低。