利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

66 条记录 (耗时 0.042 秒)

    Carotene Synthase Gene and Uses Therefor
    21.
    发明申请
    Carotene Synthase Gene and Uses Therefor 有权

    公开(公告)号：US20070269881A1

    公开(公告)日：2007-11-22

    申请号：US11557783

    申请日：2006-11-08

    申请人： Craig Weaver ,  James Metz ,  Jerry Kuner ,  Frank Overton

    发明人： Craig Weaver ,  James Metz ,  Jerry Kuner ,  Frank Overton

    IPC分类号： C12N1/20 ,  C07C53/00

    CPC分类号： C12N9/001 ,  C12N9/00 ,  C12N9/0004

    摘要： Described herein is a novel three domain gene from Schizochytrium, denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.

    Dental orthotic strut having multiple axes of movement
    24.
    发明授权
    Dental orthotic strut having multiple axes of movement 有权

    公开(公告)号：US10881547B2

    公开(公告)日：2021-01-05

    申请号：US15415118

    申请日：2017-01-25

    申请人： James Metz

    发明人： James Metz

    IPC分类号： A61F5/56 ,  A61C7/36

    摘要： A dental orthotic strut having at least one multi-axis rotable joint connecting the strut to either a maxillary and/or mandibular retainer attached to the teeth. Jaw advancement may be accomplished by periodically replacing the strut with a new strut having a slightly longer minimum length, thereby advancing the resting position of the closed jaw. The rotable joint or joints allow greater freedom of movement and comfort when the jaw is opened in a non-sagittal plane. A plurality of strut pairs having a same length, but with progressively longer sets of strut pairs is generally supplied, so that left and right struts can be progressively replaced with longer struts over time.

    DENTAL ORTHOTIC STRUT HAVING MULTIPLE AXES OF MOVEMENT
    25.
    发明申请
    DENTAL ORTHOTIC STRUT HAVING MULTIPLE AXES OF MOVEMENT 审中-公开

    公开(公告)号：US20170128256A1

    公开(公告)日：2017-05-11

    申请号：US15415118

    申请日：2017-01-25

    申请人： James Metz

    发明人： James Metz

    IPC分类号： A61F5/56 ,  A61C7/36

    CPC分类号： A61F5/566 ,  A61C7/36

    摘要： A dental orthotic strut having at least one multi-axis rotable joint connecting the strut to either a maxillary and/or mandibular retainer attached to the teeth. Jaw advancement may be accomplished by periodically replacing the strut with a new strut having a slightly longer minimum length, thereby advancing the resting position of the closed jaw. The rotable joint or joints allow greater freedom of movement and comfort when the jaw is opened in a non-sagittal plane. A plurality of strut pairs having a same length, but with progressively longer sets of strut pairs is generally supplied, so that left and right struts can be progressively replaced with longer struts over time.

    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    26.
    发明申请
    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 失效

    公开(公告)号：US20080032368A1

    公开(公告)日：2008-02-07

    申请号：US11781874

    申请日：2007-07-23

    申请人： Craig Weaver ,  Ross Zirkle ,  James Metz

    发明人： Craig Weaver ,  Ross Zirkle ,  James Metz

    IPC分类号： C07H21/04 ,  C12N5/04 ,  C12P7/64

    CPC分类号： C12P7/6472 ,  C07K14/195 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12N15/8247 ,  C12P7/62 ,  C12P7/6427

    摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    27.
    发明申请
    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 失效

    公开(公告)号：US20080032296A1

    公开(公告)日：2008-02-07

    申请号：US11689451

    申请日：2007-03-21

    申请人： Craig Weaver ,  Ross Zirkle ,  James Metz

    发明人： Craig Weaver ,  Ross Zirkle ,  James Metz

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/10

    CPC分类号： C12P7/6472 ,  C07K14/195 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12N15/8247 ,  C12P7/62 ,  C12P7/6427

    摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

    Anti-obstructive airway dental orthotic
    29.
    发明授权
    Anti-obstructive airway dental orthotic 有权
    抗阻塞性气道牙科矫正

    公开(公告)号：US08875713B2

    公开(公告)日：2014-11-04

    申请号：US13239498

    申请日：2011-09-22

    申请人： James Metz

    发明人： James Metz

    IPC分类号： A61F5/56

    CPC分类号： A61F5/566

    摘要： An anti-obstructive airway dental orthotic is described. The orthotic includes a maxillary retainer and a mandibular retainer releasably attaching to a plurality of teeth of a wearer. The retainers are attached by at least one strut, either variable in length or of a plurality of lengths, which exert a forward force on the lower jaw, tending to advance the mandible relative to the maxilla. This advancement of the lower jaw promotes a less obstructed airway in the wearer, while fenestrations in the retainers may allow for greater comfort and tongue movement.

    摘要翻译： 描述了一种抗阻塞性气道牙科矫形器。 矫形器包括上颌保持器和可释放地附接到穿戴者的多个牙齿的下颌保持器。 保持器通过至少一个长度或多个长度的支柱连接，其在下颌上施加向前的力，倾向于相对于上颌骨推进下颌骨。 下颌的这种进步促进穿用者较少阻塞的气道，而保持器中的开窗可以允许更大的舒适性和舌头移动。

    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    30.
    发明申请
    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 有权
    多不饱和脂多糖合成酶系统及其用途

    公开(公告)号：US20080044874A1

    公开(公告)日：2008-02-21

    申请号：US11781875

    申请日：2007-07-23

    申请人： Craig Weaver ,  Ross Zirkle ,  James Metz

    发明人： Craig Weaver ,  Ross Zirkle ,  James Metz

    IPC分类号： C12P7/64 ,  C12N1/13 ,  C12N1/21 ,  C12N15/52 ,  C12N15/74 ,  C12N5/10

    CPC分类号： C12P7/6472 ,  C07K14/195 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12N15/8247 ,  C12P7/62 ,  C12P7/6427

    摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

    摘要翻译： 公开了来自细菌微生物Shewanella japonica和Shewanella olleyana的完全多不饱和脂肪酸（PUFA）聚酮化合物（PKS）系统及其生物活性片段和同系物。 更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用 本文公开的PUFA PKS系统。 本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。