-
21.发明授权Systems and methods for applying signals, including contralesional signals, to neural populations 有权将信号（包括对数信号）应用于神经群体的系统和方法公开(公告)号：US08926676B2
公开(公告)日：2015-01-06
申请号：US11697696
申请日：2007-04-06
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/36082 , A61N1/36103 , A61N1/3615
摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
摘要翻译： 公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。 具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。 该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯 。
-
22.发明授权Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods 有权由神经元功能障碍，降解，损伤和/或坏死影响的组织的电磁信号传递，以及相关的系统和方法公开(公告)号：US07949401B2
公开(公告)日：2011-05-24
申请号：US11697694
申请日：2007-04-06
申请人： Brad Fowler , Bradford E. Gliner , David Himes
发明人： Brad Fowler , Bradford E. Gliner , David Himes
IPC分类号： A61N1/36
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。
-
23.发明授权公开(公告)号：US07010351B2
公开(公告)日：2006-03-07
申请号：US09802808
申请日：2001-03-08
IPC分类号： A61N1/18
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
-
24.发明授权Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation 失效通过神经刺激促进和/或实现视觉功能的发展，康复，恢复和/或恢复的系统和方法公开(公告)号：US06990377B2
公开(公告)日：2006-01-24
申请号：US10832477
申请日：2004-04-26
IPC分类号： A61N1/10
CPC分类号： A61N1/36046 , A61N1/0531 , A61N1/0534 , A61N1/36103
摘要： System and methods for effectuating and/or facilitating visual function in a patient. One embodiment of a system comprises a neural stimulation system and a visual training system. The neural stimulation system can include a pulse generator and a stimulus delivery device coupled to the pulse generator. The stimulus delivery device is configured to deliver a stimulus to the brain of the patient. The visual training system can include a computer and a display coupled to the computer. The computer has a computer operable medium containing instructions to provide a visual output to the patient via the display.
摘要翻译： 用于实现和/或促进患者视觉功能的系统和方法。 系统的一个实施例包括神经刺激系统和视觉训练系统。 神经刺激系统可以包括脉冲发生器和耦合到脉冲发生器的刺激输送装置。 刺激递送装置被配置成向患者的大脑递送刺激。 视觉训练系统可以包括计算机和耦合到计算机的显示器。 计算机具有计算机可操作介质，其包含经由显示器向患者提供视觉输出的指令。
-
公开(公告)号：US6134468A
公开(公告)日：2000-10-17
申请号：US113803
申请日：1998-07-09
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3931
摘要： An energy reduction unit is removably connectable to an external defibrillator to reduce the defibrillation energy delivered by the defibrillator to a patient. Use of the energy reduction unit is particularly suited to defibrillating pediatric patients (infants and children under 8) with an automatic or semi-automatic external defibrillator (AED). In one embodiment, the energy reduction unit includes an attenuator which partially dissipates energy produced by the AED. The attenuator is advantageously designed to present an impedance to the AED which, when connected to the patient, is approximately equal to the patient's impedance. The energy reduction unit may include a presence-detect function which enables the defibrillator to modify analysis of ECG signals to account for differences heart rhythms of pediatric and adult patients. In a second embodiment, the energy reduction unit includes an energy control modifier circuit which affects the charging operations performed internal to the AED. Other than being attached to the defibrillation equipment, the energy reduction unit does not otherwise change how an operator uses the equipment.
-
26.发明授权Techniques for selecting signal delivery sites and other parameters for treating depression and other neurological disorders, and associated systems and methods 有权用于选择信号传递部位的技术和用于治疗抑郁症和其他神经障碍的其它参数，以及相关的系统和方法公开(公告)号：US08262714B2
公开(公告)日：2012-09-11
申请号：US12395257
申请日：2009-02-27
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译： 本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。 根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。 该方法还包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。 然后至少部分地基于第二成像信息来选择目标神经群体。 该方法还包括将电磁信号应用于目标神经群体以改善患者功能。
-
27.发明申请ELECTROMAGNETIC SIGNAL DELIVERY FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS, AND ASSOCIATED SYSTEMS AND METHODS 有权由神经元功能丧失，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递公开(公告)号：US20110213440A1
公开(公告)日：2011-09-01
申请号：US13104802
申请日：2011-05-10
申请人： Brad Fowler , Bradford E. Gliner , David Himes
发明人： Brad Fowler , Bradford E. Gliner , David Himes
IPC分类号： A61N1/36
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。
-
28.发明申请Methods for Treating Neurological Disorders, Including Neuropsychiatric and Neuropsychological, Disorders, and Associated Systems 审中-公开治疗神经系统疾病，包括神经精神和神经心理学，疾病和相关系统的方法公开(公告)号：US20080208285A1
公开(公告)日：2008-08-28
申请号：US11961023
申请日：2007-12-20
IPC分类号： A61N1/02
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.
摘要翻译： 公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。 一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。 该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。 如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者 目标措施。 该方法可以进一步包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。
-
公开(公告)号：US20080139870A1
公开(公告)日：2008-06-12
申请号：US11638326
申请日：2006-12-12
IPC分类号： A61N2/02
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译： 公开了用于治疗患者高渗性的系统和方法。 根据一个实施例的方法包括识别与患者中的高渗性相关的皮质靶神经群体，以及通过向目标神经群体施加电磁信号来减少或消除患者的高渗性。 在另外的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除另外的患者功能障碍。
-
30.发明授权Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods 有权由神经元功能障碍，降解，损伤和/或坏死影响的组织的电磁信号传递，以及相关的系统和方法公开(公告)号：US08504159B2
公开(公告)日：2013-08-06
申请号：US13104802
申请日：2011-05-10
申请人： Brad Fowler , Bradford E. Gliner , David Himes
发明人： Brad Fowler , Bradford E. Gliner , David Himes
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.035 秒)
