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公开(公告)号：US20100233803A1
公开(公告)日：2010-09-16
申请号：US12466606
申请日：2009-05-15
CPC分类号： C07K14/71 , C07H21/04 , C07K16/2863 , C07K2317/31 , C07K2317/52 , C07K2317/622 , C07K2317/75 , C07K2319/30 , C12P21/02
摘要： A fusion polypeptide comprising (A)x-M-(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different ScFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.
摘要翻译： 包含（A）x-M-（A'）y的融合多肽，其中A和A'是能够结合靶受体的多肽。 本发明的融合多肽形成激活靶受体的多聚体蛋白。 A和A'可以各自为衍生自靶受体（例如相同或不同ScFv片段）的特异性抗体的抗体或片段，和/或能够结合靶蛋白质的配体或配体片段或衍生物，M为 多聚化组分，X和Y独立地为1-10之间的数。
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公开(公告)号：US08298532B2
公开(公告)日：2012-10-30
申请号：US12466606
申请日：2009-05-15
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K14/71 , C07H21/04 , C07K16/2863 , C07K2317/31 , C07K2317/52 , C07K2317/622 , C07K2317/75 , C07K2319/30 , C12P21/02
摘要： A fusion polypeptide comprising (A)x-M-(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different scFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.
摘要翻译： 包含（A）x-M-（A'）y的融合多肽，其中A和A'是能够结合靶受体的多肽。 本发明的融合多肽形成激活靶受体的多聚体蛋白。 A和A'可以各自为来自对靶受体特异的抗体的抗体或片段，例如相同或不同的scFv片段，和/或能够结合靶蛋白的配体或配体片段或衍生物，M是 多聚化组分，X和Y独立地为1-10之间的数。
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公开(公告)号：US20120045440A1
公开(公告)日：2012-02-23
申请号：US13286261
申请日：2011-11-01
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395 , A61P19/02
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译： 本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。 本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。
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公开(公告)号：US08080248B2
公开(公告)日：2011-12-20
申请号：US12780006
申请日：2010-05-14
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译： 本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。 本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。
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25.发明申请公开(公告)号：US20120258098A1
公开(公告)日：2012-10-11
申请号：US13462938
申请日：2012-05-03
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译： 本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。 本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。
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公开(公告)号：US07455988B2
公开(公告)日：2008-11-25
申请号：US10447243
申请日：2003-05-28
申请人： James P. Fandl , Changlin Dou
发明人： James P. Fandl , Changlin Dou
CPC分类号： C12N15/63 , A01K2217/05 , C07K2319/00 , C12N15/85 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/42 , C12N2840/20
摘要： Compositions and methods for the inducible expression of genes in eukaryotic cells. Expression of a nucleotide sequence of interest is controlled by a regulatory fusion protein that consists of a transcription blocking domain and a legends-binding domain. When the cognate ligand for the ligand-binding domain is present, transcription of the nucleotide sequence of interest is blocked. Upon removal of the cognate ligand, the nucleotide sequence of interest is transcribed. The method is useful for large scale production of a desired product in eukaryotic cells.
摘要翻译： 用于在真核细胞中诱导表达基因的组合物和方法。 感兴趣的核苷酸序列的表达由由转录阻断结构域和图例结合结构域组成的调节融合蛋白控制。 当配体结合结构域的同源配体存在时，目的核苷酸序列的转录被阻断。 去除同源配体后，转录目的核苷酸序列。 该方法可用于在真核细胞中大规模生产所需产物。
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公开(公告)号：US07119066B2
公开(公告)日：2006-10-10
申请号：US10281643
申请日：2002-10-28
IPC分类号： C07K14/475 , A61K38/18
CPC分类号： G01N33/6842 , A61K38/185 , C07K14/475 , G01N33/68
摘要： Modified ciliary neurotrophic factor, methods for production and methods of use, especially in the treatment of Huntington's disease, obesity, and gestational or adult onset diabetes.
摘要翻译： 改良的睫状神经营养因子，生产方法和使用方法，特别是治疗亨廷顿氏病，肥胖症和妊娠或成人发病的糖尿病。
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公开(公告)号：US20090124005A1
公开(公告)日：2009-05-14
申请号：US12132846
申请日：2008-06-04
申请人： Gang CHEN , Robert Babb , James P. Fandl
发明人： Gang CHEN , Robert Babb , James P. Fandl
CPC分类号： C12N15/85 , C07K16/00 , C07K2319/30 , C12N15/86 , C12N2740/10043 , C12N2800/30 , C12N2840/203 , C12P21/02
摘要： Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.
摘要翻译： 提供了用于在真核系统中表达的表达增强核苷酸序列，其允许重组蛋白在真核细胞中增强和稳定表达。 提供增强的表达和稳定区（EESYR）用于在真核细胞中表达感兴趣的基因。 提供染色体基因座，序列和载体用于真核细胞中基因的增强和稳定表达。
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29.发明授权Modified lam.beta. signal sequence and processes for producing recombinant neurotrophins 失效改良的lamβ信号序列和重组神经营养蛋白的制备方法
公开(公告)号：US5389529A
公开(公告)日：1995-02-14
申请号：US796106
申请日：1991-11-21
申请人： Nikos Panayotatos , James P. Fandl
发明人： Nikos Panayotatos , James P. Fandl
IPC分类号： C07K14/245 , C07K14/475 , C12N15/70 , C12N15/11
CPC分类号： C07K14/245 , C07K14/475 , C12N15/70 , C07K2319/02
摘要： Signal sequences based on LamB have been constructed. These signal sequences facilitate both the synthesis and secretion of neurotrophins in E. coli.
摘要翻译： 已经构建了基于LamB的信号序列。 这些信号序列促进大肠杆菌中神经营养蛋白的合成和分泌。
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公开(公告)号：US08409838B2
公开(公告)日：2013-04-02
申请号：US12791637
申请日：2010-06-01
申请人： Gang Chen , Darya Burakov , James P. Fandl
发明人： Gang Chen , Darya Burakov , James P. Fandl
CPC分类号： C12P21/005 , C07K16/00 , C07K16/2863 , C07K16/2866 , C07K2317/14 , C07K2317/41 , C12N9/0006 , C12N15/00 , C12Y101/01271 , Y02P20/52
摘要： An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature. Methods and compositions for making glycoproteins with reduced fucosylation are provided.
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