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130 条记录 (耗时 0.041 秒)

    Stabilizers for halogen containing polymers
    25.
    发明授权
    Stabilizers for halogen containing polymers 失效
    含卤聚合物的稳定剂

    公开(公告)号：US5340862A

    公开(公告)日：1994-08-23

    申请号：US19322

    申请日：1993-02-10

    申请人： Joseph Silbermann ,  William L. Smith

    发明人： Joseph Silbermann ,  William L. Smith

    IPC分类号： C08K3/32 ,  C08K5/00 ,  C08K5/58 ,  C08K5/57

    CPC分类号： C08K5/005 ,  C08K3/32 ,  C08K5/58

    摘要： Improved stabilizer compositions are provided which impart significant long-term stabilization to halogen containing polymers such as polyvinyl chloride. The improved stabilizer compositions incorporate an alkali-metal hydrogen phosphate compound, such as anhydrous disodium hydrogen phosphate, of a predetermined surface area. The novel inorganic phosphate enables a reduction in the amount of organmetallic stabilizer, if desired, while still yielding long-term stability in the resultant polymer, or the ability to raise process temperature and reduce cycle times of molding operations.

    摘要翻译： 提供了改进的稳定剂组合物，其对含卤聚合物如聚氯乙烯进行显着的长期稳定化。 改进的稳定剂组合物掺入预定表面积的碱金属磷酸氢盐化合物，如无水磷酸氢二钠。 如果需要，新型无机磷酸酯能够减少有机金属稳定剂的量，同时仍然在所得聚合物中产生长期稳定性，或提高加工温度并缩短成型操作的循环时间的能力。

    Tricyclic 5-HT.sub.3 receptor antagonists
    26.
    发明授权
    Tricyclic 5-HT.sub.3 receptor antagonists 失效
    三环5-HT 3受体拮抗剂

    公开(公告)号：US5202333A

    公开(公告)日：1993-04-13

    申请号：US704565

    申请日：1991-05-22

    申请人： Jacob Berger ,  Robin D. Clark ,  Richard M. Eglen ,  William L. Smith ,  Klaus K. Weinhardt

    发明人： Jacob Berger ,  Robin D. Clark ,  Richard M. Eglen ,  William L. Smith ,  Klaus K. Weinhardt

    IPC分类号： C07D487/08 ,  A61K31/47 ,  A61K31/55 ,  A61P1/00 ,  A61P1/08 ,  A61P1/14 ,  A61P9/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P43/00 ,  C07D205/12 ,  C07D209/52 ,  C07D221/22 ,  C07D401/04 ,  C07D403/04 ,  C07D451/02 ,  C07D451/04 ,  C07D451/14 ,  C07D453/02 ,  C07D453/06 ,  C07D471/06 ,  C07D471/08

    CPC分类号： C07D451/04 ,  C07D451/14 ,  C07D453/02 ,  C07D453/06 ,  C07D471/06 ,  C07D471/08 ,  Y10S514/872

    摘要： The present invention is directed to 5-HT.sub.3 receptor antagonist compounds of formula I: ##STR1## in which the dashed line denotes an optional double bond;n is 1, 2 or 3;p is 0, 1, 2 or 3;q is 0, 1 or 2;each R.sup.1 is independently selected from halogen, hydroxy, lower alkoxy, lower alkyl, nitro, amino, amino carbonyl, (lower alkyl)amino, di(lower alkyl)amino, and (lower alkanoyl)amino;each R.sup.2 is lower alkyl; andR.sup.3 is a group selected from Formulae (a), (b), (c) and (d): ##STR2## in which u is 0 or 1;z is 1, 2 or 3; andR.sup.4 is C.sub.1-7 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-2 alkyl, or a group (CH.sub.2).sub.t R.sup.5 where t is 1 or 2 and R.sup.5 is thienyl, pyrrolyl, or furyl, each optionally further substituted by one or two substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, trifluoromethyl or halogen, or is phenyl optionally substituted by one or two substituents selected from C.sub.1-4 alkoxy, trifluoromethyl, halogen, nitro, carboxy, esterified carboxy, and C.sub.1-4 alkyl optionally substituted by hydroxy, C.sub.1-4 alkoxy, carboxy, esterified carboxy or in vivo hydrolyzable acyloxy; and the pharmaceutically acceptable salts, individual isomers, mixtures of isomers, processes for preparation, compositions, and methods of use thereof.

    摘要翻译： 本发明涉及式I的5-HT 3受体拮抗剂化合物：其中虚线表示任选的双键; n为1,2或3; p为0,1,2或3; q是0,1或2; 每个R 1独立地选自卤素，羟基，低级烷氧基，低级烷基，硝基，氨基，氨基羰基，（低级烷基）氨基，二（低级烷基）氨基和（低级烷酰基）氨基; 每个R 2是低级烷基; （a），（b），（c）和（d）所示的基团：其中，（a），（c） 你是0或1; z为1,2或3; 和R 4是C 1-7烷基，C 3-8环烷基，C 3-8环烷基-C 1-2烷基或基团（CH 2）t R 5，其中t是1或2，R 5是噻吩基，吡咯基或呋喃基， 选自C 1-6烷基，C 1-6烷氧基，三氟甲基或卤素的一个或两个取代基，或被任选被一个或两个选自C 1-4烷氧基，三氟甲基，卤素，硝基，羧基，酯化羧基的取代基取代的苯基和 任选被羟基，C 1-4烷氧基，羧基，酯化羧基或体内可水解酰氧基取代的C 1-4烷基; 和其药学上可接受的盐，各异构体，异构体的混合物，制备方法，组合物及其使用方法。

    Eyedrop applicator attachment
    27.
    发明授权
    Eyedrop applicator attachment 失效
    眼睑施放器附件

    公开(公告)号：US5037406A

    公开(公告)日：1991-08-06

    申请号：US208483

    申请日：1988-06-20

    申请人： William L. Smith ,  William E. Smith

    发明人： William L. Smith ,  William E. Smith

    IPC分类号： A61F9/00

    CPC分类号： A61F9/0026 ,  A61F9/0008

    摘要： An eyedrop applicator attachment for attachment to a bottle having a large or small threaded neck. The applicator attachment is provided with a hollow cylindrical body, and an eyecup integral with the body at one end. The other end of the body has an opening, and interiorly of the body are two female threads, located coaxially and of different diameters, the threads with the larger diameter being adjacent the open end of the body. Thus, the applicator attachment may be attached to a squeeze bottle with a larger diameter neck, or to a squeeze bottle with a smaller diameter neck. In an alternate embodiment, axially of the threads for engagement with the neck of a bottle, there is an extension having a third female thread, into which a plug is threaded to provide a closure for the nozzle of a bottle attached to the cylindrical body.In an alternate embodiment, the eyecup is intergral with the neck of a bottle, which may be of molded plastic, and provided with a snap fitting for receiving a nozzle insert, there being a cylindrical extension between the neck portion of the bottle and the eyecup which is internally threaded to receive a stopper which is in part hollow to receive and engage with a surface thereof the end of the drop-forming nozzle.There are also provided an alternate embodiment in which a stopper and an attachment body have mating double threads, and the stopper has gripping means on the exterior or interior thereof. Further, a combined lid and stopper may be provided, with provision for relative sliding and rotatable movement.

    摘要翻译： 一种用于连接到具有大或小的螺纹颈部的瓶子的滴管附件。 涂抹器附件设置有中空圆柱体，并且在一端与主体成一体的眼罩。 身体的另一端具有开口，并且身体的内部是同轴且具有不同直径的两个阴螺纹，具有较大直径的螺纹邻近身体的开口端。 因此，施用器附件可以附接到具有较大直径的颈部的挤压瓶或者具有较小直径的颈部的挤压瓶。 在替代实施例中，用于与瓶颈接合的螺纹的轴向具有一个具有第三内螺纹的延伸部，塞子被螺纹拧入以提供一个用于连接到圆筒体上的瓶子的喷嘴的盖子。 在一个替代实施例中，眼罩与瓶子的颈部是一体的，瓶颈可以是模制塑料，并且设置有用于容纳喷嘴插件的卡扣配件，在瓶颈的颈部和眼罩之间有圆柱形的延伸部 其内螺纹接纳止动器，该止动器部分是中空的，用于接收和接合其滴液喷嘴的端部的表面。 还提供了一种替代实施例，其中止动件和附接体具有配合的双重螺纹，并且止动件在其外部或内部具有夹紧装置。 此外，可以提供组合的盖和止动件，其具有相对滑动和可旋转的运动。

    Viscoelastic cleaning compositions and methods of use therefor
    28.
    发明授权
    Viscoelastic cleaning compositions and methods of use therefor 失效
    粘弹性清洁组合物及其使用方法

    公开(公告)号：US5011538A

    公开(公告)日：1991-04-30

    申请号：US403553

    申请日：1989-09-06

    申请人： William L. Smith

    发明人： William L. Smith

    IPC分类号： C11D1/04 ,  C11D1/14 ,  C11D1/22 ,  C11D1/40 ,  C11D1/62 ,  C11D1/65 ,  C11D3/395 ,  C11D17/00

    CPC分类号： C11D1/65 ,  C11D1/62 ,  C11D17/003 ,  C11D3/3956 ,  C11D1/04 ,  C11D1/143 ,  C11D1/146 ,  C11D1/22 ,  C11D1/40

    摘要： A thickened aqueous cleaning composition is viscoelastic, and has utility as a drain opening composition or as a hard surface cleaner having a cleaning-effective residence time on non-horizontal surfaces. In one embodiment the composition comprises a cleaning active, a quaternary ammonium compound, and an organic counterion. In another embodiment, the viscoelastic quality of the composition is advantageously utilized as a drain opener which rapidly penetrates standing water with minimal dilution to deliver active to the clog material.

    摘要翻译： 增稠的水性清洁组合物是粘弹性的，并且可用作排水口组合物或作为在非水平表面上具有清洁有效停留时间的硬表面清洁剂。 在一个实施方案中，组合物包含清洁活性物质，季铵化合物和有机抗衡离子。 在另一个实施方案中，组合物的粘弹性质量有利地用作排水开启器，其以最小稀释速度快速渗透静止水，以将活性物质输送到堵塞材料。

    Thickened bleach composition
    30.
    发明授权
    Thickened bleach composition 失效
    增稠漂白剂组合物

    公开(公告)号：US4839077A

    公开(公告)日：1989-06-13

    申请号：US173000

    申请日：1988-03-23

    申请人： Randall J. Cramer ,  William L. Smith

    发明人： Randall J. Cramer ,  William L. Smith

    IPC分类号： C11D7/60 ,  C11D3/37 ,  C11D3/395 ,  C11D3/60

    CPC分类号： C11D3/3956 ,  C11D3/3765

    摘要： A thickened aqueous bleaching cleanser has a viscosity of at least 100 centipoise, provides a cleaning-effective residence time on non-horizontal surfaces, and maintains viscosity and bleach stability over a typical shelf life. In one embodiment the cleanser comprises a source of a halogen bleach, a copolymer thickener including a hydrophobic comonomer and a hydrophilic comonomer, and a mixed surfactant system including an uncharged surfactant and an anionic surfactant.

    摘要翻译： 增稠水性漂白清洁剂具有至少100厘泊的粘度，在非水平表面上提供清洁有效的停留时间，并且在典型的保质期内保持粘度和漂白稳定性。 在一个实施方案中，清洁剂包含卤素漂白剂源，包含疏水共聚单体和亲水共聚单体的共聚物增稠剂，以及包含不带电表面活性剂和阴离子表面活性剂的混合表面活性剂体系。