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21.发明授权
公开(公告)号：US5684134A
公开(公告)日：1997-11-04
申请号：US487069
申请日：1995-06-07
IPC分类号： C12N15/09 , C07K14/47 , C07K14/705 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12N15/64 , C12P21/02 , C12R1/91 , C07K16/06
CPC分类号： C07K16/40 , C07K14/705 , C07K14/70596 , C12N15/64 , C12N9/1051
摘要： The present invention provides a novel .beta.1.fwdarw.6 N-acetylglucosaminyltransferase, which forms core 2 oligosaccharide structures in O-glycans, and a novel acceptor molecule, leukosialin, CD43, for core 2 .beta.1.fwdarw.6 N-acetylglucosaminyltransferase activity. The amino acid sequences and nucleic acid sequences encoding these molecules, as well as active fragments thereof, also are disclosed. A method for isolating nucleic acid sequences encoding proteins having enzymatic activity is disclosed, using CHO cells that support replication of plasmid vectors having a polyoma virus origin of replication. A method to obtain a suitable cell line that expresses an acceptor molecule also is disclosed.
摘要翻译： 本发明提供了一种在O-聚糖中形成核心寡糖结构的新颖的β1-6N-乙酰氨基葡糖转移酶，以及用于核心2β1-> 6 N-乙酰葡糖胺基转移酶活性的新受体分子白细胞介素，CD43。 还公开了编码这些分子的氨基酸序列和核酸序列，以及其活性片段。 使用支持具有多瘤病毒复制起点的质粒载体的复制的CHO细胞来公开分离编码具有酶活性的蛋白质的核酸序列的方法。 公开了获得表达受体分子的合适细胞系的方法。
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公开(公告)号：US5580549A
公开(公告)日：1996-12-03
申请号：US406244
申请日：1995-03-16
IPC分类号： A61K8/368 , A61K8/44 , A61K8/46 , A61K8/67 , A61K8/73 , A61K31/60 , A61Q19/02 , C07C65/05 , A61K7/135
CPC分类号： A61K31/60 , A61K8/368 , A61K8/44 , A61K8/466 , A61K8/678 , A61K8/735 , A61Q19/02 , C07C65/05 , A61K2800/782 , Y10S424/05 , Y10S514/944
摘要： An external preparing for skin comprising one or more than two types of 2-hydroxy benzoic acid derivative and/or salt thereof represented by the following formula: ##STR1## wherein R is an alkoxy group or alkyl group in the formula. The external preparation for the skin according to the present invention has a suppression effect on melanine generation by inhibition of tyrosinase activity. Accordingly, an excellent bleaching effect based upon the suppression of chromatosis and a high degree of safety can be obtained.
摘要翻译： 包含由下式表示的一种或多于两种类型的2-羟基苯甲酸衍生物和/或其盐的外用皮肤制剂：其中R是式中的烷氧基或烷基。 根据本发明的皮肤外用制剂通过抑制酪氨酸酶活性而抑制对产生黑色素的作用。 因此，可以获得基于抑制色素沉着和高安全性的优异的漂白效果。
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公开(公告)号：US5320943A
公开(公告)日：1994-06-14
申请号：US677099
申请日：1991-03-29
申请人： Minoru Fukuda
发明人： Minoru Fukuda
IPC分类号： G01N33/569 , G01N33/573 , G01N33/574 , G01N33/53 , C07K15/00 , C12Q1/48 , G01N33/544
CPC分类号： G01N33/573 , G01N33/56972 , G01N33/57469
摘要： A method is provided for detecting T-cell dysfunctions. The method includes detecting an alteration in the level of a protein regulating synthesis of the hexasaccharide NeuNAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.3(NeuNAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.6)GalNAc on leukosialin of T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. The protein regulating synthesis of the hexasaccharide can be core 2 GlcNAc transferase and can be detected by either a change in its amount or activity. Also provided is a method of detecting T-cell dysfunctions which includes detecting an alteration in the level of leukosialin having the hexasaccharide NeuNAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.3(NeuNAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.6)GlcNAc on T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. Kits for detecting T-cell dysfunction are provided as well.
摘要翻译： 提供了用于检测T细胞功能障碍的方法。 该方法包括检测调节六糖NeuNAcα2->3Galβ1-> 3（NeuNAcα2->3Galβ1->4GlcNAcβ1-> 6）合成的蛋白质水平的变化。GalNAc对白细胞介素 与来自正常个体的静息T细胞相比，疑似患有T细胞功能障碍的受试者的T细胞。 六糖的蛋白质调节合成可以是核心2 GlcNAc转移酶，可以通过其量或活性的变化来检测。 还提供了一种检测T细胞功能障碍的方法，其包括检测具有六糖NeuNAcα2->3Galβ1-> 3（NeuNAcα2->3Galβ1-> 4GlcNAcβ1-3）的白血球蛋白水平的变化， > 6）与来自正常个体的静息T细胞相比，疑似患有T细胞功能障碍的受试者的T细胞上的GlcNAc。 还提供了用于检测T细胞功能障碍的试剂盒。
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24.发明授权
公开(公告)号：US5049741A
公开(公告)日：1991-09-17
申请号：US498064
申请日：1990-03-23
申请人： Minoru Fukuda , Shinichiro Ichikawa
发明人： Minoru Fukuda , Shinichiro Ichikawa
CPC分类号： G01S3/781
摘要： An electromagnetic wave shielding system for an optical sensor includes: a sensor body having an aperture through which an optical signal is made incident on the sensor body; a shielding plate disposed within the sensor body, the shielding plate having an opening having a dimension of at most about one-half of the wavelength of electromagnetic waves; an optical system for gathering the optical signal which passes through the aperture of the sensor body to the dimension of the opening in the shielding plate so that it can pass through the opening; and a detecting/processing unit for detecting and processing the optical signal which passes through the opening in the shielding plate. Thus, the electromagnetic waves which have entered are prevented from passing through or are remarkably attenuated by the opening in the shielding plate, and are thereby prevented from reaching the detecting/processing unit.
摘要翻译： 一种用于光学传感器的电磁波屏蔽系统，包括：具有孔径的传感器主体，通过该孔将光信号入射到传感器主体上; 设置在所述传感器主体内的屏蔽板，所述屏蔽板具有至少约为电磁波波长的一半的开口; 光学系统，其将通过传感器主体的孔的光信号收集到屏蔽板中的开口的尺寸，使得其可以穿过开口; 以及用于检测和处理通过屏蔽板中的开口的光信号的检测/处理单元。 因此，防止了进入的电磁波通过屏蔽板中的开口而被显着地衰减，从而防止了到达检测/处理单元。
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公开(公告)号：US4780796A
公开(公告)日：1988-10-25
申请号：US138591
申请日：1987-12-28
申请人： Minoru Fukuda , Hideo Yamamoto , Isao Isa
发明人： Minoru Fukuda , Hideo Yamamoto , Isao Isa
摘要： A solid electrolytic capacitor having excellent characteristics in terms of both electrical properties and thermal stability is obtained by employing a solid electrolyte comprising both an electrically conductive polymer layer (I) formed by a chemical oxidation method and an electrically conductive polymer layer (II) formed by an electrochemical oxidation method.
摘要翻译： 通过使用包含通过化学氧化法形成的导电聚合物层（I）和由导电聚合物层（I）形成的导电聚合物层（II）的固体电解质，获得了在电性能和热稳定性方面具有优异特性的固体电解电容器， 电化学氧化法。
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公开(公告)号：US4657901A
公开(公告)日：1987-04-14
申请号：US648276
申请日：1984-09-07
申请人： Haruhiko Ueda , Hidekazu Toyoda , Minoru Fukuda
发明人： Haruhiko Ueda , Hidekazu Toyoda , Minoru Fukuda
IPC分类号： A61K31/565 , A61K31/56
CPC分类号： A61K31/565 , Y10S514/859
摘要： The present invention concerns a composition for topical application which is greatly useful for the treatment of acne. The composition contains (1) a compound of the formula: ##STR1## or its ester or ether, (2) keratolytic agent and (3) pharmaceutically acceptable carrier.
摘要翻译： 本发明涉及用于局部应用的组合物，其对于治疗痤疮非常有用。 组合物包含（1）下式的化合物或其酯或醚，（2）角质分解剂和（3）药学上可接受的载体。
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公开(公告)号：US08344770B2
公开(公告)日：2013-01-01
申请号：US12929776
申请日：2011-02-15
申请人： Minoru Fukuda
发明人： Minoru Fukuda
IPC分类号： H03L7/06
摘要： A PLL circuit is provided capable of reducing phase noise and facilitating design. In the PLL circuit, a PLL receives a reference frequency and an output from a VC-TCXO, performs a lock operation. In a lock state, a selector selects an output of a first divider that divides the reference frequency. When PLL detects input of reference frequency being lost or an unlock state, the PLL outputs an alarm signal to the selector. When receiving the alarm signal from the PLL, the selector switches from the output of the first divider to an output of a second divider that frequency-divides an output of the VC-TCXO, and outputs the same. Then, a PLL receives an output of the selector and an output of a VCXO and performs a lock operation.
摘要翻译： 提供了能够减少相位噪声并促进设计的PLL电路。 在PLL电路中，PLL接收参考频率和VC-TCXO的输出，执行锁定操作。 在锁定状态下，选择器选择划分参考频率的第一分频器的输出。 当PLL检测到参考频率丢失或解锁状态的输入时，PLL向选择器输出报警信号。 当从PLL接收到报警信号时，选择器从第一分频器的输出端切换到对VC-TCXO的输出进行分频的第二分频器的输出，并输出。 然后，PLL接收选择器的输出和VCXO的输出，并执行锁定操作。
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28.发明授权Manufacturing method and manufacturing apparatus of a group III nitride crystal 有权III族氮化物晶体的制造方法和制造装置公开(公告)号：US08337617B2
公开(公告)日：2012-12-25
申请号：US11596250
申请日：2006-03-13
IPC分类号： C30B9/00
CPC分类号： C30B19/02 , C30B9/00 , C30B15/00 , C30B15/32 , C30B17/00 , C30B19/06 , C30B29/403 , C30B29/406 , Y10T117/1024 , Y10T117/1032
摘要： A method for manufacturing a group III nitride crystal on a seed crystal in a holding vessel holding therein a melt containing a group III metal, an alkali metal and nitrogen. The manufacturing method comprises the steps of causing the seed crystal to make a contact with the melt, setting an environment of the seed crystal to a first state offset from a crystal growth condition while in a state in which said seed crystal is in contact with the melt, increasing a nitrogen concentration in the melt, and setting the environment of the seed crystal to a second state suitable for crystal growth when the nitrogen concentration of the melt has reached a concentration suitable for growing the seed crystal.
摘要翻译： 一种用于在保持容器中的晶种上制造III族氮化物晶体的方法，其中容纳含有III族金属，碱金属和氮的熔体。 该制造方法包括以下步骤：使晶种与熔体接触，将晶种的环境设定为偏离晶体生长条件的第一状态，同时在所述晶种与所述晶种接触的状态下 熔融，增加熔体中的氮浓度，并且当熔体的氮浓度达到适于种植晶种的浓度时，将晶种的环境设定为适合晶体生长的第二状态。
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公开(公告)号：US07871793B2
公开(公告)日：2011-01-18
申请号：US10589841
申请日：2005-02-18
CPC分类号： C07H1/00 , C07H5/04 , C07H5/06 , C07H9/00 , C07K14/70596 , C12P21/005
摘要： Compositions useful for inhibiting the growth of bacteria, including bacteria that can cause gastric ulcers, are provided. In addition, transgenic organism that can produce such compositions are provided. Methods of using the compositions to treat or prevent gastric ulcers in a subject, including a human subject, also are provided.
摘要翻译： 提供了可用于抑制细菌生长的组合物，包括可引起胃溃疡的细菌。 此外，提供了可以生产这种组合物的转基因生物体。 还提供了使用该组合物治疗或预防受试者（包括人类受试者）胃溃疡的方法。
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公开(公告)号：US07737796B2
公开(公告)日：2010-06-15
申请号：US12009406
申请日：2008-01-18
申请人： Manabu Ito , Minoru Fukuda , Tetuo Kudo , Takeshi Uchida
发明人： Manabu Ito , Minoru Fukuda , Tetuo Kudo , Takeshi Uchida
IPC分类号： H03L1/04
CPC分类号： H03B5/36 , H03B5/04 , H03L1/04 , H05K1/0212 , H05K1/0243 , H05K3/306 , H05K2201/062 , H05K2201/09063 , H05K2201/10022 , H05K2201/10068 , H05K2201/10151 , H05K2201/10522 , H05K2201/2036
摘要： A lead wire led-out type crystal oscillator of constant temperature type for high stability is disclosed, which includes a heat supply body that supplies heat to a crystal resonator from which a plurality of lead wires are led out, to maintain the temperature constant. The heat supply body includes a heat conducting plate which has through-holes for the lead wires and is mounted on the circuit board, and which faces, and is directly thermally joined to, the crystal resonator and a chip resistor for heating which is mounted on the circuit board adjacent to the heat conducting plate, and is thermally joined to the heat conducting plate.
摘要翻译： 公开了一种用于高稳定性的恒温型引线引出型晶体振荡器，其包括向多个引线从其引出的晶体谐振器供热，以保持温度恒定的供热体。 供热体包括：导热板，其具有用于引线的通孔并且安装在电路板上，并且面向并直接热连接到晶体谐振器和用于加热的片状电阻器 电路板与导热板相邻，并且热连接到导热板。
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