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    INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS
    21.
    发明申请
    INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS 有权

    公开(公告)号：US20210252188A1

    公开(公告)日：2021-08-19

    申请号：US17237116

    申请日：2021-04-22

    Applicant: Wake Forest University Health Sciences

    Inventor： Hyun-Wook Kang ,  Sang Jin Lee ,  Anthony Atala ,  James J. Yoo

    IPC: A61L27/20 ,  B29C64/393 ,  B29C64/112 ,  A61L27/22 ,  A61L27/38 ,  A61L27/52 ,  B29C64/124 ,  A61L27/26

    Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.

    MULTI-LAYER SKIN SUBSTITUTE PRODUCTS AND METHODS OF MAKING AND USING THE SAME
    23.
    发明申请
    MULTI-LAYER SKIN SUBSTITUTE PRODUCTS AND METHODS OF MAKING AND USING THE SAME 审中-公开

    公开(公告)号：US20170354763A1

    公开(公告)日：2017-12-14

    申请号：US15542095

    申请日：2016-01-11

    Applicant: Wake Forest University Health Sciences

    Inventor： Anthony Atala ,  Gayoung Jeong ,  James J. Yoo ,  Sang Jin Lee ,  Young-Joon Seol

    IPC: A61L27/60 ,  B33Y80/00 ,  G01N33/50 ,  B33Y70/00 ,  B29C64/106 ,  A61F2/10 ,  B33Y10/00 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  B29K75/00 ,  B29K105/00

    Abstract: Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics. Described herein is an artificial mammalian skin substitute product, comprising: (a) optionally, but in some embodiments preferably, a first (“hypodermis-like”) layer comprising live mammalian adipocytes (e.g., induced pre-adipocytes) in a first hydrogel carrier; (b) a second (“dermis-like”) layer contacting or directly contacting the first layer and comprising live mammalian fibroblast cells and' live mammalian follicle dermal papilla cells in combination in a second hydrogel carrier; (c) a third (“epidermis-like”) layer contacting or directly contacting the second layer (i.e., on the opposite side thereof as the first layer, so that the second layer is sandwiched between the first and third layers when the first layer is present), the third layer comprising live mammalian keratinocytes and live mammalian melanocytes in combination in a third hydrogel carrier.

    METABOLIC DOWNREGULATION FOR CELL SURVIVAL
    24.
    发明申请
    METABOLIC DOWNREGULATION FOR CELL SURVIVAL 审中-公开
    细胞生存的代谢下调

    公开(公告)号：US20150025031A1

    公开(公告)日：2015-01-22

    申请号：US14382921

    申请日：2013-03-05

    Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

    Inventor： James Yoo ,  Sang Jin Lee ,  Jachyun Kim ,  Anthony Atala

    IPC: A61K31/7076

    CPC classification number: A61K31/7076 ,  C12N5/0018 ,  C12N2500/40 ,  C12N2501/73

    Abstract: The present invention provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged. The present invention also provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein at least one purine metabolism enzyme inhibitor is applied to the cell.

    Abstract translation: 本发明提供通过在低氧条件下下调细胞代谢速率来维持和/或增加细胞活力的系统和方法，其中细胞中腺苷或其衍生物的可用性增加和/或延长。 本发明还涉及延长在缺氧条件下进行宿主新生血管形成的植入细胞的存活的系统和方法，其中细胞中腺苷或其衍生物的可用性增加和/或延长。 本发明还提供了通过在缺氧条件下下调细胞代谢速率来维持和/或增加细胞活力的系统和方法，其中至少一种嘌呤代谢酶抑制剂被施用于细胞。

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