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公开(公告)号：US09713501B2
公开(公告)日：2017-07-25
申请号：US14325908
申请日：2014-07-08
发明人： Rohan A. Shirwaiker , Caroline Elise Webster , John D. Jackson , Richard A. Wysk , Sang Jin Lee , Ola L. A. Harrysson , James J. Yoo , Anthony Atala , Paul H. Cohen , Yuan-Shin Lee , Peter M. Prim , Molly F. Purser , Katie L. Basinger
IPC分类号： A61B17/322 , A61B19/00 , A61B90/00
CPC分类号： A61B90/02 , A61B17/322 , A61B2017/3225
摘要： Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same.
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公开(公告)号：US20150018948A1
公开(公告)日：2015-01-15
申请号：US14325908
申请日：2014-07-08
发明人： Rohan A. Shirwaiker , Caroline Elsie Webster , John D. Jackson , Richard A. Wysk , Sang Jin Lee , Ola L.A. Harrysson , James J. Yoo , Anthony Atala , Paul H. Cohen , Yuan-Shin Lee , Peter M. Prim , Molly F. Purser , Katie L. Basinger
IPC分类号： A61B19/00 , A61B17/322
CPC分类号： A61B90/02 , A61B17/322 , A61B2017/3225
摘要： Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same.
摘要翻译： 本文提供了构造成用于放置在其中的组织的轮状膨胀的组织拉伸装置。 还提供了使用该装置拉伸组织以及培养有组织的组织的方法。 还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的方法。
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公开(公告)号：US20210162017A1
公开(公告)日：2021-06-03
申请号：US17105156
申请日：2020-11-25
发明人： James YOO , Sang Jin Lee , Anthony Atala , Mark Van Dyke
摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
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公开(公告)号：US11013825B2
公开(公告)日：2021-05-25
申请号：US15672885
申请日：2017-08-09
发明人： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC分类号： B29C64/112 , A61L27/38 , A61L27/20 , B29C64/393 , A61L27/22 , A61L27/52 , B29C64/124 , A61L27/26 , C12M3/00 , C12M1/00 , C12M1/26 , A61K35/12 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , B29K105/00 , B29K267/00 , B29L31/00
摘要： A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号：US09039782B2
公开(公告)日：2015-05-26
申请号：US14256643
申请日：2014-04-18
发明人： Anthony Atala , James J. Yoo , Grace Lim , Sang Jin Lee
IPC分类号： A61F2/28 , A61K38/18 , A61L27/36 , A61L27/38 , A61L27/48 , A61L27/56 , A61L27/58 , A61K35/32 , A61K35/34
CPC分类号： A61F2/28 , A61K35/32 , A61K35/34 , A61K38/18 , A61L27/3604 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3891 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
摘要翻译： 本发明涉及生产允许协调运动的人造复合组织结构的方法。 使用具有足够刚性以提供软骨形成细胞和骨形成细胞的结构支持的生物相容性结构基质。 用肌肉细胞接种的生物相容的柔性基质连接到结构基质上以产生能够协同运动的人造复合组织构建体。
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公开(公告)号：US12006592B2
公开(公告)日：2024-06-11
申请号：US17316342
申请日：2021-05-10
发明人： Sang Jin Lee , James J. Yoo , Young Min Ju , Anthony Atala
IPC分类号： D01D5/00 , A61K31/728 , A61K31/729 , A61K31/737 , A61K35/44 , A61K38/18 , A61K38/36 , A61K38/39 , A61L27/24 , C07D315/00 , C07K16/18 , C07K16/28 , C07K16/46 , D01F1/10 , D01F6/92 , D01F4/00 , D01F6/62
CPC分类号： D01D5/003 , A61K31/728 , A61K31/729 , A61K31/737 , A61K35/44 , A61K38/1858 , A61K38/363 , A61K38/39 , A61L27/24 , C07D315/00 , C07K16/18 , C07K16/289 , C07K16/46 , D01D5/0076 , D01F1/10 , D01F6/92 , C07K16/2896 , D01F4/00 , D01F6/625
摘要： The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
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公开(公告)号：US11028502B2
公开(公告)日：2021-06-08
申请号：US16171504
申请日：2018-10-26
发明人： Sang Jin Lee , James J. Yoo , Young Min Ju , Anthony Atala
IPC分类号： D01D5/00 , A61L27/24 , A61K35/44 , C07K16/46 , A61K31/737 , A61K38/36 , A61K38/18 , A61K31/729 , A61K38/39 , C07K16/28 , C07D315/00 , A61K31/728 , D01F6/92 , C07K16/18 , D01F1/10 , D01F6/62 , D01F4/00
摘要： The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
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公开(公告)号：US20190127884A1
公开(公告)日：2019-05-02
申请号：US16171504
申请日：2018-10-26
发明人： Sang Jin Lee , James J. Yoo , Young Min Ju , Anthony Atala
IPC分类号： D01D5/00 , A61K35/44 , C07K16/46 , A61L27/24 , A61K31/737 , A61K38/36 , A61K31/728 , A61K31/729 , A61K38/39 , C07K16/28 , C07D315/00 , A61K38/18
摘要： The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
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9.发明授权公开(公告)号：US10092679B2
公开(公告)日：2018-10-09
申请号：US14518352
申请日：2014-10-20
发明人： Hyunhee Ahn , Young Min Ju , Anthony Atala , Sang Jin Lee
摘要： Vascular scaffolds and methods of fabricating the same are disclosed for tissue engineering of vascular constructs. By combining electrospun matrices with cell sheet technologies, vascular constructs with more mature cell layers can be obtained for reconstruction of blood vessels, heart valves and the like. A engineered smooth muscle cell sheet, wrapped around an electrospun vascular scaffold, is able to provide a mature SMC layer that expresses strong cell-to-cell junction markers and contractile proteins. In addition, preconditioning of the cell sheet covered vascular scaffold maintained cell viability and infiltration into the scaffold.
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公开(公告)号：US11806445B2
公开(公告)日：2023-11-07
申请号：US16947053
申请日：2020-07-16
发明人： Anthony Atala , Gayoung Jeong , James J. Yoo , Sang Jin Lee , Young-Joon Seol
IPC分类号： A61F2/10 , A61L27/60 , B33Y80/00 , B33Y70/00 , C08L5/08 , A61L27/20 , C08L89/06 , C12N5/071 , B29C64/106 , B33Y10/00 , A61L27/18 , A61L27/38 , A61L27/52 , G01N33/50 , B29K75/00 , B29K105/00
CPC分类号： A61L27/60 , A61F2/10 , A61L27/18 , A61L27/20 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/3891 , A61L27/52 , B29C64/106 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C08L5/08 , C08L89/06 , C12N5/0698 , G01N33/502 , G01N33/5044 , A61F2210/0076 , A61F2240/001 , A61L2300/64 , A61L2430/34 , B29K2075/00 , B29K2105/0061 , C12N2502/091 , C12N2502/092 , C12N2502/094 , C12N2502/1305 , C12N2502/1323 , C12N2533/30 , C12N2533/54 , C12N2533/80
摘要： Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics.
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