公开(公告)号：US09040164B2

公开(公告)日：2015-05-26

申请号：US13126524

申请日：2009-07-28

申请人： Jun Lin

发明人： Jun Lin

IPC分类号： B32B27/20 ,  B32B27/26 ,  C09D183/00 ,  C08K5/5415 ,  C08K5/5419 ,  C08K5/5435 ,  C08K5/5455 ,  C09D183/04 ,  C08G18/62 ,  C09D133/04 ,  C09D175/04 ,  C08G77/14 ,  C08G77/20 ,  C08G77/26 ,  C08K3/36

CPC分类号： C09D183/04 ,  C08G18/6295 ,  C08G77/14 ,  C08G77/20 ,  C08G77/26 ,  C08K3/36 ,  C08L2312/00 ,  C09D133/04 ,  C09D175/04

摘要： Self-assembled silica condensates are described as well as their use in coating compositions. The self-assembled silica condensates can be formed from the hydrolysis of medium to long chain trialkoxy silane compounds. Coating compositions containing the self-assembled silica condensates can provide coatings having improved scratch and mar resistance and can have excellent recoat adhesion.

摘要翻译： 描述了自组装二氧化硅冷凝物以及它们在涂料组合物中的用途。 自组装二氧化硅缩合物可以由中长链三烷氧基硅烷化合物的水解形成。 含有自组装二氧化硅冷凝物的涂料组合物可以提供具有改善的耐划痕性和抗划痕性的涂层，并且可以具有优异的重涂层附着力

公开(公告)号：US08926972B2

公开(公告)日：2015-01-06

申请号：US12727188

申请日：2010-03-18

申请人： Joe Zhou ,  Jianyang Zhao ,  Jiuru Sun ,  Jun Wang ,  Shaoxiong Wang ,  Xinxing Ma ,  Jun Lin

发明人： Joe Zhou ,  Jianyang Zhao ,  Jiuru Sun ,  Jun Wang ,  Shaoxiong Wang ,  Xinxing Ma ,  Jun Lin

IPC分类号： A61K38/18 ,  C07K14/71 ,  A61K38/00

CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K2319/30

摘要： The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a multimerizing component, which have a superior binding capacity with human VEGF and placental growth factor (PIGF). The fusion protein has improved stability, prolonged half-life and the ability to form multivalent interactions with VEGF, and can be used for anti-angiogenesis, treating VEGF related diseases and inhibiting tumor growth.

摘要翻译： 本公开提供了一种新的抗血管生成融合蛋白。 本发明将嵌合血管内皮细胞生长因子（VEGF）受体或其片段与多聚化成分组合，其与人VEGF和胎盘生长因子（PIGF）具有优异的结合能力。 融合蛋白具有改善的稳定性，延长的半衰期和与VEGF形成多价相互作用的能力，并且可用于抗血管生成，治疗VEGF相关疾病和抑制肿瘤生长。

公开(公告)号：US20100006913A1

公开(公告)日：2010-01-14

申请号：US12499197

申请日：2009-07-08

申请人： Jun Lin ,  Hiroyuki Ogawa

发明人： Jun Lin ,  Hiroyuki Ogawa

IPC分类号： H01L27/108 ,  H01L21/8234 ,  H01L21/8242

CPC分类号： H01L27/0629 ,  H01L21/76232 ,  H01L27/1087 ,  H01L29/66181 ,  H01L29/945

摘要： A semiconductor device includes: a semiconductor substrate including a trench; a capacitor electrode formed in the trench; a first insulation film formed on a bottom of the trench and between the semiconductor substrate and the capacitor electrode; a second insulation film formed on a side wall of the trench and between the semiconductor substrate and the capacitor electrode; and a first metal oxide film formed at the bottom of the trench and between the capacitor electrode and the first insulation film.

摘要翻译： 半导体器件包括：包括沟槽的半导体衬底; 形成在沟槽中的电容器电极; 形成在所述沟槽的底部和所述半导体衬底与所述电容器电极之间的第一绝缘膜; 形成在所述沟槽的侧壁上以及所述半导体衬底和所述电容器电极之间的第二绝缘膜; 以及形成在所述沟槽的底部以及所述电容器电极与所述第一绝缘膜之间的第一金属氧化物膜。

公开(公告)号：US07592216B2

公开(公告)日：2009-09-22

申请号：US12127067

申请日：2008-05-27

申请人： Jun Lin ,  Hiroyuki Ogawa ,  Hideyuki Kojima

发明人： Jun Lin ,  Hiroyuki Ogawa ,  Hideyuki Kojima

IPC分类号： H01L21/8234

CPC分类号： H01L27/0629 ,  H01L27/0802 ,  H01L27/0805 ,  H01L28/40

摘要： A method of manufacturing a semiconductor device includes forming a first trench in a capacitor device region of a semiconductor substrate, forming a capacitor insulation film over a sidewall surface of the first trench, forming a semiconductor film to cover the first trench, a resistor device region of the semiconductor substrate and a logic device region of the semiconductor substrate, introducing a first impurity element into the semiconductor film formed over the first trench, patterning the semiconductor film to form a top electrode in the capacitor device region, a resistor in the resistor device region and a gate electrode in the logic device region, annealing the semiconductor substrate, and introducing a second impurity element in the resistor.

摘要翻译： 一种制造半导体器件的方法包括在半导体衬底的电容器器件区域中形成第一沟槽，在第一沟槽的侧壁表面上形成电容器绝缘膜，形成覆盖第一沟槽的半导体膜，电阻器器件区域 的半导体衬底和半导体衬底的逻辑器件区域，在第一沟槽上形成的半导体膜中引入第一杂质元素，对半导体膜进行构图以在电容器器件区域中形成顶电极，电阻器件中的电阻器 区域和逻辑器件区域中的栅电极，退火半导体衬底，并在电阻器中引入第二杂质元素。

公开(公告)号：US20070292623A1

公开(公告)日：2007-12-20

申请号：US11818456

申请日：2007-06-14

申请人： Jun Lin

发明人： Jun Lin

IPC分类号： B05D7/00 ,  C08K9/00

CPC分类号： C09D1/00 ,  C08K3/36 ,  C08K9/06 ,  C09D201/005 ,  H05K3/285

摘要： Disclosed herein is a clear coating composition comprising a dispersion of silica nano-particles prepared from silica nano-particles having reactive silane groups of 1-500 nm particle size, and at least 0.001 parts by weight of oligomer having at least two groups reactive with the silica nano-particles, or oligomer in combination with a film forming polymer, a low molecular weight coupling agent, or a combination of a film forming polymer and a low molecular weight coupling agent.

摘要翻译： 本文公开了一种透明涂料组合物，其包含由具有1-500nm粒度的反应性硅烷基团的二氧化硅纳米颗粒制备的二氧化硅纳米颗粒的分散体和至少0.001重量份具有至少两个与 二氧化硅纳米颗粒或低聚物与成膜聚合物，低分子量偶联剂或成膜聚合物和低分子量偶联剂的组合组合。

公开(公告)号：US20050198892A1

公开(公告)日：2005-09-15

申请号：US10796087

申请日：2004-03-10

申请人： Jun Lin

发明人： Jun Lin

IPC分类号： A01K69/06 ,  A01M23/08

CPC分类号： A01K69/06

摘要： An improved underwater trap structure is disclosed. The trap structure is easily assembled and conveniently disassembling, and facilitates the trapping of fishes and crabs. The trap structure can sink down to the bottom of waters without being hooked. The trap structure has a trapping cylinder having a handle positioned at the center of the cylinder, and an entrance at the front portion of the trapping cylinder. The entrance is positioned with a rubber funnel having a front grip which is fastened using a front mount. The rear section of the trapping cylinder is mounted with a securing hole and a bait cylinder for holding bait is placed which is secured by a rear cover.

摘要翻译： 公开了一种改进的水下陷阱结构。 捕捉结构易于组装，方便拆卸，便于钓鱼和捕蟹。 陷阱结构可以下沉到水底而不被钩住。 捕集器结构具有捕捉缸，其具有位于气缸中心的手柄，以及在捕集筒前部的入口。 入口设置有具有前把手的橡胶漏斗，该前把手使用前支架紧固。 捕集筒的后部安装有固定孔，并且放置用于保持诱饵的诱饵筒，其由后盖固定。

公开(公告)号：US20050125849A1

公开(公告)日：2005-06-09

申请号：US10974265

申请日：2004-10-27

申请人： Sergey Shmelkov ,  Shahin Rafii ,  Jun Lin

发明人： Sergey Shmelkov ,  Shahin Rafii ,  Jun Lin

IPC分类号： C12N15/85 ,  A01K67/027 ,  C07H21/04 ,  C12N5/08 ,  C12N9/10 ,  C12Q1/68

CPC分类号： C12N15/85 ,  A01K2217/05 ,  C12N2830/008 ,  C12N2830/46

摘要： The present invention relates to a method of isolating stem cells from a mixed population of different cell types. This method involves selecting a promoter which functions only in said stem cells and not in the other cell types. The promoter can have a nucleotide sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8. A nucleic acid molecule encoding a marker protein under control of said promoter is introduced into all cell types of said mixed population and only the stem cells, but not the other cell types, within said mixed population are allowed to express said marker protein. The cells of said mixed population of cell types that are expressing the marker protein, which are restricted to the stem cells are identified and separated from the mixed population, where the separated cells are restricted to the stem cells. The promoter, nucleic acid constructs comprising it, and the resulting stem cells are also disclosed. The nucleic constructs can be incorporated in transgenic animals in order to monitor stem cell movement. A disorder mediated by stem cell proliferation can be carried out by administering both (1) a nucleic acid construct comprising the promoter of the present application and an enzyme capable of converting a prodrug to a cytotoxic drug and (2) the prodrug.

摘要翻译： 本发明涉及从不同细胞类型的混合群体中分离干细胞的方法。 该方法包括选择仅在所述干细胞中起作用但不在其它细胞类型中起作用的启动子。 启动子可以具有选自SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO：7和SEQ ID NO：8的核苷酸序列。 将所述启动子控制下的标记蛋白引入所述混合群体的所有细胞类型中，并且仅允许所述混合群体内的干细胞，而不是其他细胞类型表达所述标记蛋白。 将所述混合的表达限制于干细胞的标记蛋白的细胞类型的细胞群从混合群体中鉴定和分离，其中分离的细胞限于干细胞。 还公开了启动子，包含其的核酸构建体和所得干细胞。 核酸构建体可以并入转基因动物中以监测干细胞运动。 通过施用（1）包含本申请的启动子的核酸构建体和能够将前药转化为细胞毒性药物的酶和（2）前药，可以进行由干细胞增殖介导的病症。

公开(公告)号：US06849894B2

公开(公告)日：2005-02-01

申请号：US10317063

申请日：2002-12-12

申请人： Jun Lin ,  Toshiya Suzuki ,  Katsuhiko Hieda

发明人： Jun Lin ,  Toshiya Suzuki ,  Katsuhiko Hieda

IPC分类号： H01L21/322 ,  H01L21/02 ,  H01L21/314 ,  H01L21/316 ,  H01L21/8242 ,  H01L27/10 ,  H01L27/108 ,  H01L29/94

CPC分类号： H01L27/10852 ,  H01L21/31604 ,  H01L27/10894 ,  H01L28/40 ,  H01L28/55 ,  H01L28/90

摘要： On a semiconductor substrate, a transistor and a capacitor electrically connected to the transistor are formed, the capacitor having two electrodes made of metal and a capacitor dielectric layer between the two electrodes made of oxide dielectric material. A temporary protective film is formed over the capacitor, the temporary protective film covering the capacitor. The semiconductor substrate with the temporary protective film is subjected to a heat treatment in a reducing atmosphere. The temporary protective film is removed. The semiconductor substrate with the temporary protective film removed is subjected to a heat treatment in an inert gas atmosphere or in a vacuum state. A protective film is formed over the capacitor, the protective film covering the capacitor. With these processes, leak current of the capacitor can be reduced.

摘要翻译： 在半导体衬底上，形成与晶体管电连接的晶体管和电容器，该电容器具有由金属制成的两个电极和由氧化物介电材料制成的两个电极之间的电容器电介质层。 在电容器上形成临时保护膜，临时保护膜覆盖电容器。 具有临时保护膜的半导体衬底在还原气氛中进行热处理。 移除临时保护膜。 将除去了临时保护膜的半导体基板在惰性气体气氛或真空状态下进行热处理。 在电容器上形成保护膜，保护膜覆盖电容器。 通过这些处理，可以减小电容器的漏电流。

公开(公告)号：US20130165771A1

公开(公告)日：2013-06-27

申请号：US13716780

申请日：2012-12-17

申请人： Ming Ni ,  Kun Xu ,  Jun Lin

发明人： Ming Ni ,  Kun Xu ,  Jun Lin

IPC分类号： A61B3/12

CPC分类号： A61B3/1241 ,  A61K49/0043 ,  A61K49/0054

摘要： A novel fundus angiographic application and method using fluorescein isothiocyanate dextrans (FITC-dextran) as fluorescence angiographic dye for diagnosis and evaluation of eye diseases on humans is disclosed. The method involves the process of constitution of FITC-dextran solution and intravenous injection of the said solution, followed by observation and photography of ocular fundus circulation using a fluorescence fundus camera with an image system. The invention offers improved fundus angiograms over the traditional Na-fluorescein fundus angiography (Na-fluorescein) and indocyanine green fundus angiography (ICG) with the advantages of higher clarity and higher resolution; capable of visualizing both the retinal and the choroidal circulations systems simultaneously; providing longer fundus image duration so that it can be used as a directly mapping guidance in retinal surgery or to complete the angiograms for both eyes by a single process; providing more information about the pathological changes occurred among retinal, sub-retinal and choroidal circulation systems.

摘要翻译： 公开了一种使用荧光素异硫氰酸酯葡聚糖（FITC-葡聚糖）作为荧光血管造影染色来诊断和评估人类眼部疾病的新型眼底血管造影应用和方法。 该方法涉及FITC-葡聚糖溶液的构成和静脉注射所述溶液的过程，然后使用具有图像系统的荧光眼底照相机观察和摄影眼底循环。 本发明提供了比传统的钠 - 荧光素眼底血管造影术（Na-荧光素）和吲哚菁绿眼底血管造影（ICG）更好的眼底血管造影，具有更高的清晰度和更高分辨率的优点; 能够同时观察视网膜和脉络膜循环系统; 提供更长的眼底图像持续时间，使其可以用作视网膜手术中的直接映射指导或通过单个过程完成双眼的血管造影检查; 提供更多关于视网膜，子视网膜和脉络膜循环系统发生病理变化的信息。

公开(公告)号：US20130150013A1

公开(公告)日：2013-06-13

申请号：US13546515

申请日：2012-07-11

申请人： Yuan Liu ,  Jun Lin ,  Yaxin Cao ,  Sethuraman Gurumoorthy ,  Tong Chen ,  Rami Mehio ,  Jin-Sheng Su ,  Arun Visvanath

发明人： Yuan Liu ,  Jun Lin ,  Yaxin Cao ,  Sethuraman Gurumoorthy ,  Tong Chen ,  Rami Mehio ,  Jin-Sheng Su ,  Arun Visvanath

IPC分类号： H04W4/00

CPC分类号： H04W8/183 ,  H04W48/18 ,  H04W68/005 ,  H04W88/06 ,  Y02D70/10

摘要： Systems and methods are presented to support operation of a multiple subscriber identity module (SIM) device. A timing conflict may exist when a scheduled high priority communication of a first SIM overlaps with a scheduled paging monitoring activity for a second SIM. The multiple SIM device may preempt transitioning communication resources to the second SIM when the first SIM executes high priority communications. Or, the multiple SIM device may execute a rescheduling action to resolve the timing conflict. The high priority communication of the first SIM may be rescheduled. Alternatively, normal priority paging monitoring actions may be rescheduled to resolve the timing conflict.

摘要翻译： 呈现系统和方法以支持多用户识别模块（SIM）设备的操作。 当第一SIM的调度的高优先级通信与用于第二SIM的调度的寻呼监视活动重叠时，可能存在定时冲突。 当第一SIM执行高优先级通信时，多SIM设备可抢占向第二SIMC转换通信资源。 或者，多SIM设备可以执行重新调度动作以解决定时冲突。 可以重新安排第一SIM的高优先级通信。 或者，可以重新安排正常优先寻呼监视动作以解决定时冲突。