公开(公告)号：US20080193359A1

公开(公告)日：2008-08-14

申请号：US11707601

申请日：2007-02-13

申请人： Zhaoning Yu ,  Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang ,  R. Stanley Williams

发明人： Zhaoning Yu ,  Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang ,  R. Stanley Williams

IPC分类号： C01B21/068

CPC分类号： C30B29/10 ,  C30B29/60

摘要： Various embodiments of the present invention are directed to methods of forming single-crystal metal-silicide nanowires and resulting nanowire structures. In one embodiment of the present invention, a method of fabricating nanowires is disclosed. In the method, a number of nanowire-precursor members are formed. Each of the nanowire-precursor members includes a substantially single-crystal silicon region and a polycrystalline- metallic region. The substantially single-crystal silicon region and the polycrystalline-metallic region of each of the nanowire-precursor members is reacted to form corresponding substantially single-crystal metal-silicide nanowires. In another embodiment of the present invention, a nanowire structure is disclosed. The nanowire structure includes a substrate having an electrically insulating layer. A number of substantially single-crystal metal-silicide nanowires are positioned on the electrically insulating layer.

摘要翻译： 本发明的各种实施方案涉及形成单晶金属硅化物纳米线和所得纳米线结构的方法。 在本发明的一个实施例中，公开了一种制造纳米线的方法。 在该方法中，形成许多纳米线前体部件。 每个纳米线前体构件包括大致单晶硅区域和多晶金属区域。 每个纳米线前体部件的大致单晶硅区域和多晶金属区域反应形成对应的基本单晶金属硅化物纳米线。 在本发明的另一个实施方案中，公开了一种纳米线结构。 纳米线结构包括具有电绝缘层的衬底。 大量单晶金属硅化物纳米线位于电绝缘层上。

公开(公告)号：US20080093217A1

公开(公告)日：2008-04-24

申请号：US11584678

申请日：2006-10-20

申请人： Wei Wu ,  R. Stanley Williams ,  Shih-Yuan Wang ,  Philip J. Kuekes ,  Zhiyong Li

发明人： Wei Wu ,  R. Stanley Williams ,  Shih-Yuan Wang ,  Philip J. Kuekes ,  Zhiyong Li

IPC分类号： G01N27/26

CPC分类号： G01N21/658

摘要： A method of forming a plurality of NERS-active structures is disclosed. Particularly, a substrate having a surface and a liquid including nanoparticles is deposited on at least a portion of the surface of the substrate. At least one electric field may be generated proximate to the surface and at least a portion of the nanoparticles may be arranged via the electric field. A system includes at least two electrodes configured for producing at least one electric field for substantially arranging nanoparticles substantially according to a selected pattern. A NERS-active structure includes a substrate and a plurality of features located at predetermined positions on a surface of the substrate and at least one NERS-active nanoparticle at least partially embedded therein.

摘要翻译： 公开了一种形成多个NERS-活性结构的方法。 特别地，具有表面和包含纳米颗粒的液体的基底沉积在基底表面的至少一部分上。 可以在表面附近产生至少一个电场，并且可以经由电场布置至少一部分纳米颗粒。 一种系统包括至少两个电极，所述至少两个电极被配置用于产生至少一个电场，用于基本上根据所选择的图案基本上布置纳米颗粒。 NERS活性结构包括基底和位于基底表面上的预定位置的多个特征以及至少部分地嵌入其中的至少一个NERS-活性纳米颗粒。

公开(公告)号：US07151599B2

公开(公告)日：2006-12-19

申请号：US11044421

申请日：2005-01-27

申请人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

发明人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658 ,  G01N2201/0873

摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

摘要翻译： 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在波导中。 该分子分析装置还包括布置在基板上的波长解复用器和辐射传感器，并且被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射。

公开(公告)号：US20080116490A1

公开(公告)日：2008-05-22

申请号：US11583262

申请日：2006-10-19

申请人： Duncan R. Stewart ,  William M. Tong ,  R. Stanley Williams ,  Philip J. Kuekes ,  Sean Xiao-an Zhang ,  Kevin F. Peters ,  Kenneth J. Ward

发明人： Duncan R. Stewart ,  William M. Tong ,  R. Stanley Williams ,  Philip J. Kuekes ,  Sean Xiao-an Zhang ,  Kevin F. Peters ,  Kenneth J. Ward

IPC分类号： H01L27/10 ,  H01L29/73

CPC分类号： G01N27/128 ,  Y10S977/762 ,  Y10S977/957

摘要： A sensing method includes exposing a nano-transducer having a controlled surface to a sample including at least one species. Adsorption of the species on the nano-transducer is transduced to a measurable signal as a function of time. Desorption of the species from the nano-transducer is also transduced to a measurable signal as a function of time. A residence time of the at least one species adsorbed on the nano-transducer is extracted from the measurable signals. The adsorption and desorption each define an individual measurable event.

摘要翻译： 感测方法包括将具有受控表面的纳米换能器暴露于包括至少一种的样品。 物种在纳米转换器上的吸附作为时间的函数被转导到可测量的信号。 物种从纳米转换器的解吸也被转换为可测量的信号作为时间的函数。 从可测量信号中提取吸附在纳米换能器上的至少一种物质的停留时间。 吸附和解吸各自定义一个单独的可测量事件。

公开(公告)号：US09279767B2

公开(公告)日：2016-03-08

申请号：US13879255

申请日：2010-10-20

申请人： Zhiyong Li ,  R. Stanley Williams

发明人： Zhiyong Li ,  R. Stanley Williams

IPC分类号： G01N21/00 ,  G01N21/64 ,  G01N21/65

CPC分类号： G01N21/6428 ,  G01N21/648 ,  G01N21/658 ,  G01N33/54373

摘要： A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing. The chemical-analysis device includes a metallic-nanofinger device, and a platform. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A method for using, and a chemical-analysis apparatus including the chemical-analysis device are also provided.

摘要翻译： 与用于化学感测的金属纳米酮装置集成的化学分析装置。 化学分析装置包括金属纳米装置和平台。 金属纳米装置包括衬底和与衬底耦合的多个纳米器件。 多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。 至少纳米角蛋白和多个纳米针的第二纳米角键将与至少一个分析物分子自组织成紧密堆积的构型。 金属盖的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了一种使用方法和包括该化学分析装置的化学分析装置。

公开(公告)号：US09274058B2

公开(公告)日：2016-03-01

申请号：US13879245

申请日：2010-10-20

申请人： Zhiyong Li ,  R. Stanley Williams

发明人： Zhiyong Li ,  R. Stanley Williams

IPC分类号： G01N21/65 ,  G01N21/64

CPC分类号： G01N21/658 ,  G01N21/648

摘要： A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided.

摘要翻译： 用于化学感应的金属纳米膜装置。 该装置包括基板和多个纳米装置。 纳米针框包括柔性柱和与柔性柱的顶点相连的金属帽。 至少纳米酮和第二纳米酮将自排列成紧密堆积的构型，其中至少一个分析物分子设置在至少金属盖和相应的纳芬酮和第二纳米酮之间的第二金属盖之间。 金属帽的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了包封金属盖以在暴露于液体时响应的涂层，以及包括金属纳米酮装置的化学感测芯片。

公开(公告)号：US08395768B2

公开(公告)日：2013-03-12

申请号：US12772161

申请日：2010-04-30

申请人： Zhiyong Li ,  David A. Fattal ,  Jingjing Li ,  R. Stanley Williams

发明人： Zhiyong Li ,  David A. Fattal ,  Jingjing Li ,  R. Stanley Williams

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J3/1895 ,  G01N21/658

摘要： A scattering spectroscopy apparatus, system and method employ guided mode resonance (GMR) and a GMR grating. The apparatus includes a GMR grating having a subwavelength grating, and an optical detector configured to receive a portion of a scattered signal produced by an interaction between an excitation signal and an analyte associated with a surface of the GMR grating. A propagation direction of the received portion of the scattered signal is substantially different from a propagation direction of a GMR-coupled portion of the excitation signal within the GMR grating. The system includes the apparatus and an optical source. The method includes exciting a GMR in a GMR grating, interacting a GMR-coupled portion of the excitation signal with an analyte to produce a scattered signal and detecting a portion of the scattered signal.

摘要翻译： 散射光谱装置，系统和方法采用导模共振（GMR）和GMR光栅。 该装置包括具有亚波长光栅的GMR光栅和配置成接收由激发信号与与GMR光栅的表面相关联的分析物之间的相互作用产生的散射信号的一部分的光学检测器。 散射信号的接收部分的传播方向与GMR光栅内的激励信号的GMR耦合部分的传播方向基本上不同。 该系统包括该装置和光源。 该方法包括激励GMR光栅中的GMR，将激发信号的GMR耦合部分与分析物相互作用以产生散射信号并检测散射信号的一部分。

公开(公告)号：US08390805B2

公开(公告)日：2013-03-05

申请号：US12846524

申请日：2010-07-29

申请人： Huei Pei Kuo ,  Zhiyong Li ,  R. Stanley Williams

发明人： Huei Pei Kuo ,  Zhiyong Li ,  R. Stanley Williams

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J3/0227 ,  G01J3/26 ,  G01J3/36 ,  G01N21/658

摘要： A surface enhanced Raman spectroscopy system includes a surface enhanced Raman spectroscopy substrate and a laser source configured to emit light within a spectrum of wavelengths toward a predetermined species on or near the surface enhanced Raman spectroscopy substrate. The system further includes a set of filters positioned to be in optical communication with light scattered after the laser light interacts with the predetermined species. Each of the filters in the set is respectively configured to pass scattered light within a different predetermined narrow band of wavelengths. The system also includes a plurality of photodetectors, where each photodetector is positioned adjacent to a respective one of the filters in the set and is configured to output a signal if the scattered light passes through the respective one of the filters. The set of filters is targeted for detection of characteristic peaks of the predetermined species.

摘要翻译： 表面增强拉曼光谱系统包括表面增强拉曼光谱基板和激光源，该激光源被配置为向表面增强拉曼光谱基板上或附近的预定物质发射波长光谱的光。 该系统还包括一组滤光器，其被定位成在激光与预定物质相互作用之后与散射的光光通信。 集合中的每个滤光器分别被配置成使不同预定的窄波段内的散射光通过。 该系统还包括多个光电检测器，其中每个光电检测器被定位成与集合中的相应一个滤光器相邻，并且被配置为如果散射光通过相应的一个滤光器则输出信号。 该组滤波器用于检测预定种类的特征峰。

公开(公告)号：US20080270042A1

公开(公告)日：2008-10-30

申请号：US11796455

申请日：2007-04-26

申请人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Zhaoning Yu ,  R. Stanley Williams

发明人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Zhaoning Yu ,  R. Stanley Williams

IPC分类号： G01J3/44

CPC分类号： G01N21/658

摘要： An apparatus and related methods for facilitating surface-enhanced Raman spectroscopy (SERS) is described. A SERS-active structure near which a plurality of analyte molecules is disposed is periodically deformed at an actuation frequency. A synchronous measuring device synchronized with the actuation frequency receives Raman radiation scattered from the analyte molecules and generates therefrom at least one Raman signal measurement.

摘要翻译： 描述了用于促进表面增强拉曼光谱（SERS）的装置和相关方法。 多个分析物分子附近的SERS-活性结构以致动频率周期性地变形。 与致动频率同步的同步测量装置接收从分析物分子散射的拉曼辐射，并由此产生至少一个拉曼信号测量。

公开(公告)号：US07359048B2

公开(公告)日：2008-04-15

申请号：US11413910

申请日：2006-04-28

申请人： Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

发明人： Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658 ,  G01J3/44

摘要： Raman systems include a radiation source, a radiation detector, and a Raman device or signal-enhancing structure. Raman devices include a tunable resonant cavity and a Raman signal-enhancing structure coupled to the cavity. The cavity includes a first reflective member, a second reflective member, and an electro-optic material disposed between the reflective members. The electro-optic material exhibits a refractive index that varies in response to an applied electrical field. Raman signal-enhancing structures include a substantially planar layer of Raman signal-enhancing material having a major surface, a support structure extending from the major surface, and a substantially planar member comprising a Raman signal-enhancing material disposed on an end of the support structure opposite the layer of Raman signal-enhancing material. The support structure separates at least a portion of the planar member from the layer of Raman signal-enhancing material by a selected distance of less than about fifty nanometers.

摘要翻译： 拉曼系统包括辐射源，辐射检测器和拉曼器件或信号增强结构。 拉曼器件包括耦合到空腔的可调谐谐振腔和拉曼信号增强结构。 空腔包括第一反射构件，第二反射构件和设置在反射构件之间的电光材料。 电光材料表现出响应于所施加的电场而变化的折射率。 拉曼信号增强结构包括具有主表面的基本平坦的拉曼信号增强材料层，从主表面延伸的支撑结构和包括设置在支撑结构的端部上的拉曼信号增强材料的基本上平面的构件 与拉曼信号增强材料层相对。 支撑结构将平面构件的至少一部分与拉曼信号增强材料层分开小于约五十纳米的选定距离。