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公开(公告)号：US11371003B2
公开(公告)日：2022-06-28
申请号：US15016753
申请日：2016-02-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Yei Hwan Jung , Michael Phillips , David Gamm , Shaoqin Gong
Abstract: Photoreceptor scaffolds and scaffold systems including the photoreceptor scaffolds are described herein. The scaffolds and scaffold systems can be used for transplantation of organized photoreceptor tissue, with or without RPE, which may improve grafted cell survival, integration, and functional visual rescue. Particularly, the photoreceptor scaffold is structured from a biocompatible film, patterned with an array of unique through-holes having a curvilinear cell receiver and at least one cell guide channel.
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公开(公告)号：US11351263B2
公开(公告)日：2022-06-07
申请号：US16282174
申请日：2019-02-21
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Yuyuan Wang , Krishanu Saha , Amr Ashraf Abdeen
Abstract: Provided herein are nanoplexes comprising a payload selected from a protein and/or a polynucleic acid; and a plurality of copolymers comprising a first copolymer that is poly(N,N′-bis(acryloyl)cystamine-poly(aminoalkyl)) (PBAP), a second copolymer that is poly(C2-3 akylene glycol)-PBAP-poly(C2-3 akylene glycol), and a third copolymer that is TG-poly(C2-3 akylene glycol)-PBAP-poly(C2-3 akylene glycol)-TG wherein TG at each occurrence is independently a targeting ligand, a cell penetrating peptide, an imaging agent or a capping group, provided that a plurality of TG groups is a targeting ligand; wherein the payload is non-covalently complexed to one or more of the copolymers, one or more of the first, second, and/or third copolymers comprises an endosomal escape group having a pKa of about 4.5 to about 6.5, and optionally one or more of the first, second, and/or third copolymers comprises a host and a guest non-covalent crosslinker.
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公开(公告)号：US20210205473A1
公开(公告)日：2021-07-08
申请号：US17057415
申请日：2019-05-23
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US10749062B2
公开(公告)日：2020-08-18
申请号：US15865662
申请日：2018-01-09
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Kanglin Xiong , Hongyi Mi , Tzu-Hsuan Chang , Shaoqin Gong , Jung-Hun Seo
IPC: H01L31/18 , H01L31/0693
Abstract: Tandem solar cells comprising two or more solar cells connected in a solar cell stack via pn diode tunnel junctions and methods for fabricating the tandem solar cells using epitaxial lift off and transfer printing are provided. The tandem solar cells have improved tunnel junction structures comprising a current tunneling layer integrated between the p and n layers of the pn diode tunnel junction that connects the solar cells.
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25.发明授权公开(公告)号：US10660860B2
公开(公告)日：2020-05-26
申请号：US15892140
申请日：2018-02-08
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Wei Xu , Yuyuan Wang , Fabao Liu
Abstract: Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.
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Patent Agency Ranking
公开(公告)号：US20200078312A1
公开(公告)日：2020-03-12
申请号：US16562133
申请日：2019-09-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Zachary Scott Morris , Mingzhou Ye , Ravi Bhasker Patel , Paul M. Sondel
Abstract: Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
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公开(公告)号：US10350576B2
公开(公告)日：2019-07-16
申请号：US14522866
申请日：2014-10-24
Applicant: Wisconsin Alumni Research Foundation , The United States of America as Represented by the Secretary of Agriculture
Inventor： Shaoqin Gong , Zhiyong Cai , Qifeng Zheng
IPC: B01J20/32 , B01J20/28 , C08B15/02 , C02F1/28 , B01J20/26 , B01J20/24 , B01J20/30 , C02F101/32 , C02F101/20
Abstract: Highly porous, lightweight, and sustainable organosilane-coated organic aerogels with ultra-low densities and excellent material properties and methods for preparing them are provided. The aerogels are modified to have a superhydrophobic and superoleophilic surface, thus leading to an extremely high affinity for oils and/or organic solvents.
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公开(公告)号：US09899556B2
公开(公告)日：2018-02-20
申请号：US14853184
申请日：2015-09-14
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Kanglin Xiong , Hongyi Mi , Tzu-Hsuan Chang , Shaoqin Gong , Jung-Hun Seo
IPC: H01L31/0693
CPC classification number: H01L31/0693 , Y02E10/544
Abstract: Tandem solar cells comprising two or more solar cells connected in a solar cell stack via pn diode tunnel junctions and methods for fabricating the tandem solar cells using epitaxial lift off and transfer printing are provided. The tandem solar cells have improved tunnel junction structures comprising a current tunneling layer integrated between the p and n layers of the pn diode tunnel junction that connects the solar cells.
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公开(公告)号：US20180040806A1
公开(公告)日：2018-02-08
申请号：US15648796
申请日：2017-07-13
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Qifeng Zheng , Zhenqiang Ma , Yanfeng Tang
IPC: H01L41/193 , C08J5/24 , H01L41/45 , H02N2/18 , H01L41/047 , H01L41/113
CPC classification number: H01L41/193 , C08J5/24 , C08J9/0061 , C08J9/28 , C08J9/365 , C08J2201/0482 , C08J2205/026 , C08J2301/02 , C08J2305/08 , C08J2383/04 , C08J2425/06 , C08J2427/06 , C08J2427/18 , C08J2429/04 , C08J2433/06 , C08J2459/00 , C08J2483/04 , H01L41/0477 , H01L41/113 , H01L41/45 , H02N2/185 , H02N2/186
Abstract: Power generators that incorporate porous electric generation layers composed of mechanoradical-forming polymers are provided. Also provided are methods for using the generators to convert mechanical energy into and electrical signal to power electronic devices. The porous electric generation material includes an organic polymer that forms free radicals when covalent bonds are homolytically ruptured upon the application of a compressive force to the porous structure.
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30.发明申请公开(公告)号：US20250009918A1
公开(公告)日：2025-01-09
申请号：US18712655
申请日：2022-11-22
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Ying Zhang , Zachary Morris , Raghava N. Sriramaneni
IPC: A61K51/12 , A61K38/20 , A61K45/06 , A61K47/54 , A61K47/64 , A61K47/69 , A61K49/00 , A61K51/04 , A61N5/10 , A61P35/00
Abstract: The present technology provides nanoparticles comprising a positively charged polymer (e.g., polylysine) electrostatically bound to iron oxide nanoparticles and CpG oligodeoxy nucleotide. Further provided are compositions comprising same and methods of sensitizing tumor cells to radiation therapy, methods of stimulating antigen presenting cells, methods of enhancing stimulation of a type I interferon, and methods of treatment using said nanoparticles and compositions.
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