公开(公告)号：US20060174624A1

公开(公告)日：2006-08-10

申请号：US10541055

申请日：2003-12-10

Applicant: Tony Grabowski ,  Arun Jaura ,  Walt Ortmann ,  Robert Natkin ,  Steve Szwabowski ,  Edward Jih ,  Bret Oltmans ,  Adam Denlinger ,  Jas Dhillon ,  Yin Chen ,  Brad Boyer

Inventor： Tony Grabowski ,  Arun Jaura ,  Walt Ortmann ,  Robert Natkin ,  Steve Szwabowski ,  Edward Jih ,  Bret Oltmans ,  Adam Denlinger ,  Jas Dhillon ,  Yin Chen ,  Brad Boyer

IPC: F01B21/04 ,  B60K6/04

CPC classification number: B60W20/10 ,  B60K6/40 ,  B60K6/445 ,  B60K6/46 ,  B60K6/48 ,  B60K6/54 ,  B60K15/07 ,  B60W10/06 ,  B60W10/08 ,  B60W20/00 ,  B60W2510/0671 ,  B60Y2400/435 ,  Y02T10/6217 ,  Y02T10/6221 ,  Y02T10/6239 ,  Y02T10/6286 ,  Y02T90/42 ,  Y10T477/26

Abstract: A hydrogen-powered hybrid powertrain system includes a hydrogen-fuelled internal combustion engine operating at a lean air/fuel mixture, and a supercharger for boosting a primary drive torque produced by the engine primarily over a high operating speed range. An electric motor/generator generates a secondary drive torque for the vehicle, such that the secondary drive torque complements the boosted primary drive torque over at least a low operating speed range of the powertrain. A disconnect clutch disposed between the engine and the motor/generator engages and disengages the engine from the motor/generator, and serves to transfer the boosted primary driver torque through the motor/generator and to a power transmission system. The input at the power transmission is thus a combination of the boosted primary drive torque and the secondary drive torque having an enhanced torque characteristic over at least the low operating speed range.

公开(公告)号：US06818446B2

公开(公告)日：2004-11-16

申请号：US09990613

申请日：2001-11-21

Applicant: Reen Wu ,  Yin Chen

Inventor： Reen Wu ,  Yin Chen

IPC: C12N1574

CPC classification number: C07K14/4727

Abstract: The invention relates to compositions and methods for the assessment of mucin gene expression. The invention also relates to compositions and methods for the identification of compounds useful in the treatment of various disorders caused by mucin overproduction. The invention provides novel MUC5B promoter sequences and reporter constructs comprising these MUC5B promoter sequences. The invention further provides methods for drug screening to identify compounds have the ability to inhibit MUC5B gene expression. Compounds having the ability to inhibit MUC5B gene expression find use in the treatment of diseases characterized by mucin hyperproduction.

Abstract translation: 本发明涉及用于评估粘蛋白基因表达的组合物和方法。 本发明还涉及用于鉴定可用于治疗由粘蛋白过量产生引起的各种疾病的化合物的组合物和方法。 本发明提供新的MUC5B启动子序列和包含这些MUC5B启动子序列的报道构建体。 本发明进一步提供用于药物筛选以鉴定化合物具有抑制MUC5B基因表达的能力的方法。 具有抑制MUC5B基因表达能力的化合物可用于治疗以粘蛋白过量产生为特征的疾病。

公开(公告)号：US06502550B1

公开(公告)日：2003-01-07

申请号：US09683702

申请日：2002-02-05

Applicant: Allan J. Kotwicki ,  Siamak Hashemi ,  Steven Joseph Szwabowski ,  Woong-chul Yang ,  Yin Chen ,  Yong-Wha Kim

Inventor： Allan J. Kotwicki ,  Siamak Hashemi ,  Steven Joseph Szwabowski ,  Woong-chul Yang ,  Yin Chen ,  Yong-Wha Kim

IPC: F02P500

CPC classification number: F02D41/009 ,  F02D37/02 ,  F02P7/067

Abstract: An ignition and fuel control system 10 of a vehicle 18 is provided including a controller 22. The controller 22 is electrically coupled to an ignition system 14, a fuel system 16, a crankshaft position sensor 32, and a camshaft position sensor 34. The crankshaft position sensor 32 senses a crankshaft position and generates a crankshaft position signal. A camshaft position sensor 34 senses a camshaft position and generates a camshaft position signal. The controller 22 determines a crankshaft position and a camshaft position in response to the crankshaft position signal and the camshaft position signal respectively. The controller 22 identifies a reference engine cylinder in response to the crankshaft position and the camshaft position and generates a synchronization value. The controller 22 also enables the ignition system 14 and the fuel system 16 in response to the synchronization value.

Abstract translation: 车辆18的点燃和燃料控制系统10设置有控制器22.控制器22电连接到点火系统14，燃料系统16，曲轴位置传感器32和凸轮轴位置传感器34.曲轴 位置传感器32感测曲轴位置并产生曲轴位置信号。 凸轮轴位置传感器34感测凸轮轴位置并产生凸轮轴位置信号。 控制器22分别响应于曲轴位置信号和凸轮轴位置信号来确定曲轴位置和凸轮轴位置。 控制器22响应于曲轴位置和凸轮轴位置识别参考发动机气缸，并产生同步值。 控制器22还能够响应于同步值启用点火系统14和燃料系统16。

公开(公告)号：US08993575B2

公开(公告)日：2015-03-31

申请号：US14008693

申请日：2012-04-01

Applicant: Guisen Zhang ,  Yin Chen ,  Xiangqing Xu ,  Bifeng Liu ,  Xiaojun Feng ,  Song Zhao ,  Shicheng Liu ,  Minquan Yu ,  Yu Lan ,  Yinli Qiu

Inventor： Guisen Zhang ,  Yin Chen ,  Xiangqing Xu ,  Bifeng Liu ,  Xiaojun Feng ,  Song Zhao ,  Shicheng Liu ,  Minquan Yu ,  Yu Lan ,  Yinli Qiu

IPC: A61K31/496 ,  A61K31/454 ,  A61K31/4545 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D417/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention belongs to the medicinal chemistry field, and specifically discloses a [1,3,4]oxadiazole derivative with the structure of general formula (I) and pharmaceutically acceptable salt thereof. The compound can be used to prepare a medicine for preventing or treating a disease of the central nervous system.

Abstract translation: 本发明属于药物化学领域，具体公开了具有通式（I）结构的[1,3,4]恶二唑衍生物及其药学上可接受的盐。 该化合物可用于制备用于预防或治疗中枢神经系统疾病的药物。

公开(公告)号：US08548497B2

公开(公告)日：2013-10-01

申请号：US13328613

申请日：2011-12-16

Applicant: Dimitrios Lymberopoulos ,  Jie Liu ,  Nissanka Arachchige Bodhi Priyantha ,  Yin Chen

Inventor： Dimitrios Lymberopoulos ,  Jie Liu ,  Nissanka Arachchige Bodhi Priyantha ,  Yin Chen

IPC: H04W64/00

CPC classification number: H04W4/04 ,  G01S5/0252 ,  H04W4/043 ,  H04W4/60 ,  H04W64/00

Abstract: A commercial frequency-modulated (FM) radio signal indoor localization system and method for finding a location of a mobile embedded device (such as a smartphone) within a building. Indoor localization is performed by receiving commercial FM radio signals on the device, analyzing the signals using signal quality metrics, and generating signal quality vectors for each signal and signal quality metric used for the signal. The signal quality metric can be any physical signal quality indicator. The signal quality vectors are added to obtain a current location fingerprint. The current location fingerprint is compared to fingerprints stored in a fingerprint database. The location associated with the stored fingerprint that is the closest match to the current fingerprint location is designated as the current location in the building of the mobile embedded device. Locally generated radio signals can be used in conjunction with the commercial FM radio signals to improve localization accuracy.

Abstract translation: 商业频率调制（FM）无线电信号室内定位系统和用于在建筑物内找到移动嵌入式设备（例如智能电话机）的位置的方法。 通过在设备上接收商业FM无线电信号来进行室内定位，使用信号质量度量来分析信号，以及为信号使用的每个信号和信号质量度量生成信号质量向量。 信号质量度量可以是任何物理信号质量指标。 添加信号质量向量以获得当前位置指纹。 将当前位置指纹与存储在指纹数据库中的指纹进行比较。 与存储的指纹相关联的与当前指纹位置最接近的位置的位置被指定为移动嵌入式设备的建筑物中的当前位置。 本地生成的无线电信号可以与商业FM无线电信号结合使用，以提高定位精度。

公开(公告)号：US20130157683A1

公开(公告)日：2013-06-20

申请号：US13328613

申请日：2011-12-16

Applicant: Dimitrios Lymberopoulos ,  Jie Liu ,  Nissanka Arachchige Bodhi Priyantha ,  Yin Chen

Inventor： Dimitrios Lymberopoulos ,  Jie Liu ,  Nissanka Arachchige Bodhi Priyantha ,  Yin Chen

IPC: H04W24/00

CPC classification number: H04W4/04 ,  G01S5/0252 ,  H04W4/043 ,  H04W4/60 ,  H04W64/00

Abstract: A commercial frequency-modulated (FM) radio signal indoor localization system and method for finding a location of a mobile embedded device (such as a smartphone) within a building. Indoor localization is performed by receiving commercial FM radio signals on the device, analyzing the signals using signal quality metrics, and generating signal quality vectors for each signal and signal quality metric used for the signal. The signal quality metric can be any physical signal quality indicator. The signal quality vectors are added to obtain a current location fingerprint. The current location fingerprint is compared to fingerprints stored in a fingerprint database. The location associated with the stored fingerprint that is the closest match to the current fingerprint location is designated as the current location in the building of the mobile embedded device. Locally generated radio signals can be used in conjunction with the commercial FM radio signals to improve localization accuracy.

公开(公告)号：US20070160581A1

公开(公告)日：2007-07-12

申请号：US11586797

申请日：2006-10-26

Applicant: Charles Conrad ,  Yin Chen

Inventor： Charles Conrad ,  Yin Chen

IPC: A61K48/00 ,  C12N15/86 ,  C12N5/08

CPC classification number: A61K48/005

Abstract: Methods and compositions comprising a DNA expression cassette for producing ss-cDNA inside a host cell (in vivo). The expression system optionally contains a reverse transcriptase/RNAse H coding gene, and a restriction endonuclease gene. The cassette carries cloning sites in two distinct locations for cloning and expressing a sequence of interest. The mRNA then serves as a template for reverse transcriptase and synthesis of the ss-cDNA. In one embodiment, the ss-cDNA folds and forms a dsDNA “stem-loop” structure which can be designed to contain restriction endonuclease recognition site the stem portion for cutting off the ssDNA loop containing the SOI having minimal flanking sequence attached. In another embodiment, the mRNA template folds prior to reverse transcription and serves as a termination signal for the RT. Again, a ss-cDNA is formed having only minimal flanking sequence. The data shows the usefulness of this system for producing ss-DNA inside a host/target cell.

Abstract translation: 包含用于在宿主细胞内（体内）产生ss-cDNA的DNA表达盒的方法和组合物。 表达系统任选地含有逆转录酶/ RNA酶H编码基因和限制性内切核酸酶基因。 该盒携带在两个不同位置的克隆位点用于克隆和表达感兴趣的序列。 然后，mRNA用作逆转录酶和ss-cDNA合成的模板。 在一个实施方案中，ss-cDNA折叠并形成dsDNA“茎 - 环”结构，其可被设计为含有限制性内切核酸酶识别位点，用于切断含有附着有最小侧翼序列的SOI的ssDNA环的茎部分。 在另一个实施方案中，mRNA模板在逆转录之前折叠并用作RT的终止信号。 再次，形成仅具有最小侧翼序列的ss-cDNA。 数据显示该系统在宿主/靶细胞内产生ss-DNA的有用性。

公开(公告)号：US20050273245A1

公开(公告)日：2005-12-08

申请号：US10858800

申请日：2004-06-03

Applicant: Yin Chen ,  Woong-chul Yang ,  William Dutcher ,  David Trumpy ,  In Yoo ,  Chris Glugla ,  Diana Brehob

Inventor： Yin Chen ,  Woong-chul Yang ,  William Dutcher ,  David Trumpy ,  In Yoo ,  Chris Glugla ,  Diana Brehob

IPC: F02B75/04 ,  F02D13/02 ,  F02D35/02 ,  F02D41/30 ,  G06F17/00 ,  G06F19/00 ,  G06G7/70

CPC classification number: F02D41/3076 ,  F02D13/0207 ,  F02D35/027 ,  Y02T10/18

Abstract: A method and system for operating an internal combustion engine. The internal combustion engine is operable in a plurality of compression ratio operating modes. The method includes determining a relationship between a base engine threshold load where the high compression and low compression provide substantially the same engine fuel consumption and engine speed. The determined nominal relationship is modified by a factor, such factor being a function of a condition under which such engine is operating, to obtain a modified relationship. The modified relationship is a function of engine speed and the condition has an effect on knock generation in such engine. The modified relationship and engine speed are used in selecting one of the plurality of compression ratio operating modes for the engine. A hysteresis load as a function of engine speed is determined and applied to the determined hysteresis load to the modified relationship to inhibit switching oscillations between a pair of the plurality of compression ratio operating modes.

Abstract translation: 一种用于操作内燃机的方法和系统。 内燃机可以多个压缩比操作模式操作。 该方法包括确定高压缩和低压缩提供基本相同的发动机燃料消耗和发动机转速之间的基本发动机阈值负荷之间的关系。 所确定的标称关系由因子修改，这种因素是这种发动机运行的条件的函数，以获得修改的关系。 改进的关系是发动机转速的函数，该条件对这种发动机的爆震产生有影响。 改变的关系和发动机转速用于选择发动机的多个压缩比操作模式之一。 确定作为发动机转速的函数的滞后负载并将其应用于所确定的滞后负载至修改关系，以禁止一对多个压缩比操作模式之间的开关振荡。

公开(公告)号：US06970781B1

公开(公告)日：2005-11-29

申请号：US10858800

申请日：2004-06-03

Applicant: Yin Chen ,  Woong-chul Yang ,  William R. Dutcher ,  David K. Trumpy ,  In Kwang Yoo ,  Chris P. Glugla ,  Diana Brehob

Inventor： Yin Chen ,  Woong-chul Yang ,  William R. Dutcher ,  David K. Trumpy ,  In Kwang Yoo ,  Chris P. Glugla ,  Diana Brehob

IPC: F02B75/04 ,  F02D13/02 ,  F02D35/02 ,  F02D41/30 ,  G06F17/00 ,  G06F19/00 ,  G06G7/70

CPC classification number: F02D41/3076 ,  F02D13/0207 ,  F02D35/027 ,  Y02T10/18

Abstract: A method and system for operating an internal combustion engine. The internal combustion engine is operable in a plurality of compression ratio operating modes. The method includes determining a relationship between a base engine threshold load where the high compression and low compression provide substantially the same engine fuel consumption and engine speed. The determined nominal relationship is modified by a factor, such factor being a function of a condition under which such engine is operating, to obtain a modified relationship. The modified relationship is a function of engine speed and the condition has an effect on knock generation in such engine. The modified relationship and engine speed are used in selecting one of the plurality of compression ratio operating modes for the engine. A hysteresis load as a function of engine speed is determined and applied to the determined hysteresis load to the modified relationship to inhibit switching oscillations between a pair of the plurality of compression ratio operating modes.

Abstract translation: 一种用于操作内燃机的方法和系统。 内燃机可以多个压缩比操作模式操作。 该方法包括确定高压缩和低压缩提供基本相同的发动机燃料消耗和发动机转速之间的基本发动机阈值负荷之间的关系。 所确定的标称关系由因子修改，这种因素是这种发动机运行的条件的函数，以获得修改的关系。 改进的关系是发动机转速的函数，该条件对这种发动机的爆震产生有影响。 改变的关系和发动机转速用于选择发动机的多个压缩比操作模式之一。 确定作为发动机转速的函数的滞后负载并将其应用于所确定的滞后负载至修改关系，以禁止一对多个压缩比操作模式之间的开关振荡。

公开(公告)号：US20050020526A1

公开(公告)日：2005-01-27

申请号：US10818158

申请日：2004-04-05

Applicant: Yin Chen ,  Xin Tan

Inventor： Yin Chen ,  Xin Tan

IPC: A61K48/00 ,  C07H21/04 ,  C09D7/00 ,  C12N1/21 ,  C12N5/071 ,  C12N5/10 ,  C12N15/10 ,  C12N15/113 ,  C12N15/63 ,  C12N15/74 ,  C12Q1/68 ,  C12N5/08

CPC classification number: C12N15/113 ,  C07H21/04 ,  C12N15/1034 ,  C12N15/111 ,  C12N15/74 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/127 ,  C12N2320/11 ,  C12N2330/31 ,  C12Q1/6837 ,  C12Q2565/531

Abstract: A method for producing ODNs in bacterial or fungal cells in vivo for treatment of sepsis so that, when the ODNs reach and knock down their target genes, and thereby kill bacterial or fungal cells or inhibit their growth, the bacterial or fungal accumulation in the bloodstream is held constant or diminished and the sepsis syndrome is reduced or eliminated. The invention also contemplates of certain ODNs for use in treatment of sepsis.

Abstract translation: 用于在体内在细菌或真菌细胞中产生ODN的方法，用于治疗败血症，使得当ODN达到并击倒其靶基因，从而杀死细菌或真菌细胞或抑制其生长时，血液中的细菌或真菌积累 保持不变或减少，败血症综合征减少或消除。 本发明还考虑用于治疗败血症的某些ODN。