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公开(公告)号：US06423965B1
公开(公告)日：2002-07-23
申请号：US09378767
申请日：1999-08-23
IPC分类号： H01J4900
CPC分类号： H01J49/04
摘要： Plasma ion source mass spectrometers or liquid chromatograph/mass spectrometers are provided: wherein photon noises and matrix molecule ions produced by the ion source are decreased, the decrease of the quantity of signal is suppressed, and the apparatus maintenance is improved. The photon noises are decreased with a shielding plate and a 90 degrees deflector. The maintainability in cleaning is improved by a combination of a leading electrode, the shielding plate having a small hole, and a gate valve. The decrease in the quantity of signal is suppressed with the leading electrode, and a double cylindrical type static lens. Position adjustment of the leading electrode is performed with a flat plate having plural holes. Using an ion trap mass analyzer, matrix molecule ions are eliminated by applying a resonance voltage between its end cap electrodes. Decrease in the quantity of signals, which has been a problem, can be prevented, and a high transmission can be realized with a preferable reproducibility against disturbance of an electric field caused by ion lens and the like. A detectable limit of atomic ions of the sample can be improved by eliminating the matrix molecule ions.
摘要翻译： 提供了等离子体离子源质谱仪或液相色谱仪/质谱仪：其中由离子源产生的光子噪声和基质分子离子减少，抑制了信号量的减少，从而改善了设备的维护。 光子噪声随屏蔽板和90度偏转器而减小。 通过前导电极，具有小孔的屏蔽板和闸阀的组合来提高清洁的可维护性。 用前导电极和双圆柱形静电透镜抑制信号量的减少。 引导电极的位置调整用具有多个孔的平板进行。 使用离子阱质量分析仪，通过在其端盖电极之间施加谐振电压来消除基质分子离子。 可以防止已经存在问题的信号量的减少，并且以离子透镜等引起的电场干扰的优选再现性可以实现高透射率。 可以通过消除基质分子离子来改善样品的原子离子的可检测极限。
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公开(公告)号：US06194716B1
公开(公告)日：2001-02-27
申请号：US09143399
申请日：1998-08-28
IPC分类号： B01D5944
CPC分类号： H01J49/424 , H01J49/0009 , H01J49/428
摘要： A method for performing a mass calibration under an application of a desired ion peak position of mass spectrum attained by a mass scanning of ions of substance having a known value of m/z and the known value of m/z is added with a step for ejecting an amount of unnecessary ions not contributing to the aforesaid mass calibration accumulated in the aforesaid ion trap type mass analysis region prior to the aforesaid mass scanning operation. An accumulation of a large amount of unnecessary ions in the ion trap type mass analysis region is restricted, a disturbance of electric field in the ion trap mass analysis region generated under an influence of a spatial charge caused by accumulation of the unnecessary ions can be prevented and the aforesaid mass calibration can be performed in an easy and accurate manner.
摘要翻译： 在通过具有已知m / z值的物质的离子的质量扫描和已知的m / z值获得的质谱所需离子峰位置的施加下进行质量校准的方法添加了用于 在上述质量扫描操作之前，排出在上述离子阱型质量分析区域中累积的对上述质量校准无贡献的不需要的离子的量。 离子阱型质量分析区域中的大量不需要的离子的积聚受到限制，可以防止在由不需要的离子的积聚引起的空间电荷的影响下产生的离子阱质量分析区域中的电场的扰动 并且可以容易且准确地进行上述质量校准。
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公开(公告)号：US07645983B2
公开(公告)日：2010-01-12
申请号：US10139241
申请日：2002-05-07
IPC分类号： H01J49/00
CPC分类号： H01J49/045
摘要： An ion source includes a body having a gas passage and an orifice. A capillary is inserted into the gas passage so that a tip portion of the capillary extends into the orifice. A gas supplier supplies a gas into the gas passage to form a gas flow through the gas passage along the capillary and through the orifice past a tip of the capillary so that the gas flow sprays a sample solution flowing through the capillary from the tip of the capillary. A flow controller regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20° C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the tip portion of the capillary in the orifice.
摘要翻译： 离子源包括具有气体通道和孔的主体。 毛细管插入到气体通道中，使得毛细管的尖端部分延伸到孔中。 气体供应商将气体供应到气体通道中以形成沿着毛细管的气体通道的气流，并且通过孔经过毛细管的尖端，使得气流从其中的尖端喷射流过毛细管的样品溶液 毛细管。 流量控制器调节气体通道中的气体的压力，以将特征值F / S调节到预定值，其中F是在标准条件（20℃，1个大气压）下气流的流量，以及 S是孔口的截面与孔口中的毛细管的尖端部分的横截面之间的差异。
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公开(公告)号：US06188065B1
公开(公告)日：2001-02-13
申请号：US09260552
申请日：1999-03-02
IPC分类号： G01D5944
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer includes a sample supplier which supplies a sample solution, the sample solution including a solvent, ions, and a solute, the solute being a sample to be analyzed, an ion converter, disposed after the sample supplier, which converts the ions in the sample solution into gaseous ions, an ion source, disposed after the ion converter, which ionizes the sample in the sample solution, thereby producing sample ions, a mass analyzer which analyzes masses of the sample ions produced by the ion source, and an ion blocking electrode which prevents the gaseous ions produced by the ion converter from reaching the ion source, thereby preventing the mass analyzer from analyzing masses of the gaseous ions produced by the ion converter.
摘要翻译： 质谱仪包括供样品溶液的样品供应商，包含溶剂的样品溶液，离子和溶质，作为待分析样品的溶质，设置在样品供应者之后的离子转化器，其将离子转化为 将样品溶液变成气态离子，离子源，设置在离子转换器之后，将样品溶液中的样品离子化，从而产生样品离子;分析质量分析器，其分析由离子源产生的样品离子的质量;以及离子 阻止由离子转换器产生的气体离子到达离子源的阻挡电极，从而防止质量分析器分析由离子转换器产生的气态离子的质量。
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公开(公告)号：US5877495A
公开(公告)日：1999-03-02
申请号：US511804
申请日：1995-08-07
IPC分类号： G01N27/62 , G01N27/447 , H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer comprising a capillary electrophoresis region for separating a solution containing molecules of sample by capillary electrophoresis in a capillary, a nebulization region for nebulizing the solution containing molecules of the sample under an atmospheric pressure from the end of the capillary and forming liquid droplets of the solution containing the molecules of the sample, a vaporization region for vaporizing the liquid droplets under an atmospheric pressure to form gaseous molecules of the sample, a chemical ionization region for forming ions relevant to the molecules of the sample under the atmospheric pressure or the reduced pressure by a chemical reaction between the ions attributable to the gaseous molecules present in the atmosphere and the gaseous molecules of the sample, and a vacuum region having a sample aperture for introducing the ions formed by the chemical ionization means and incorporating a mass analysis region for mass analysis of ions introduced from the sample aperture. The mass spectrometer is combined with the capillary electrophoresis apparatus and is particularly suitable to formation and mass analysis of ions relevant to the neutral molecules of the sample.
摘要翻译： 一种质谱仪，其包括用于通过毛细管中的毛细管电泳分离含有样品分子的溶液的毛细管电泳区域，用于在大气压下从毛细管端部喷雾含有样品分子的溶液的雾化区域，并形成液滴 含有样品分子的溶液，用于在大气压下蒸发液滴的汽化区域以形成样品的气态分子;用于在大气压下形成与样品分子相关的离子的化学电离区域，或减少 存在于大气中的气体分子的离子和样品的气体分子之间的化学反应产生的压力，以及具有用于引入由化学电离装置形成的离子的样品孔的真空区域，并且包含用于 离子质量分析介绍f 取样孔。 质谱仪与毛细管电泳装置结合，特别适用于与样品中性分子相关的离子的形成和质量分析。
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公开(公告)号：US20080237459A1
公开(公告)日：2008-10-02
申请号：US12081625
申请日：2008-04-18
IPC分类号： B01D59/44
CPC分类号： H01J49/045
摘要： An ion source includes a body having a gas passage and an orifice. A capillary is inserted into the gas passage so that a tip portion of the capillary extends into the orifice. A gas supplier supplies a gas into the gas passage to form a gas flow through the gas passage along the capillary and through the orifice past a tip of the capillary so that the gas flow sprays a sample solution flowing through the capillary from the tip of the capillary. A flow controller regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20.degree. C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the tip portion of the capillary in the orifice.
摘要翻译： 离子源包括具有气体通道和孔的主体。 毛细管插入到气体通道中，使得毛细管的尖端部分延伸到孔中。 气体供应商将气体供应到气体通道中以形成沿着毛细管的气体通道的气流，并且通过孔经过毛细管的尖端，使得气流从其中的尖端喷射流过毛细管的样品溶液 毛细管。 流量控制器调节气体通道中的气体的压力，以将特性值F / S调节到预定值，其中F是在标准条件（20℃，1个大气压）下的气体流量的流量， ，S是孔口的截面与孔口中的毛细管的前端部的截面的差。
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公开(公告)号：US06384411B1
公开(公告)日：2002-05-07
申请号：US09627334
申请日：2000-07-27
IPC分类号： B01D5944
CPC分类号： H01J49/045
摘要： An ion source includes a gas supplier which supplies a gas through a gas inlet into a gas passage defined in a body to form a gas flow through the gas passage along a capillary inserted into the body and through an orifice defined in the body past a tip of the capillary so that the gas flow sprays a sample solution from the tip of the capillary. The gas supplier regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20° C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of a tip portion of the capillary in the orifice.
摘要翻译： 离子源包括气体供应器，其通过气体入口将气体供给到限定在体内的气体通道中，以形成沿着插入到体内的毛细管通过气体通道的气流，并且通过限定在体内的孔经过尖端 的毛细管，使得气流从毛细管的尖端喷射样品溶液。 气体供给器调节气体通道中的气体的压力，以将特性值F / S调整到预定值，其中F是在标准条件（20℃，1个大气压）下的气体流量的流量， S是孔口的截面与孔口中的毛细管的尖端部分的横截面之间的差异。
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公开(公告)号：US06335525B1
公开(公告)日：2002-01-01
申请号：US09525529
申请日：2000-03-15
IPC分类号： B01D5944
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer includes a sample separation apparatus which separates a sample solution into gaseous molecules, a plurality of ion sources which ionize the gaseous molecules to produce ions, and a mass analysis region which mass-analyzes ions produced by one of the ion sources. One of the ion sources may include a needle electrode which generates corona discharge for use in ionizing the gaseous molecules. The ion sources may be provided under a first pressure condition, and the mass analysis region may be provided under a second pressure condition lower than the first pressure condition.
摘要翻译： 质谱仪包括将样品溶液分离成气态分子的样品分离装置，使气态分子离子化产生离子的多个离子源，以及质量分析离子源之一产生的离子的质量分析区域。 离子源之一可以包括产生用于电离气态分子的电晕放电的针状电极。 可以在第一压力条件下提供离子源，并且可以在低于第一压力条件的第二压力条件下提供质量分析区域。
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公开(公告)号：US6147347A
公开(公告)日：2000-11-14
申请号：US328664
申请日：1999-06-09
CPC分类号： H01J49/045
摘要： A mass spectrometer includes a sample passage through which a sample solution flows towards a tip of the sample passage, a gas passage which produces a gas flow along the sample passage towards an orifice of the gas passage, a gas supplier which supplies a gas to the gas passage so that the gas flow has a velocity effective for spraying the sample solution near the tip of the sample passage, and an analyzer which analyzes a mass of gaseous ions formed from the sample solution sprayed by the gas flow. The gas flow has a characteristic value F/S between 350 meters/second (m/s) and 700 m/s, where F is a flow rate of the gas at standard conditions (20.degree. C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the sample passage at the orifice. An exposed length of the sample passage between an external opening of the orifice and the tip of the sample passage may be between -0.25 mm and 1.2 mm.
摘要翻译： 质谱仪包括样品通道，样品溶液通过该样品通道流向样品通道的尖端，气体通道，其沿着样品通道朝向气体通道的孔口产生气流;气体供应器，其向 气体通道使得气流具有用于喷射样品通道末端附近的样品溶液的速度，以及分析器，其分析由气流喷射的样品溶液形成的气态离子的质量。 气体流量在350米/秒（m / s）和700m / s之间具有特征值F / S，其中F是在标准条件（20℃，1个大气压）下气体的流速，S 是孔口的横截面和孔口处的样品通道的横截面之间的差异。 在孔的外部开口和样品通道的尖端之间的样品通道的暴露长度可以在-0.25mm和1.2mm之间。
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30.发明申请公开(公告)号：US20060192101A1
公开(公告)日：2006-08-31
申请号：US11414177
申请日：2006-05-01
申请人： Yasuaki Takada , Minoru Sakairi
发明人： Yasuaki Takada , Minoru Sakairi
CPC分类号： H01J49/0031 , G01N33/0057 , H01J49/004 , H01J49/424
摘要： An analyzing method which includes ionizing a sample, dissociating plurality of precursor ions which have different m/z values, and deciding if fragment ions of a predetermined m/z value are present.
摘要翻译： 一种分析方法，其包括电离样品，解离多个具有不同m / z值的前体离子，并确定是否存在具有预定m / z值的碎片离子。
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