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公开(公告)号：US06437327B2
公开(公告)日：2002-08-20
申请号：US09859508
申请日：2001-05-18
IPC分类号： H01J4910
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/168
摘要： A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to or at an angle with respect to a center axis of the aperture, and a tip of the needle is disposed facing to an electrode having the aperture.
摘要翻译： 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎与孔的中心轴垂直或成一定角度，并且针的尖端面向具有孔的电极。
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2.发明授权Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 有权用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US6114693A
公开(公告)日：2000-09-05
申请号：US299638
申请日：1999-04-27
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer comprising a passage through which a sample solution flows, the passage including a capillary having an open tip, the sample solution flowing through the capillary out of the open tip of the capillary, a gas passage which forms a gas flow around the open tip of the capillary, the gas flow spraying the sample solution flowing out of the open tip of the capillary, a first electrode which contacts the sample solution flowing in the passage and applies an electric potential to the sample solution flowing in the passage, a second electrode disposed around the capillary near the open tip of the capillary, the second electrode being downstream from the first electrode with respect to a direction in which the sample solution flows in the passage, there being no gap extending downstream from the open tip of the capillary to the second electrode in a direction in which the sample solution flows out of the open tip of the capillary, the second electrode being electrically isolated from the sample solution flowing in the capillary and applying an electric field to the sample solution flowing in the capillary, and an analyzer which analyzes a mass of gaseous ions formed from the sample solution sprayed by the gas flow.
摘要翻译： 一种质谱仪，包括样品溶液流过的通道，所述通道包括具有开口尖端的毛细管，所述样品溶液从毛细管的开口尖端流过毛细管，气体通道围绕开口形成气流 毛细管的尖端，气流喷射从毛细管的开口尖端流出的样品溶液，第一电极，其接触在通道中流动的样品溶液，并向在通道中流动的样品溶液施加电位，第二电极 设置在毛细管附近的毛细管周围的电极，第二电极相对于样品溶液在通道中流动的方向从第一电极下游，在毛细管的开口尖端的下游没有间隙 在样品溶液从毛细管的开口尖端流出的方向到第二电极，第二电极是电隔离的 从在毛细管中流动的样品溶液流出并向在毛细管中流动的样品溶液施加电场，以及分析器，其分析由气流喷射的样品溶液形成的气态离子的质量。
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公开(公告)号：US06188065B1
公开(公告)日：2001-02-13
申请号：US09260552
申请日：1999-03-02
IPC分类号： G01D5944
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer includes a sample supplier which supplies a sample solution, the sample solution including a solvent, ions, and a solute, the solute being a sample to be analyzed, an ion converter, disposed after the sample supplier, which converts the ions in the sample solution into gaseous ions, an ion source, disposed after the ion converter, which ionizes the sample in the sample solution, thereby producing sample ions, a mass analyzer which analyzes masses of the sample ions produced by the ion source, and an ion blocking electrode which prevents the gaseous ions produced by the ion converter from reaching the ion source, thereby preventing the mass analyzer from analyzing masses of the gaseous ions produced by the ion converter.
摘要翻译： 质谱仪包括供样品溶液的样品供应商，包含溶剂的样品溶液，离子和溶质，作为待分析样品的溶质，设置在样品供应者之后的离子转化器，其将离子转化为 将样品溶液变成气态离子，离子源，设置在离子转换器之后，将样品溶液中的样品离子化，从而产生样品离子;分析质量分析器，其分析由离子源产生的样品离子的质量;以及离子 阻止由离子转换器产生的气体离子到达离子源的阻挡电极，从而防止质量分析器分析由离子转换器产生的气态离子的质量。
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公开(公告)号：US6121608A
公开(公告)日：2000-09-19
申请号：US968898
申请日：1997-11-06
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/168
摘要： A mass spectrometric apparatus includes a device for supplying a sample solution to an outlet, the sample solution including a solvent and a solute, a first ionization device for receiving the sample solution from the outlet and electrospraying the received sample solution, thereby ionizing at least a portion of the received sample solution, a second ionization device for receiving at least a portion of the electrosprayed sample solution produced by the first ionization device and ionizing at least a portion of the received electrospayed sample solution, thereby producing ions, and a mass spectrometric device for receiving at least some of the ions produced by the second ionization device and analyzing masses of the received ions.
摘要翻译： 质谱装置包括用于将样品溶液供应到出口的装置，所述样品溶液包括溶剂和溶质，用于从所述出口接收样品溶液并对所接收的样品溶液进行电喷雾的第一离子化装置，从而将至少一种 接收样品溶液的一部分，第二电离装置，用于接收由第一离子化装置产生的电喷雾样品溶液的至少一部分，并且电离至少一部分接收的电喷雾样品溶液，从而产生离子，以及质谱仪 用于接收由第二电离装置产生的至少一些离子并分析所接收的离子的质量。
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公开(公告)号：US5877495A
公开(公告)日：1999-03-02
申请号：US511804
申请日：1995-08-07
IPC分类号： G01N27/62 , G01N27/447 , H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer comprising a capillary electrophoresis region for separating a solution containing molecules of sample by capillary electrophoresis in a capillary, a nebulization region for nebulizing the solution containing molecules of the sample under an atmospheric pressure from the end of the capillary and forming liquid droplets of the solution containing the molecules of the sample, a vaporization region for vaporizing the liquid droplets under an atmospheric pressure to form gaseous molecules of the sample, a chemical ionization region for forming ions relevant to the molecules of the sample under the atmospheric pressure or the reduced pressure by a chemical reaction between the ions attributable to the gaseous molecules present in the atmosphere and the gaseous molecules of the sample, and a vacuum region having a sample aperture for introducing the ions formed by the chemical ionization means and incorporating a mass analysis region for mass analysis of ions introduced from the sample aperture. The mass spectrometer is combined with the capillary electrophoresis apparatus and is particularly suitable to formation and mass analysis of ions relevant to the neutral molecules of the sample.
摘要翻译： 一种质谱仪，其包括用于通过毛细管中的毛细管电泳分离含有样品分子的溶液的毛细管电泳区域，用于在大气压下从毛细管端部喷雾含有样品分子的溶液的雾化区域，并形成液滴 含有样品分子的溶液，用于在大气压下蒸发液滴的汽化区域以形成样品的气态分子;用于在大气压下形成与样品分子相关的离子的化学电离区域，或减少 存在于大气中的气体分子的离子和样品的气体分子之间的化学反应产生的压力，以及具有用于引入由化学电离装置形成的离子的样品孔的真空区域，并且包含用于 离子质量分析介绍f 取样孔。 质谱仪与毛细管电泳装置结合，特别适用于与样品中性分子相关的离子的形成和质量分析。
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公开(公告)号：US20080237459A1
公开(公告)日：2008-10-02
申请号：US12081625
申请日：2008-04-18
IPC分类号： B01D59/44
CPC分类号： H01J49/045
摘要： An ion source includes a body having a gas passage and an orifice. A capillary is inserted into the gas passage so that a tip portion of the capillary extends into the orifice. A gas supplier supplies a gas into the gas passage to form a gas flow through the gas passage along the capillary and through the orifice past a tip of the capillary so that the gas flow sprays a sample solution flowing through the capillary from the tip of the capillary. A flow controller regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20.degree. C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the tip portion of the capillary in the orifice.
摘要翻译： 离子源包括具有气体通道和孔的主体。 毛细管插入到气体通道中，使得毛细管的尖端部分延伸到孔中。 气体供应商将气体供应到气体通道中以形成沿着毛细管的气体通道的气流，并且通过孔经过毛细管的尖端，使得气流从其中的尖端喷射流过毛细管的样品溶液 毛细管。 流量控制器调节气体通道中的气体的压力，以将特性值F / S调节到预定值，其中F是在标准条件（20℃，1个大气压）下的气体流量的流量， ，S是孔口的截面与孔口中的毛细管的前端部的截面的差。
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公开(公告)号：US06384411B1
公开(公告)日：2002-05-07
申请号：US09627334
申请日：2000-07-27
IPC分类号： B01D5944
CPC分类号： H01J49/045
摘要： An ion source includes a gas supplier which supplies a gas through a gas inlet into a gas passage defined in a body to form a gas flow through the gas passage along a capillary inserted into the body and through an orifice defined in the body past a tip of the capillary so that the gas flow sprays a sample solution from the tip of the capillary. The gas supplier regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20° C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of a tip portion of the capillary in the orifice.
摘要翻译： 离子源包括气体供应器，其通过气体入口将气体供给到限定在体内的气体通道中，以形成沿着插入到体内的毛细管通过气体通道的气流，并且通过限定在体内的孔经过尖端 的毛细管，使得气流从毛细管的尖端喷射样品溶液。 气体供给器调节气体通道中的气体的压力，以将特性值F / S调整到预定值，其中F是在标准条件（20℃，1个大气压）下的气体流量的流量， S是孔口的截面与孔口中的毛细管的尖端部分的横截面之间的差异。
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公开(公告)号：US06335525B1
公开(公告)日：2002-01-01
申请号：US09525529
申请日：2000-03-15
IPC分类号： B01D5944
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer includes a sample separation apparatus which separates a sample solution into gaseous molecules, a plurality of ion sources which ionize the gaseous molecules to produce ions, and a mass analysis region which mass-analyzes ions produced by one of the ion sources. One of the ion sources may include a needle electrode which generates corona discharge for use in ionizing the gaseous molecules. The ion sources may be provided under a first pressure condition, and the mass analysis region may be provided under a second pressure condition lower than the first pressure condition.
摘要翻译： 质谱仪包括将样品溶液分离成气态分子的样品分离装置，使气态分子离子化产生离子的多个离子源，以及质量分析离子源之一产生的离子的质量分析区域。 离子源之一可以包括产生用于电离气态分子的电晕放电的针状电极。 可以在第一压力条件下提供离子源，并且可以在低于第一压力条件的第二压力条件下提供质量分析区域。
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公开(公告)号：US6147347A
公开(公告)日：2000-11-14
申请号：US328664
申请日：1999-06-09
CPC分类号： H01J49/045
摘要： A mass spectrometer includes a sample passage through which a sample solution flows towards a tip of the sample passage, a gas passage which produces a gas flow along the sample passage towards an orifice of the gas passage, a gas supplier which supplies a gas to the gas passage so that the gas flow has a velocity effective for spraying the sample solution near the tip of the sample passage, and an analyzer which analyzes a mass of gaseous ions formed from the sample solution sprayed by the gas flow. The gas flow has a characteristic value F/S between 350 meters/second (m/s) and 700 m/s, where F is a flow rate of the gas at standard conditions (20.degree. C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the sample passage at the orifice. An exposed length of the sample passage between an external opening of the orifice and the tip of the sample passage may be between -0.25 mm and 1.2 mm.
摘要翻译： 质谱仪包括样品通道，样品溶液通过该样品通道流向样品通道的尖端，气体通道，其沿着样品通道朝向气体通道的孔口产生气流;气体供应器，其向 气体通道使得气流具有用于喷射样品通道末端附近的样品溶液的速度，以及分析器，其分析由气流喷射的样品溶液形成的气态离子的质量。 气体流量在350米/秒（m / s）和700m / s之间具有特征值F / S，其中F是在标准条件（20℃，1个大气压）下气体的流速，S 是孔口的横截面和孔口处的样品通道的横截面之间的差异。 在孔的外部开口和样品通道的尖端之间的样品通道的暴露长度可以在-0.25mm和1.2mm之间。
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10.发明授权Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 失效用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US5898175A
公开(公告)日：1999-04-27
申请号：US708415
申请日：1996-09-05
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer employing an ion source includes a capillary for spraying therethrough liquid into the atmospheres and an orifice through which a portion in the vicinity of a tip of the capillary is inserted, the orifice being designed in such a way that gases are caused to flow up to the tip of the capillary along a peripheral wall face of the capillary. The flow rate of gas in the vicinity of the tip of the capillary is about the sonic velocity, and a voltage is applied across the liquid flowing through the capillary and the orifice or an electrode arranged in the vicinity of the tip of the capillary.
摘要翻译： 使用离子源的质谱仪包括用于将液体喷射到气氛中的毛细管和插入毛细管的尖端附近的部分的孔，孔被设计成使气体流动 直到毛细管的尖端沿着毛细管的周壁面。 毛细管尖端附近的气体的流速大约是声速，并且在流过毛细管的液体和布置在毛细管尖端附近的孔或电极之间施加电压。
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