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    Magenta dye developers
    21.
    发明授权
    Magenta dye developers 失效
    洋红染料开发商

    公开(公告)号：US4264701A

    公开(公告)日：1981-04-28

    申请号：US143284

    申请日：1980-04-24

    申请人： Louis Locatell, Jr. ,  Howard G. Rogers ,  Ruth C. Bilofsky ,  Ronald F. Cieciuch ,  Charles M. Zepp

    发明人： Louis Locatell, Jr. ,  Howard G. Rogers ,  Ruth C. Bilofsky ,  Ronald F. Cieciuch ,  Charles M. Zepp

    IPC分类号： C09B11/24 ,  G03C8/18 ,  G03C1/40 ,  G03C5/54

    CPC分类号： G03C8/18 ,  C09B11/24

    摘要： Diffusion transfer color processes and products are disclosed employing image-dye providing materials providing magenta image dyes having the chromophoric system represented by the formula ##STR1## wherein each R is the same or different and is an alkyl group, and each X is the same or different and is hydrogen or an alkyl group (including substituted alkyl). The dye image-providing material includes a diffusion control moiety, such as a hydroquinonyl group, and may be diffusible or nondiffusible as a function of the diffusion control moiety.

    摘要翻译： 公开了扩散转移着色方法和产品，其使用提供具有由式“IMAGE”表示的发色体系的品红色图像染料的图像染料提供材料，其中每个R相同或不同，为烷基，并且每个X相同或 不同的是氢或烷基（包括取代的烷基）。 染料图像提供材料包括扩散控制部分，例如氢醌基，并且可以作为扩散控制部分的函数可扩散或不扩散。

    Methods and apparatus for rendering an optically encoded medium unreadable and tamper-resistant
    24.
    发明授权
    Methods and apparatus for rendering an optically encoded medium unreadable and tamper-resistant 失效
    用于使光学编码介质呈现不可读和防篡改的方法和装置

    公开(公告)号：US06531262B1

    公开(公告)日：2003-03-11

    申请号：US09690405

    申请日：2000-10-17

    申请人： Nabil M. Lawandy ,  Charles M. Zepp ,  Andrei Smuk ,  Marianne Krieg-Kowald

    发明人： Nabil M. Lawandy ,  Charles M. Zepp ,  Andrei Smuk ,  Marianne Krieg-Kowald

    IPC分类号： G11B370

    CPC分类号： G11B7/26 ,  G11B7/005 ,  G11B7/252 ,  G11B20/00086 ,  G11B20/00608 ,  G11B20/00695 ,  G11B20/0084 ,  G11B23/281 ,  Y10S430/146

    摘要： Methods and apparatus are provided for making an optically readable media unreadable and tamper-resistant. A method has steps of (a) providing the media with a readout surface layer that is non-flat (i.e., textured in some way, such as by embossing, scratching, depositing a non-planar layer or regions, such as droplets) and that inhibits optical readout of the media; (b) applying a coating layer to the non-flat surface layer to smooth the non-flat surface and to enable optical readout of the media; and, after an initiation of a readout period, (c) removing the coating layer so as to expose the non-flat readout surface layer, thereby inhibiting optical readout of the media. Preferably, the coating layer is substantially index matched to the readout surface layer. The step of removing includes at least one of evaporating or subliming a component material of the coating layer A method is also disclosed for discouraging tampering with a readout-limiting mechanism by (a) providing the media with at least one layer that embodies the readout-limiting mechanism; (b) providing a textured surface that forms part of a layer that underlies the at least one layer, where the textured surface inhibits optical readout of the media; and (c) applying a coating layer over the textured surface to smooth the textured surface and to enable optical readout of the media, wherein removal of the coating layer exposes the textured surface thereby inhibiting optical readout of the media.

    摘要翻译： 提供了用于制造光可读介质不可读和防篡改的方法和装置。 一种方法具有以下步骤：（a）向介质提供非平坦的读出表面层（即，以某种方式，例如通过压花，刮擦，沉积非平面层或诸如液滴的区域）和 这抑制了介质的光学读出; （b）将涂层施加到非平坦表面层上以平滑非平坦表面并使光学读出介质; 并且在读出期间开始之后，（c）去除涂层以露出非平面读出表面层，从而抑制介质的光学读出。 优选地，涂层基本上与读出表面层相匹配。 还公开了去除步骤中的至少一种，其中包括使涂层的组分材料蒸发或升华的方法。方法还公开了通过（a）向介质提供体现读出限制机构的至少一层的阻止篡改读出限制机构的方法， 限制机制; （b）提供纹理表面，其形成位于所述至少一个层下面的层的一部分，其中织构化表面禁止介质的光学读出; 并且（c）在纹理化表面上涂覆涂层以平滑纹理化表面并且使得能够光学读出介质，其中去除涂层暴露纹理化表面，从而抑制介质的光学读出。

    Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
    26.
    发明授权
    Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens 失效
    使用来自粘质沙雷氏菌的酯酶对1,4-苯并二恶烷-2-羧酸烷基酯进行光学拆分

    公开(公告)号：US5529929A

    公开(公告)日：1996-06-25

    申请号：US477381

    申请日：1995-06-07

    申请人： Richard F. Rossi, Jr. ,  Charles M. Zepp ,  Donald L. Heefner

    发明人： Richard F. Rossi, Jr. ,  Charles M. Zepp ,  Donald L. Heefner

    IPC分类号： C12P17/06 ,  C12P41/00

    CPC分类号： C12P17/06 ,  C12P41/005 ,  Y10S435/881

    摘要： A process for resolving racemic alkyl 1,4-benzodioxan-2-carboxylates useful as intermediates in the synthesis of optically pure pharmaceutical compounds such as (S)-doxazosin is disclosed. The process utilizes a microbial enzyme derived from Serratia marcescens to catalyze the enantioselective hydrolysis of the alkyl (S)-1,4-benzodioxan-2-carboxylate enantiomer of the racemic mixture to its corresponding carboxylic acid at a faster rate than the R-enantiomer. An enantiomerically pure S-configured carboxylic acid is thereby formed for subsequent pharmaceutical synthesis. The nonhydrolyzed alkyl (R)-1,4-benzodioxan-2-carboxylate enantiomer can also be isolated and racemized, and the enzymatic hydrolysis reaction repeated.

    摘要翻译： 公开了用于合成光学纯药物化合物如（S） - 恶唑嗪的中间体的外消旋烷基1,4-苯并二恶烷-2-羧酸酯的方法。 该方法利用来自粘质沙雷氏菌的微生物酶催化外消旋混合物的（S）-1,4-苯并二恶烷-2-羧酸烷基酯对映异构体对映选择性水解速率比R对映异构体 。 由此形成对映异构体纯的S-构型的羧酸用于随后的药物合成。 还可以分离非水解的（R）-1,4-苯并二恶烷-2-羧酸烷基酯对映异构体并进行外消旋化，并重复酶水解反应。

    Compounds useful in enzymatic resolution systems and their preparation
    28.
    发明授权
    Compounds useful in enzymatic resolution systems and their preparation 失效
    可用于酶解体系及其制备的化合物

    公开(公告)号：US5196568A

    公开(公告)日：1993-03-23

    申请号：US178735

    申请日：1988-04-07

    申请人： Charles M. Zepp ,  Stephen A. Wald ,  David R. Dodds

    发明人： Charles M. Zepp ,  Stephen A. Wald ,  David R. Dodds

    IPC分类号： B01J19/24 ,  C07C219/10 ,  C07C305/04 ,  C07C305/10 ,  C07C309/65 ,  C07C309/66 ,  C07C327/32 ,  C07F9/09 ,  C12N11/02 ,  C12P1/00 ,  C12P7/40 ,  C12P41/00

    CPC分类号： C12P41/005 ,  B01J19/2475 ,  C07C219/10 ,  C07C305/04 ,  C07C305/10 ,  C07C309/65 ,  C07C309/66 ,  C07C327/32 ,  C07F9/091 ,  C12N11/02 ,  C12P1/00 ,  C12P41/00 ,  C12P7/40 ,  B01J2219/00159 ,  B01J2219/00162 ,  B01J2219/00177

    摘要： This invention relates to novel compositions of matter which are esters with enhanced water solubility, for use in aqueous enzymatic resolution reactions of racemic mixtures of these esters for producing the separate chiral isomers of the racemic mixture. The invention also relates to novel methods for preparing these esters. The importance of the production of the separate chiral isomers of the racemic mixtures resides in the isolation of the isomers which frequently have different biological activities. Of particular significance regarding the water soluble esters of this invention is that they are derivatized with groups which enhance their aqueous solubility and their reactivity with enzymatic resolving methods which are mediated in an aqueous environment. In addition, the importance of these compounds resides in their being useful in novel methods for facilitating the enzymatic resolution reactions of racemic mixtures of esters, which are derivatized with groups which enhance the esters' aqueous solubility, in 1) a homogeneous aqueous reaction system where an extractive phase is not present, 2) a multiphase dispersion extractive reaction where an extractive phase is present, and 3) an extractive membrane reactor where the enzyme is placed alternatively either (a) in the aqueous phase, (b) in association with the membrane, or (c) in the aqueous phase and in association with the membrane, wherein the aqueous ester phase is contacted with one side of the membrane, and where an organic extractive phase is contacted with the other side of the membrane, wherein the extractive phase serves to remove the resolving reaction product.

    摘要翻译： 本发明涉及物质的新型组合物，其是具有增强的水溶性的酯，用于这些酯的外消旋混合物的水性酶拆分反应中用于产生外消旋混合物的分离的手性异构体。 本发明还涉及制备这些酯的新方法。 外消旋混合物的分离手性异构体的生产的重要性在于分离经常具有不同生物活性的异构体。 对于本发明的水溶性酯具有特别意义的是它们用增强其水溶性的基团和它们与在水性环境中介导的酶拆分方法的反应性的基团衍生化。 此外，这些化合物的重要性在于它们可用于促进酯的外消旋混合物的酶拆分反应的新方法，其通过增强酯的水溶性的基团衍生化，在1）均匀的水反应体系中，其中 萃取相不存在，2）存在萃取相的多相分散萃取反应，和3）提取膜反应器，其中酶在（a）在水相中交替放置，（b）与 膜或（c）在水相中并与膜结合，其中酯水相与膜的一侧接触，并且其中有机萃取相与膜的另一侧接触，其中提取物 相用于除去分解反应产物。