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34 条记录 (耗时 0.051 秒)

    BLOOD CONTACTING SENSOR
    21.
    发明申请
    BLOOD CONTACTING SENSOR 有权
    血液接触传感器

    公开(公告)号：US20090149728A1

    公开(公告)日：2009-06-11

    申请号：US12264810

    申请日：2008-11-04

    申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    IPC分类号： A61B5/1468

    CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

    摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

    摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

    Methods and materials for stabilizing analyte sensors
    22.
    发明申请
    Methods and materials for stabilizing analyte sensors 有权
    用于稳定分析物传感器的方法和材料

    公开(公告)号：US20080027287A1

    公开(公告)日：2008-01-31

    申请号：US11493054

    申请日：2006-07-26

    申请人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

    发明人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6849

    摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

    摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括靠近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。

    Methods and materials for stabilizing analyte sensors
    24.
    发明授权
    Methods and materials for stabilizing analyte sensors 有权
    用于稳定分析物传感器的方法和材料

    公开(公告)号：US09492111B2

    公开(公告)日：2016-11-15

    申请号：US11493054

    申请日：2006-07-26

    申请人： Rajiv Shah ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

    发明人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

    IPC分类号： A61B5/00 ,  A61B5/1486 ,  A61B5/145

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6849

    摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

    摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括邻近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。

    Methods and systems for detecting the hydration of sensors
    25.
    发明授权
    Methods and systems for detecting the hydration of sensors 有权
    检测传感器水合的方法和系统

    公开(公告)号：US08602992B2

    公开(公告)日：2013-12-10

    申请号：US12887465

    申请日：2010-09-21

    申请人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

    发明人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

    IPC分类号： A61B5/05 ,  A61B5/00

    CPC分类号： G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

    摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

    摘要翻译： 传感器系统包括传感器和传感器电子设备。 传感器包括多个电极。 传感器电子设备包括连接检测装置，电源和延迟电路。 连接检测装置确定传感器电子设备是否连接到传感器并发送连接信号。 延迟电路接收连接信号，等待预设的水合时间，并且在经过预设水合时间之后将调节的电压从电源耦合到传感器中的电极。 或者，传感器电子设备可以包括电检测电路和微控制器。 电检测电路确定多个电极是否水合，并且如果电极是水合的则产生中断。 微控制器接收中断，并将代表电压的信号传送到多个电极的电极。

    METHOD OF AND SYSTEM FOR STABILIZATION OF SENSORS
    27.
    发明申请
    METHOD OF AND SYSTEM FOR STABILIZATION OF SENSORS 有权
    传感器稳定方法和系统

    公开(公告)号：US20110125446A1

    公开(公告)日：2011-05-26

    申请号：US13004646

    申请日：2011-01-11

    申请人： RAJIV SHAH ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

    发明人： RAJIV SHAH ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

    IPC分类号： G06F19/00 ,  G01R35/00

    CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0223 ,  A61M5/1723 ,  A61M2230/201 ,  G01N27/327 ,  G01N27/3274

    摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic—cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

    摘要翻译： 血糖感测系统包括传感器和传感器电子设备。 传感器包括多个电极。 传感器电子设备包括稳定电路。 稳定电路使得第一电压被施加到第一时间帧中的一个电极，并且使得第二电压被施加到第二时间范围中的一个电极。 稳定电路重复施加第一电压和第二电压以继续阳极 - 阴极循环。 传感器电子设备可以包括电源，调节器和电压施加装置，其中电压施加装置从调节器接收调节电压，在第一时间帧向电极施加第一电压，并施加第二电压 第二时间段的电极。