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21.发明申请COMPUTERIZED CONTROL OF HIGH-THROUGHPUT EXPERIMENTAL PROCESSING AND DIGITAL ANALYSIS OF COMPARATIVE SAMPLES FOR A COMPOUND OF INTEREST 审中-公开高效率实验处理的计算机控制和用于化合物的比较样品的数字分析公开(公告)号：US20070020662A1
公开(公告)日：2007-01-25
申请号：US11467061
申请日：2006-08-24
申请人： Michael Cima , Douglas Levinson , Donovan Chin , Christopher McNulty , Christopher Moore , Anthony Lemmo , Javier Gonzalez-Zugasti , Alasdair Johnson , Hongming Chen , Orn Almarsson
发明人： Michael Cima , Douglas Levinson , Donovan Chin , Christopher McNulty , Christopher Moore , Anthony Lemmo , Javier Gonzalez-Zugasti , Alasdair Johnson , Hongming Chen , Orn Almarsson
CPC分类号： G16C20/60 , B01J2219/007 , B01J2219/00756 , G16B15/00 , G16B35/00 , G16B40/00
摘要： The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention allow determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as pharmaceuticals. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for an intended use or purpose.
摘要翻译： 本发明涉及计算机控制的自动化高通量系统和/或计算机程序产品，用于设计，制备，处理和分析大量具有实验制剂的样品，每个试样含有不同成分组合配制的感兴趣的化合物， 浓度和组分特征。 本发明的计算机控制方法允许确定附加或不活泼组分如赋形剂，载体，增强剂，粘合剂，添加剂等对目标化合物如药物的作用。 因此，本发明包括计算机系统，计算机方法和用于药物组合物或制剂的计算机控制的自动化高通量测试的计算机程序产品，以便为预期用途或目的确定总体最佳组成或配方。
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公开(公告)号：US20060052432A1
公开(公告)日：2006-03-09
申请号：US10528244
申请日：2003-09-16
申请人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
发明人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
IPC分类号： A61K9/00 , A61K31/18 , A61K31/415 , A61K31/365
CPC分类号： A61K9/0019 , A61K9/145 , A61K9/146 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10
摘要： The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
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公开(公告)号：US20050027019A1
公开(公告)日：2005-02-03
申请号：US10629308
申请日：2003-07-29
申请人： Zhong Zhang , Orn Almarsson , Hongming Chen
发明人： Zhong Zhang , Orn Almarsson , Hongming Chen
IPC分类号： A61K47/04 , A61K9/10 , A61K31/05 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/26 , A61K47/28 , A61K47/34 , A61P23/00 , A61K31/14
CPC分类号： A61K47/28 , A61K9/0019 , A61K9/10 , A61K31/05 , A61K45/06 , A61K47/10 , A61K47/186 , A61K47/26 , A61K2300/00
摘要： The present invention relates to aqueous pharmaceutical compositions comprising 2,6-diisopropylphenol (propofol). A composition of the present invention can comprise propofol and two or more excipients as an aqueous mixture. The propofol containing compositions are preferably sterile and are parenterally administered to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions.
摘要翻译： 本发明涉及包含2,6-二异丙基苯酚（丙泊酚）的水性药物组合物。 本发明的组合物可以包含异丙酚和两种或更多种作为水性混合物的赋形剂。 含有异丙酚的组合物优选是无菌的，并且肠胃外给予任何动物，包括人。 组合物在宽范围的环境条件下也是化学和物理稳定的。
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24.发明授权Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery 失效靶向M细胞的聚合脂质体可用于口服或粘膜药物递送公开(公告)号：US06387397B1
公开(公告)日：2002-05-14
申请号：US09324458
申请日：1999-06-02
申请人： Hongming Chen , Robert S. Langer
发明人： Hongming Chen , Robert S. Langer
IPC分类号： A61K9127
CPC分类号： A61K39/05 , A61K9/1273 , A61K38/28 , A61K39/00 , A61K48/00 , A61K2039/541 , A61K2039/55555 , Y02A50/401 , Y10S436/829 , Y10T428/2984
摘要： The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type. More particularly, the invention relates to the use of polymerized liposomes modified to contain a carbohydrate or lectin on their surface.
摘要翻译： 本发明涉及用于口服和/或粘膜递送疫苗，变应原和治疗剂的目标聚合脂质体。 特别地，本发明涉及在其表面上被修饰以包含将聚合脂质体靶向特定部位或细胞类型的分子或配体的聚合脂质体。 更具体地说，本发明涉及经修饰的聚合脂质体在其表面上含有碳水化合物或凝集素的用途。
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公开(公告)号：US20080253935A1
公开(公告)日：2008-10-16
申请号：US12143220
申请日：2008-06-20
申请人： Nathan Kane , Michael Cima , Javier Gonzalez-Zugasti , Jeanie Cherng , Anthony Lemmo , J. Richard Gyory , Wendy Pryce-Lewis , Hongming Chen
发明人： Nathan Kane , Michael Cima , Javier Gonzalez-Zugasti , Jeanie Cherng , Anthony Lemmo , J. Richard Gyory , Wendy Pryce-Lewis , Hongming Chen
CPC分类号： B01F3/18 , B01F7/00258 , B01F7/18 , B01F11/0065 , B01F13/0059 , B01F13/0272 , B01F13/08 , B01L3/0217 , B01L2200/0657 , G01F11/021 , G01F11/10 , G01F11/18 , G01G19/00 , G01N1/286 , G01N1/36 , G01N35/0099 , G01N2001/368 , Y10T436/2575
摘要： The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.
摘要翻译： 本发明涉及用于操作少量固体的方法和装置。 本发明的具体实施方案特别适用于少量固体的自动转移。 在一个实施方案中，将均匀的粉末床轻轻压缩成粉末塞并分配。 在另一个实施方案中，将固体置于液体载体中以形成浆液，分配，随后除去液体组分。 在另一个实施方案中，使用粘合剂表面操纵固体。
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26.发明授权公开(公告)号：US07172859B2
公开(公告)日：2007-02-06
申请号：US10371372
申请日：2003-02-20
申请人： Michael J. Cima , Hongming Chen , J. Richard Gyory
发明人： Michael J. Cima , Hongming Chen , J. Richard Gyory
IPC分类号： C12Q1/00
CPC分类号： G01N33/5088 , G01N13/00
摘要： The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.
摘要翻译： 本发明涉及高通量系统和方法，以同时以不同的浓度和同一性制备大量组分组合，以及高通量方法来测试组织屏障转移，例如透皮转移 每个组合。 本发明的方法允许测定非活性组分如溶剂，赋形剂，增强剂，粘合剂和添加剂对活性组分如药物的组织屏障转移的影响。 因此，本发明包括药物组合物或制剂的高通量测试，以便确定用于改善组织转运的总体最佳组合物或制剂，例如透皮转运。
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公开(公告)号：US20060134198A1
公开(公告)日：2006-06-22
申请号：US10541216
申请日：2003-12-24
申请人： Mark Tawa , Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Oliveira
发明人： Mark Tawa , Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Oliveira
IPC分类号： A61K9/20
CPC分类号： A61K9/1652 , A61K9/145 , A61K9/146 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/32 , C07D231/12
摘要： The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
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28.发明授权公开(公告)号：US06758099B2
公开(公告)日：2004-07-06
申请号：US09904725
申请日：2001-07-13
IPC分类号： G01F100
CPC分类号： G01N33/5044 , B01L3/50255 , G01N13/00 , G01N33/5008 , G01N33/5088 , G01N2500/00
摘要： The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.
摘要翻译： 本发明涉及高通量系统和方法，以同时以不同的浓度和同一性制备大量组分组合，以及高通量方法来测试组织屏障转移，例如透皮转移 每个组合。 本发明的方法允许测定非活性组分如溶剂，赋形剂，增强剂，粘合剂和添加剂对活性组分如药物的组织屏障转移的影响。 因此，本发明包括药物组合物或制剂的高通量测试，以便确定用于改善组织转运的总体最佳组合物或制剂，例如透皮转运。
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公开(公告)号：US6060082A
公开(公告)日：2000-05-09
申请号：US844138
申请日：1997-04-18
申请人： Hongming Chen , Robert S. Langer
发明人： Hongming Chen , Robert S. Langer
CPC分类号： A61K39/05 , A61K38/28 , A61K39/00 , A61K48/00 , A61K9/1273 , A61K2039/541 , A61K2039/55555 , Y10S436/829 , Y10T428/2984
摘要： The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type. More particularly, the invention relates to the use of polymerized liposomes modified to contain a carbohydrate or lectin on their surface.
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