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    Targeted polymerized liposomes for improved drug delivery
    2.
    发明授权
    Targeted polymerized liposomes for improved drug delivery 失效
    用于改善药物递送的靶向聚合脂质体

    公开(公告)号：US6004534A

    公开(公告)日：1999-12-21

    申请号：US844137

    申请日：1997-04-18

    申请人： Robert S. Langer ,  Hongming Chen

    发明人： Robert S. Langer ,  Hongming Chen

    IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K49/00

    CPC分类号： A61K9/1273 ,  Y10S424/812 ,  Y10T428/2984

    摘要： The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type in order to optimize the immune response to the encapsulated antigen or the efficacy of the encapsulated drug.

    摘要翻译： 本发明涉及用于口服和/或粘膜递送疫苗，变应原和治疗剂的目标聚合脂质体。 特别地，本发明涉及在其表面上已被修饰以包含将聚合的脂质体靶向特定部位或细胞类型的分子或配体的聚合脂质体，以便优化对包封的抗原的免疫应答或其功效 胶囊化药物。

    Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
    3.
    发明授权
    Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery 失效
    靶向M细胞的聚合脂质体可用于口服或粘膜药物递送

    公开(公告)号：US06387397B1

    公开(公告)日：2002-05-14

    申请号：US09324458

    申请日：1999-06-02

    申请人： Hongming Chen ,  Robert S. Langer

    发明人： Hongming Chen ,  Robert S. Langer

    IPC分类号： A61K9127

    CPC分类号： A61K39/05 ,  A61K9/1273 ,  A61K38/28 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/541 ,  A61K2039/55555 ,  Y02A50/401 ,  Y10S436/829 ,  Y10T428/2984

    摘要： The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type. More particularly, the invention relates to the use of polymerized liposomes modified to contain a carbohydrate or lectin on their surface.

    摘要翻译： 本发明涉及用于口服和/或粘膜递送疫苗，变应原和治疗剂的目标聚合脂质体。 特别地，本发明涉及在其表面上被修饰以包含将聚合脂质体靶向特定部位或细胞类型的分子或配体的聚合脂质体。 更具体地说，本发明涉及经修饰的聚合脂质体在其表面上含有碳水化合物或凝集素的用途。

    Crosslinked, degradable polymers and uses thereof
    7.
    发明授权
    Crosslinked, degradable polymers and uses thereof 有权
    交联的可降解聚合物及其用途

    公开(公告)号：US08808681B2

    公开(公告)日：2014-08-19

    申请号：US11758078

    申请日：2007-06-05

    申请人： Daniel Griffith Anderson ,  Jason Alan Burdick ,  Robert S. Langer

    发明人： Daniel Griffith Anderson ,  Jason Alan Burdick ,  Robert S. Langer

    IPC分类号： A61K47/32 ,  A61K35/00 ,  C08F2/48 ,  C08G73/00 ,  C08F299/04 ,  C08F290/06 ,  C08F283/00 ,  C08G73/02 ,  C08F299/02 ,  C08L79/02 ,  C08G63/685

    CPC分类号： C08L79/02 ,  C08F283/00 ,  C08F290/06 ,  C08F290/061 ,  C08F290/065 ,  C08F299/024 ,  C08F299/0485 ,  C08G63/6858 ,  C08G73/02

    摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.

    摘要翻译： 丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。 将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。 由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。 这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。 这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。 因此，可以调整材料的性质以达到期望的用途。 制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

    POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF
    9.
    发明申请
    POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 有权
    聚（氨基 - 氨基醇），其制备及其用途

    公开(公告)号：US20130302401A1

    公开(公告)日：2013-11-14

    申请号：US13819280

    申请日：2011-08-26

    申请人： Minglin Ma ,  Wendy F. Liu ,  Robert S. Langer ,  Daniel Griffith Anderson

    发明人： Minglin Ma ,  Wendy F. Liu ,  Robert S. Langer ,  Daniel Griffith Anderson

    IPC分类号： C08G73/02 ,  C09D179/02

    CPC分类号： C08G73/0206 ,  A61K9/1273 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/59 ,  A61L31/10 ,  C08G59/22 ,  C08G59/306 ,  C08G59/50 ,  C08G73/02 ,  C09D5/1637 ,  C09D179/02 ,  Y10T428/31725

    摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.

    摘要翻译： 使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。 本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。 当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。 这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。 此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。 这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。 本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。