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    Raised surface assay plate
    3.
    发明授权
    Raised surface assay plate 失效
    升高的表面测定板

    公开(公告)号：US07763455B2

    公开(公告)日：2010-07-27

    申请号：US10556996

    申请日：2004-05-13

    申请人： Michael Cima ,  Wendy Pryce-Lewis ,  Javier Gonzalez-Zugasti ,  J. Richard Gyory ,  Anthony Lemmo ,  Julie Monagle

    发明人： Michael Cima ,  Wendy Pryce-Lewis ,  Javier Gonzalez-Zugasti ,  J. Richard Gyory ,  Anthony Lemmo ,  Julie Monagle

    IPC分类号： C12M1/20 ,  A61F13/00 ,  A61K9/70

    CPC分类号： B01L3/5085 ,  B01L3/5025 ,  B01L3/5088 ,  B01L2300/0609 ,  B01L2300/0819 ,  B01L2300/0829

    摘要： The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.

    摘要翻译： 测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。 凸起垫包括基本平坦的样品接收表面，其构造成用于将样品保持在其上用于原位实验。 样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。 样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。 还提供了使用上述测定板的方法。 一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。 随后使用凸起垫上的样品进行实验。

    COMPUTING METHODS FOR CONTROL OF HIGH-THROUGHPUT EXPERIMENTAL PROCESSING, DIGITAL ANALYSIS, AND RE-ARRAYING COMPARATIVE SAMPLES IN COMPUTER-DESIGNED ARRAYS
    5.
    发明申请
    COMPUTING METHODS FOR CONTROL OF HIGH-THROUGHPUT EXPERIMENTAL PROCESSING, DIGITAL ANALYSIS, AND RE-ARRAYING COMPARATIVE SAMPLES IN COMPUTER-DESIGNED ARRAYS 审中-公开
    用于控制高速实验处理，数字分析和计算机设计的阵列中的重新排列比较样本的计算方法

    公开(公告)号：US20070021929A1

    公开(公告)日：2007-01-25

    申请号：US11467096

    申请日：2006-08-24

    申请人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

    发明人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

    IPC分类号： G06F19/00

    CPC分类号： G01N35/0092 ,  G01N35/00613 ,  G01N35/00712 ,  G01N2015/1493

    摘要： Computer-controlled automated high-throughput systems can be used to design, prepare, process, screen, and analyze a large number of samples in removable sample vials each containing a compound of interest formulated with differing component combinations and varying concentrations. The computer-controlled methods of the present invention allow for a determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as a pharmaceutical. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of experimental formulations in order to identify experimental formulations that can be further processed. Identified experimental formulations from multiple arrays can be removed and re-arrayed together to form a new array for further processing.

    摘要翻译： 计算机控制的自动化高通量系统可用于设计，制备，处理，筛选和分析大量可拆卸样品瓶中的样品，每个样品瓶均含有不同成分组合和不同浓度配制的感兴趣的化合物。 本发明的计算机控制的方法允许确定附加或非活性组分如赋形剂，载体，增强剂，粘合剂，添加剂等对目的化合物如药物的作用。 本发明因此包括计算机系统，计算机方法和计算机程序产品，用于实验制剂的计算机控制的自动高通量测试，以便鉴定可进一步处理的实验制剂。 来自多个阵列的识别的实验制剂可以被去除并重新排列在一起以形成用于进一步处理的新阵列。

    Raised surface assay plate
    7.
    发明申请
    Raised surface assay plate 审中-公开
    升高的表面测定板

    公开(公告)号：US20050208477A1

    公开(公告)日：2005-09-22

    申请号：US11137592

    申请日：2005-05-25

    申请人： Michael Cima ,  Wendy Lewis ,  Javier Gonzalez-Zugasti ,  J. Gyory ,  Anthony Lemmo ,  Julie Monagle

    发明人： Michael Cima ,  Wendy Lewis ,  Javier Gonzalez-Zugasti ,  J. Gyory ,  Anthony Lemmo ,  Julie Monagle

    IPC分类号： B01L3/00 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/24 ,  C12Q1/68 ,  G01N20060101

    CPC分类号： B01L3/5088 ,  B01L2300/0829

    摘要： The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in-situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.

    摘要翻译： 测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。 凸起垫包括被配置用于将样品保持在其上以用于现场实验的基本平坦的样品接收表面。 样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。 样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。 还提供了使用上述测定板的方法。 一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。 随后使用凸起垫上的样品进行实验。

    Apparatus and method for transcellular testing
    8.
    发明申请
    Apparatus and method for transcellular testing 审中-公开
    用于跨细胞测试的装置和方法

    公开(公告)号：US20060141443A1

    公开(公告)日：2006-06-29

    申请号：US10542477

    申请日：2004-01-20

    申请人： J. Gyory ,  Michael Cima ,  Javier Gonzalez-Zugasti ,  Anthony Lemmo

    发明人： J. Gyory ,  Michael Cima ,  Javier Gonzalez-Zugasti ,  Anthony Lemmo

    IPC分类号： C12Q1/00 ,  C12M1/34

    CPC分类号： G01N33/5008 ,  G01N33/502

    摘要： The present invention relates to a device and method for facilitating high throughput transcellular flux testing of compounds, such as pharmaceuticals or drugs, other compounds, or compound combinations. In one embodiment, the system and methods of the present invention may be used to identify the optimal components (e.g., solvents, carriers, transport enhancers, adhesives, additives, inhibitors, or other excipients) for pharmaceutical compositions or formulations that are delivered to a patient via tissue transport, including without limitation, pharmaceutical compositions or formulations administered or delivered transcellularly, topically, and ocularly.

    摘要翻译： 本发明涉及促进化合物如药物或药物，其它化合物或化合物组合的高通量跨细胞通量测试的装置和方法。 在一个实施方案中，本发明的系统和方法可用于鉴定用于药物组合物或制剂的最佳组分（例如，溶剂，载体，运输增强剂，粘合剂，添加剂，抑制剂或其它赋形剂） 患者通过组织运输，包括但不限于药物组合物或通过跨细胞，局部和眼睛施用或递送的制剂。