公开(公告)号：US20080216758A1

公开(公告)日：2008-09-11

申请号：US11863829

申请日：2007-09-28

申请人： Wan Soo KIM

发明人： Wan Soo KIM

IPC分类号： A01K61/00 ,  A01K63/00

CPC分类号： A01K63/02

摘要： A method and an apparatus for inducing artificial hibernation of marine animal, wherein the temperature of sea water with marine animals is gradually lowered in stepwise process, while the sea water temperature is kept as is for a predetermined period of time at each step of lowering temperature, whereby the predetermined period of time maintained for each step of the lowered temperature is gradually increased to a point where changes of oxygen consumption by the marine animals greatly decreased or the changes of oxygen consumption is reached almost zero, and starting from this point, the time of constantly maintaining the sea water temperature at each step is gradually reduced to thereby ensuring a long survival rate (viability) of marine animals.

摘要翻译： 一种用于诱导海洋动物人造冬眠的方法和装置，其中随着海洋动物的海水温度逐步降低，同时在降低温度的每个步骤期间将海水温度保持为预定时间段 由此，将降低温度的各步骤保持的规定时间逐渐增加到海洋动物的氧消耗变化大大降低或氧消耗变化达到几乎为零的点，从这一点开始 不断维持每一步海水温度的时间逐渐减少，从而确保了海洋动物的长寿命（生存能力）。

公开(公告)号：US09012179B2

公开(公告)日：2015-04-21

申请号：US14117225

申请日：2011-05-17

申请人： Hakjun Kim ,  Sungho Kang ,  Junhyuck Lee ,  Sunggu Lee ,  Sejong Han ,  Jongchan Park ,  Kyoungsun Park

发明人： Hakjun Kim ,  Sungho Kang ,  Junhyuck Lee ,  Sunggu Lee ,  Sejong Han ,  Jongchan Park ,  Kyoungsun Park

IPC分类号： C12P21/02 ,  C07K14/39 ,  C12N15/81

CPC分类号： C07K14/39 ,  C12N15/815

摘要： The present invention relates to a method for mass-producing an antifreeze protein derived from a polar yeast, and more particularly, to a method for mass-producing an antifreeze protein derived from Leucosporidium sp., which is the polar yeast, for synthesizing a recombinant polynucleotide by optimizing and altering a gene, which codes the antifreeze protein derived from the polar yeast, for a yeast expression system, and for expressing same using the yeast expression system.

摘要翻译： 本发明涉及一种大规模生产来自极性酵母的防冻蛋白质的方法，更具体地说，涉及用于大量生产来自作为极性酵母的嗜蓝细菌的防冻蛋白的方法，用于合成重组 通过优化和改变编码来自极性酵母的抗冻蛋白的基因，用于酵母表达系统，并使用酵母表达系统进行表达，从而实现多核苷酸的多态性。

公开(公告)号：US20140315738A1

公开(公告)日：2014-10-23

申请号：US14256609

申请日：2014-04-18

申请人： Korea Institute of Ocean Science & Technology

发明人： Seungshic Yum ,  Seonock Woo ,  Hyokyoung Won ,  Aekyung Lee ,  Jae-Chun Ryu

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N33/743

摘要： The present invention relates to marine medaka genes responding to the exposure of endocrine-disrupting chemicals, and a method for diagnosing an aquatic eco-system contamination using the marine medaka genes. Specifically, the method for diagnosing an aquatic eco-system contamination, according to the present invention, makes use of marine medaka genes of which the expression amount changes according to 17β-estradiol, or marine medaka genes of which the expression amount changes according to bisphenol A. Since it was verified that genes of marine medaka exposed to 17β-estradiol are changed or genes of marine medaka exposed to bisphenol A are changed, the present invention can be used in a useful manner for a microarray chip in which marine medaka genes responding to 17β-estradiol or marine medaka genes responding to bisphenol A are integrated, for a diagnosis using same, and for a method for diagnosing health or detecting stress of a marine eco-system by applying a kit having the microarray chip.

摘要翻译： 本发明涉及响应于内分泌干扰物质的暴露的海洋中间基因基因，以及使用海洋中间基因基因诊断水生生态系统污染的方法。 具体而言，根据本发明的水生生态系统污染的诊断方法利用表达量根据17＆bgr-雌二醇或表达量变化的海洋medaka基因的表达量变化的海洋medaka基因 双酚A。由于证实了暴露于17＆bgr-雌二醇的海洋中间药的基因发生变化或暴露于双酚A的海马medaka的基因发生了改变，所以本发明可以有用的方式用于其中海洋medaka的微阵列芯片 综合应用于双酚A的17＆bgr-雌二醇或海洋中间基因基因的基因，用于使用其的诊断，以及通过应用具有微阵列芯片的试剂盒来诊断健康或检测海洋生态系统的应力的方法。

公开(公告)号：US08846750B2

公开(公告)日：2014-09-30

申请号：US13878196

申请日：2011-07-01

申请人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC分类号： A61K31/357 ,  C07D321/10 ,  A61K36/09 ,  A23L1/30 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12

CPC分类号： C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

公开(公告)号：US08807917B2

公开(公告)日：2014-08-19

申请号：US12744316

申请日：2008-11-21

申请人： Jin Soon Park ,  Kwang Soo Lee ,  Ki Dai Yum ,  Seong Eun Kim ,  Myoung Hak Oh ,  Choong Beom Lee ,  Hyung Jin An

发明人： Jin Soon Park ,  Kwang Soo Lee ,  Ki Dai Yum ,  Seong Eun Kim ,  Myoung Hak Oh ,  Choong Beom Lee ,  Hyung Jin An

IPC分类号： F03B13/12

CPC分类号： F03B11/00 ,  F03D13/10 ,  F03D13/20 ,  F03D80/70 ,  F05B2230/60 ,  F05B2230/70 ,  Y02E10/226 ,  Y02E10/728 ,  Y02P70/523 ,  Y02P70/525

摘要： Disclosed is an assembled helical turbine system, which can prevent its assembly/disassembly from being hindered by a rotational force generated during the assembly/disassembly process. The assembled helical turbine system includes a helical turbine formed with a plurality of blades in such a manner as to continuously generate a rotational force under unidirectional or multidirectional fluid flow; a housing assembly for rotatably supporting the helical turbine while surrounding the helical turbine; stoppers formed on a peripheral surface of the housing assembly in such a manner as to protrude to a predetermined height from the peripheral surface; and a housing supporter for supporting the housing assembly in such a manner that the housing assembly can be inserted into and withdrawn from the housing supporter, the housing supporter having catch grooves that are recessed in a shape corresponding to the stoppers so as to fix the stoppers.

摘要翻译： 公开了一种组装的螺旋涡轮机系统，其可以防止其组装/拆卸受到在组装/拆卸过程期间产生的旋转力的阻碍。 组装的螺旋涡轮机系统包括形成有多个叶片的螺旋涡轮机，以便在单向或多向流体流动下连续地产生旋转力; 壳体组件，用于可旋转地支撑所述螺旋涡轮机，同时围绕所述螺旋涡轮机; 形成在壳体组件的外周表面上的止动件以从外围表面突出到预定高度的方式; 以及壳体支撑件，用于以这样的方式支撑壳体组件，使得壳体组件可以插入到壳体支撑件中并从壳体支撑件中取出，该壳体支撑件具有凹槽，该凹槽以对应于止动件的形状凹陷以便将止动件 。

公开(公告)号：US08703814B1

公开(公告)日：2014-04-22

申请号：US13900361

申请日：2013-05-22

申请人： Korea Ocean Research and Development Institute

发明人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC分类号： A61K31/343 ,  C07D307/88

CPC分类号： C07D307/88 ,  A23L33/105 ,  C07D321/10

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

公开(公告)号：US20140094514A1

公开(公告)日：2014-04-03

申请号：US13900361

申请日：2013-05-22

申请人： Korea Ocean Research and Development Institute

发明人： Joung Han YIM ,  Il Chan KIM ,  Doc Kyu KIM ,  Se Jong HAN ,  Hyoung Seok LEE ,  Bhattarai HARI DATTA ,  Jung Eun KIM ,  Tai Kyoung KIM ,  Hyun Cheol OH ,  Dong-Gyu JO ,  Cheolsoon LEE ,  Keun-Sik KIM ,  Pyung Cheon LEE ,  Mi Ra PARK ,  Yu-Kyung PARK ,  Sung Jin KIM ,  Pil-Sung KANG ,  Heeyong PARK ,  Ha Ju PARK

IPC分类号： C07D307/88 ,  A23L1/30

CPC分类号： C07D307/88 ,  A23L33/105 ,  C07D321/10

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

摘要翻译： 本发明涉及用于预防或治疗糖尿病或肥胖症的药物和食品组合物，更具体地涉及用于预防或治疗糖尿病或肥胖症的药物组合物和功能性食品，其含有由分离的化合物合成的新化合物作为活性成分 从Stereocaulon alpinum的提取物。 本发明的新型化合物具有非常优异的PTP-1b（蛋白酪氨酸磷酸酶-1b）抑制活性，仅在蛋白酪氨酸磷酸酶中仅对PTP-1b起作用，并且是可有效预防或治疗糖尿病的实质性PTP-1b抑制剂 肥胖。

公开(公告)号：US20130261174A1

公开(公告)日：2013-10-03

申请号：US13878196

申请日：2011-07-01

申请人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC分类号： C07D321/10

CPC分类号： C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

摘要翻译： 本发明涉及用于预防或治疗糖尿病或肥胖症的药物和食品组合物，更具体地涉及用于预防或治疗糖尿病或肥胖症的药物组合物和功能性食品，其含有由分离的化合物合成的新化合物作为活性成分 从Stereocaulon alpinum的提取物。 本发明的新型化合物具有非常优异的PTP-1b（蛋白酪氨酸磷酸酶-1b）抑制活性，仅在蛋白酪氨酸磷酸酶中仅对PTP-1b起作用，并且是可有效预防或治疗糖尿病的实质性PTP-1b抑制剂 肥胖。

公开(公告)号：US08367355B2

公开(公告)日：2013-02-05

申请号：US12759589

申请日：2010-04-13

申请人： Do Hyung Kang ,  Kwang Sik Choi ,  Hee Do Jeoung ,  Heung Sik Park

发明人： Do Hyung Kang ,  Kwang Sik Choi ,  Hee Do Jeoung ,  Heung Sik Park

IPC分类号： C07K7/06 ,  C07K16/02 ,  C07K16/18 ,  G01N33/53 ,  G01N33/543 ,  G01N33/567

CPC分类号： G01N33/689

摘要： Disclosed are an antigen protein of black-lip pearl oyster egg extract, an antibody specific thereto, and a method of quantitative assessment of the reproductive effort of black-lip pearl oyster using the antibody. The method accomplishes quantitative assessment of reproductive effort of black-lip pearl oysters easily and accurately. In addition, the method provides important information for the study of life cycles of black-lip pearl oysters, and allows efficient management of black-lip pearl oysters.

摘要翻译： 公开了黑唇珍珠牡蛎卵提取物，特异性抗体的抗原蛋白质和使用该抗体对黑唇珍珠牡蛎的繁殖力进行定量评估的方法。 该方法容易准确地对黑唇珍珠牡蛎的繁殖力进行定量评估。 此外，该方法为黑唇珍珠牡蛎生命周期的研究提供了重要信息，并且能够有效地管理黑唇珍珠牡蛎。

公开(公告)号：US08222761B2

公开(公告)日：2012-07-17

申请号：US12516663

申请日：2007-11-27

申请人： Jin-Soon Park ,  Ki-Dai Yum ,  Kwang-Soo Lee ,  Sok-Kuh Kang ,  Jae-Youll Jin ,  Woo-Sun Park

发明人： Jin-Soon Park ,  Ki-Dai Yum ,  Kwang-Soo Lee ,  Sok-Kuh Kang ,  Jae-Youll Jin ,  Woo-Sun Park

IPC分类号： F03D9/00 ,  F03B13/00

CPC分类号： F03B13/26 ,  F03D3/02 ,  F05B2210/16 ,  F05B2250/25 ,  Y02E10/28 ,  Y02E10/38 ,  Y02E10/74

摘要： Disclosed is a helical turbine power generation system for generating electricity by using a helical turbine and a synchronous generator, the system including: a helical turbine rotatably provided in a frame so as to continuously generate rotation force under unidirectional or multidirectional fluid flow; a step-up gear for increasing a rotational velocity of the helical turbine up to a level required for generating electricity; a fluid coupling for preventing the rotational velocity increased by the step-up gear from increasing above a required velocity at a temporarily high rate of fluid flow; and a synchronous generator for generating electricity by using the rotational velocity transferred from the fluid coupling. Therefore, it is possible to reduce equipment costs and to prevent environmental pollution.

摘要翻译： 公开了一种用于通过使用螺旋涡轮机和同步发电机发电的螺旋涡轮发电系统，该系统包括：可旋转地设置在框架中的螺旋涡轮机，以便在单向或多向流体流动下连续产生旋转力; 用于将螺旋式涡轮机的旋转速度提高到发电所需的水平的升降装置; 流体联接器，用于防止升压齿轮在临时高流量流速下增加到高于所需速度的旋转速度; 以及通过使用从所述流体联轴器传递的旋转速度发电的同步发电机。 因此，可以降低设备成本，防止环境污染。