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公开(公告)号：US11043745B2
公开(公告)日：2021-06-22
申请号：US16273112
申请日：2019-02-11
Applicant: Old Dominion University Research Foundation
Inventor： Shu Xiao , Xianbing Zou
Abstract: Resistively loaded dielectric biconical antenna apparatuses, including systems and devices, that may be used to transmit very short electrical pulses (e.g., nanosecond, sub-nanosecond, picosecond, etc.) into tissue non-invasively at energy levels sufficient to invoke biological changes in the tissue. These resistively loaded dielectric biconical antenna apparatuses may include a resistor ring reducing internal reflection and reducing energy loss, as well as delivering longer pulses (e.g. microsecond to millisecond) to tissue.
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22.发明授权公开(公告)号：US10660693B2
公开(公告)日：2020-05-26
申请号：US16057115
申请日：2018-08-07
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Richard Heller , James Camp , Stephen P. Beebe , Shu Xiao , Amy Donate
IPC: A61B18/12 , A61N1/40 , A61N1/32 , A61N5/00 , A61N5/02 , A61N5/06 , A61B18/18 , A61B18/20 , A61B18/00 , A61N5/067 , A61B18/24
Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
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公开(公告)号：US10653880B2
公开(公告)日：2020-05-19
申请号：US15654625
申请日：2017-07-19
Inventor： Stephen J. Beebe , Karl H. Schoenbach
Abstract: A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
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公开(公告)号：US10603503B2
公开(公告)日：2020-03-31
申请号：US15554808
申请日：2016-03-02
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. Pakhomov , Christian W. Zemlin
Abstract: Methods for terminating fibrillation in a fibrillating heart employing nanosecond pulsed electric fields (nsPEFs) are disclosed. nsPEF defibrillation demonstrates its effectiveness as a new defibrillation modality, achieving reliable defibrillation with energies that are an order of magnitude lower than those needed for conventional defibrillation (millisecond shocks with mono- and bi-phasic waveforms). Tests did not reveal any negative effect of nsPEF defibrillation on cardiac tissue, in particular, cardiac tissue treated with nsPEFs does not exhibit a baseline shift in the optical transmembrane potential signal (distinctive feature that indicates electroporation), or changes in action potential duration or shape. The mechanism of nsPEF defibrillation is likely different from conventional defibrillation since it does not rely on membrane charging but on the basis of displacement currents that flow within nanoseconds after the shock is applied. nsPEFs provide the technology for the next generation of defibrillators that help emergency medical services to treat patients effectively.
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25.发明授权公开(公告)号：US10143519B2
公开(公告)日：2018-12-04
申请号：US13378532
申请日：2010-04-29
Applicant: Karl H. Schoenbach , Shu Xiao
Inventor： Karl H. Schoenbach , Shu Xiao
Abstract: A method of treating a patient is described herein. The method can include the steps of identifying a target that contains biological tissue and directing one or more pulses of electromagnetic radiation at the target. The pulses of electromagnetic radiation can cause a temperature increase per unit of time in the biological tissue. Additionally, the temperature increase per unit of time can cause the change in the cell function in the biological tissue and can be within a range of approximately one degree Celsius per second to approximately one degree Celsius per microsecond.
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Patent Agency Ranking
公开(公告)号：US10131900B2
公开(公告)日：2018-11-20
申请号：US13994508
申请日：2011-12-13
Applicant: Olga Pakhomova , Andrei G. Pakhomov
Inventor： Olga Pakhomova , Andrei G. Pakhomov
Abstract: Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.
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公开(公告)号：US09999858B2
公开(公告)日：2018-06-19
申请号：US14540359
申请日：2014-11-13
Applicant: Old Dominion University Research Foundation
Inventor： Helmut Baumgart , Gon Namkoong , Diefeng Gu , Tarek Abdel-Fattah
CPC classification number: B01D61/427 , B01D67/0062 , B01D67/0072 , B01D69/02 , B01D71/02 , B01D71/022 , B01D71/024 , B01D2313/345 , B01D2325/08 , C23C16/01 , C23C16/403 , F04B19/006
Abstract: Methods for making multiple walled nested coaxial nanostructures and devices incorporating the coaxial nanostructures are disclosed. The coaxial nanostructures include an inner nanostructure, a first outer nanotube disposed around the inner nanostructure, and a first annular channel between the inner nanostructure and the first outer nanotube. The coaxial nanostructures have extremely high aspect ratios, ranging from about 5 to about 1,200, or about 300 to about 1200.
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公开(公告)号：US20180110557A1
公开(公告)日：2018-04-26
申请号：US15789727
申请日：2017-10-20
Applicant: Old Dominion University Research Foundation
Inventor： Claudia Muratori , Andrei G. Pakhomov , Olga N. Pakhomova
IPC: A61B18/12
Abstract: The methods disclosed herein are directed towards improving ablation efficiency associated with applying nanosecond electric pulses (nsEP) to tissue. In particular, applying nsEP to tissue can open pores in the cellular membranes of the tissue. These pores can be kept open longer by cooling the tissue. The combined application of nsEP and the cooling of tissue may have synergistic effects on triggering apoptosis of cells in the tissue. This allows for numerous practical benefits associated with nsEP-based tissue ablation to be realized. For instance, nsEP of lower pulse strength or lower numbers of pulses to be used, which can be provided by smaller pulse generators operating on less power.
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公开(公告)号：US09943684B2
公开(公告)日：2018-04-17
申请号：US14869286
申请日：2015-09-29
Inventor： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
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公开(公告)号：US09351791B2
公开(公告)日：2016-05-31
申请号：US13145220
申请日：2010-01-20
Applicant: Karl H. Schoenbach , Shu Xiao
Inventor： Karl H. Schoenbach , Shu Xiao
CPC classification number: A61B18/18 , A61B18/1815 , A61N7/02
Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrow-band and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
Abstract translation: 提供了一种在患者组织中诱导局部细胞死亡的方法。 该方法包括产生第一和第二辐射，将辐射传送到聚焦元件，并且将辐射与聚焦元件聚焦在目标上。 还提供了用于诱导患者组织中的局部细胞死亡的系统。 该系统包括用于产生窄带和/或超宽带辐射的电源，以及用于将辐射聚焦在目标上的聚焦元件。
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