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公开(公告)号:US10058574B2
公开(公告)日:2018-08-28
申请号:US15592178
申请日:2017-05-10
CPC分类号: A61K35/74 , A23C9/12 , A23L33/135 , A23V2002/00 , A61K9/19 , A61K39/0216 , A61K2039/52 , A61K2039/545 , A61K2039/58 , C12R1/01
摘要: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
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22.
公开(公告)号:US20180237828A1
公开(公告)日:2018-08-23
申请号:US15754288
申请日:2016-09-01
CPC分类号: C12Q1/689 , A61K35/74 , A61K39/0208 , A61K2039/521 , A61P31/04 , C07K14/195 , C12N1/20 , C12N15/74 , C12Q2600/158
摘要: Methods of assessing expression of a PrfA mediated expression construct in a Listerial host cell are provided. Aspects of the methods include maintaining a Listerial host cell that includes a PrfA mediated expression construct in a defined medium containing a reducing agent and evaluating expression of a product from the expression construct to assess expression of the PrfA mediated expression construct. Also provided are methods of producing and using a Listerial vaccine, as well as defined media for use in such methods.
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公开(公告)号:US20180228840A1
公开(公告)日:2018-08-16
申请号:US15750787
申请日:2016-08-08
申请人: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) , UNIVERSIDAD AUTÓNOMA DE MADRID , FUNDACIÓN PARA LA INVESTIGACIÓN BIOMEDICA DEL HOSPITAL DE LA PRINCESA
发明人: Esteban VEIGA CHACÓN , Aranzazu CRUZ ADALIA , Guillermo RAMÍREZ SANTIAGO , Balbino ALARCÓN SÁNCHEZ , Francisco SÁCHEZ MADRID
IPC分类号: A61K35/17 , A61K35/13 , A61K35/74 , C12N5/0783 , C12N5/0784
CPC分类号: A61K35/17 , A61K35/13 , A61K35/74 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , C12N5/0636 , C12N5/0639 , C12N2510/00
摘要: The present invention relates to lymphocytes, preferably that have been transinfected from dendritic cells with a bacterium, preferably CD4+ T cells, preferably Listeria monocytogenes, wherein said bacterium comprises a tumor peptide. It also relates to the use of lymphocytes for therapy and/or treatment of solid tumors, preferably melanoma, the kit or device which comprises for this purpose. Furthermore, it also refers to the transinfection method thereof.
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公开(公告)号:US10034904B2
公开(公告)日:2018-07-31
申请号:US15661708
申请日:2017-07-27
摘要: The present invention comprises methods and composition for control of plant pathogens. Isolated bacteria, deposited with ATCC under the Budapest Treaty, are effective to control plant pathogens.
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公开(公告)号:US20180200311A1
公开(公告)日:2018-07-19
申请号:US15744211
申请日:2016-07-07
发明人: Lotta STENMAN , Sampo LAHTINEN , John KONHILAS
IPC分类号: A61K35/745 , A23L33/135 , A61P9/00
CPC分类号: A61K35/745 , A23L33/135 , A23V2002/00 , A23V2200/326 , A23Y2300/21 , A61K35/74 , A61P9/00
摘要: This invention relates to new uses of Bifidobacteria (particularly, although not exclusively, probiotic Bifidobacteria), and to food products, feed products, dietary supplements and pharmaceutical formulations containing them. The bacteria are suitable for the treatment of myocardial infarction, dilated cardiomyopathy, inflammatory heart disease (including endocarditis, inflammatory cardiomegaly and myocarditisl, and congestive heart failure.
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26.
公开(公告)号:US20180179488A1
公开(公告)日:2018-06-28
申请号:US15852634
申请日:2017-12-22
IPC分类号: C12N1/20 , A61K35/74 , A23K50/70 , A23K50/75 , A23K50/10 , A23K20/142 , A23K20/147 , A23K20/158 , A23K20/22 , A23K20/26 , A23K20/24
CPC分类号: C12N1/20 , A23K20/142 , A23K20/147 , A23K20/158 , A23K20/22 , A23K20/24 , A23K20/26 , A23K50/10 , A23K50/70 , A23K50/75 , A61K35/74 , C07K14/255 , C12N15/01
摘要: A method for restoring the sensitivity of antibiotic resistant bacteria to antibiotics and a method for reducing the expression of hilA gene in animals. In particular, the method includes the step of introducing a fermented product into the diet of an animal. Certain components of the fermented product interact with the bacteria within the animal such that the method produces the beneficial effects of reducing the expression of the hilA gene and also restores the sensitivity of antibiotic resistant bacteria to antibiotics.
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27.
公开(公告)号:US10004772B2
公开(公告)日:2018-06-26
申请号:US15496686
申请日:2017-04-25
IPC分类号: A61K35/66 , A61K35/747 , A01N63/00 , A01N63/02 , C12R1/225 , A23L33/135
CPC分类号: A61K35/747 , A01N63/00 , A01N63/02 , A23L33/135 , A23V2002/00 , A23Y2220/35 , A61K35/74 , C12R1/225
摘要: The subject invention provides compositions and methods for treating human dermatological conditions by employing a microbiome-centered treatment approach. Preferred embodiments of the invention provide pharmaceutical and cosmetic compositions, and the methods of using the same, comprising a strain of Lactobacillus fermentum bacterium, or bioactive extracts thereof, derived from human microbiota and capable of growing in biofilm phenotype.
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公开(公告)号:US20180169157A1
公开(公告)日:2018-06-21
申请号:US15884029
申请日:2018-01-30
发明人: Jessica Schneider , Yun-Gi Kim , Bernat Olle , Shilpa Reddy , Jason Norman , Juan Patarroyo
IPC分类号: A61K35/747 , A61K35/74 , A61K35/742 , A61K9/00 , A61K9/48
CPC分类号: A61K35/747 , A23K10/18 , A23K50/30 , A23L5/00 , A23L33/135 , A61K9/0053 , A61K9/48 , A61K35/74 , A61K35/742
摘要: Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.
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29.
公开(公告)号:US20180169153A1
公开(公告)日:2018-06-21
申请号:US15664310
申请日:2017-07-31
发明人: David Berry , Noubar B. Afeyan , Johanne Kaplan , Neal Gordon , Shaila Rahman
IPC分类号: A61K35/74 , A61K35/741 , A61K38/46 , A61K35/747 , A61K35/745 , A61K35/744 , A61K35/742 , A61K9/00 , A61K35/39 , A61K31/715 , A61K31/7016 , A61K31/7004 , A61K9/19 , A61K35/00
CPC分类号: A61K35/74 , A61K9/0031 , A61K9/0053 , A61K9/19 , A61K31/7004 , A61K31/7016 , A61K31/715 , A61K35/39 , A61K35/741 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K38/46 , A61K2035/115 , Y02A50/401 , Y02A50/414 , Y02A50/473
摘要: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
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公开(公告)号:US09994809B2
公开(公告)日:2018-06-12
申请号:US14428341
申请日:2013-09-13
发明人: Sangeeta N. Bhatia , Tal Danino
IPC分类号: C12N15/74 , C12N1/20 , A61K38/02 , A61K49/00 , A61K35/74 , A23L1/30 , A61K45/08 , A61K45/06 , A23L33/135 , A61K38/00
CPC分类号: C12N1/20 , A23L33/135 , A23V2002/00 , A23Y2220/00 , A23Y2300/00 , A61K35/74 , A61K38/00 , A61K38/02 , A61K45/06 , A61K49/0017 , C07K2319/55 , C12N15/74
摘要: The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
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