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    Process for production of amines
    22.
    发明授权
    Process for production of amines 有权
    胺的生产工艺

    公开(公告)号：US07902207B2

    公开(公告)日：2011-03-08

    申请号：US10587279

    申请日：2005-01-26

    申请人： Masahiro Terada ,  Daisuke Uraguchi ,  Keiichi Sorimachi ,  Hideo Shimizu

    发明人： Masahiro Terada ,  Daisuke Uraguchi ,  Keiichi Sorimachi ,  Hideo Shimizu

    IPC分类号： C07F9/02

    CPC分类号： C07C231/08 ,  B01J31/0258 ,  B01J2231/346 ,  C07C221/00 ,  C07C245/14 ,  C07C245/18 ,  C07C269/06 ,  C07D307/58 ,  C07F9/657127 ,  C07F9/65742 ,  C07F9/65744 ,  C07F9/6578 ,  C07F9/65842 ,  C07F9/65848 ,  C07C233/76 ,  C07C271/18

    摘要： A process for producing an amine which is characterized by reacting an imine with a nucleophilic compound (except a trialkylsilyl vinyl ether) in the presence of a phosphoric acid derivative represented by the formula (1): wherein A1 represents a spacer; X1 and X2 represent each independently a divalent nonmetal atom or a divalent nonmetal atomic group; and Y1 is oxygen or sulfur. The invention provides a process by which amines (particularly optically active amines) useful as intermediates of medicines, agricultural chemicals, or the like can be produced without special post-treatment in high yield at high optical purity; and phosphoric acid derivatives (particularly optically active phosphoric acid derivatives) useful in the production of the amines.

    摘要翻译： 一种制备胺的方法，其特征在于在由式（1）表示的磷酸衍生物存在下使亚胺与亲核化合物（三烷基甲硅烷基乙烯基醚除外）反应：其中A1表示间隔基; X1和X2各自独立地表示二价非金属原子或二价非金属原子团; Y1是氧或硫。 本发明提供了一种以高光学纯度可高产率地用于药物，农药等作为中间体的胺（特别是光学活性胺）而不进行特殊后处理的方法。 和可用于制备胺的磷酸衍生物（特别是光学活性磷酸衍生物）。

    Polyfluoroether-based phosphates
    24.
    发明授权
    Polyfluoroether-based phosphates 失效
    聚氟醚类磷酸盐

    公开(公告)号：US07815816B2

    公开(公告)日：2010-10-19

    申请号：US12691292

    申请日：2010-01-21

    申请人： Sheng Peng ,  Stephen James Getty ,  Xianjun Meng

    发明人： Sheng Peng ,  Stephen James Getty ,  Xianjun Meng

    IPC分类号： D06M15/667 ,  D06M15/00

    CPC分类号： C07F9/02 ,  C04B41/009 ,  C04B41/4994 ,  C07F9/091 ,  C07F9/65742 ,  C08K5/52 ,  D06M15/667 ,  Y10T428/31544 ,  Y10T428/31989 ,  Y10T428/31993 ,  Y10T428/31996 ,  C04B41/466 ,  C04B14/048 ,  C04B14/28 ,  C04B28/02

    摘要： A composition comprising one or more compounds of formula (I) or (II): wherein: Rf is a linear or branched perfluoroalkyl having 1 to 7 carbon atoms, optionally interrupted by one to three oxygen atoms, r and q are each independently an integer of 1 to 3, j is 0 or 1, or a mixture thereof, x is from about 1 to about 2, Z is —O—, —S—, or —NR—, R is hydrogen or an alkyl group containing 1 to 4 carbon atoms X is hydrogen or M, and M is an ammonium ion, an alkali metal ion, or an alkanolammonium ion, and its use in providing surface properties to substrates is disclosed.

    摘要翻译： 包含一种或多种式（I）或（II）化合物的组合物：其中：Rf是具有1至7个碳原子的直链或支链全氟烷基，任选地被一至三个氧原子间隔，r和q各自独立地是整数 为1〜3，j为0或1，或其混合物，x为约1〜约2，Z为-O - ， - S-或-NR-，R为氢或含有1〜 4个碳原子X是氢或M，M是铵离子，碱金属离子或链烷醇铵离子，并且其在向基材提供表面性质中的用途被公开。

    Cytarabine monophosphate prodrugs
    26.
    发明授权
    Cytarabine monophosphate prodrugs 有权
    阿糖胞苷单磷酸前药

    公开(公告)号：US07553826B2

    公开(公告)日：2009-06-30

    申请号：US11582383

    申请日：2006-10-18

    申请人： Serge Boyer ,  Mark D. Erion

    发明人： Serge Boyer ,  Mark D. Erion

    IPC分类号： A61K31/661 ,  C07D239/20 ,  C07F9/6558

    CPC分类号： C07F9/65742 ,  C07H19/04

    摘要： Compounds of Formula I, their preparation and uses are described: wherein: M and V are cis to one another and MH is cytarabine; the 5′ oxygen of said cytarabine is attached to the phosphorus; V is 4-pyridyl; and pharmaceutically acceptable prodrugs and salts thereof.

    摘要翻译： 描述式I化合物及其制备和用途：其中：M和V彼此是顺式的，MH是阿糖胞苷; 所述阿糖胞苷的5'氧与磷结合; V是4-吡啶基; 及其药学上可接受的前药及其盐。

    Highly active lysophosphatidic acid and method of screening therewith
    29.
    发明申请
    Highly active lysophosphatidic acid and method of screening therewith 失效
    高活性溶血磷脂酸及其筛选方法

    公开(公告)号：US20070161604A1

    公开(公告)日：2007-07-12

    申请号：US10584283

    申请日：2004-12-22

    申请人： Akio Hayashi ,  Shinji Nakade ,  Hidehiro Suzuki

    发明人： Akio Hayashi ,  Shinji Nakade ,  Hidehiro Suzuki

    IPC分类号： A61K31/665 ,  G01N33/53 ,  C07F9/02 ,  C07F9/28 ,  C07K16/18

    CPC分类号： A61K31/665 ,  A61K45/06 ,  C07F9/10 ,  C07F9/65742 ,  C07K16/18 ,  G01N33/92 ,  G01N2500/00 ,  A61K2300/00

    摘要： There is provided a method of screening a preventive and/or therapeutic substance for diseases in which LPA takes part, characterized in that a compound represented by any of formula (I), (II) and (III): [wherein the meaning of characters are described in the description] is used. The compounds obtained by the screening method or the screening kit of the present invention, their salts, their solvates and prodrugs thereof would modulate the binding of highly active LPA with LPA receptor in human and other mammals, so that they can be used as a preventive and/or therapeutic agent for diseases in which LPA takes part, for example, urinary diseases, central nervous diseases, inflammatory diseases, circulatory diseases, cancer, diabetes, immune system disorders and alimentary diseases.

    摘要翻译： 提供了一种筛选LPA参与的疾病的预防和/或治疗物质的方法，其特征在于由式（I），（II）和（III）中任何一种表示的化合物：[其中字符的含义 在描述中被描述]被使用。 通过本发明的筛选方法或筛选试剂盒获得的化合物，它们的盐，它们的溶剂合物和前体药物将调节人和其它哺乳动物中高活性LPA与LPA受体的结合，从而可以将其用作预防 和/或其中LPA参与的疾病的治疗剂，例如尿病，中枢神经疾病，炎性疾病，循环系统疾病，癌症，糖尿病，免疫系统疾病和消化性疾病。

    Method for producing organoacylphosphites
    30.
    发明申请
    Method for producing organoacylphosphites 失效
    有机酰基亚磷酸酯的制备方法

    公开(公告)号：US20070117995A1

    公开(公告)日：2007-05-24

    申请号：US10584492

    申请日：2004-10-27

    申请人： Dagmara Ortmann ,  Klaus-Diether Wiese ,  Oliver Moller ,  Dirk Fridag

    发明人： Dagmara Ortmann ,  Klaus-Diether Wiese ,  Oliver Moller ,  Dirk Fridag

    IPC分类号： C07F9/02

    CPC分类号： C07F9/65746 ,  C07F9/65719 ,  C07F9/65742 ,  C07F9/65744

    摘要： The present invention relates to a process for preparing organophosphites, organosphonites and organophosphinites by condensing phosphorus trihalides or organophosphorus halides with organic compounds bearing hydroxyl groups in the presence of polymeric basic ion exchange resins. The process according to the invention makes possible in a simple manner the preparation of trivalent organophosphorus compounds which may serve, for example, as ligands in rhodium complexes which may be used as a catalyst in hydroformylation.

    摘要翻译： 本发明涉及在聚合碱性离子交换树脂存在下，通过将三卤化磷或有机磷卤化物与带有羟基的有机化合物相结合来制备有机亚磷酸酯，有机硅和有机磷腈的方法。 根据本发明的方法可以以简单的方式制备三价有机磷化合物，其可以用作例如可用作加氢甲酰化中的催化剂的铑络合物中的配体。