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315 条记录 (耗时 0.029 秒)

    Method of producing salts of 1,3-dioxolane-4-carboxylic acids and method of using same
    21.
    发明授权
    Method of producing salts of 1,3-dioxolane-4-carboxylic acids and method of using same 失效
    1,3-二氧戊环-4-羧酸盐的制造方法及其使用方法

    公开(公告)号：US4745200A

    公开(公告)日：1988-05-17

    申请号：US808594

    申请日：1985-12-13

    申请人： Hinrich Moeller

    发明人： Hinrich Moeller

    IPC分类号： B01J20/24 ,  A61K8/00 ,  A61K8/41 ,  A61K8/49 ,  A61Q19/00 ,  C07D317/32 ,  C07D317/00

    CPC分类号： A61Q19/00 ,  A61K8/4973 ,  C07D317/32 ,  A61Q5/00

    摘要： A new process for the production of salts of 1,3-dioxolane-4-carboxylic acid corresponding to the following formula ##STR1## using as a starting material an isomer mixture of a 4-hydroxymethyl-1,3-dioxolane and a 5-hydroxy-1,3-dioxane obtained by reacting glycerin with an aldehyde or ketone having the formula R.sup.1 R.sup.2 CO. The 4-hydroxymethyl-1,3-dioxolane may be selectively oxidized from the isomer mixture in the presence of a platinum metal catalyst at an alkaline pH. The unreacted 5-hydroxy-1,3-dioxane may be extracted from the reaction mixture and the 1,3-dioxolane-4-carboxylic acid salt isolated in pure form.

    摘要翻译： 对应于下列式（Ⅰ）的1,3-二氧戊环-4-羧酸盐的新方法，以4-羟甲基-1,3-二氧戊环和 通过使甘油与式R1R2CO的醛或酮反应得到的5-羟基-1,3-二恶烷。 在铂性金属催化剂的存在下，在碱性pH下，可以从异构体混合物中选择性地氧化4-羟甲基-1,3-二氧戊环。 可以从反应混合物中提取未反应的5-羟基-1,3-二恶烷，以纯形式分离出1,3-二氧戊环-4-羧酸盐。

    1-Cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl- methyl)-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents
    23.
    发明授权
    1-Cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl- methyl)-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents 失效
    1-环丙基-1,4-二氢-4-氧代-7-（4-（2-氧代-1,3-二氧杂环戊烯-4-基 - 甲基）-1-哌嗪基）-3-喹啉羧酸抗菌剂

    公开(公告)号：US4703047A

    公开(公告)日：1987-10-27

    申请号：US822714

    申请日：1986-01-27

    申请人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    发明人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P33/02 ,  C07D215/56 ,  C07D317/00 ,  C07D333/00 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14

    摘要： Novel antibacterially active 1-cyclopropyl-1,4-dihydro-4-oxo-7-[4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl]-3-quinolinecarboxyic acids of the formula in which ##STR1## R is hydrogen or, together with R.sup.1, forms an alkylene radical with 2 or 3 carbon atoms,R.sup.1 is hydrogen, alkyl with 1 to 4 carbon atom or phenyl,R.sup.2 and R.sup.3 each independently is hydrogen, methyl, ethyl, cyclohexyl, methylene-dioxphenyl, furyl, tetrahydrofuryl or thienyl; or phenyl which is optionally mono-, di or tri-substituted by fluorine, chlorine, bromine, methyl, phenyl, cyano, hydroxyl, ethoxy, benzyloxy, amino, methylamino, dimethylamino, piperidino or nitro,X.sup.1 is hydrogen, halogen, or nitro, andX.sup.2 is hydrogen or halogen,or pharmaceutically acceptable hydrates, acid addition salts, alkali metal salts or alkaline earth metal salts thereof.

    摘要翻译： 新型抗菌活性1-环丙基-1,4-二氢-4-氧代-7- [4-（2-氧代-1,3-二氧杂环戊烯-4-基 - 甲基）-1-哌嗪基] -3-喹啉羧酸 其中 R是氢或与R1一起形成具有2或3个碳原子的亚烷基的式，R 1是氢，具有1至4个碳原子的烷基或苯基，R 2和R 3各自独立地是氢，甲基 乙基，环己基，亚甲基二氧苯基，呋喃基，四氢呋喃基或噻吩基; 或苯基，其任选被氟，氯，溴，甲基，苯基，氰基，羟基，乙氧基，苄氧基，氨基，甲基氨基，二甲基氨基，哌啶子基或硝基单，二或三取代，X 1为氢，卤素或硝基 ，X2为氢或卤素，或其药学上可接受的水合物，酸加成盐，碱金属盐或碱土金属盐。

    Novel decahydroquinolinol derivatives, and pharmaceutical compositions and methods using them
    25.
    发明授权
    Novel decahydroquinolinol derivatives, and pharmaceutical compositions and methods using them 失效
    新型十氢喹啉醇衍生物，以及使用它们的药物组合物和方法

    公开(公告)号：US4663330A

    公开(公告)日：1987-05-05

    申请号：US744213

    申请日：1985-06-13

    申请人： Maurice Prost ,  Michel de Claviere ,  Peter Polster

    发明人： Maurice Prost ,  Michel de Claviere ,  Peter Polster

    IPC分类号： C07D215/22 ,  A61K31/47 ,  A61P3/00 ,  A61P9/00 ,  C07D215/233 ,  C07D317/00 ,  C07D405/12

    CPC分类号： C07D215/233

    摘要： The invention relates to novel decahydroquinolinol derivatives represented by the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which X represents oxygen or sulphur, R represents an alkyl radical having from 1 to 3 carbon atoms, R.sub.1 represents fluorine, chlorine, bromine or methoxy, R.sub.2 represents hydrogen or methoxy or R.sub.1 and R.sub.2, when they are taken together, represent a 2,3-methylenedioxy or 3,4-methylenedioxy radical.The compounds of the invention are inhibitors of calcium translocation at the level of the cell membrane and are useful more particularly in the treatment of pathological syndromes of the cardiovascular system such as, for instance, angina pectoris.

    摘要翻译： 本发明涉及由以下通式表示的新型十氢喹啉醇衍生物：其中X代表氧或硫，R代表具有1至3个碳原子的烷基，R1代表氟，氯 ，溴或甲氧基，R 2表示氢或甲氧基或R 1和R 2，当它们一起时，表示2,3-亚甲二氧基或3,4-亚甲二氧基。 本发明的化合物是细胞膜水平的钙易位的抑制剂，并且更具体地用于治疗心血管系统的病理综合征，例如心绞痛。

    Pyridoindole derivatives, compositions and use
    29.
    发明授权
    Pyridoindole derivatives, compositions and use 失效
    吡啶并吲哚衍生物，组合物和用途

    公开(公告)号：US4564613A

    公开(公告)日：1986-01-14

    申请号：US651001

    申请日：1984-09-14

    申请人： Karl-Heinz Boltze ,  Margaret A. Davies ,  Bodo Junge ,  Teunis Schuurman ,  Jorg Traber

    发明人： Karl-Heinz Boltze ,  Margaret A. Davies ,  Bodo Junge ,  Teunis Schuurman ,  Jorg Traber

    IPC分类号： A61K31/435 ,  A61K31/445 ,  A61K31/535 ,  A61P25/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07C67/00 ,  C07C239/00 ,  C07C251/34 ,  C07D217/04 ,  C07D317/00 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D491/20 ,  C07D495/20 ,  A61K31/44

    CPC分类号： C07D471/04 ,  C07D217/04 ,  C07D471/14

    摘要： Pyridoindoles of the formula ##STR1## in which R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 -alkyl, which is optionally substituted by the radical ##STR2## R.sub.2 and R.sub.3 represent H or form a bond, or R.sub.1 and R.sub.2 together represent O, --O--CH.sub.2 --CH.sub.2 --O-- or --S--CH.sub.2 --CH.sub.2 --S--,R.sub.4 represents H or the ##STR3## or R.sub.3 and R.sub.4 represent O, orR.sub.1 and R.sub.4 are members of an N-containing six-membered ring andR.sub.8 and R.sub.9 represent H or C.sub.1 -C.sub.4 -alkyl, or optionally form, with the N atom, a heterocyclic 5-membered or 6-membered ring, which can optionally also contain a further hetero-atom from the series comprising N, O or S,R.sub.5 represents H, C.sub.1 -C.sub.4 -alkyl or the group ##STR4## or R.sub.5 and R.sub.3 form a bond, andR.sub.10 and R.sub.11 represent C.sub.1 -C.sub.4 -alkyl or are members of an N-containing 5-membered or 6-membered ring,R.sub.6 represents H or C.sub.1 -C.sub.4 -alkyl andR.sub.7 represents halogen,or acid addition salts thereof, which are active on the central nervous system. Novel intermediates are also shown.

    摘要翻译： 其中R 1表示氢或任选被基团R 2和R 3取代的C 1 -C 4 - 烷基的吡咯并吲哚表示H或形成键，或者R 1和R 2一起表示O，-O- CH2-CH2-O-或-S-CH2-CH2-S-，R4代表H或者“或”，R3和R4代表O，或R1和R4是含N的六元环的成员，R8和 R9代表H或C1-C4-烷基，或任选地与N原子形成杂环的5元或6元环，其可以任选地还含有来自包含N，O或S的系列的另外的杂原子， R5表示H，C1-C4-烷基或基团，或R5和R3形成键，R10和R11表示C1-C4-烷基，或是含有N元5元或6元环的成员， R6表示H或C1-C4-烷基，R7表示在中枢神经系统上有活性的卤素或其酸加成盐。 还显示了新的中间体。

    4,5-Dichloro-2,2,4,5,-tetrafluoro-1,3-dioxolane
    30.
    发明授权
    4,5-Dichloro-2,2,4,5,-tetrafluoro-1,3-dioxolane 失效
    4,5-二氯-2,2,4,5， - 四氟-1,3-二氧戊环

    公开(公告)号：US4533741A

    公开(公告)日：1985-08-06

    申请号：US658666

    申请日：1984-10-09

    申请人： Edward N. Squire

    发明人： Edward N. Squire

    IPC分类号： C07D317/42 ,  C08F34/02 ,  C08F214/26 ,  C07D317/00

    CPC分类号： C08F34/02 ,  C07D317/42 ,  C08F214/262

    摘要： Perfluoro-1,3-dioxole, prepared by dechlorinating 4,5-dichloro-2,2,4,5-tetrafluoro-1,3-dioxolane with magnesium, is a useful monomer, which polymerizes to either amorphous or liquid homopolymers and copolymerizes with tetrafluoroethylene as well as with other monomers to both crystalline and amorphous copolymers having one or more such comonomers incorporated therein. Amorphous homopolymers and copolymers of perfluoro-1,3-dioxole are useful in such applications as glazing for reactors for hydrogen fluoride reactions. Amorphous homopolymers and amorphous or crystalline copolymers form self-supporting films and can be used for coatings and linings which are inert to most chemicals and are stain and weather resistant and as dielectrics for electrical and electronic equipment. Liquid homopolymers can be used as hydraulic fluids and heat exchange media.

    摘要翻译： 通过用4,5-二氯-2,2,4,5-四氟-1,3-二氧杂环戊烷与镁脱氯制备的全氟-1,3-二氧杂环戊烯是一种有用的单体，其可以与无定形或液体均聚物聚合并共聚 四氟乙烯以及其它单体与结合有一种或多种这样的共聚单体的结晶和无定形共聚物。 全氟-1,3-二氧杂环戊烯的无定形均聚物和共聚物可用于诸如用于氟化氢反应的反应器的玻璃的应用。 无定形均聚物和无定形或结晶共聚物形成自支撑膜，并且可用于对大多数化学品是惰性的并且具有耐污染和耐候性以及用于电气和电子设备的电介质的涂层和衬里。 液体均聚物可用作液压油和热交换介质。