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    Methods and compositions for modulating complex mixtures by selective deletion chromatography
    25.
    发明授权
    Methods and compositions for modulating complex mixtures by selective deletion chromatography 有权

    公开(公告)号：US11478524B1

    公开(公告)日：2022-10-25

    申请号：US16050621

    申请日：2018-07-31

    申请人： UNIVERSITY OF SOUTH FLORIDA

    发明人： Bill J. Baker

    IPC分类号： B01D15/16 ,  B01D15/24 ,  B01D15/32 ,  B01D15/42 ,  G01N30/34 ,  G01N30/72 ,  G01N30/74 ,  G01N30/82 ,  G01N30/86 ,  G01N30/02 ,  G01N30/84 ,  A61K36/82

    摘要： The present disclosure relates to methods of modifying complex extracts such that components or mixtures of components are selectively removed or added, thus providing a complex mixture that does not naturally occur with a refined or a tuned therapeutic or nutraceutical effect. In various aspects, the complex extract can be an extract obtained from one or more plants, e.g., an extract obtained from green tea leaves. The present disclosure pertains to compositions obtained by the disclosed methods, nutraceutical compositions comprising same, pharmaceutical compositions comprising same, and methods of treating various conditions, including physiological dysfunctions associated with elevated reactive oxygen species and/or inflammatory molecule, e.g., TNFα, expression using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

    PREPARATIVE LIQUID CHROMATOGRAPH
    26.
    发明申请
    PREPARATIVE LIQUID CHROMATOGRAPH 有权

    公开(公告)号：US20220317101A1

    公开(公告)日：2022-10-06

    申请号：US17702849

    申请日：2022-03-24

    申请人： SHIMADZU CORPORATION

    发明人： Shiori UEDA ,  Tomohiro SHAGAWA ,  Soichiro TAMAOKI

    IPC分类号： G01N30/86 ,  G01N30/82 ,  G01N30/16

    摘要： A separation column (6), an injector (4) that injects a sample into a mobile phase flowing through a flow path (16) leading to the separation column (6), at least one detector (8;10) that is fluidly connected downstream of the separation column (6), and generates a plurality of detector signals different from each other derived from a component in a sample separated by the separation column (6), a fraction collector (12) for fractionating and collecting a portion containing a component separated by the separation column (6) in an eluate from the separation column (6) into an individual collection container, and a controller (14) that detects a component peak in a plurality of chromatograms based on each of a plurality of the detector signals and controls operation of the fraction collector (12) based on a result of the detection are included. The controller (14) includes a fractionating collection part (26) configured to execute fractionating collection in which a portion detected as a component peak only in one chromatogram of a plurality of the chromatograms and a portion detected as a component peak in all of a plurality of the chromatograms are collected separately in collection containers different from each other.

    AUTOMATED SEMI-PREPARATIVE GRADIENT RECYCLING LIQUID CHROMATOGRAPHY
    27.
    发明申请
    AUTOMATED SEMI-PREPARATIVE GRADIENT RECYCLING LIQUID CHROMATOGRAPHY 有权

    公开(公告)号：US20220308020A1

    公开(公告)日：2022-09-29

    申请号：US17699775

    申请日：2022-03-21

    申请人： Waters Technologies Corporation

    发明人： Fabrice Gritti

    IPC分类号： G01N30/46 ,  G01N30/82

    摘要： The disclosure relates to a gradient twin column recycling chromatography method that is used to separate a mixture containing closely eluting compounds. In one embodiment, a sample includes a primary organic compound and one or more impurities that closely elute with the primary organic compound. A gradient mobile phase is initially used to remove unwanted early eluting and late eluting impurities from the sample. After the gradient removal of some of the impurities is complete, the remaining mixture of the primary organic compound and the closely eluting impurities are separated using recycle chromatography methodology with an isocratic mobile phase.

    Gas chromatograph
    28.
    发明授权
    Gas chromatograph 有权

    公开(公告)号：US11333638B2

    公开(公告)日：2022-05-17

    申请号：US16330908

    申请日：2016-09-08

    申请人： SHIMADZU CORPORATION

    发明人： Masahiro Kojima

    IPC分类号： G01N30/32 ,  G01N30/86 ,  G01N30/02 ,  G01N30/82

    摘要： A main controller 201 of a main substrate 20 performs serial communications with a sub controller 214 of each flowrate control substrate 21. The flowrate of the carrier gas is controlled with the flowrate control circuit 213 under the control performed by each sub controller 214. Thus, the main controller 201 only needs to execute the processing of performing the serial communications with each sub controller 214. As a result, the processing executed by the main controller 201 can be reduced, and the processing executed by the main controller 201 is less likely to overwhelm its processing capability even when the number of flowrate control substrates 21 is increased. In addition, a signal line 40 between the main controller 201 and each sub controller 214 can be made long. Thus, the distance between the main substrate 20 and each of the flowrate control substrates 21 can be made long.