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    NLRP3 INFLAMMASOME INHIBITORY PEPTIDE FOR TREATMENT OF INFLAMMATORY DISEASES
    293.
    发明公开
    NLRP3 INFLAMMASOME INHIBITORY PEPTIDE FOR TREATMENT OF INFLAMMATORY DISEASES 审中-公开

    公开(公告)号：US20240309045A1

    公开(公告)日：2024-09-19

    申请号：US18279772

    申请日：2022-04-20

    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Sangdun CHOI ,  Bilal Anmad RATHER

    IPC: C07K7/08 ,  A61P29/00 ,  C07K7/06

    CPC classification number: C07K7/08 ,  A61P29/00 ,  C07K7/06 ,  C07K2319/00

    Abstract: An inflammasome activates caspase-1 for cytokine maturation and cell death, and thus induces host defense in cells. An NLRP3 inflammasome promotes the release of highly inflammatory cytokines IL-1β and IL-18 to induce gasdermin D-mediated pyroptosis (pyroptotic cell death), and thus is involved in inflammatory processes. Therefore, targeting an NLRP3 pathway and modulating relevant immune responses can be a promising strategy for designing drug candidates for inflammatory diseases. A rationally designed α2-helix-based peptide NIP3 inhibits the NLRP3 pathway. NIP3 has remarkably inhibited both the secretion of NLRP3-induced IL-1β and IL-18 and the expression of downstream proteins in lipopolysaccharide-primed nigericin-activated THP-1 cells. In addition, binding energy data suggests that NIP3 has a stronger affinity for ASCPYD than for NLRP3PYD. Therefore, according to empirical and in silico results, NIP3 exclusively inhibits the NLRP3-ASC-caspase-1 pathway.

    FEDERATED LEARNING METHOD AND DEVICE USING DEVICE CLUSTERING
    294.
    发明公开
    FEDERATED LEARNING METHOD AND DEVICE USING DEVICE CLUSTERING 审中-公开

    公开(公告)号：US20240303505A1

    公开(公告)日：2024-09-12

    申请号：US18595389

    申请日：2024-03-04

    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Young-Bae Ko ,  June-Pyo Jung

    IPC: G06N3/098

    CPC classification number: G06N3/098

    Abstract: Disclosed are a federated learning method and device using device clustering. The federated learning method includes obtaining an arbitrary client group including some clients as a result of performing clustering on a plurality of clients; determining one of the some clients as a leader client based on a centroid associated with the clustering, wherein the leader client receives data associated with at least one parameter of a pre-trained model from each of the some clients; determining at least one client among the some clients as a target client based on an amount of computing resources of the pre-trained model and a training loss of the pre-trained model; and receiving some data associated with at least one parameter of the model of the target client from the leader client, wherein the some data is included in the data.

    BIOSENSOR, METHOD FOR MANUFACTURING THE SAME, AND ANALYSIS METHOD USING THE SAME
    295.
    发明公开
    BIOSENSOR, METHOD FOR MANUFACTURING THE SAME, AND ANALYSIS METHOD USING THE SAME 审中-公开

    公开(公告)号：US20240255410A1

    公开(公告)日：2024-08-01

    申请号：US18007348

    申请日：2021-07-28

    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Hyun Chul YOON ,  Jae-Ho KIM ,  Ka Ram KIM

    IPC: G01N15/1434 ,  G01N21/51 ,  G01N33/483

    CPC classification number: G01N15/1434 ,  G01N21/51 ,  G01N33/4833

    Abstract: The present invention provides a cell measurement device and method in which retroreflective particles are introduced to measure cells, and thus, an optical signal is obtained without fixing of life activity of cells and performing a separate staining process. An example of the use of retroreflection-based cytometry is evaluation of cell migration. The cells capture the retroreflective particles during cell migration or growth, and migrate in a state that the particles are captured in the cell or bind to the cells. The migrated cells are observed in a form of bright dots inside the cells under irradiation of white light as a non-spectroscopic light source to the cells in the retroreflective optical system. The number of bright spots is counted, and thus, the number of cells and the presence thereof thus can be easily measured based on an image.

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