公开(公告)号：US20160001244A1

公开(公告)日：2016-01-07

申请号：US14851195

申请日：2015-09-11

Applicant: Shiseido Company, Ltd.

Inventor： Yuki SUGIYAMA ,  Tomoko SATO ,  Ken SHOJI

IPC: B01F17/00 ,  A61Q13/00 ,  C11B9/00

CPC classification number: B01F17/0028 ,  A61K8/062 ,  A61K8/8152 ,  A61K8/91 ,  A61K2800/10 ,  A61K2800/54 ,  A61K2800/95 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/005 ,  B01F17/0021 ,  C08F220/14 ,  C08F220/18 ,  C08F220/28 ,  C08F290/062 ,  C08L33/10 ,  C08L33/12 ,  C11B9/00 ,  C08F2220/1825 ,  C08F2220/286 ,  C08F2222/1013

Abstract: The present invention provides a corona-core microgel emulsifying agent composed of a copolymer obtained by polymerizing polyethylene oxide macromonomers, hydrophobic monomers, and cross-linking monomers under specific conditions as well as an oil-in-water emulsified composition characteristically using said emulsifying agent for emulsification.The object of the present invention is to provide a new corona-core microgel emulsifying agent to be used to prepare an oil-in-water emulsified composition that manifests superior emulsification stability, stability over time, and low skin irritation, and is free of stickiness at the time of application, manifests dewy freshness, is free of powdery sensation and/or squeakiness, and is superior in durability of fragrance, as well as an oil-in-water emulsified composition emulsified with said emulsifying agent.

Abstract translation: 本发明提供了一种电晕核微凝胶乳化剂，其特征在于，在特定条件下聚合聚环氧乙烷大分子单体，疏水性单体和交联单体得到的共聚物以及特征性地使用所述乳化剂 乳化。 本发明的目的是提供一种新的电晕核微凝胶乳化剂，其用于制备水乳化组合物，其表现出优异的乳化稳定性，随时间的稳定性和低皮肤刺激性，并且不含粘性 在使用时，呈现露洁的新鲜感，无粉感和/或吱吱声，并且具有优异的香料耐久性，以及用所述乳化剂乳化的水包油型乳化组合物。

公开(公告)号：US20150290097A1

公开(公告)日：2015-10-15

申请号：US14442850

申请日：2013-11-14

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Mio Nakamura ,  Shinichiro Haze ,  Akira Ito ,  Rumiko Fujiwara ,  Takako Shibata

IPC: A61K8/37 ,  A61Q19/02

CPC classification number: A61K8/37 ,  A61K2800/782 ,  A61Q19/02

Abstract: Provided is a novel drug capable of inhibiting excessive formation of melanin in skin and a skin whitening agent incorporated therewith.Phenylethyl cinnamate is incorporated as an active ingredient.

Abstract translation: 本发明提供能够抑制皮肤中过度形成黑色素的新型药物和与其结合的皮肤美白剂。 加入肉桂酸苯乙酯作为活性成分。

公开(公告)号：US20150282595A1

公开(公告)日：2015-10-08

申请号：US14434983

申请日：2013-10-11

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Tomoko Kimura ,  Naomi Kanno ,  Satoshi Yamaki

IPC: A45D40/30

CPC classification number: A45D40/30 ,  A45D2200/1036 ,  A61K8/0204 ,  A61K8/0216 ,  A61K8/735 ,  A61K8/85 ,  A61K2800/884 ,  A61Q17/04

Abstract: The present invention provides a cosmetic method having an excellent secondary adhesion resistance effect.The cosmetic method of the present invention has a step of applying a cosmetic material on the skin, a step of pasting the base material film surface of a thin film on the skin, and a step of removing the support body of the pasted thin film, wherein the thin film consists of a base material film of the thickness of 10 to 500 nm and a support body.

Abstract translation: 本发明提供了具有优异的二次粘合性效果的美容方法。 本发明的美容方法具有将化妆品涂敷在皮肤上的步骤，将薄膜的基材薄膜表面粘贴在皮肤上的步骤，以及除去粘贴薄膜的支持体的步骤， 其中所述薄膜由厚度为10〜500nm的基材膜和支撑体构成。

公开(公告)号：US20150190336A1

公开(公告)日：2015-07-09

申请号：US14419715

申请日：2013-03-29

Applicant: Shiseido Company, Ltd.

Inventor： Yoko Gozu ,  Shinichiro Haze

IPC: A61K8/97 ,  A61Q19/00 ,  A61K8/49 ,  A61K8/37 ,  A61K8/41

CPC classification number: A61K8/97 ,  A61K8/37 ,  A61K8/411 ,  A61K8/44 ,  A61K8/445 ,  A61K8/4926 ,  A61K8/922 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/2068 ,  A61K9/5042 ,  A61K31/235 ,  A61K31/245 ,  A61K36/14 ,  A61K36/185 ,  A61K36/23 ,  A61K36/53 ,  A61K36/67 ,  A61K36/73 ,  A61K36/758 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K2800/70 ,  A61K2800/74 ,  A61Q19/00 ,  A61Q19/007 ,  A61K2300/00

Abstract: The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1′-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents.

Abstract translation: 本发明提供促进丝胶蛋白基因表达的新型物质，其涉及改善皮肤的保湿功能。 本发明的发明人发现丝聚蛋白基因的表达在大约24小时周期内有节奏地波动，基于候选物质添加后表达达到最大值的时间筛选候选物质，并鉴定了花椒提取物3-（1 β-哌啶）丙酸，天竺葵油，柏油，玫瑰油，原油，胡椒油，罗勒油，甲基邻甲苯甲酸酯，邻氨基苯甲酸甲酯和邻氨基苯甲酸二甲酯作为丝胶蛋白基因表达促进剂。

公开(公告)号：US20150118686A1

公开(公告)日：2015-04-30

申请号：US14534427

申请日：2014-11-06

Applicant: Shiseido Company, Ltd.

Inventor： TOSHIHIKO HIBINO ,  YAYOI KAMATA ,  MAMI YAMAMOTO

IPC: C12Q1/68 ,  G01N33/573

CPC classification number: C12Q1/6883 ,  C12Q1/37 ,  C12Q2600/158 ,  G01N33/573 ,  G01N33/6881 ,  G01N2333/914 ,  G01N2333/96466 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/202

Abstract: The present invention provides a method for screening and evaluating ameliorants of dry skin caused by atopic dermatitis, comprising: evaluating a candidate drug as being an ameliorant of dry skin caused by atopic dermatitis in the case the candidate drug significantly increases expression and/or activity of bleomycin hydrolase in comparison with a control drug.

Abstract translation: 本发明提供了筛选和评价由特应性皮炎引起的干性皮肤变性的方法，其包括：在候选药物显着增加表型和/或活性的情况下，将候选药物评估为由特应性皮炎引起的干性皮肤的改善剂 博来霉素水解酶与对照药相比。

公开(公告)号：US20150072031A1

公开(公告)日：2015-03-12

申请号：US14540248

申请日：2014-11-13

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Keiko Mori ,  Shinichiro Haze ,  Yoko Gozu ,  Atsushi Joichi

IPC: A61K36/537 ,  A61K31/085 ,  A61K36/534 ,  A61K36/14 ,  A61K8/34 ,  A23L1/30 ,  A61K8/97 ,  A61Q19/00 ,  A61Q5/02 ,  A61Q19/10 ,  A61L9/16 ,  A61L9/013 ,  A61K31/045 ,  A61K8/33

CPC classification number: A61K36/537 ,  A23G3/48 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/00 ,  A61K8/33 ,  A61K8/34 ,  A61K8/342 ,  A61K8/97 ,  A61K8/9789 ,  A61K31/045 ,  A61K31/085 ,  A61K36/14 ,  A61K36/185 ,  A61K36/534 ,  A61K2800/242 ,  A61L9/013 ,  A61L9/16 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10 ,  A23V2200/318 ,  A23V2250/21

Abstract: Disclosed here is a method for elevating skin temperature comprising administering to a subject in need thereof a composition comprising an effective amount of one or more compounds selected from the group consisting of dihydro-β-ionol and 4-methoxystyrene. Also disclosed is a method for elevating skin temperature comprising administering to a subject in need thereof a composition comprising an effective amount of one or more compounds selected from the group consisting of dihydro-β-ionol, 4-methoxystyrene, clary sage extract, Japanese peppermint extract, juniper berry extract, and geraniol.

Abstract translation: 这里公开了一种用于升高皮肤温度的方法，其包括向有需要的受试者施用包含有效量的一种或多种选自二氢 - 苯乙醇和4-甲氧基苯乙烯的化合物的组合物。 还公开了一种用于升高皮肤温度的方法，其包括向有需要的受试者施用包含有效量的一种或多种选自二氢 - 苯乙醇，4-甲氧基苯乙烯，谷类精液提取物，日本 薄荷提取物，杜松子提取物和香叶醇。

公开(公告)号：US20150064797A1

公开(公告)日：2015-03-05

申请号：US14472982

申请日：2014-08-29

Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Masashi MITA ,  Kenji HAMASE

IPC: G01N31/00

CPC classification number: G01N31/005 ,  G01N33/6815 ,  Y10T436/182

Abstract: A method for quantitatively analyzing cysteine and cysteine includes a first step of adding a methyl-sulfurating agent to a sample that includes cysteine and cystine to obtain a methyl-sulfurated cysteine, a second step of adding a derivatizing agent to the methyl-sulfurated cysteine and the cystine to obtain a cysteine derivative and a cystine derivative, respectively, and a third step of quantifying the cysteine derivative and the cystine derivative.

Abstract translation: 用于定量分析半胱氨酸和半胱氨酸的方法包括向包含半胱氨酸和胱氨酸的样品中加入甲基硫化剂以获得甲基 - 硫化半胱氨酸的第一步骤，向甲基 - 硫化半胱氨酸添加衍生化试剂的第二步骤和 分别得到半胱氨酸衍生物和胱氨酸衍生物的胱氨酸，第三步是定量半胱氨酸衍生物和胱氨酸衍生物。

公开(公告)号：US20150054758A1

公开(公告)日：2015-02-26

申请号：US14382124

申请日：2013-02-28

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yoshimasa Miura ,  Sayaka Suzuki ,  Naruhito Toyoda

IPC: G06F3/041

CPC classification number: G06F3/0414 ,  G01L1/205 ,  G01L25/00 ,  G01N17/004 ,  G06F3/03547

Abstract: An application operation evaluating apparatus, includes a detecting unit that detects pressing force obtained by a plurality of sensors provided at an application target surface in accordance with an application operation to the application target surface; an estimating unit that estimates a pressed position of the application operation on the application target surface based on pressing forces respectively applied to the sensors obtained by the detecting unit; a load distribution generating unit that generates load distribution in accordance with the application operation based on the pressing force obtained by the detecting unit and the pressed position obtained by the estimating unit; and a display unit that displays the load distribution obtained by the load distribution generating unit on a screen.

Abstract translation: 一种应用操作评估装置，包括检测单元，其根据对应用对象表面的应用操作来检测由设置在应用对象表面上的多个传感器获得的按压力; 估计单元，其基于分别施加到由所述检测单元获得的所述传感器的按压力，估计所述应用对象表面上的所述应用操作的按压位置; 负载分布生成单元，其基于由所述检测单元获得的按压力和由所述推定单元获得的所述按压位置，生成根据所述应用操作的负荷分布; 以及显示单元，其在屏幕上显示由所述负载分布生成单元获得的负载分布。

公开(公告)号：US08946137B2

公开(公告)日：2015-02-03

申请号：US13705517

申请日：2012-12-05

Applicant: Shiseido Company, Ltd.

Inventor： Tomohiko Kimura ,  Hidefumi Araki

IPC: A61K8/39 ,  A61K8/81 ,  A61Q19/10 ,  A61K8/42 ,  C11D1/835 ,  C11D1/72 ,  C11D1/62

CPC classification number: A61K8/39 ,  A61K8/42 ,  A61K8/8158 ,  A61K8/817 ,  A61Q19/10 ,  C11D1/62 ,  C11D1/72 ,  C11D1/835

Abstract: To provide a skin washing agent which is excellent in the foaming speed and the foam creaminess in washing therewith, and which, after washing therewith, is excellent in the moist feeling and the absence of pulling feeling of the skin and does not change the moisture content of skin. A foamable skin washing agent comprising (a) a fatty acid salt, (b) one or more selected from a homopolymer, a dipolymer and a terpolymer derived from a specific cationated monomer (e.g., dimethyldiallylammonium chloride), (c) a polyglyceryl monoalkyl ether, and (d) one or more selected from an acylmethyltaurine salt and a hydroxy ether carboxylate salt.

Abstract translation: 本发明提供发泡速度优异，洗涤时的泡沫奶油的皮肤清洗剂，其洗涤后的皮肤湿润感和无牵拉感优异，不会使水分含量变化 的皮肤。 一种可发泡皮肤洗涤剂，其包含（a）脂肪酸盐，（b）选自均聚物，二聚物和衍生自特定阳离子化单体（例如二甲基二烯丙基氯化铵）的三元共聚物中的一种或多种，​​（c）聚甘油单烷基醚 ，和（d）选自酰基甲基牛磺酸盐和羟基醚羧酸盐中的一种或多种。

公开(公告)号：US20150020835A1

公开(公告)日：2015-01-22

申请号：US14361590

申请日：2012-12-05

Applicant: SHISEIDO COMPANY, LTD. ,  FIGLA COMPANY, LTD.

Inventor： Motoki Takata ,  Takashi Tajima

IPC: A45D40/26 ,  A45D34/04

CPC classification number: A45D40/265 ,  A45D34/045 ,  A46B5/0075 ,  A46B2200/1053

Abstract: The mascara applicator includes an application stick that is attached to a cap sealing and covering an opening part of a mascara accommodation container and that can be accommodated in the mascara accommodation container, and an application body that is rotatably attached to a tip end of the application stick and that extends in a substantially axial direction of the application stick, in which one side surface on a side opposite to a rotating direction of the application body is orthogonal to a plane including a rotation path, and a ridge part that is formed by the one side surface and a side surface adjacent to the one side surface is used, while the application body is rotated and an axis of the application body is bent with respect to an axis of the application stick, so as to apply mascara.

Abstract translation: 睫毛膏涂抹器包括贴在盖子上的应用棒，所述盖子密封并覆盖睫毛膏容纳容器的开口部分，并且可以容纳在睫毛膏容纳容器中，以及可旋转地附接到所述应用的尖端的涂抹体 并且其在施加棒的大致轴向方向上延伸，其中与施加体的旋转方向相反的一侧的一个侧表面与包括旋转路径的平面正交;以及脊部，其由 使用与一个侧面相邻的一个侧面和侧面，同时施用体旋转并且施加体的轴线相对于施加杆的轴线弯曲，以便施加睫毛膏。