公开(公告)号：US11971420B2

公开(公告)日：2024-04-30

申请号：US17012675

申请日：2020-09-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Yannic Hafner ,  Thomas Lienert ,  Florian Wenzler ,  Dominik Schnarwiler ,  Philipp Heinz ,  Bert Taeymans

IPC: G01N35/00 ,  G01N35/04

CPC classification number: G01N35/00584 ,  G01N35/04 ,  G01N2035/0406 ,  G01N2035/0477

Abstract: A method of operating a laboratory sample distribution system is presented. The system comprises container carriers, a transport plane, and drive elements. The container carriers carry sample containers. The transport plane supports the container carriers. The drive elements move the container carriers on the transport plane. The method comprises planning a movement path for a container carrier from a start to a goal on the transport plane modelled by nodes. The nodes are free for one time-window or reserved for one-time window. The planning comprises analyzing the reachability out of a free time-window of one node to free time-windows of a next node and an over-next node such that planned movement of the container carrier is nonstop. The method comprises reserving the planned movement path comprising a sequence of time-windows of nodes and moving the container carrier along the reserved movement path on the transport plane by a drive element.

公开(公告)号：US20240135736A1

公开(公告)日：2024-04-25

申请号：US18485600

申请日：2023-10-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Nils Bruenggel ,  Patrick Conway ,  Jan-Gerrit Hoogendijk ,  Pascal Vallotton

IPC: G06V20/69 ,  G06T7/00 ,  G06T11/20 ,  G06V10/774 ,  G06V10/82 ,  G16B15/00 ,  G16B40/20

CPC classification number: G06V20/698 ,  G06T7/0012 ,  G06T11/206 ,  G06V10/774 ,  G06V10/82 ,  G16B15/00 ,  G16B40/20 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024 ,  G06T2210/41 ,  G06V2201/03

Abstract: A clinical support system comprises a processor and a display component, wherein: the processor is configured to: receive image data, the image data representing an image of a plurality of cells obtained from a human or animal subject, the image data comprising a plurality of subsets of image data, each subset comprising data representing a portion of the image data corresponding to a respective cell of the plurality of cells; apply a trained deep learning neural network model to each subset of the image data, the deep learning neural network model comprising: a plurality of convolutional neural network layers each comprising a plurality of nodes; and a bottleneck layer comprising no more than ten nodes, wherein the processor is configured to apply the trained deep learning neural network model to each subset of the image data by applying the plurality of CNN layers, and subsequently applying the bottleneck layer, each node of the bottleneck layer of the machine-learning model configured to output a respective activation value for that subset of the image data; for each subset of the image data, derive a dataset comprising no more than three values, the values derived from the activation values of the nodes in the bottleneck layer; and generate instructions, which when executed by the display component of a clinical support system, cause the display component of the computer to display a plot in no more than three dimensions of the respective dataset of each subset of the image data. Associated computer-implemented methods, including for training the deep learning neural network model, are provided.

公开(公告)号：US11965886B2

公开(公告)日：2024-04-23

申请号：US17115069

申请日：2020-12-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Dieter Heindl ,  Thomas Froehlich ,  Stefanie Froehner

IPC: G01N33/50 ,  C12N5/00 ,  C12N11/06 ,  C12N11/089 ,  C12N11/14 ,  G01N33/543 ,  G01N33/554 ,  G01N33/569

CPC classification number: G01N33/56972 ,  C12N5/0068 ,  C12N11/06 ,  C12N11/089 ,  C12N11/14 ,  G01N33/5005 ,  G01N33/54353 ,  G01N33/56966 ,  C12N2503/00 ,  C12N2533/20 ,  C12N2533/30

Abstract: The present invention relates to a method of immobilizing a cell on a support, the method comprising a) providing a compound or salt thereof comprising, preferably consisting of, one or more hydrophobic domains attached to a hydrophilic domain, wherein the one or more hydrophobic domains are covalently bound to said hydrophilic domain, and wherein the one or more hydrophobic domains each comprise a linear lipid, a steroid or a hydrophobic vitamin, and wherein the hydrophilic domain comprises a polyethylene glycol (PEG) moiety, and wherein the compound comprises a linking group; b) contacting a cell with the compound under conditions allowing the interaction of the compound with the membrane of the cell, thereby immobilizing the linking group on the surface of the cell; and c) contacting the linking group immobilized on the cell with a support capable of binding the linking group, thereby immobilizing the cell on the support.

公开(公告)号：US11946938B2

公开(公告)日：2024-04-02

申请号：US16899629

申请日：2020-06-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ursula-Henrike Wienhues-Thelen ,  Johann Karl ,  Peter Kastner ,  Vinzent Rolny ,  Andre Ziegler ,  David Conen

IPC: G01N33/53 ,  G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/4745 ,  G01N2333/515 ,  G01N2800/326 ,  G01N2800/50

Abstract: The present disclosure demonstrates a method for predicting the risk of stroke of a subject and a method for improving the prediction accuracy of a clinical stroke risk score. The methods are based on the determination of the amount of Angiopoietin-2 (Ang-2) and/or the amount of Insulin-like growth factor-binding protein 7 (IGFBP7) in a sample from a subject. Moreover, disclose is the use of i) the biomarker Ang-2 and/or the biomarker IGFBP7, and/or ii) at least one detection agent that specifically binds to Ang-2 and/or at least one detection agent that specifically binds to IGFBP7 in a sample from a subject for predicting the risk of stroke of said subject.

公开(公告)号：US11940427B2

公开(公告)日：2024-03-26

申请号：US17448063

申请日：2021-09-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Benjamin Tiemann ,  Stefan Quint ,  Florian Schweinberger

IPC: G01N30/72 ,  G01N30/02 ,  G01N30/88

CPC classification number: G01N30/7266 ,  G01N30/88 ,  G01N2030/027

Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current. The controller is further configured to carry out adjusting detection conditions of one or more of the multiple fluidic streams responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream to be detected by the mass spectrometer in the respective detection time window.

公开(公告)号：US20240096456A1

公开(公告)日：2024-03-21

申请号：US18463834

申请日：2023-09-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Asad Preuss-Dodhy

IPC: G16H10/40 ,  G06F21/60 ,  G16H10/60 ,  H04L9/40

CPC classification number: G16H10/40 ,  G06F21/602 ,  G16H10/60 ,  H04L63/0421

Abstract: A healthcare computer system, the computer system comprising a communications module, a string generation module, a one-way function module and an anonymised data generation module. The communications module is configured to receive one or more healthcare data packets, each healthcare data packet including: data pertaining to one or more medical analytical tests performed on a sample; a sample identifier, identifying the sample; and a timestamp, indicating when the analytical test(s) was performed. The string generation module is configured to generate a string based on the sample identifier and the timestamp. The one-way function module is configured to apply a one-way function to the generated string to generate an anonymised sample identifier. The anonymised data generation module is configured to generate an anonymised healthcare data packet including the data pertaining to the one or more medical analytical tests and the anonymised sample identifier.

公开(公告)号：US20240079101A1

公开(公告)日：2024-03-07

申请号：US18457388

申请日：2023-08-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Javier Lira Rueda

IPC: G16H10/40 ,  G06F9/48 ,  G16H40/20

CPC classification number: G16H10/40 ,  G06F9/4843 ,  G16H40/20

Abstract: A healthcare data management system for managing processing capacity in a healthcare data management system. The healthcare data management system includes: one or more processing pipelines connected to one or more of the medical devices and configured to receive medical data therefrom, wherein each processing pipeline comprises a plurality of processing stages arranged in series and configured to perform respective operations on the received healthcare data, wherein each processing stage is implemented on a stateless atomic processing unit; a healthcare middleware is configured to receive processed data therefrom and to provide the processed data to a healthcare information management system; a performance management unit is configured to monitor a performance of the or each processing pipeline and adjust a number of stateless atomic processing units implementing a given processing stage within a given processing pipeline based on the monitored performance.

公开(公告)号：US11890623B2

公开(公告)日：2024-02-06

申请号：US16953868

申请日：2020-11-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Andreas Drechsler

IPC: B04B7/12 ,  B04B5/04

CPC classification number: B04B7/12 ,  B04B5/0421

Abstract: A bucket insert for use in a centrifuge is disclosed. The bucket insert comprises an insert body, the insert body comprising a plurality of elongated receptacles for receiving elongated sample vessels. The bucket insert is configured for orienting the elongated sample vessels in a tilted orientation. In the tilted orientation, at least some of the elongated sample vessels are oriented in a non-parallel fashion.

公开(公告)号：US20230368874A1

公开(公告)日：2023-11-16

申请号：US18360355

申请日：2023-07-27

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Tech Corporaion

Inventor： Richard Allwinn ,  Sascha Seyffert ,  Ronald Huser ,  Andre Bitzer ,  Stephan Schweighauser ,  Nobuhiro Koizumi ,  Yoshihiro Seki

IPC: G16H10/40 ,  G16H40/40

CPC classification number: G16H10/40 ,  G16H40/40

Abstract: The present disclosure relates to a laboratory data management system 100 comprising a data source layer 10 comprising at least one laboratory device 11, 12, 13, 14, 15 as a data source, a data adapter layer 20 comprising at least one data source agent 21, 22, 23, 24, 25 configured to obtain data from the at least one data source and to convert the data from a data source format to a data-source independent format, a consumer layer 30 configured for installation and/or execution of consumer application software 31, 32, 33, 34, and a data management layer 40 between the data adapter layer 20 and the consumer layer 30. The data management layer 40 comprises a data storage 50 configured to store data 1-n converted by the at least one data source agent 21, 22, 23, 24, 25, at least one data manager 41, 42, 43, 44 programmed to execute instructions from the consumer application software 31, 32, 33, 34, which when executed cause the at least one data manager 41, 42, 43, 44 to select application-specific data in the data storage 50 and to make them accessible to a consumer via the consumer application software 31, 32, 33, 34 in a consumer format. The data adapter layer 20 and the data management layer 40 are arranged in a laboratory gateway 60 connected to the data-source layer 10 and to the consumer layer 30.

公开(公告)号：US11817212B2

公开(公告)日：2023-11-14

申请号：US16907605

申请日：2020-06-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Maik Hadorn ,  Markus Bornhoeft ,  Herbert Schurtenberger

IPC: G16H40/40 ,  G16H40/67 ,  G16H10/40 ,  G06F11/00 ,  G06N7/01

CPC classification number: G16H40/67 ,  G16H40/40 ,  G06F11/004 ,  G06N7/01 ,  G16H10/40

Abstract: A maintenance method for a laboratory system comprising a first and second group of laboratory instruments for processing biological samples, data collection components connected to the groups of instruments, and a remote maintenance system connected to the data collection components is presented. The method comprises collecting operational data from the laboratory instruments by the data collection components, detecting an anomaly related to the laboratory instruments by a first data collection component, transmitting context data to the remote maintenance system upon detection of an anomaly, determining correlation(s) between the operational data and the anomaly(s), validating the correlation(s), determining at the remote maintenance system predictive rules corresponding to validated correlations, transmitting the predictive rule(s) to the data collection components, and predicting occurrence of an anomaly of laboratory instruments based on the one or more predictive rule(s) by the data collection components.