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31.发明申请公开(公告)号：US20190383782A1
公开(公告)日：2019-12-19
申请号：US16090947
申请日：2017-03-20
发明人： Gerald STEINER , Grit PREUSSE , Roberta GALLI , Edmund KOCH
摘要： Method and a device for the optical in ovo sex determination of fertilized and incubated birds' eggs. The method includes monitoring formation of at least one identifiable blood vessel, creating a hole in the shell of the egg, finding and irradiating the blood vessel with at least one laser beam source emitting an excitation wavelength, recording backscatter radiation of the irradiated blood vessel and evaluating backscatter radiation from recorded spectral intensity of fluorescence radiation in a spectral range redshifted to an excitation wavelength. Sex-specific properties of male and female blood are contained in the intensity and spectral profile of the recorded fluorescence radiation. where intensity levels for male blood has an evaluable value distinct from that of female blood. Further, determining the sex of the bird egg from difference values of the fluorescence intensity and displaying the sex determined for the embryo in the egg.
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公开(公告)号：US20160377608A1
公开(公告)日：2016-12-29
申请号：US14902437
申请日：2014-07-02
发明人： Weilin LIN , Robert WIEDUWILD , Luca MANNOCCI , Jana HERRMANN , Yixin ZHANG , Francesco REDDAVIDE
IPC分类号： G01N33/543 , C12Q1/68
摘要： Method and arrangement for detecting binding events of molecules, in which, to at least one first molecule which is immobilised on a bioactive surface by a covalent bond, at least one second molecule has been bonded or is bonded, with formation of at least one specific non-covalent bond, the second molecule being bonded or having been bonded chemically covalently to a ligand. The bioactive surface can be contacted with at least one analyte molecule, binding events between the analyte molecule and the ligand being able to be detected by means of an analytical measuring method. The at least one specific non-covalent bond between the first and second molecule is breakable again by supplying a buffer solution. According to the invention, a third molecule is bonded to the second molecule, the third molecule also having a ligand. A specific ligand, or two specific ligands which are different from each other, can hence be available on the bioactive surface in an easily reversible manner,
摘要翻译： 用于检测分子的结合事件的方法和装置，其中至少一个通过共价键固定在生物活性表面上的第一分子至少一个第二分子已被结合或键合，形成至少一个特定的 非共价键，第二分子键合或已被化学共价键合到配体上。 生物活性表面可以与至少一种分析物分子接触，通过分析测量方法结合分析物分子和配体之间的事件能够被检测。 通过提供缓冲溶液，第一和第二分子之间的至少一个特定的非共价键可再次破裂。 根据本发明，第三分子与第二分子结合，第三分子也具有配体。 因此，可以以易于逆转的方式在生物活性表面上获得彼此不同的特定配体或两个特异性配体，
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33.发明授权公开(公告)号：US09260397B2
公开(公告)日：2016-02-16
申请号：US12864750
申请日：2009-01-30
申请人： Thomas Strassner , Sebastian Ahrens
发明人： Thomas Strassner , Sebastian Ahrens
IPC分类号： C07D233/58 , B01J31/02 , C07D233/60 , C07D249/08 , B01D15/38
CPC分类号： C07D233/58 , B01D15/38 , B01J31/0284 , B01J31/0298 , C07D233/60 , C07D249/08
摘要： The present invention relates to salts comprising novel aryl-alkyl-substituted imidazolium and triazolium cations and arbitrary anions. The invention further relates to methods for the chemical conversion and separation of substances, comprising the salts according to the invention as solvents, solvent additives, or extraction means, and to the use of the salts according to the invention, for example as solvents or solvent additives in chemical reactions, as extracting agents for the separation of substances, or for storing hydrogen. According to the invention, the object is achieved by salts of the general formula (I), where X— is an anion, Y1 and Y2 are CH, or Y1 is CH and Y2 is N, or Y1 is N and Y2 is CH, n is a number from 1 up to an including 18, Q is selected from —CH3, —OH, —ORx, —S03H, —S03Rx, —COOH, —COORx, —CORx, NH2, —NHRx, —N(Rx)2, and —CH(Rx)2, Z is H or Rx, R1, R2, R3, R4 and R5 independently from each other are —H, -halogen, —N02, —NH2, —NHRx, —N(Rx)2, —Rx, —COORx or —ORx, where Rx is an optionally substituted and/or branched C1 to C18-alkyl group, excluding compounds of the general formula (I), where Y1 and Y2 are CH and R1, R2, R3, R4 and R5 are H, excluding compounds of the general formula (I), where Y1 and Y2 are CH, R1=R3=R5=CH3 is true, n=1, 2, 6 and Q=CH3 is true, excluding compounds of the general formula (I), where Y1 is CH and Y2 is N, R1, R2, R3, R4 and R5 are H, n=1 is true, and Q=CH3 is true, and excluding compounds of the general formula (I), where Y1 and Y2 are CH, R1, R2, R4, R5=H is true, R3=ORx is true, and Rx is a hydrocarbon having 3 or 12 carbon atoms.
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公开(公告)号：US20140306202A1
公开(公告)日：2014-10-16
申请号：US14248437
申请日：2014-04-09
发明人： Hans Kleemann , Bjoern Luessem , Karl Leo
CPC分类号： H01L51/0512 , H01L51/0001 , H01L51/002 , H01L51/0508 , H01L51/0541 , H01L51/0545 , H01L51/0562
摘要： The present disclosure relates to an organic field effect transistor, comprising a first electrode and a second electrode, the electrodes providing a source electrode and a drain electrode, a gate electrode, an electronically active region at least in part made of an organic material and providing a charge a carrier channel, and a gate electrode separation, comprising a doped organic semiconducting layer directly provided on the gate electrode, wherein the doped organic semiconducting layer comprises an organic matrix material and an organic dopant. Furthermore, a method for producing an organic field effect transistor is provided.
摘要翻译： 本公开涉及一种有机场效应晶体管，包括第一电极和第二电极，所述电极提供源电极和漏电极，栅电极，至少部分由有机材料制成的电子有源区，并提供 电荷载体通道和栅电极分离，包括直接设置在栅电极上的掺杂有机半导体层，其中掺杂的有机半导体层包含有机基质材料和有机掺杂剂。 此外，提供了一种制造有机场效应晶体管的方法。
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35.发明申请METHOD AND ARRANGEMENT FOR GENERATING A CLOCK SIGNAL BY MEANS OF A PHASE LOCKED LOOP 有权用于通过相位锁定环路产生时钟信号的方法和装置公开(公告)号：US20140240011A1
公开(公告)日：2014-08-28
申请号：US14189410
申请日：2014-02-25
IPC分类号： H03L7/08
摘要： A method and an arrangement for generating a clock signal by a phase locked loop in which the time for adjusting to a prescribed frequency and phase of a clock signal is reduced by virtue of the fact that a plurality of selection signals respectively shifted by a time difference delta t are generated from the divided clock signal. A comparison signal (capture) is generated under control by an edge of the reference clock and a comparison is started in the case of which what is selected is that selection signal shifted by delta t which exhibits with its edge the least possible time deviation from the edge of the comparison signal, and the selected selection signal is output.
摘要翻译： 一种用于通过锁相环产生时钟信号的方法和装置，其中通过分别偏移时差的多个选择信号减少用于调整到时钟信号的规定频率和相位的时间 delta t从分频时钟信号产生。 在参考时钟的边沿的控制下产生比较信号（捕捉），并且在所选择的情况下开始比较，该选择信号被偏移了Δt，其具有与其边缘相差最小的时间偏差 比较信号的边沿，并输出所选择的选择信号。
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公开(公告)号：US20130216544A1
公开(公告)日：2013-08-22
申请号：US13814510
申请日：2011-08-05
申请人： Michael Bachmann
发明人： Michael Bachmann
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , C07K16/18 , C07K16/2809 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73
摘要： The invention relates to antibodies against the human La protein and to their use in immunotargeting, in particular the immunotargeting of tumour cells. The object of the invention is to provide improved antibodies which bind universal target structures on the surface of tumour cells, and to provide novel anti-La antibodies, in particular with a high affinity for La, a universal target structure on tumour cells, which make it possible to use the antibodies as recombinant fragments for immunotargeting. The invention comprises recombinant antibodies comprising: i. a binding unit of an antibody which specifically binds to an epitope of a human nuclear antigen, preferably human La protein, and ii. a binding unit of an antibody which specifically binds to an effector cell or of a ligand which specifically binds to an effector cell. The invention furthermore comprises novel antibodies which specifically bind the human La protein.
摘要翻译： 本发明涉及抗人类La蛋白的抗体及其在免疫靶向中的用途，特别是肿瘤细胞的免疫靶向。 本发明的目的是提供改进的抗体，其结合肿瘤细胞表面上的通用靶结构，并提供新的抗-La抗体，特别是对La的肿瘤细胞上的通用靶结构具有高亲和力，其使得 可以将抗体用作免疫靶向的重组片段。 本发明包括重组抗体，其包含： 特异性结合人核抗原，优选人La蛋白的表位的抗体的结合单元，和ii。 特异性结合效应细胞或特异性结合效应细胞的配体的抗体的结合单元。 本发明还包括与人La蛋白特异性结合的新型抗体。
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公开(公告)号：US08474320B2
公开(公告)日：2013-07-02
申请号：US13178682
申请日：2011-07-08
申请人： Ulrich Kordon , Steffen Kuerbis , Matthias Wolff , Marco Kuettner , Marco Stephan , Torsten Berth
发明人： Ulrich Kordon , Steffen Kuerbis , Matthias Wolff , Marco Kuettner , Marco Stephan , Torsten Berth
CPC分类号： G01R31/083
摘要： An electrical pulse fed into an electrical cable, e.g. a power transmission or distribution cable buried underground, produces an acoustic signal, e.g. an arc-over or discharge noise, at a fault in the cable. This acoustic signal is detected and used to locate the fault. But the acoustic signal has interference noise superimposed on it, which makes it difficult to identify the acoustic signal in the noise-burdened received signal, and thus also makes it difficult or impossible to accurately locate the fault. To minimize or avoid the influence of interference noises, the relevant acoustic signal is identified in the received signal by comparing the received signal with predetermined sample data, such as signal patterns, characteristics or characteristic sets.
摘要翻译： 馈入电缆的电脉冲，例如， 埋在地下的电力传输或分配电缆，产生一个声信号。 在电缆故障时产生电弧或放电噪声。 该声信号被检测并用于定位故障。 但声信号叠加有干扰噪声，难以在噪声负担的接收信号中识别声信号，因此难以准确定位故障。 为了最小化或避免干扰噪声的影响，通过将接收信号与诸如信号图案，特性或特征集之类的预定采样数据相比较，在接收信号中识别相关声信号。
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38.发明申请公开(公告)号：US20120322990A1
公开(公告)日：2012-12-20
申请号：US13578321
申请日：2011-02-10
申请人： Lars Passauer , Falk Liebner , Klaus Fischer , Joachim Katzur
发明人： Lars Passauer , Falk Liebner , Klaus Fischer , Joachim Katzur
IPC分类号： C08H7/00
摘要： The invention relates to a method for producing a lignin-based substrate for soil improvement having a water-storing property, characterized by the following steps: providing lignin, oxidizing the lignin in either an aqueous alkaline suspension or a pH-neutral aqueous suspension, the pH-neutral aqueous suspension being converted into an alkaline substance after the lignin has been oxidized, cross-linking the lignin in an aqueous alkaline medium using multifunctional compounds, and neutralizing, drying, and comminuting the lignin.
摘要翻译： 本发明涉及一种具有储水性的用于土壤改良的木质素基底物的制备方法，其特征在于以下步骤：提供木质素，在含水碱性悬浮液或pH-中性水性悬浮液中氧化木质素， 在木质素被氧化之后，pH-中性水性悬浮液转化为碱性物质，使用多官能化合物在碱性水溶液中交联木质素，并中和，干燥和粉碎木质素。
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公开(公告)号：US08286429B2
公开(公告)日：2012-10-16
申请号：US13066138
申请日：2011-04-07
申请人： Stephan Heide , Uwe Gampe , Manfred Freimark
发明人： Stephan Heide , Uwe Gampe , Manfred Freimark
摘要： A solar hybrid combined cycle gas-steam power plant and method including a solar unit, a gas turbine unit and a steam turbine unit. The solar unit includes a receiver. The gas turbine unit includes a gas turbine with a waste heat boiler arranged downstream, and a steam turbine with a feed water heater. The power plant includes a heat transfer medium cycle for transferring solar heat. The heat transfer medium cycle is coupled to the gas turbine unit through a gas turbine heat exchanger and to the steam turbine unit through a solar boiler. Alternatively to the gas turbine unit and the steam turbine unit, the solar hybrid combined cycle power plant includes an integrated gas-steam turbine having a waste heat boiler arranged downstream, wherein the heat transfer medium cycle is coupled to the integrated gas-steam turbine through the gas turbine heat exchanger and through the solar boiler.
摘要翻译： 一种太阳能混合式联合循环燃气 - 蒸汽发电厂和包括太阳能单元，燃气轮机单元和蒸汽涡轮机单元的方法。 太阳能单元包括一个接收器。 燃气轮机单元包括具有布置在下游的废热锅炉的燃气轮机和具有给水加热器的蒸汽轮机。 发电厂包括用于传递太阳能热量的传热介质循环。 传热介质循环通过燃气轮机热交换器连接到燃气轮机单元，并通过太阳能锅炉连接到蒸汽涡轮机单元。 作为燃气轮机单元和蒸汽轮机单元的替代方案，太阳能混合式联合循环发电厂包括具有布置在下游的废热锅炉的集成气体 - 汽轮机，其中传热介质循环通过 燃气轮机热交换器和太阳能锅炉。
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40.发明申请Method for Producing Temperature-Stable Large-Size Emitting LEDs and LEDs 审中-公开生产温度稳定的大尺寸发光LED和LED的方法公开(公告)号：US20110233573A1
公开(公告)日：2011-09-29
申请号：US13133387
申请日：2009-12-09
摘要： The invention relates to a method for producing temperature-stable large-size emitting LEDs and LEDs produced by said method. The method is characterised in that a large-area emitting light emitter is provided in the form of semiconductor nanocrystals which furthermore is temperature-stable and has a narrow band emission. A colloidal solution of emitting nanocrystals and a matrix of either inorganic gels or at least one polymer are alternately applied to the substrate with the first electrode by spraying, as a result of the electrostatic interactions between substrate, nanoparticles and inorganic gels or polymers, the nanopartides or the polymers of the matrix are adsorbed and the impurities run down with the solvent. The layer of alternately sprayed nanocrystals and matrix are heated to give a gel cross-linking the metal oxide nanoparticles, wherein thee size of thee semiconductor nanocrystals which determine the emission wavelength are determined by the temperature and duration of the heating. The second electrode is then applied by means of a conventional PVD method.
摘要翻译： 本发明涉及通过所述方法制造温度稳定的大尺寸发光LED和LED的方法。 该方法的特征在于，以半导体纳米晶体的形式提供大面积发射光发射器，该半导体纳米晶体还具有温度稳定性并具有窄带发射。 由于底物，纳米颗粒和无机凝胶或聚合物之间的静电相互作用，将纳米晶体和无机凝胶或至少一种聚合物的基质的胶体溶液与第一电极通过喷涂交替施加到基底上，纳米颗粒 或者基质的聚合物被吸附并且杂质随着溶剂而流失。 加热交替喷射的纳米晶体和基质层，使凝胶交联金属氧化物纳米颗粒，其中确定发射波长的半导体纳米晶体的尺寸由加热的温度和持续时间决定。 然后通过常规PVD方法施加第二电极。
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