公开(公告)号：US20230411009A1

公开(公告)日：2023-12-21

申请号：US18337780

申请日：2023-06-20

申请人： University of Chicago

发明人： Ishanu Chattopadhyay ,  Dmytro Onishchenko

IPC分类号： G16H50/20 ,  G16H10/60 ,  G16H50/30

CPC分类号： G16H50/20 ,  G16H70/60 ,  G16H50/30 ,  G16H10/60

摘要： A method including receiving a plurality of electronic health records stored in a database and partitioning the plurality of electronic health records in a first set of plurality of electronic health records and a second set of plurality of health records is disclosed. The method includes, for each electronic health record of the first and second sets of the plurality of electronic health records, generating a plurality of data streams, and in accordance with the generated data streams corresponding to the respective group of related disorders, inferring probabilistic finite state automaton (PFSA) models corresponding to a positive cohort and a control cohort for a specific health condition. The method includes determining a respective sequence likelihood defect of an electronic health record data of a new patient to match one of the inferred PFSA models for determining a likelihood of the new patient to acquire the specific health condition.

公开(公告)号：US20230395665A1

公开(公告)日：2023-12-07

申请号：US18052017

申请日：2022-11-02

申请人： Samsung Electronics Co., Ltd. ,  THE UNIVERSITY OF CHICAGO ,  Center for Technology Licensing at Cornell University

发明人： Minhyun LEE ,  Jiwoong PARK ,  Saien XIE ,  Jinseong HEO ,  Hyeonjin SHIN

IPC分类号： H01L29/15 ,  H01L29/10

CPC分类号： H01L29/158 ,  H01L29/1054

摘要： Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.

公开(公告)号：US20230392292A1

公开(公告)日：2023-12-07

申请号：US18071339

申请日：2022-11-29

申请人： The University of Chicago

发明人： Jiwoong Park ,  Andrew Mannix ,  Andrew Ye

IPC分类号： C30B29/68 ,  C30B23/02 ,  C30B29/46 ,  C30B29/40 ,  C30B29/02 ,  C30B25/02

CPC分类号： C30B29/68 ,  C30B23/02 ,  C30B29/46 ,  C30B29/403 ,  C30B29/02 ,  C30B25/02

摘要： Multi-layer materials and related systems and methods are generally described.

公开(公告)号：US20230392254A1

公开(公告)日：2023-12-07

申请号：US17833841

申请日：2022-06-06

申请人： UCHICAGO ARGONNE, LLC ,  THE UNIVERSITY OF CHICAGO

发明人： Elena Shevchenko ,  Supratik Guha ,  Zhongbo Zhang ,  Cheng Ji

IPC分类号： C23C16/04 ,  C09D5/00 ,  C09D1/00 ,  C23C16/455 ,  C23C16/40

CPC分类号： C23C16/045 ,  C09D5/006 ,  C09D1/00 ,  C23C16/45553 ,  C23C16/403

摘要： Polymers of intrinsic microporosity are used herein as polymer templates for forming mechanical robust inorganic porous coatings that can be beneficially used as anti-reflective coatings.

公开(公告)号：US11826426B2

公开(公告)日：2023-11-28

申请号：US16634486

申请日：2018-08-02

申请人： The University of Chicago

发明人： Wenbin Lin ,  Kaiyuan Ni ,  Guangxu Lan

IPC分类号： A61K41/00 ,  A61P35/00 ,  A61K33/243 ,  A61K45/06 ,  A61K47/34 ,  A61N5/10

CPC分类号： A61K41/0071 ,  A61K33/243 ,  A61K41/0057 ,  A61K45/06 ,  A61K47/34 ,  A61N5/10 ,  A61P35/00

摘要： Metal-organic layers (MOLs) and metal-organic nanoplates (MOPs) comprising photosensitizers are described. The MOLs and MOPs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the MOL or MOP. Also described are methods of using MOLs and MOPs in photodynamic therapy, X-ray induced photodynamic therapy (X-PDT), radiotherapy (RT), radiodynamic therapy, or in radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator.

公开(公告)号：US20230348881A1

公开(公告)日：2023-11-02

申请号：US18022004

申请日：2021-08-18

申请人： Onchilles Pharma, Inc. ,  The University of Chicago

发明人： Lev BECKER ,  Marc NASOFF

IPC分类号： A61P35/00 ,  C12N9/64

CPC分类号： C12N9/6448 ,  A61P35/00 ,  C12Y304/21036

摘要： Provided are modified serine protease proproteins, such as porcine pancreatic elastase (PPE) proproteins, comprising a heterologous protease cleavage site that is cleavable by a tumor site protease, and related pharmaceutical compositions and methods of use for treating diseases such as cancers.

公开(公告)号：US20230314374A1

公开(公告)日：2023-10-05

申请号：US17998316

申请日：2021-05-10

申请人： University of Chicago

发明人： Kevin C. Miao ,  David D. Awschalom

IPC分类号： G01N27/82 ,  G06N10/40

CPC分类号： G01N27/82 ,  G06N10/40

摘要： The disclosure is directed to devices, systems, and methods for a generation of a decoherence-protected subspace in a quantum system. The decoherence-protected subspace provides the quantum system with reduced sensitivity to environmental magnetic, electric, and thermal noises. Quantum information operation based on the quantum system can be performed while this decoherence-protected subspace is maintained.

公开(公告)号：US20230280349A1

公开(公告)日：2023-09-07

申请号：US18176909

申请日：2023-03-01

申请人： The University of Chicago ,  Inova Health System ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： Ayman Al-Hendy ,  Hiba Alkelani ,  Thomas Patrick Conrads ,  George Larry Maxwell ,  Nicholas William Bateman ,  Waleed Barakat

IPC分类号： G01N33/574

CPC分类号： G01N33/57488 ,  G01N2800/7028

摘要： In aspects, the disclosure provides a method of differentiating a malignant tumor from a non-malignant tumor in a mammal having a tumor comprising determining in a sample from the mammal the level of one or more of: (1) transthyretin (TTR) RNA or protein, (2) dual oxidase 2 (DUOX2) RNA or protein, and (3) G-protein coupled receptor 179 (GPR179) RNA or protein.

公开(公告)号：US20230279197A1

公开(公告)日：2023-09-07

申请号：US18172146

申请日：2023-02-21

申请人： The University of Chicago

发明人： Aaron Esser-Kahn ,  Jun Wang ,  Zhao Wang ,  Jorge Luis Ayarza-Leon

IPC分类号： C08K3/22 ,  C08F20/14 ,  C08F12/08 ,  H10N30/85 ,  H10N30/00

CPC分类号： C08K3/22 ,  C08F20/14 ,  C08F12/08 ,  H10N30/85 ,  H10N30/1061 ,  C08F2810/20 ,  C08F2810/40 ,  C08K2003/2296 ,  C08K2201/001 ,  C08K2201/011

摘要： Provided are mechanically adaptive materials that include a composite gel that is responsive to input energy. In some embodiments, input vibrational energy results in strengthening the composite gel. The strengthening may be reversible or irreversible according to various embodiments. In some embodiments, input vibrational energy generates chemical promotors for cross-linking reactions and/or linear polymerization via mechano-chemical transducers. In some embodiments, an applied shear stress is used to control charge generation and generate chemical promoters for cross-linking and/or linear polymerization. In some embodiments, the composite gels include a polymer network and/or polymer network precursors, reactive groups and/or linkers formed by reaction of the reactive groups, and a mechano-chemical transducer. Also provided are methods of mechanically promoted synthesis of polymers and polymer gels.

公开(公告)号：US20230270861A1

公开(公告)日：2023-08-31

申请号：US18006482

申请日：2021-07-22

申请人： The University of Chicago

发明人： Ralph WEICHSELBAUM ,  Hua Laura LIANG ,  Yuzhu HOU

IPC分类号： A61K41/00 ,  A61K31/4995 ,  C07K16/28 ,  A61N5/10 ,  C12N9/22 ,  C12N15/11 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61K31/4995 ,  C07K16/2827 ,  C07K16/2818 ,  A61N5/10 ,  C12N9/22 ,  C12N15/11 ,  A61P35/00 ,  C12N2310/20

摘要： This disclosure relates to compositions and methods for treating cancer by modulating the artemin pathway.