公开(公告)号：US10889832B2

公开(公告)日：2021-01-12

申请号：US16060409

申请日：2016-12-09

Applicant: The Trustees of the University of Pennsylvania

Inventor： James M. Wilson ,  Daniel J. Rader

IPC: A61K48/00 ,  C12N15/861 ,  C07K14/705 ,  C12N15/86 ,  A61P3/06 ,  A61K9/00

Abstract: Compositions and regimens useful in reducing one or more of: LDL-cholesterol, total cholesterol, and/or fasting triglycerides in a subject, and/or modifying fractional catabolic rate (FCR) of LDL apolipoprotein B (apoB) from baseline to a selected time point after rAAV administration are provided. The method involves administering to the human subject via a peripheral vein by infusion of a suspension of replication deficient recombinant adeno-associated virus (rAAV).

公开(公告)号：US10481233B2

公开(公告)日：2019-11-19

申请号：US15509402

申请日：2015-09-08

Applicant: The Trustees of the University of Pennsylvania

Inventor： Ragini Verma ,  Luke Macyszyn ,  Emmanuel Caruyer ,  Jeremy Lecoeur ,  Mark Elliot ,  Steven Brem

IPC: G01V3/00 ,  G01R33/563 ,  G01R33/56

Abstract: Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a multi-compartment model; and (iii) reconstructing the fibers through a probabilistic tracking algorithm using a fiber orientation distribution which has streamlines fitted to the output of said probabilistic tracking algorithm.

公开(公告)号：US10172958B2

公开(公告)日：2019-01-08

申请号：US15383474

申请日：2016-12-19

Applicant: Tris Pharma, Inc.

Inventor： Ketan Mehta ,  Yu-Hsing Tu

IPC: A61K9/16 ,  A61K31/137 ,  A61K31/155 ,  A61K31/192 ,  A61K31/216 ,  A61K31/485 ,  A61K47/14 ,  A61K47/32 ,  A61K9/00 ,  A61K9/50 ,  A61K47/58 ,  A61K9/10 ,  A61K9/20 ,  A61K31/135 ,  A61K31/4458 ,  A61K9/14 ,  A61K31/4402 ,  A61K31/24 ,  A61K9/48 ,  A61K47/69 ,  A61K45/06

Abstract: An aqueous liquid suspension containing a coated drug-ion exchange resin complex comprising a core composed of an amphetamine complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated amphetamine-ion exchange resin complex is provided. The coated amphetamine-ion exchange resin complex is in admixture with a polymer to form a matrix. Methods of making the coated complex and the liquid suspension are described.

公开(公告)号：US09732428B2

公开(公告)日：2017-08-15

申请号：US14664884

申请日：2015-03-22

Applicant: Houghton Technical Corp.

Inventor： Mores Basaly

IPC: B44C1/22 ,  C23F1/00 ,  C03C15/00 ,  C03C25/68 ,  C25F3/00 ,  C23F1/20 ,  C11D3/04 ,  C11D3/20 ,  C11D11/00 ,  C23F1/16 ,  C23F3/03 ,  C23G1/12 ,  C25D11/16

CPC classification number: C23F1/20 ,  C11D3/042 ,  C11D3/046 ,  C11D3/2082 ,  C11D11/0029 ,  C23F1/16 ,  C23F3/03 ,  C23G1/125 ,  C25D11/16 ,  Y10T428/12993

Abstract: The invention relates to compositions and methods that are useful in etching a metal surface. In particular, the invention relates to novel acid compositions and methods of using such compositions in etching a metal surface, preferably an aluminum surface prior to anodizing to dissolve impurities, imperfections, scale, and oxide. The compositions are effective in maintaining their etching capacity and in removing smut produced by the etching of a surface as well as in general cleaning.

公开(公告)号：US08628822B2

公开(公告)日：2014-01-14

申请号：US12145051

申请日：2008-06-24

Applicant: Marc L Rothstein ,  Dianne M Rothstein ,  Dan P Lee

Inventor： Marc L Rothstein ,  Dianne M Rothstein ,  Dan P Lee

IPC: B05D7/00

CPC classification number: C07H21/00 ,  C03C11/00 ,  C03C17/32 ,  C03C17/328 ,  G01N33/54313 ,  G01N33/54353 ,  G01N33/552 ,  Y10T428/2989 ,  Y10T428/2996 ,  Y10T428/2998

Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.

Abstract translation: 提供了一种制备交联聚合物涂层控制孔隙玻璃（CPG）颗粒的方法。 该方法包括在低于10℃的温度下将CPG颗粒混合在包含聚乙烯基苄基氯和第一溶剂的溶液中。加入第二溶剂并向混合物中加入交联剂。 第一溶剂在加入交联剂的1小时内迅速除去。 允许交联反应进行，然后将混合物冷却并处理以除去任何残留的溶剂。 将所得涂覆的CPG颗粒洗涤并干燥。 还提供了用于在其上负载配体的聚合物涂覆的CPG颗粒。

公开(公告)号：US07617935B2

公开(公告)日：2009-11-17

申请号：US11972181

申请日：2008-01-10

Applicant: Shawn P. Reilley ,  Curtis Knutson ,  Ronald J. Seibert

Inventor： Shawn P. Reilley ,  Curtis Knutson ,  Ronald J. Seibert

IPC: B65D83/04

CPC classification number: B65D83/0463 ,  A61J1/035 ,  A61J7/00 ,  B65D2215/02 ,  Y02W30/807

Abstract: A child-resistant and senior-friendly unit dose package has a hollow container body containing a separate tray carrying a plurality of tablets or like items for being dispensed from the container body. The container body has an end with an opening, and the tray can be slid to a retracted position in which the tray is located within the container body and a dispensing position in which a proximal end part of the tray extends through the opening of the container body. The package includes a separate cap removably securable to the container body to seal the opening and prevent access to the trays. The container body can be positioned in a tray re-loading position that permits a spent tray to be removed from the container body and replaced with a new tray. Thus, the container body is reusable.

Abstract translation: 具有耐儿童和高级友好的单位剂量包装具有中空的容器主体，该中空容器主体包含携带多个片剂或类似物品的单独的托盘，用于从容器主体分配。 容器主体具有带开口的端部，并且托盘可以滑动到托盘位于容器主体内的缩回位置和托盘的近端部分延伸穿过容器的开口的分配位置 身体。 该包装包括可拆卸地固定到容器主体以密封开口并防止进入托盘的单独盖。 容器主体可以被定位在托盘重新装载位置，该位置允许用过的托盘从容器主体移除并且用新的托盘代替。 因此，容器主体是可重复使用的。