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31.发明授权公开(公告)号：US07256033B2
公开(公告)日：2007-08-14
申请号：US11166993
申请日：2005-06-24
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12P7/6472 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N9/0083 , C12N15/8247 , C12P7/6427 , A23V2300/21
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast.
Abstract translation: 分离的核酸片段和包含编码Δ-8去饱和酶的片段的重组构建物以及使用该植物中的δ-8去饱和酶和油质酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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32.发明授权Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms 有权高山被孢霉溶血磷脂酸酰基转移酶同源物，用于改变多不饱和脂肪酸和含油生物中的油含量公开(公告)号：US07189559B2
公开(公告)日：2007-03-13
申请号：US11251466
申请日：2005-10-14
Applicant: Howard Glenn Damude , Zhixiong Xue
Inventor： Howard Glenn Damude , Zhixiong Xue
CPC classification number: C12P7/6472 , C12N9/1029 , C12P7/6463
Abstract: Lysophosphatidic acid acyltransferase (LPAAT) participates in the second step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids produced in oils of oleaginous organisms. The present application provides a nucleic acid fragment (identified as “LPAAT2”) isolated from Mortierella alpina encoding a LPAAT homolog that is suitable for use in the manufacture of oils enriched in omega fatty acids in oleaginous organisms. Most desirably, the substrate specificity of the instant LPAAT2 will be particularly useful to enable accumulation of long-chain PUFAs having chain lengths equal to or greater than C20 in oleaginous yeast, such as Yarrowia lipolytica.
Abstract translation: 溶血磷脂酰基转移酶（LPAAT）参与石油生物合成的第二步，预计在改变含油生物油中产生的长链多不饱和脂肪酸的量方面发挥关键作用。 本申请提供了从编码LPAAT同源物的高山被孢霉分离的核酸片段（鉴定为“LPAAT2”），其适用于制造含油生物体中富含ω-脂肪酸的油。 最理想的是，本发明的LPAAT2的底物特异性将特别适用于在含油酵母例如解脂耶氏酵母中积累具有等于或大于C 20的链长的长链PUFA。
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公开(公告)号：US08993840B2
公开(公告)日：2015-03-31
申请号：US12917024
申请日：2010-11-01
Applicant: Stephen M. Allen , Howard Glenn Damude , John D. Everard , Knut Meyer , Byung-Chun Yoo
Inventor： Stephen M. Allen , Howard Glenn Damude , John D. Everard , Knut Meyer , Byung-Chun Yoo
CPC classification number: C12N15/8247 , C07K14/415 , C12N9/1029 , C12Q1/6895 , C12Q2600/13 , C12Q2600/16 , C12Y203/0102
Abstract: This invention relates to polynucleotide sequences encoding SUT2 or SUT4 sucrose transporter genes. Methods for increasing seed oil content and evaluating increased oil content in a plant seed are described. The compositions and methods disclosed herein employ a variety of sequences that encode sucrose transporters and a variety of sequences that influence fatty acid accumulation, including for example, DGAT, Lec1 and ODP1 transcription factor. In specific embodiments, overexpression of SUT2 and/or SUT4 sucrose transporters in combination with DGAT genes further increase plant seed oil production compared to a high oil plant comprising recombinant DNA constructs that do not overexpress SUT2 or SUT4 transporters.
Abstract translation: 本发明涉及编码SUT2或SUT4蔗糖转运蛋白基因的多核苷酸序列。 描述了增加种子油含量和评估植物种子中增加的油含量的方法。 本文公开的组合物和方法使用编码蔗糖转运蛋白的多种序列和影响脂肪酸积累的多种序列，包括例如DGAT，Lec1和ODP1转录因子。 在具体实施方案中，与包含不过表达SUT2或SUT4转运蛋白的重组DNA构建体的高油植物相比，SUT2和/或SUT4蔗糖转运蛋白与DGAT基因的过表达进一步增加植物种子油产量。
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34.发明授权DGAT genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants 有权DGAT基因用于增加油籽植物中的种子储存脂质生成和改变的脂肪酸分布公开(公告)号：US08455714B2
公开(公告)日：2013-06-04
申请号：US13329939
申请日：2011-12-19
Applicant: Keith Roesler , Knut Meyer , Howard Glenn Damude , Bo Shen , Changjiang Li , Ericka Bermudez , Mitchell C. Tarczynski
Inventor： Keith Roesler , Knut Meyer , Howard Glenn Damude , Bo Shen , Changjiang Li , Ericka Bermudez , Mitchell C. Tarczynski
CPC classification number: C12N15/8247 , A23K10/30 , A23L11/00 , A23V2002/00 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of null segregant oilseeds are described. Novel DGAT genes are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与无分离油籽油的总脂肪酸含量相比，具有总脂肪酸含量增加至少10％和改变的脂肪酸分布的转基因油籽。 新型DGAT基因用于实现种子储存脂质的增加。
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35.发明授权Delta-8 desaturases and their use in making polyunsaturated fatty acids 失效Delta-8去饱和酶及其在制备多不饱和脂肪酸中的应用公开(公告)号：US08338152B2
公开(公告)日：2012-12-25
申请号：US13449395
申请日：2012-04-18
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
IPC: C12N9/02
CPC classification number: C12P7/6427 , C12N9/0083 , C12N15/8247
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-8 desaturases in plants.
Abstract translation: 分离的核酸片段和包含编码δ-8去饱和酶的片段以及制备长链多不饱和脂肪酸（PUFA）的方法并在植物中使用这些δ-8去饱和酶的重组构建体。
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Patent Agency Ranking
36.发明授权公开(公告)号：US08318463B2
公开(公告)日：2012-11-27
申请号：US12825537
申请日：2010-06-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12P7/6427 , C12N9/0083 , C12N15/8247
Abstract: The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ8 desaturases in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸（EDA; 20：2ω-6）转化为二高-γ-亚麻酸（DGLA; 20：3ω-6）和/或二十碳三烯酸的能力的Dgr .8去饱和酶基因 分离的核酸片段和重组DNA构建体，其包含编码“Dgr。8”去饱和酶的片段，以及一种制备长链多糖的方法， 公开了在含油酵母中使用这些＆Dgr。8去饱和酶的链多不饱和脂肪酸（PUFA）。
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37.发明申请公开(公告)号：US20120100595A1
公开(公告)日：2012-04-26
申请号：US13347938
申请日：2012-01-11
Applicant: Howard Glenn DAMUDE , Quinn Qun Zhu
Inventor： Howard Glenn DAMUDE , Quinn Qun Zhu
IPC: C12N9/10
CPC classification number: C12N9/1029 , A23D9/00 , A23D9/007 , A23K20/158 , A23L33/12 , A23V2002/00 , A23V2250/1862 , A23V2250/187 , A23V2250/1868
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-9 elongases in plants.
Abstract translation: 分离的核酸片段和包含编码Δ-9延伸酶的片段的重组构建物以及制备长链多不饱和脂肪酸（PUFA）的方法并在植物中使用这些δ-9延伸酶。
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38.发明申请DGAT GENES FROM OLEAGINOUS ORGANISMS FOR INCREASED SEED STORAGE LIPID PRODUCTION AND ALTERED FATTY ACID PROFILES IN OILSEED PLANTS 有权来自有机体的DGAT基因，用于增加种子储存脂肪生产和改变油脂植物中的脂肪酸分布公开(公告)号：US20120096588A1
公开(公告)日：2012-04-19
申请号：US13328677
申请日：2011-12-16
Applicant: Knut Meyer , Howard Glenn Damude , Kevin G. Ripp , Kevin L. Stecca
Inventor： Knut Meyer , Howard Glenn Damude , Kevin G. Ripp , Kevin L. Stecca
CPC classification number: C12N15/8247 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from oleaginous organisms are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与非转基因，无偏分离大豆种子的总脂肪酸含量相比，具有至少10％的总脂肪酸含量增加和改变的脂肪酸分布的转基因大豆种子。 来自含油生物的DGAT基因用于实现种子储存脂质的增加。
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39.发明申请DELTA-5 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开DELTA-5去饱和酶及其在制备聚氨酯脂肪酸中的用途公开(公告)号：US20120076894A1
公开(公告)日：2012-03-29
申请号：US13240258
申请日：2011-09-22
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N9/0083
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-5 desaturase in plants and oleaginous yeast are disclosed.
Abstract translation: 公开了分离的核酸片段和包含编码δ-5去饱和酶的片段的重组构建物，以及在植物和油质酵母中使用该δ-5去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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40.发明申请公开(公告)号：US20120015420A1
公开(公告)日：2012-01-19
申请号：US13238766
申请日：2011-09-21
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
IPC: C12N9/02
CPC classification number: C12N15/8247 , C12N9/0083
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast are disclosed.
Abstract translation: 公开了分离的核酸片段和重组构建体，其包含编码Δ-8去饱和酶的片段以及使用该植物中的δ-8去饱和酶和油性酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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