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42 条记录 (耗时 0.047 秒)

    Diagnosis of tauopathies
    31.
    发明申请
    Diagnosis of tauopathies 有权
    tau蛋白病诊断

    公开(公告)号：US20040091942A1

    公开(公告)日：2004-05-13

    申请号：US10682103

    申请日：2003-10-09

    申请人： INNOGENETICS N.V.

    发明人： Eugeen Vanmechelen ,  Hugo Vanderstichele

    IPC分类号： G01N033/53 ,  C07K014/47

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/52 ,  Y10S435/975 ,  Y10T436/10

    摘要： The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.

    摘要翻译： 本发明提供了一种用于诊断个体中tau蛋白病的方法和/或用于根据检测所述个体中的tau-tau蛋白（181）/总tau的比例，对tau蛋白病与非tau蛋白病的鉴别诊断。 本发明还提供了用于本发明方法中的标准化的磷酸肽。

    Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms
    32.
    发明申请
    Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms 审中-公开
    衍生自16S和23S rRNA基因之间的间隔区的杂交探针用于检测非病毒微生物

    公开(公告)号：US20040053320A1

    公开(公告)日：2004-03-18

    申请号：US10672238

    申请日：2003-09-25

    申请人： N.V. Innogenetics S.A.

    发明人： Rudi Rossau ,  Hugo Van Heuverswyn

    IPC分类号： C12Q001/68 ,  C07H021/04

    CPC分类号： C12Q1/6888 ,  C12Q1/689

    摘要： The invention relates to a probe consisting of at least about 15 nucleotides from the spacer region between rRNA genes of a non-viral organism, particularly prokaryotic organism and more particularly bacteria, and preferably from about 15 nucleotides to about the maximum number of nucleotides of the spacer region and more preferably from about 15 to about 100 nucleotides to be used for the detection of non-viral microorganisms.

    摘要翻译： 本发明涉及由非病毒生物体的rRNA基因之间的间隔区至少约15个核苷酸组成的探针，特别是原核生物，更特别是细菌，优选约15个核苷酸至约最大数目的核苷酸 间隔区，更优选约15至约100个核苷酸用于检测非病毒微生物。

    32-kDa protein derived from mycobacterium tuberculosis and related peptides
    34.
    发明申请
    32-kDa protein derived from mycobacterium tuberculosis and related peptides 失效
    来自结核分枝杆菌和相关肽的32-kDa蛋白质

    公开(公告)号：US20030225249A1

    公开(公告)日：2003-12-04

    申请号：US10329087

    申请日：2002-12-23

    申请人： N.V. Innogenetics S.A., a Belgium corporation

    发明人： Jean Content ,  Lucas De Wit ,  Jacqueline De Bruyn ,  Jean-Paul Van Vooren

    IPC分类号： C07K001/00 ,  C07K014/00 ,  C07K017/00

    CPC分类号： C07K7/08 ,  C07K14/35

    摘要： The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the extremity constituted by nucleotide at position (1) to the extremity constituted by nucleotide at position (194) represented in FIG. 4a and FIG. 4b. The polypeptides and peptides of the invention can be used for the diagnostic of tuberculosis, and can also be part of the active principle in the preparation of vaccine against tuberculosis.

    摘要翻译： 本发明涉及重组多肽和肽，特别涉及在其多肽链中含有以下氨基酸序列的多肽：从由位置（1）的核苷酸构成的末端延伸至由位置（194）处的核苷酸构成的末端的氨基酸序列 在 b。 本发明的多肽和肽可以用于诊断结核病，并且也可以是制备结核病疫苗的活性成分的一部分。

    Detection and identification of human papillomavirus by PCR and type-specific reverse hybridization
    36.
    发明申请
    Detection and identification of human papillomavirus by PCR and type-specific reverse hybridization 审中-公开
    通过PCR和类型特异性反向杂交检测和鉴定人乳头瘤病毒

    公开(公告)号：US20030165821A1

    公开(公告)日：2003-09-04

    申请号：US10241780

    申请日：2002-09-11

    申请人： INNOGENETICS S.A.

    发明人： Leen-Jan Van Doorn ,  Wim Quint ,  Bernhard Kleter ,  Jan Ter Schegget

    IPC分类号： C12Q001/70 ,  C12Q001/68 ,  C12P019/34

    CPC分类号： C12Q1/708 ,  C12Q2531/113

    摘要： A method for detection and/or identification of HPV present in a biological sample comprising amplification of HPV polynucleic acids and of hybridization of said amplified polynucleic acids to a number of probes whereby a short fragment of the L1 gene of HPV is amplified after which, the amplimers are contacted with probes that specifically hybridize to the said short fragment of the L1 gene of at least one HPV type and a diagnostic kit to perform said method and primers and probes used in the said method.

    摘要翻译： 存在于生物样品中的HPV的检测和/或鉴定方法，包括HPV多核酸的扩增和所述扩增的多核酸与许多探针的杂交，从而扩增HPV的L1基因的短片段，之后， 使扩增子与至少一种HPV类型的L1基因的所述短片段和诊断试剂盒特异性杂交的探针接触，以执行所述方法以及用于所述方法的引物和探针。

    Monoclonal antibodies specific PHF-TAU, hybridomas secreting them, antigen recognition by these antibodies and their applications
    37.
    发明申请
    Monoclonal antibodies specific PHF-TAU, hybridomas secreting them, antigen recognition by these antibodies and their applications 审中-公开
    单克隆抗体特异性PHF-TAU，分泌它们的杂交瘤，这些抗体的抗原识别及其应用

    公开(公告)号：US20030138972A1

    公开(公告)日：2003-07-24

    申请号：US10247853

    申请日：2002-09-20

    申请人： Innogenetics N.V.

    发明人： Marc Vandermeeren ,  Eugeen Vanmechelen ,  Andre Van De Voorde

    IPC分类号： G01N033/543 ,  C12N005/06 ,  C07K016/40

    CPC分类号： C07K16/18 ,  C07K14/4711

    摘要： A peptide from 6 to 100 amino acids long, including an amino acid sequence depicted by one of a) Val-Arg-Thr-Pro-Pro (amino acid 229-233; human tau numbering, SEQ ID NO 2) wherein the peptide is able to form an immunological complex with the monoclonal antibody AT180 produced by the hybridoma deposited at the ECACC on Dec. 22, 1992 under No.92122204 and b) Pro-Lys-Thr-Pro-Pro (amino acid 179-183; human tau numbering, SEQ ID NO 3) wherein the peptide is able to form an immunological complex with the monoclonal antibody AT270 produced by the hybridoma deposited at the ECACC on Jul. 7,1993 under No.93070774, with Thr being phosphorylated. A method of detecting PHF-tau protein one of the peptides is also disclosed.

    摘要翻译： 6至100个氨基酸长的肽，包括a）Val-Arg-Thr-Pro-Pro（氨基酸229-233;人tau编号，SEQ ID NO 2）之一所示的氨基酸序列，其中肽是 能够与1992年12月22日在ECACC于1992年12月22日保藏的杂交瘤产生的单克隆抗体AT180形成免疫复合物，以及b）Pro-Lys-Thr-Pro-Pro（氨基酸179-183;人tau 编号，SEQ ID NO 3），其中所述肽能够与由在ECACC于1993年7月7日在No.93070774上沉积的杂交瘤产生的单克隆抗体AT270形成免疫复合物，Thr被磷酸化。 还公开了检测PHF-tau蛋白之一的方法。

    Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
    40.
    发明申请
    Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents 失效
    丙型肝炎病毒基因型的序列及其作为治疗和诊断剂的用途

    公开(公告)号：US20030032005A1

    公开(公告)日：2003-02-13

    申请号：US09878281

    申请日：2001-06-12

    申请人： INNOGENETICS S.A.

    发明人： Geert Maerterns ,  Lieven Stuyver

    IPC分类号： C12Q001/70 ,  C07H021/04 ,  A61K039/245 ,  C12N007/00

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2770/24222 ,  Y02A50/396

    摘要： The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide sequence from the region spanning positions 417 to 957 of the Core/E1 region of HCV type 3; and/or the region spanning positions 4664 to 4730 of the NS3 region of HCV type 3; and/or the region spanning positions 4892 to 5292 of the NS3/4 region of HCV type 3; and/or the region spanning positions 8 023 to 8 235 of the NS5 region of the BR36 subgroup of HCV type 3a; and/or the coding region of HCV type 4a starting at nucleotide 379 in the core region; and/or the coding region of HCV type 4; and/or the coding region of HCV type 5, with said nucleotide numbering being with respect to the numbering of HCV nucleic acids as shown in Table 1, and with said polynucleic acids containing at least one nucleotide difference with known HCV type 1, and/or HCV type 2 genomes in the above-indicated region, or the complement thereof.

    摘要翻译： 本发明涉及包含至少一种含有8个或更多个连续核苷酸的多核苷酸的多核酸组合物，其对应于来自HCV 3型核心/ E1区域的位置417至957的区域的核苷酸序列; 和/或跨越HCV 3型NS3区域的位置4664至4730的区域; 和/或跨越HCV 3型NS3 / 4区的位置4892至5292的区域; 和/或跨越HCV3a型BR36亚组的NS5区域的位置8 023至8 235的区域; 和/或从核心区域的核苷酸379开始的HCV型4a的编码区; 和/或HCV 4型的编码区; 和/或HCV 5型的编码区，其中所述核苷酸编号相对于表1所示的HCV核酸的编号，并且所述多核苷酸与已知的HCV I型具有至少一个核苷酸差异，和/ 或上述区域中的HCV 2型HCV基因组，或其补体。