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    Method for typing of HLA alleles
    1.
    发明申请
    Method for typing of HLA alleles 审中-公开
    HLA等位基因的分型方法

    公开(公告)号：US20030180763A1

    公开(公告)日：2003-09-25

    申请号：US10334488

    申请日：2002-12-30

    申请人： Innogenetics N.V.

    发明人： Ilse De Canck ,  Guy Mersch ,  Rudi Rossau

    IPC分类号： C12Q001/68 ,  C12P019/34

    CPC分类号： C12Q1/6881 ,  C07K14/70539 ,  C12Q2600/156 ,  C12Q2600/16

    摘要： The present invention relates to the typing of HLA alleles. The sequence of exon 2 and exon 3 of the alleles HLA-B*3913, HLA-B*1406, and HLA-B*51new and of exon 2 of the alleles HLA-DRB1*0820, HLA-DRB1*04new and HLA-DRB4*01new are disclosed. The present invention relates to methods for typing of said alleles. According to a preferred embodiment, said typing comprises the following steps: i) amplifying a relevant fragment of said alleles using at least one suitable pair of primers; ii) hybridizing the amplification product of step i) to at least one probe that specifically hybridizes to a target region comprising one or more polymorphic nucleotides in said relevant fragment; iii) determining from the result of step ii) the absence or presence of said alleles in the sample. The present invention further provides primers and probes to be used in said methods for typing. A diagnostic kit comprising said primers and probes is also part of the present invention.

    摘要翻译： 本发明涉及HLA等位基因的分型。 等位基因HLA-B * 3913，HLA-B * 1406和HLA-B * 51新的外显子2和外显子3的序列和等位基因HLA-DRB1 * 0820，HLA-DRB1 * 04新和HLA- DRB4 * 01新公开。 本发明涉及所述等位基因的分型方法。 根据优选实施方案，所述分型包括以下步骤：i）使用至少一对合适的引物扩增所述等位基因的相关片段; ii）将步骤i）的扩增产物杂交至至少一种与所述相关片段中包含一个或多个多核苷酸的靶区域特异性杂交的探针; iii）从步骤ii）的结果确定样品中不存在或存在所述等位基因。 本发明还提供了用于所述打字方法的引物和探针。 包含所述引物和探针的诊断试剂盒也是本发明的一部分。

    Methylated, SmD homologous peptides, reactive with the antibodies from sera of living beings affected with systemic lupus erythematosus
    5.
    发明申请
    Methylated, SmD homologous peptides, reactive with the antibodies from sera of living beings affected with systemic lupus erythematosus 审中-公开
    甲基化，SmD同源肽与受系统性红斑狼疮影响的生物血清的抗体反应

    公开(公告)号：US20020165355A1

    公开(公告)日：2002-11-07

    申请号：US10056407

    申请日：2002-01-24

    申请人： INNOGENETICS N.V.

    发明人： Lydie Meheus ,  Reinhard Georg Luhrmann ,  Ann Union ,  Joseph Raymackers

    IPC分类号： C07K001/00 ,  C07K014/00 ,  C07K017/00

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/001 ,  C07K14/4713 ,  C07K14/525 ,  C07K2319/00

    摘要： The present invention relates to a method of producing certain peptides containing methylated arginines that are followed by a glycine residue and that constitute immunogenic determinants of antibodies present in sera from patients with systemic lupus erythematosus, or Epstein-Barr virus and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said peptides for diagnosis and treatment of systemic lupus erythematosus and related diseases, and diseases in which Epstein-Barr virus has been implicated.

    摘要翻译： 本发明涉及一种生产含有甲基化精氨酸的某些肽，其后面是甘氨酸残基并且构成存在于患有系统性红斑狼疮或爱泼斯坦 - 巴尔病毒的患者的血清中的抗体的免疫原性决定簇的方法，其中甲基化是先决条件 用于与所述抗体反应。 本发明还涉及所述肽用于诊断和治疗系统性红斑狼疮及相关疾病以及涉及爱泼斯坦 - 巴尔病毒的疾病的用途。

    DETECTION, IDENTIFICATION AND DIFFERENTIATION OF SERRATIA SPECIES USING THE SPACER REGION
    6.
    发明申请
    DETECTION, IDENTIFICATION AND DIFFERENTIATION OF SERRATIA SPECIES USING THE SPACER REGION 审中-公开

    公开(公告)号：US20130177910A1

    公开(公告)日：2013-07-11

    申请号：US13788676

    申请日：2013-03-07

    申请人： Innogenetics N.V. ,  Roche Diagnostics GMBH

    发明人： Geert JANNES ,  Wouter Mijs ,  Thomas Emrich ,  Gerd Haberhausen

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  Y10T436/143333

    摘要： The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S rRNA genes, to be used for the specific detection and/or identification of Serratia species, in particular of Serratia marcescens, Serratia ficaria and/or Serratia fonticola, in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Serratia species, in particular Serratia marcescens, Serratia ficaria and/or Serratia fonticola, using said new nucleic acid sequences derived from the ITS region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Serratia species in a sample.

    Process for typing of HCV isolates
    7.
    发明申请
    Process for typing of HCV isolates 失效
    HCV分离株的分型方法

    公开(公告)号：US20040191768A1

    公开(公告)日：2004-09-30

    申请号：US10822711

    申请日：2004-04-13

    申请人： INNOGENETICS, S.A.

    发明人： Geert Maertens ,  Lieven Stuyver ,  Rudi Rossau ,  Hugo Van Heuverswyn

    IPC分类号： C12Q001/70

    CPC分类号： C12Q1/707 ,  C12Q1/6834 ,  C12Q2563/131 ,  C12Q2545/101 ,  C12Q2525/101 ,  C12Q2531/113

    摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position null291 to nucleotide at position null66 of the 5null untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes, detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.

    摘要翻译： 本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤： 如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，其中所述编号的位置开始于编码HCV多蛋白的开放阅读框的第一个ATG密码子，或与所述探针 与上述定义的探针互补，检测可能形成在所述探针与H的核苷酸序列之间的复合物 CV分离鉴定。

    Monoclonal antibodies specific for PHF-TAU, hybridomas secreting them, antigen recognition by these antibodies and their applications
    9.
    发明申请
    Monoclonal antibodies specific for PHF-TAU, hybridomas secreting them, antigen recognition by these antibodies and their applications 审中-公开
    对PHF-TAU特异性的单克隆抗体，分泌它们的杂交瘤，这些抗体的抗原识别及其应用

    公开(公告)号：US20040038430A1

    公开(公告)日：2004-02-26

    申请号：US10641416

    申请日：2003-08-14

    申请人： Innogenetics N.V.

    发明人： Marc Vandermeeren ,  Eugeen Vanmechelen ,  Andre Van De Voorde

    IPC分类号： G01N033/543 ,  C07K016/18

    CPC分类号： C07K16/18 ,  C07K14/4711

    摘要： The present invention relates more particularly to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to abnormally phosphorylated tau (PHF-tau) residing in the region spanning positions (143-254), and with said monoclonal antibody being characterized by the fact that it is capable of specifically detecting abnormally phosphorylated tau protein (PHF-tau) in cerebrospinal fluid (CSF).

    摘要翻译： 本发明更具体地涉及与位于跨越位置区域（143-254）的属于异常磷酸化tau（PHF-τ）的抗原的磷酸化表位形成免疫复合物的单克隆抗体，并且所述单克隆抗体是 其特征在于其能够特异性检测脑脊液（CSF）中的异常磷酸化tau蛋白（PHF-tau）。

    Process for typing HCV isolates
    10.
    发明申请
    Process for typing HCV isolates 失效
    分离HCV分离株的方法

    公开(公告)号：US20030036053A1

    公开(公告)日：2003-02-20

    申请号：US09899044

    申请日：2001-07-06

    申请人： Innogenetics N.V.

    发明人： Geert Maertens ,  Lieven Stuyver ,  Rudi Rossau ,  Hugo Van Heuverswyn

    IPC分类号： C12Q001/70 ,  C12Q001/68

    CPC分类号： C12Q1/707 ,  C12Q1/6834 ,  C12Q2563/131 ,  C12Q2545/101 ,  C12Q2525/101 ,  C12Q2531/113

    摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position null291 to nucleotide at position null66 of the 5null untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes, detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.

    摘要翻译： 本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤： 如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，其中所述编号的位置开始于编码HCV多蛋白的开放阅读框的第一个ATG密码子，或与所述探针 与上述定义的探针互补，检测可能形成在所述探针与H的核苷酸序列之间的复合物 CV分离鉴定。